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Category:cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 212.50 °C. @ 760.00 mm Hg
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| Soluble in: |
| | water, 3.00E+05 mg/L @ 20 °C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic ingredient for skin conditioning |
| Recommendation for sarcosine usage levels up to: | | | not for fragrance use.
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| Recommendation for sarcosine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acetic acid, (methylamino)- | | | glycine, N-methyl- | | ( | methylamino)acetic acid | | 2-( | methylamino)acetic acid | | ( | methylamino)ethanoic acid | | N- | methylaminoacetic acid | | | methylglycine | | N- | methylglycine | | | sarcosin | | | sarcosinic acid |
Articles:
| PubMed:Some Operational Characteristics of Glycine Release in Rat Retina: The Role of Reverse Mode Operation of Glycine Transporter Type-1 (GlyT-1) in Ischemic Conditions. |
| PubMed:Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells. |
| PubMed:Maternal Choline Status, but Not Fetal Genotype, Influences Cord Plasma Choline Metabolite Concentrations. |
| PubMed:Creatine is a scavenger for methylglyoxal under physiological conditions via formation of N-(4-methyl-5-oxo-1-imidazolin-2-yl)sarcosine (MG-HCr). |
| PubMed:Possible glyphosate tolerance mechanism in pitted morningglory (Ipomoea lacunosa L.). |
| PubMed:Postprandial plasma betaine and other methyl donor-related responses after consumption of minimally processed wheat bran or wheat aleurone, or wheat aleurone incorporated into bread. |
| PubMed:Effects of betaine on performance and body composition: a review of recent findings and potential mechanisms. |
| PubMed:PEG-amine-initiated polymerization of sarcosine N-thiocarboxyanhydrides toward novel double-hydrophilic PEG-b-polysarcosine diblock copolymers. |
| PubMed:1-Sarcosine-angiotensin II infusion effects on food intake, weight loss, energy expenditure, and skeletal muscle UCP3 gene expression in a rat model. |
| PubMed:Use of sodium lauroyl sarcosinate (sarkosyl) in viable real-time PCR for enumeration of Escherichia coli. |
| PubMed:Metabolomic analysis of cold acclimation of Arctic Mesorhizobium sp. strain N33. |
| PubMed:Comparative study of the use of sarcosine, proline and glycine as acrylamide inhibitors in ripe olive processing. |
| PubMed:Thermodynamic analysis of osmolyte effect on thermal stability of ribonuclease A in terms of water activity. |
| PubMed:Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 induce different age-related metabolic profiles revealed by 1H-NMR spectroscopy in urine and feces of mice. |
| PubMed:Effects of carbohydrates on the oNPG converting activity of β-galactosidases. |
| PubMed:DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women. |
| PubMed:Theaflavins, dimeric catechins, inhibit peptide transport across Caco-2 cell monolayers via down-regulation of AMP-activated protein kinase-mediated peptide transporter PEPT1. |
| PubMed:Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study. |
| PubMed:Transport of IRW, an ovotransferrin-derived antihypertensive peptide, in human intestinal epithelial Caco-2 cells. |
| PubMed:Nutritional attributes of ash (Fraxinus spp.) outer bark and phloem and their relationships to resistance against the emerald ash borer. |
| PubMed:Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model. |
| PubMed:Characterization of new stable ghrelin analogs with prolonged orexigenic potency. |
| PubMed:Pool of resistance mechanisms to glyphosate in Digitaria insularis. |
| PubMed:Nuclear magnetic resonance-based metabolomics enable detection of the effects of a whole grain rye and rye bran diet on the metabolic profile of plasma in prostate cancer patients. |
| PubMed:Tolerance and safety evaluation of N,N-dimethylglycine, a naturally occurring organic compound, as a feed additive in broiler diets. |
| PubMed:Peptide absorption after massive proximal small bowel resection: mechanisms of ileal adaptation. |
| PubMed:Glycine-N methyltransferase expression in HepG2 cells is involved in methyl group homeostasis by regulating transmethylation kinetics and DNA methylation. |
| PubMed:GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation. |
| PubMed:Taste contribution of (R)-strombine to dried scallop. |
| PubMed:Oseltamivir (tamiflu) is a substrate of peptide transporter 1. |
| PubMed:Permeabilization of baker's yeast with N-lauroyl sarcosine. |
| PubMed:Expression and putative roles in attachment of outer membrane proteins of Escherichia coli O157 from planktonic and sessile culture. |
| PubMed:Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. |
| PubMed:DNA induces folding in alpha-synuclein: understanding the mechanism using chaperone property of osmolytes. |
| PubMed:Treatment for mitochondrial disorders. |
| PubMed:Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis. |
| PubMed:Homocysteine metabolism in children with Down syndrome: in vitro modulation. |
| PubMed:Bile acid replacement therapy with cholylsarcosine for short-bowel syndrome. |
| PubMed:Actions of amylin on subfornical organ neurons and on drinking behavior in rats. |
| PubMed:Comment: N,N-dimethylglycine and L-carnitine as performance enhancers in athletes. |
| PubMed:Effect of replacement therapy with cholylsarcosine on fat malabsorption associated with severe bile acid malabsorption. Studies in dogs with ileal resection. |
| PubMed:Bradykinin-induced dipsogenesis in captopril-treated rats. |
| PubMed:The effects of recessive lethal Notch mutations of Drosophila melanogaster on flavoprotein enzyme activities whose inhibitions cause Notch-like phenocopies. |
| PubMed:Abundance of dimethylamine in seafoods: possible implications in the incidence of human cancer. |
| PubMed:Nitrosation of sarcosine, proline and 4-hydroxyproline by exposure to nitrogen oxides. |
| PubMed:Mutagenicity of pyrolysates from guanidine, ureide, secondary amines and polyamines found by the Salmonella/mammalian-microsome test. |
| PubMed:[On the problems with respect to the formation of N-nitroso compound precursors when using alkylating agents in the fumigation of foodstuffs. II. N-methylation of various amino acids by the action of methyl bromide (author's transl)]. |
| PubMed:Kinetics of uptake of an amino acid and a dipeptide into hamster jejunum and ileum: the effect of semistarvation and starvation. |
| PubMed:Determination of a non-volatile N-nitrosamine on a food matrix. |
| PubMed:The rate of nitrosation of sarcosine in the presence of hydrophile and lipophilic antioxidants. |
| PubMed:Identification and quantitative determination of nitrosoproline and nitrososarcosine and preliminary investigations on nitrosohydroxyproline in cured meat products. |
| PubMed:Toxicities of methionine and other amino acids. |
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an amino acid intermediate in the metabolism of choline. Sarcosine is the N-methyl derivative of glycine. Sarcosine is metabolized to glycine by the enzyme sarcosine dehydrogenase, while glycine-N-methyl transferase generates sarcosine from glycine. Sarcosine is a natural amino acid found in muscles and other body tissues. In the laboratory it may be synthesized from chloroacetic acid and methylamine. Sarcosine is naturally found in the metabolism of choline to glycine. Sarcosine is sweet to the taste and dissolves in water. It is used in manufacturing biodegradable surfactants and toothpastes as well as in other applications. Sarcosine is ubiquitous in biological materials and is present in such foods as egg yolks, turkey, ham, vegetables, legumes, etc. Sarcosine is formed from dietary intake of choline and from the metabolism of methionine, and is rapidly degraded to glycine. Sarcosine has no known toxicity, as evidenced by the lack of phenotypic manifestations of sarcosinemia, an inborn error of sarcosine metabolism. Sarcosinemia can result from severe folate deficiency because of the folate requirement for the conversion of sarcosine to glycine (Wikipedia). Sarcosine has recently been identified as a biomarker for invasive prostate cancer. It was found to be greatly increased during prostate cancer progression to metastasis and could be detected in urine. Sarcosine levels were also increased in invasive prostate cancer cell lines relative to benign prostate epithelial cells.(PMID: 19212411) [HMDB]
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3D/inchi