sebacic acid
1,10-decanedioic acid
 
Notes:
Sebacic acid is a saturated, straight-chain naturally occurring dicarboxylic acid with 10 carbon atoms. Sebacic acid is a normal urinary acid. In patients with multiple acyl-CoA-dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII) are a group of metabolic disorders due to deficiency of either electron transfer flavoprotein or electron transfer flavoprotein ubiquinone oxidoreductase, biochemical data shows an increase in urine sebacic acid excretion. Sebacic acid is a white flake or powdered crystal slightly soluble in water that has been proposed as an alternative energy substrate in total parenteral nutrition. Sebacic Acid was named from the Latin sebaceus (tallow candle) or sebum (tallow) in reference to its use in the manufacture of candles. Sebacic Acid and its derivatives such as azelaic acid have a variety of industrial uses as plasticizers, lubricants, hydraulic fluids, cosmetics, candles, etc. It is used in the synthesis of polyamide and alkyd resins. It is also used as an intermediate for aromatics, antiseptics and painting materials. (PMID: 10556649, 1738216, 8442769, 12706375) [HMDB]
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decanedioic acid (Click)
CAS Number: 111-20-6Picture of molecule
ECHA EINECS - REACH Pre-Reg: 203-845-5
FDA UNII: 97AN39ICTC
Nikkaji Web: J10.109E
Beilstein Number: 1210591
MDL: MFCD00004440
XlogP3: 2.10 (est)
Molecular Weight: 202.25026000
Formula: C10 H18 O4
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: buffering agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Google Patents: Search
US Patents: Search
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Pubchem Patents: Search
PubMed: Search
NCBI: Search
DG SANTE Food Contact Materials: sebacic acid
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Physical Properties:
Appearance: white granular powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 130.80 °C. @ 760.00 mm Hg
Boiling Point: 364.00 to  365.00 °C. @ 760.00 mm Hg
Boiling Point: 235.00 to  234.00 °C. @ 10.00 mm Hg
Flash Point: 389.00 °F. TCC ( 198.30 °C. ) (est)
logP (o/w): 1.706 (est)
Soluble in:
 water, 1000 mg/L @ 20 °C (exp)
 water, 1420 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: buffering agents
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Suppliers:
Aceto
Sebacic Acid
Acme-Hardesty
Sebacic Acid
Odor: characteristic
Use: Grease Additive, Corrosion Inhibitor, Alkyl Resins and Intermediate for Nylon and Polyamides.
Coompo
For experimental / research use only.
Decanedioic Acid from Plants ≥96%
Covalent Chemical
Sebacic Acid
Graham Chemical
Sebacic Acid
Penta International
SEBACIC ACID
Sigma-Aldrich: Aldrich
For experimental / research use only.
Sebacic acid 99%
Silver Fern Chemical
Sebacic Acid
Odor: characteristic
Use: In its purest form, Sebacic Acid is a powdered crystal or white flaky substance. It’s a naturally occurring dicarboxylic acid that is non-hazardous, though it can be vulnerable to flash ignition in its powder form. One of the most common uses for sebacic acid is in the manufacturing of candles. Sebacic acid also shows up in the industrial industry, being used as a monomer and intermediate for various products and materials.
SysKem Chemie
Sebacic Acid Granulate
SysKem Chemie
Sebacic Acid, Powder
Universal Preserv-A-Chem Inc.
SEBACIC ACID TECH GRADE
Odor: characteristic
Use: In the industrial setting, sebacic acid and its homologues such as azelaic acid can be used as a monomer for nylon 610, plasticizers, lubricants, hydraulic fluids, cosmetics, candles, etc. Sebacic acid is also used as an intermediate for aromatics, antiseptics, and painting materials.
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mammal (species unspecified) LD50  1175 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(5), Pg. 48, 1980.

oral-mammal (species unspecified) LD50  > 11000 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(9), Pg. 72, 1983.

intraperitoneal-mouse LD50  500 mg/kg
National Technical Information Service. Vol. AD277-689

oral-mouse LD50  6000 mg/kg
Biochemical Journal. Vol. 34, Pg. 1196, 1940.

oral-rat LD50  14375 mg/kg
BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: EXCITEMENT BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(2), Pg. 17, 1992.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
inhalation-mammal (species unspecified) LC > 900 mg/m3
BEHAVIORAL: EXCITEMENT SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(5), Pg. 48, 1980.

inhalation-rat LC50 > 4500 mg/m3
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(2), Pg. 17, 1992.

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Safety in Use Information:
Category: buffering agents
Recommendation for sebacic acid usage levels up to:
 not for fragrance use.
 
Recommendation for sebacic acid flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
NIOSH International Chemical Safety Cards: search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 111-20-6
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 5192
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 decanedioic acid
Chemidplus: 0000111206
EPA/NOAA CAMEO: hazardous materials
RTECS: 111-20-6
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References:
 decanedioic acid
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 111-20-6
Pubchem (cid): 5192
Pubchem (sid): 134974869
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
KEGG (GenomeNet): C08277
HMDB (The Human Metabolome Database): HMDB00792
FooDB: FDB022247
Export Tariff Code: 2917.13.0000
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 buffering agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 decanedioic acid
1,10-decanedioic acid
1,8-dicarboxyoctane
 ipomic acid
1,8-octanedicarboxylic acid
 sebacicacid
 seracic acid
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Articles:
PubMed: From zero to hero - Production of bio-based nylon from renewable resources using engineered Corynebacterium glutamicum.
PubMed: Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model.
PubMed: Synthesis and Biological Evaluation of 5'-O-Dicarboxylic Fatty Acyl Monoester Derivatives of Anti-HIV Nucleoside Reverse Transcriptase Inhibitors.
PubMed: The battle for the "green" polymer. Different approaches for biopolymer synthesis: bioadvantaged vs. bioreplacement.
PubMed: In vitro release of model compounds with different hydrophilicity from poly(ester-anhydride) microspheres.
PubMed: Metabonomic analysis of quercetin against the toxicity of chronic exposure to low-level dichlorvos in rats via ultra-performance liquid chromatography-mass spectrometry.
PubMed: Characterization and optimization of glycerol/sebacate ratio in poly(glycerol-sebacate) elastomer for cell culture application.
PubMed: Antimicrobial activity of untypical lipid compounds in the cuticular and internal lipids of four fly species.
PubMed: Sustained delivery of a HIF-1 antagonist for ocular neovascularization.
PubMed: Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke.
PubMed: Functionalization of polyanhydride microparticles with di-mannose influences uptake by and intracellular fate within dendritic cells.
PubMed: Retention of structure, antigenicity, and biological function of pneumococcal surface protein A (PspA) released from polyanhydride nanoparticles.
PubMed: Calcium-deficiency assessment and biomarker identification by an integrated urinary metabonomics analysis.
PubMed: Multistep enzymatic synthesis of long-chain α,ω-dicarboxylic and ω-hydroxycarboxylic acids from renewable fatty acids and plant oils.
PubMed: Repair of bile duct defect with degradable stent and autologous tissue in a porcine model.
PubMed: Evaluation of poly (1, 6-bis-(p-carboxyphenoxy) hexane-co-sebacic acid microspheres for controlled basal insulin delivery.
PubMed: Harvesting murine alveolar macrophages and evaluating cellular activation induced by polyanhydride nanoparticles.
PubMed: Chemistry-dependent adsorption of serum proteins onto polyanhydride microparticles differentially influences dendritic cell uptake and activation.
PubMed: Synthesis of elastic biodegradable polyesters of ethylene glycol and butylene glycol from sebacic acid.
PubMed: Thermosensitive hydrogel based on poly(ether-ester anhydride) nanoparticle as drug delivery system: preparation, characterization and biocompatibility.
PubMed: Use of dicarboxylic acids in type 2 diabetes.
PubMed: One type of novel thermosensitive polymeric micelles.
PubMed: [Floppy female infant with congenital hydrocephalus, hepatic dysfunction and refractory convulsions].
PubMed: Sebacic and succinic acid derived plasticised PVC for the inhibition of biofouling in its initial stages.
PubMed: Synthesis and characterization of hydrolytically degradable copolyester biomaterials based on glycolic acid, sebacic acid and ethylene glycol.
PubMed: Kinetics of monomer biodegradation in soil.
PubMed: Biocompatibility and biodegradation of polycaprolactone-sebacic acid blended gels.
PubMed: Organo/layered double hydroxide nanohybrids used to remove non ionic pesticides.
PubMed: Injectable biodegradable polycaprolactone-sebacic acid gels for bone tissue engineering.
PubMed: Host-guest interactions between a nonmicellized amphiphilic invertible polymer and insoluble cyclohexasilane in acetonitrile.
PubMed: Study of the GC-MS determination of the palmitic-stearic acid ratio for the characterisation of drying oil in painting: La Encarnación by Alonso Cano as a case study.
PubMed: Atomic layer deposition of organic-inorganic hybrid materials based on saturated linear carboxylic acids.
PubMed: Polyanhydride microparticles enhance dendritic cell antigen presentation and activation.
PubMed: Easy fabrication and morphology control of supramolecular liquid-crystalline polymer microparticles.
PubMed: Biobased poly(propylene sebacate) as shape memory polymer with tunable switching temperature for potential biomedical applications.
PubMed: Direct electrospray ionization mass spectrometry quantitative analysis of sebacic and terephthalic acids in biodegradable polymers.
PubMed: Fatty acids derived from royal jelly are modulators of estrogen receptor functions.
PubMed: Preparation and characterization of biodegradable electrospun polyanhydride nano/microfibers.
PubMed: Six weeks' sebacic acid supplementation improves fasting plasma glucose, HbA1c and glucose tolerance in db/db mice.
PubMed: Bioconjugate functionalization of thermally carbonized porous silicon using a radical coupling reaction.
PubMed: Protein adsorption on biodegradable polyanhydride microparticles.
PubMed: Effect of oral sebacic Acid on postprandial glycemia, insulinemia, and glucose rate of appearance in type 2 diabetes.
PubMed: Retinal transplantation using surface modified poly(glycerol-co-sebacic acid) membranes.
PubMed: In vivo biodegradation and biocompatibility of PEG/sebacic acid-based hydrogels using a cage implant system.
PubMed: Zero-order controlled release of ciprofloxacin-HCl from a reservoir-based, bioresorbable and elastomeric device.
PubMed: Biodegradable xylitol-based elastomers: in vivo behavior and biocompatibility.
PubMed: Osteoblast biocompatibility on poly(octanediol citrate)/sebacate elastomers with controlled wettability.
PubMed: Development of delivery methods for carbohydrate-based drugs: controlled release of biologically-active short chain fatty acid-hexosamine analogs.
PubMed: Thermosensitive micelles from PEG-based ether-anhydride triblock copolymers.
PubMed: A functionalizable polyester with free hydroxyl groups and tunable physiochemical and biological properties.
PubMed: Encapsulation into amphiphilic polyanhydride microparticles stabilizes Yersinia pestis antigens.
PubMed: Exploring chain length selectivity in HIC-catalyzed polycondensation reactions.
PubMed: Polyoctanediol citrate/sebacate bioelastomer films: surface morphology, chemistry and functionality.
PubMed: Tailoring the mechanical properties of 3D-designed poly(glycerol sebacate) scaffolds for cartilage applications.
PubMed: μ-Decane-dioato-bis-[aqua-bis-(1,10-phenanthroline-κN,N')manganese(II)] dinitrate-sebacic acid-water (1/1/2).
PubMed: The use of surface modified poly(glycerol-co-sebacic acid) in retinal transplantation.
PubMed: Novel, high throughput method to study in vitro protein release from polymer nanospheres.
PubMed: Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier.
PubMed: Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo.
PubMed: Epirubicin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers.
PubMed: Breath-by-breath measurement of particle deposition in the lung of spontaneously breathing rats.
PubMed: Effect of polymer chemistry and fabrication method on protein release and stability from polyanhydride microspheres.
PubMed: The simultaneous effect of polymer chemistry and device geometry on the in vitro activation of murine dendritic cells.
PubMed: High throughput cell-based screening of biodegradable polyanhydride libraries.
PubMed: Evaluation of polyanhydride microspheres for basal insulin delivery: Effect of copolymer composition and zinc salt on encapsulation, in vitro release, stability, in vivo absorption and bioactivity in diabetic rats.
PubMed: A new injectable thermogelling material: methoxy poly(ethylene glycol)-poly(sebacic acid-D,L-lactic acid)-methoxy poly(ethylene glycol) triblock co-polymer.
PubMed: Local controlled delivery of anti-neoplastic RNAse to the brain.
PubMed: Efficacy of poly(sebacic acid-co-ricinoleic acid) biodegradable delivery system for intratumoral delivery of paclitaxel.
PubMed: Potential of hydrogels based on poly(ethylene glycol) and sebacic acid as orthopedic tissue engineering scaffolds.
PubMed: Three-dimensional porous biodegradable polymeric scaffolds fabricated with biodegradable hydrogel porogens.
PubMed: Biocompatibility and safety evaluation of a ricinoleic acid-based poly(ester-anhydride) copolymer after implantation in rats.
PubMed: In vitro and in vivo degradation of poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) elastomers.
PubMed: Polymer chemistry influences monocytic uptake of polyanhydride nanospheres.
PubMed: Biodegradable poly(polyol sebacate) polymers.
PubMed: Mechanism of hydrolysis of dicholine esters with long polymethylene chain by human butyrylcholinesterase.
PubMed: Development of biodegradable and injectable macromers based on poly(ethylene glycol) and diacid monomers.
PubMed: Modulation of protein release from photocrosslinked networks by gelatin microparticles.
PubMed: Polymeric particles conjugated with a ligand to VCAM-1 exhibit selective, avid, and focal adhesion to sites of atherosclerosis.
PubMed: Photocrosslinked anhydride systems for long-term protein release.
PubMed: Amino alcohol-based degradable poly(ester amide) elastomers.
PubMed: Structural characterization of synthetic poly(ester amide) from sebacic acid and 4-amino-1-butanol by matrix-assisted laser desorption ionization time-of-flight/time-of-flight tandem mass spectrometry.
PubMed: Synthesis and evaluation of novel biodegradable hydrogels based on poly(ethylene glycol) and sebacic acid as tissue engineering scaffolds.
PubMed: Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate (MDI): impact of vehicle for topical induction.
PubMed: Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue.
PubMed: In vitro degradation characteristics of photocrosslinked anhydride systems for bone augmentation applications.
PubMed: Synthesis and characterization of photocurable elastomers from poly(glycerol-co-sebacate).
PubMed: Hydroxy fatty acid based polyanhydride as drug delivery system: synthesis, characterization, in vitro degradation, drug release, and biocompatibility.
PubMed: Pulsatile release of parathyroid hormone from an implantable delivery system.
PubMed: Preparation and degradation behavior of polyanhydrides nanoparticles.
PubMed: Synthesis and erosion properties of PEG-containing polyanhydrides.
PubMed: Synthesis of poly(sebacic anhydride)-indomethacin controlled release composites via supercritical carbon dioxide assisted impregnation.
PubMed: Solid-state preparation of hybrid organometallic-organic macrocyclic adducts with long chain dicarboxylic acids.
PubMed: Microspheres from new biodegradable poly(ester amide)s with different ratios of L- and D-alanine for controlled drug delivery.
PubMed: Synthesis and monoamine transporter binding properties of 2,3-cyclo analogues of 3beta-(4'-aminophenyl)-2beta-tropanemethanol.
PubMed: Copolymers of pharmaceutical grade lactic acid and sebacic acid: drug release behavior and biocompatibility.
PubMed: Intracranial drug-delivery scaffolds: biocompatibility evaluation of sucrose acetate isobutyrate gels.
PubMed: Lactacystin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers.
PubMed: Influence of PEG endgroup and molecular weight on its reactivity for lipase-catalyzed polyester synthesis.
PubMed: [GC-MS analysis of the fatty components of pollen Typhae before and after being carbonized].
PubMed: Protein stability in the presence of polymer degradation products: consequences for controlled release formulations.
PubMed: Poly(sebacic acid-co-ricinoleic acid) biodegradable injectable in situ gelling polymer.
PubMed: Single dose vaccine based on biodegradable polyanhydride microspheres can modulate immune response mechanism.
PubMed: Investigation into the erosion mechanism of salicylate-based poly(anhydride-esters).
PubMed: Local delivery of a synthetic endostatin fragment for the treatment of experimental gliomas.
PubMed: Novel copolyanhydrides combining strong inherent fluorescence and a wide range of biodegradability: synthesis, characterization and in vitro degradation.
PubMed: Sequence determination in aliphatic poly(ester amide)s by matrix-assisted laser desorption/ionization time-of-flight and time-of-flight/time-of-flight tandem mass spectrometry.
PubMed: Hydrolytic degradation of ricinoleic-sebacic-ester-anhydride copolymers.
PubMed: Poly(sebacic acid-co-ricinoleic acid) biodegradable carrier for paclitaxel--effect of additives.
PubMed: Synthesis and characterization of polyanhydride for local BCNU delivery carriers.
PubMed: [Spectroscopy studies on the interaction of bis(p-nitrophenyl) esters and beta-cyclodextrin].
PubMed: D-Serine-induced nephrotoxicity: a HPLC-TOF/MS-based metabonomics approach.
PubMed: [Search for yeast producers of brassylic and sebacic fatty acids].
PubMed: Effect of postmolding heat treatment on in vitro properties of a polyanhydride implant containing gentamicin sulfate.
PubMed: Poly(ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs.
PubMed: Poly[[aquaneodymium(III)]-micro(3)-decane-1,10-dicarboxylato-micro(3)-9-carboxynonanecarboxylato].
PubMed: Poly(sebacic acid-co-ricinoleic acid) biodegradable carrier for paclitaxel: in vitro release and in vivo toxicity.
PubMed: Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam radiotherapy.
PubMed: Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma.
PubMed: Simultaneous enantioselective analysis of chiral urinary metabolites in patients with Zellweger syndrome.
PubMed: In vivo degradation characteristics of poly(glycerol sebacate).
PubMed: Lipase-catalyzed polycondensations: effect of substrates and solvent on chain formation, dispersity, and end-group structure.
PubMed: In vitro release and antibacterial activity of poly (oleic/linoleic acid dimer: sebacic acid)-gentamicin.
PubMed: Biodegradable micelles/polymersomes from fumaric/sebacic acids and poly(ethylene glycol).
PubMed: Tumor treatment by sustained intratumoral release of 5-fluorouracil: effects of drug alone and in combined treatments.
PubMed: Crystalline and dynamic mechanical behaviors of synthesized poly(sebacic anhydride-co-ethylene glycol).
PubMed: The effect of storage temperatures on the in vitro properties of a polyanhydride implant containing gentamicin.
PubMed: New polymeric carriers for controlled drug delivery following inhalation or injection.
PubMed: A novel polyethylene depot device for the study of PLGA and P(FASA) microspheres in vitro and in vivo.
PubMed: Stereocomplexes of enantiomeric lactic acid and sebacic acid ester-anhydride triblock copolymers.
PubMed: Pharmacokinetics of the carmustine implant.
PubMed: A tough biodegradable elastomer.
PubMed: Phase behavior and miscibility in blends of poly(sebacic anhydride)/poly(ethylene glycol).
PubMed: Novel fluorescent copolyanhydrides as potential visible matrices for drug delivery.
PubMed: Efficacy of BCNU and paclitaxel loaded subcutaneous implants in the interstitial chemotherapy of U-87 MG human glioblastoma xenografts.
PubMed: Static and dynamic light scattering approach to the hydration of hemoglobin and its supertetramers in the presence of osmolites.
PubMed: Nonlinear fatty acid terminated polyanhydrides.
PubMed: Gamma-irradiation stability of saturated and unsaturated aliphatic polyanhydrides--ricinoleic acid based polymers.
PubMed: The lock-in phase in the urotropine-sebacic acid system.
PubMed: IUdR polymers for combined continuous low-dose rate and high-dose rate sensitization of experimental human malignant gliomas.
PubMed: Effects of aliphatic dioic acids and glycerol-1,2,3-tris(dodecanedioate) on D-glucose-stimulated insulin release in rat pancreatic islets.
PubMed: FTIR-ATR spectroscopy for monitoring polyanhydride/anhydride-amine reactions.
PubMed: Sustained-release butorphanol microparticles.
PubMed: [Synthesis of dicarboxylic esters by lipase].
PubMed: Synthetic, implantable polymers for IUdR radiosensitization of experimental human malignant glioma.
PubMed: Synthetic, implantable, biodegradable polymers for controlled release of radiosensitizers.
PubMed: Pharmacokinetics of sebacic acid in rats.
PubMed: Investigation of the in vitro release of gentamicin from a polyanhydride matrix.
PubMed: A new HPLC method for the direct analysis of triglycerides of dicarboxylic acids in biological samples.
PubMed: Implantable polymers for tirapazamine treatments of experimental intracranial malignant glioma.
PubMed: Tumor radiosensitization by sustained intratumoral release of bromodeoxyuridine.
PubMed: A GC/MS/MS screening method for multiple organic acidemias from urine specimens.
PubMed: Ricinoleic acid-based biopolymers.
PubMed: Crosslinked polyanhydrides for use in orthopedic applications: degradation behavior and mechanics.
PubMed: Poly(fumaric-co-sebacic anhydride). A degradation study as evaluated by FTIR, DSC, GPC and X-ray diffraction.
PubMed: Biodegradable products by lipase biocatalysis.
PubMed: Influence of Three Contrasting Detrital Carbon Sources on Planktonic Bacterial Metabolism in a Mesotrophic Lake.
PubMed: Synthetic, implantable polymers for local delivery of IUdR to experimental human malignant glioma.
PubMed: Degradation of porous poly(anhydride-co-imide) microspheres and implications for controlled macromolecule delivery.
PubMed: Gas chromatography-mass spectrometric method for quantitative determination in human urine of dicarboxylic (dioic) acids produced in the body as a consequence of cholesterol biosynthesis inhibition.
PubMed: Effect of fabrication technique on the erosion characteristics of polyanhydride matrices.
PubMed: Entropy-driven intermediate steps of oxygenation may regulate the allosteric behavior of hemoglobin.
PubMed: Surface modification of polyanhydride microspheres.
PubMed: Alpha-subunit oxidation in T-state crystals of a sebacyl cross-linked human hemoglobin with unusual autoxidation properties.
PubMed: Tumor treatment by sustained intratumoral release of cisplatin: effects of drug alone and combined with radiation.
PubMed: Controlled protein delivery from biodegradable tyrosine-containing poly(anhydride-co-imide) microspheres.
PubMed: Implantable biodegradable polymers for IUdR radiosensitization of experimental human malignant glioma.
PubMed: Biologically erodable microspheres as potential oral drug delivery systems.
PubMed: Treatment of experimental osteomyelitis by surgical debridement and the implantation of bioerodable, polyanhydride-gentamicin beads.
PubMed: Erosion of composite polymer matrices.
PubMed: Optimizing interstitial delivery of BCNU from controlled release polymers for the treatment of brain tumors.
PubMed: Mechanisms for the transport of alpha,omega-dicarboxylates through the mitochondrial inner membrane.
PubMed: Production and characteristics of an infusible oxygen-carrying fluid based on hemoglobin intramolecularly cross-linked with sebacic acid.
PubMed: Morphological characterization of polyanhydride biodegradable implant gliadel during in vitro and in vivo erosion using scanning electron microscopy.
PubMed: In vitro bone biocompatibility of poly (anhydride-co-imides) containing pyromellitylimidoalanine.
PubMed: Interstitial delivery of carboplatin via biodegradable polymers is effective against experimental glioma in the rat.
PubMed: Cytotoxicity testing of poly(anhydride-co-imides) for orthopedic applications.
PubMed: Excretion of a radiolabelled anticancer biodegradable polymeric implant from the rabbit brain.
PubMed: Polymethylene spacer linked bis(Ala) peptides form modified beta-sheet structures. Crystal structure and self-assembly pattern of adipoyl and suberoyl analogues.
PubMed: Dicarboxylic acids, an alternate fuel substrate in parenteral nutrition: an update.
PubMed: Effectiveness of controlled release of a cyclophosphamide derivative with polymers against rat gliomas.
PubMed: Intramolecular cross-linking of oxy hemoglobin by bis sulfosuccinimidyl suberate and sebacate: generation of cross-linked hemoglobin with reduced oxygen affinity.
PubMed: Erosion of a new family of biodegradable polyanhydrides.
PubMed: Polymer delivery of chemotherapy for squamous cell carcinoma of the head and neck.
PubMed: Dicarboxylic acids affect the growth of dermatophytes in vitro.
PubMed: Metabolic disposition and elimination studies of a radiolabelled biodegradable polymeric implant in the rat brain.
PubMed: Chemical interactions between drugs containing reactive amines with hydrolyzable insoluble biopolymers in aqueous solutions.
PubMed: Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma.
PubMed: A study of urinary metabolites in patients with dicarboxylic aciduria for differential diagnosis.
PubMed: In vivo versus in vitro degradation of controlled release polymers for intracranial surgical therapy.
PubMed: Biodegradable polymers for controlled delivery of chemotherapy with and without radiation therapy in the monkey brain.
PubMed: Dicarboxylic acids and glucose utilization in humans: effect of sebacate.
PubMed: Injectable polyanhydride granules provide controlled release of water-soluble drugs with a reduced initial burst.
PubMed: Design, synthesis, and preliminary characterization of tyrosine-containing polyarylates: new biomaterials for medical applications.
PubMed: Pharmacokinetics of etoposide delivery by a bioerodible drug carrier implanted at glaucoma surgery.
PubMed: Controlled release of macromolecules from a degradable polyanhydride matrix.
PubMed: Excretion of 3,6-epoxydicarboxylic acids in peroxisomal disorders.
PubMed: Sustained local anesthetic release from bioerodible polymer matrices: a potential method for prolonged regional anesthesia.
PubMed: Prolonged regional nerve blockade by controlled release of local anesthetic from a biodegradable polymer matrix.
PubMed: Effects of Cy to sine Arabino side-Impregnated Bioerodible Polymers on Glaucoma Filtration Surgery in Rabbits.
PubMed: Kinetics and thermogenesis of medium-chain monocarboxylic and dicarboxylic acids in man: sebacate and medium-chain triglycerides.
PubMed: Controlled delivery systems for proteins using polyanhydride microspheres.
PubMed: Bioerodible polyanhydrides for antibiotic drug delivery: in vivo osteomyelitis treatment in a rat model system.
PubMed: Polyanhydride microspheres that display near-constant release of water-soluble model drug compounds.
PubMed: Sebacic acid binding to human plasma albumin.
PubMed: Controlled antibody delivery systems.
PubMed: Dextran retention in the rat brain following release from a polymer implant.
PubMed: Molecular weight changes in polymer erosion.
PubMed: The intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers.
PubMed: [Toxicological characteristics of sebacic acid and the substantiation of its maximum permissible exposure level in atmospheric air].
PubMed: Use of even-numbered carbon atom dicarboxylic salts in parenteral nutrition as fuel substrate.
PubMed: Metabolic effects and disposition of sebacate, an alternate dicarboxylic fuel substrate.
PubMed: Azelaic and pimelic acids: metabolic intermediates or artefacts?
PubMed: Tracer study of metabolism and tissue distribution of sebacic acid in rats.
PubMed: In vitro release of hydrophobic drugs from polyanhydride disks.
PubMed: Tissue uptake and oxidation of disodium sebacate in man.
PubMed: [Toxicity of bis(2-methoxyethyl)ether of sebacic acid].
PubMed: Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas.
PubMed: Polymers to treat brain tumours.
PubMed: Polyanhydrides. V. Branched polyanhydrides.
PubMed: Biodegradable polymers derived from amino acids.
PubMed: Marking the rhizopseudomonas strain 7NSK2 with a Mu d(lac) element for ecological studies.
PubMed: Toxicity of disodium sebacate.
PubMed: Intracerebral drug delivery in rats with lesion-induced memory deficits.
PubMed: [Use of sebacic acid for identifying anaerobic bacteria using gas phase chromatography].
PubMed: Brain biocompatibility of a biodegradable, controlled-release polymer in rats.
PubMed: Biocompatibility of a biodegradable, controlled-release polymer in the rabbit brain.
PubMed: [Gas chromatographic detection of sebacic acid in the air].
PubMed: The use of bioerodible polymers and 5-fluorouracil in glaucoma filtration surgery.
PubMed: Influence of sodium salts of saturated medium chain length (C6, C9, C10 and C12) dicarboxylic acids on the uterine horn of rat in vitro.
PubMed: The influence of i.v. MCT and carnitine on the excretion of dicarboxylic acids.
PubMed: Glaucoma filtration surgery in rabbits using bioerodible polymers and 5-fluorouracil.
PubMed: Effects of fatty acids on membrane currents in the squid giant axon.
PubMed: The influence of intravenous medium- and long-chain triglycerides and carnitine on the excretion of dicarboxylic acids.
PubMed: [Dicarboxylic acids inhibit the growth of keratinocytes in vitro].
PubMed: Mass spectrometric identification of 2-hydroxy-sebacic acid in the urines of patients with neonatal adrenoleukodystrophy and Zellweger syndrome.
PubMed: In vitro studies on the oxidation of medium-chain dicarboxylic acids in rat liver.
PubMed: Bioerodible polyanhydrides as drug-carrier matrices. II. Biocompatibility and chemical reactivity.
PubMed: Effect of fatty acids on aflatoxin production by Aspergillus parasiticus.
PubMed: [Comparative evaluation of the action of oxythiamine and its derivatives on animals with Erhlich's ascitic cancer].
PubMed: [Use of a method of accelerated hygienic standardization for the chemical content in reservoir water exemplified by adipic and sebacic acids].
PubMed: [Environmental hygiene in the production of aliphatic dicarbonic acids].
PubMed: Urinary excretion of dicarboxylic acids from patients with the Zellweger syndrome. Importance of peroxisomes in beta-oxidation of dicarboxylic acids.
PubMed: [Determination of sebacic acid dimethyl ester in natural and sewage waters by the gas-chromatographic method].
PubMed: Prenatal diagnosis of glutaric aciduria type II by direct chemical analysis of dicarboxylic acids in amniotic fluid.
PubMed: On the effect of aliphatic saturated dicarboxylic acids on anaerobic glycolysis in chicken embryo.
PubMed: On the biologic origin of C6-C10-dicarboxylic and C6-C10-omega-1-hydroxy monocarboxylic acids in human and rat with acyl-CoA dehydrogenation deficiencies: in vitro studies on the omega- and omega-1-oxidation of medium-chain (C6-C12) fatty acids in human and rat liver.
PubMed: [Health standardization of sebacic and adipic acids in water reservoirs].
PubMed: General (medium-chain) acyl-CoA dehydrogenase deficiency (non-ketotic dicarboxylic aciduria): quantitative urinary excretion pattern of 23 biologically significant organic acids in three cases.
PubMed: [Determination of sebacic acid in natural water and sewage].
PubMed: The biological origin of ketotic dicarboxylic aciduria. II. In vivo and in vitro investigations of the beta-oxidation of C8-C16-dicarboxylic acids in unstarved, starved and diabetic rats.
PubMed: Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice.
PubMed: C6-C10-dicarboxylic aciduria: biochemical considerations in relation to diagnosis of beta-oxidation defects.
PubMed: C6--C10-dicarboxylic aciduria in starved, fat-fed and diabetic rats receiving decanoic acid or medium-chain triacylglycerol. An in vivo measure of the rate of beta-oxidation of fatty acids.
PubMed: Urinary excretion of C4--C10-dicarboxylic acids and antiketogenic properties of adipic acid in ketogenic-stimulated rats due to diabetes, long-chain and short-chain monocarboxylic acids.
PubMed: The occurrence of C6--C10-dicarboxylic acids in urine from patients and rats treated with dipropylacetate.
PubMed: [Data for establishing the maximum permissible concentration of sebacic acid in the air of a work area].
PubMed: Non-ketotic C6-C10-dicarboxylic aciduria: biochemical investigations of two cases.
PubMed: Purification and characterization of tubulin-tyrosine ligase from porcine brain.
PubMed: The excretion of C6-C10-dicarboxylic acids in the urine of newborn infants during starvation. Evidence for omega-oxidation of fatty acids in the newborn.
PubMed: Copper metabolism in mottled mouse mutants: copper therapy of brindled (Mobr) mice.
PubMed: [Occupational hygiene in the production of sebacic acid].
PubMed: Suberylglycine excretion in the urine from a patient with dicarboxylic aciduria.
PubMed: [Sanitary working conditions in the production of sebacic acid].
PubMed: DETERMINATION OF STEAM-VOLATILE ORGANIC ACIDS IN FERMENTATION MEDIA BY GAS-LIQUID CHROMATOGRAPHY.
PubMed: [Pharmacology of alpha omega-bis quaternary ammonium compounds; IV. Effects of bis-choline ester of sebacic acid on respiration and blood pressure].
PubMed: High molecular weight hydrocarbons; five new hydrocarbons derived from sebacic acid.
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