EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

scopoletin
2H-1-benzopyran-2-one, 7-hydroxy-6-methoxy- (9CI)

Supplier Sponsors

Name:7-hydroxy-6-methoxychromen-2-one
CAS Number: 92-61-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:202-171-9
FDA UNII: KLF1HS0SXJ
Nikkaji Web:J4.658B
Beilstein Number:0156296
MDL:MFCD00006872
XlogP3-AA:1.50 (est)
Molecular Weight:192.17056000
Formula:C10 H8 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 204.00 °C. @ 760.00 mm Hg
Boiling Point: 413.50 °C. @ 760.00 mm Hg (est)
Flash Point: 342.00 °F. TCC ( 172.40 °C. ) (est)
logP (o/w): 1.280 (est)
Soluble in:
 water, 8879 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Scopoletin 98%
BOC Sciences
For experimental / research use only.
Scopoletin >98%
Odor: characteristic
Use: Scopoletin, that comes from the herbs of Atropa belladonna L, can ameliorate alcohol-induced hepatic lipid accumulation by modulating AMPK-SREBP pathway-mediated lipogenesis in mice fed a high-fat diet.
ExtraSynthese
For experimental / research use only.
Scopoletin (HPLC) ≥95%
Santa Cruz Biotechnology
For experimental / research use only.
Scopoletin ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Scopoletin ≥99%
sds
TCI AMERICA
For experimental / research use only.
Scopoletin >98.0%(HPLC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 350 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 1330, 1968.

oral-rat LD50 3800 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 210, Pg. 27, 1974.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for scopoletin usage levels up to:
 not for fragrance use.
 
Recommendation for scopoletin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5280460
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
7-hydroxy-6-methoxychromen-2-one
Chemidplus:0000092615
RTECS:GN6930000 for cas# 92-61-5
 
References:
 7-hydroxy-6-methoxychromen-2-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5280460
Pubchem (sid):134972356
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C01752
HMDB (The Human Metabolome Database):HMDB34344
FooDB:FDB012705
Export Tariff Code:2932.99.7000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 angelica acutiloba
Search Trop Picture
 anise leaf
Search Trop Picture
 anise seed
Search Trop Picture
 anise tissue culture
Search Trop Picture
 barley plant
Search Trop Picture
 barley protoplast
Search Trop Picture
 bean field bean
Search Trop Picture
 bean field bean
Search Trop Picture
 bean field bean
Search Trop Picture
 bean mung bean
Search Trop Picture
 blueberry plant
Search Trop Picture
 caraway plant
Search Trop Picture
 caraway root
Search Trop Picture
 carrot root
Search Trop Picture
 cayenne fruit
Search Trop Picture
 celery leaf
Search Trop Picture
 chamomile garden chamomile plant
Search Trop Picture
 chicory flower
Search Trop Picture
 chicory plant
Search Trop Picture
 coffee bean
Search Trop Picture
 coriander fruit
Search Trop Picture
 coriander shoot
Search Trop Picture
 dandelion flower
Search Trop Picture
 dill root
Search Trop Picture
 dill seed
Search Trop Picture
 dill seed oil
Search Trop Picture
 dill shoot
Search Trop Picture
 eggplant fruit
Search Trop Picture
 fennel seed
Search Trop Picture
 fig leaf
Search Trop Picture
 goosefoot plant
Search Trop Picture
 leek wild leek plant
Search Trop Picture
 lemon leaf
Search Trop Picture
 lemon shoot
Search Trop Picture
 mugwort plant
Search Trop Picture
 oat root
Search Trop Picture
 oat sprout
Search Trop Picture
 orange
Search Trop Picture
 pepper bell pepper fruit
Search Trop Picture
 potato tuber epidermis
Search Trop Picture
 roselle root bark
Search Trop Picture
 sunflower plant
Search Trop Picture
 tarragon leaf
Search Trop Picture
 tarragon plant
Search Trop Picture
 tarragon shoot
Search Trop Picture
 
Synonyms:
2H-1-benzopyran-2-one, 7-hydroxy-6-methoxy- (9CI)
 chrysatropic acid
 coumarin, 7-hydroxy-6-methoxy-
 escopoletin
 esculetin 6-methyl ether
 gelseminic acid
7-hydroxy-6-methoxy-2H-1-benzopyran-2-one
7-hydroxy-6-methoxychromen-2-one
7-hydroxy-6-methoxycoumarin
6-methoxy-7-hydroxycoumarin
6-methylesculetin
6-O-methylesculetin
beta-methylesculetin
 murrayetin
 scopoletine
 scopoletol
 

Articles:

PubMed:Rapid simultaneous determination of marmelosin, umbelliferone and scopoletin from Aegle marmelos fruit by RP-HPLC.
PubMed:Scopoletin prevents alcohol-induced hepatic lipid accumulation by modulating the AMPK-SREBP pathway in diet-induced obese mice.
PubMed:Inhibition of Orobanche crenata seed germination and radicle growth by allelochemicals identified in cereals.
PubMed:Pentadecyl ferulate, a potent antioxidant and antiproliferative agent from the halophyte Salicornia herbacea.
PubMed:Pre-clinical anti-inflammatory aspects of a cuisine and medicinal millennial herb: Malva sylvestris L.
PubMed:Antioxidant markers based TLC-DPPH differentiation on four commercialized botanical sources of Shankhpushpi (A Medhya Rasayana): A preliminary assessment.
PubMed:[Study on chemical constituents of root bark of Discocleidion rufescens].
PubMed:Antioxidant activity-guided separation of coumarins and lignan from Melicope glabra (Rutaceae).
PubMed:Scopoletin and scopolin isolated from Artemisia iwayomogi suppress differentiation of osteoclastic macrophage RAW 264.7 cells by scavenging reactive oxygen species.
PubMed:Potent α-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris.
PubMed:Identification of polyphenols and their metabolites in human urine after cranberry-syrup consumption.
PubMed:Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation.
PubMed:Aqueous extract of Artemisia iwayomogi Kitamura attenuates cholestatic liver fibrosis in a rat model of bile duct ligation.
PubMed:Scopoletin attenuates allergy by inhibiting Th2 cytokines production in EL-4 T cells.
PubMed:A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit.
PubMed:Changes in scopoletin concentration in cassava chips from four varieties during storage.
PubMed:Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice.
PubMed:Extraction and identification of three major aldose reductase inhibitors from Artemisia montana.
PubMed:Maple syrup phytochemicals include lignans, coumarins, a stilbene, and other previously unreported antioxidant phenolic compounds.
PubMed:Cassava: an appraisal of its phytochemistry and its biotechnological prospects.
PubMed:Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and CCl4- and high-fat diet-treated mice.
PubMed:Phenolic compounds in chestnut (Castanea sativa Mill.) heartwood. Effect of toasting at cooperage.
PubMed:Anti-proliferative and antioxidative activities of Thai noni/Yor (Morinda citrifolia Linn.) leaf extract.
PubMed:Constituents and secondary metabolite natural products in fresh and deteriorated cassava roots.
PubMed:Bioactive metabolites from Spilanthes acmella Murr.
PubMed:[Studies on chemical constituents of Saussurea laniceps].
PubMed:Involvement of limonene hydroperoxides formed after oil gland injury in the induction of defense response against Penicillium digitatum in lemon fruit.
PubMed:Identification of TLC markers and quantification by HPLC-MS of various constituents in noni fruit powder and commercial noni-derived products.
PubMed:New constituents from noni (Morinda citrifolia) fruit juice.
PubMed:Antifungal and antibacterial activities of Mexican tarragon (Tagetes lucida).
PubMed:Biological and physical approaches to improve induced resistance against green mold of stored citrus fruit.
PubMed:Sodium carbonate treatment induces scoparone accumulation, structural changes, and alkalinization in the albedo of wounded citrus fruits.
PubMed:Antifungal synergistic effect of scopoletin, a hydroxycoumarin isolated from Melia azedarach L. fruits.
PubMed:Characterization of cigarette tobacco by direct electrospray ionization-ion trap mass spectrometry (ESI-ITMS) analysis of the aqueous extract--a novel and simple approach.
PubMed:Influence of distillation system, oak wood type, and aging time on composition of cider brandy in phenolic and furanic compounds.
PubMed:Potential functional foods in the traditional Maori diet.
PubMed:Mode of action of hot-water dip in reducing decay of lemon fruit.
PubMed:Ultraviolet C irradiation at 0.5 kJ.m(-)(2) reduces decay without causing damage or affecting postharvest quality of star ruby grapefruit (C. paradisi Macf.).
PubMed:A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases.
PubMed:Metabolic and analytical interactions of grapefruit juice and 1,2-benzopyrone (coumarin) in man.
PubMed:Coumarin compounds in cassava diets: 2 health implications of scopoletin in gari.
PubMed:Identification of scopoletin in dried bract of the cotton plant.
PubMed:Scopoletin as a trace constituent of compounded feeds and the lack of an association with the haemorrhagic bowel syndrome in the pig.
 
Notes:
plant growth factor derived from the root of scopolia carniolica or scopolia japonica. Isol. from Angelica acutiloba (Dong Dang Gui)
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy