|
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 175.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 423.40 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 373.00 °F. TCC ( 189.70 °C. ) (est)
|
| logP (o/w): | 1.600 (est) |
| Soluble in: |
| | water, 753.1 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
unreported-man LDLo 15 mg/kg
"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
intraperitoneal-mouse LD50 130 mg/kg
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 52, Pg. 79S, 1956.
intravenous-mouse LD50 180 mg/kg
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02213
oral-mouse LD50 900 mg/kg
Drugs in Japan Vol. 6, Pg. 301, 1982.
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for alpha-santonin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for alpha-santonin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
| | (3aS,5aS,9bS)-3,5a,9-trimethyl-3a,4,5,9b-tetrahydro-3H-benzo[g][1]benzofuran-2,8-dione |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 10201 |
| Pubchem (sid): | 134974692 |
| Pherobase: | View |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | eudesma-1,4-dien-12-oic acid, 6-alpha-hydroxy-3-oxo-, gamma-lactone, (11S)-(-)- | | 11-epiiso | eusantona-1,4-dienic acid, 6alpha-hydroxy-3-oxo-, gamma-lactone | | | naphtho(1,2-b)puran-2,8(3H,4H)-dione, 3a,5,5a,9b-tetrahydro-3,5a,9-trimethyl- | | (3S)-2,3,3a,4,5,5a,8,9bbeta- | octahydro-3,5abeta,9-trimethylnaphtho(1,2-b)furan-2,8-dion | | | santonin | | | santoninum | | | semenen | | (3aS,5aS,9bS)-3,5a,9- | trimethyl-3a,4,5,9b-tetrahydro-3H-benzo[g][1]benzofuran-2,8-dione |
Articles:
| PubMed:Synthesis and structure-activity relationships of guaiane-type sesquiterpene lactone derivatives with respect to inhibiting NO production in lipopolysaccharide-induced RAW 264.7 macrophages. |
| PubMed:[Sesquiterpenoids from Solanum lyratum]. |
| PubMed:New eudesmane-type sesquiterpenoid from Solanum lyratum with cytotoxic activity. |
| PubMed:Induction of G₂/M arrest, caspase activation and apoptosis by α-santonin derivatives in HL-60 cells. |
| PubMed:Synthesis and anticancer activity of novel spiro-isoxazoline and spiro-isoxazolidine derivatives of α-santonin. |
| PubMed:Total syntheses of ainsliadimer B and gochnatiolides a and B. |
| PubMed:Diminutive effect on T and B-cell proliferation of non-cytotoxic α-santonin derived 1,2,3-triazoles: a report. |
| PubMed:8-[(2-Hy-droxy-phen-yl)imino]-3,5a,9-trimethyl-3a,4,5,5a,8,9b-hexa-hydro-naphtho-[1,2-b]furan-2(3H)-one. |
| PubMed:3,5a,9-Trimethyl-8-(2-phenylhydrazin-1-ylidene)-4,5,5a,9b-tetrahydro-3aH,8H-naphtho[1,2-b]furan-2(3H)-one. |
| PubMed:Theoretical studies on the photoinduced rearrangement mechanism of α-santonin. |
| PubMed:In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei. |
| PubMed:Synthesis of novel α-santonin derivatives as potential cytotoxic agents. |
| PubMed:A biomimetic total synthesis of (+)-ainsliadimer A. |
| PubMed:Synthesis and cytotoxic activity of alpha-santonin derivatives. |
| PubMed:Biotransformation of tetrahydro-alpha-santonins by Absidia coerulea. |
| PubMed:Periplasmically located α-santonin binding factor in Sphingomonas paucimobilis strain S ATCC 43388. |
| PubMed:Natural products in parallel chemistry--novel 5-lipoxygenase inhibitors from BIOS-based libraries starting from alpha-santonin. |
| PubMed:The photoarrangement of alpha-santonin is a single-crystal-to-single-crystal reaction: a long kept secret in solid-state organic chemistry revealed. |
| PubMed:Seven-membered cyclic sulfite eudesmane derivatives: partial synthesis, structural determination, and enzymatic resolution. |
| PubMed:Biotransformation of alpha- and 6beta-santonin by fungus and plant cell cultures. |
| PubMed:Biotransformation of alpha-santonin by cell suspension cultures of five plants. |
| PubMed:Microbial transformations of alpha-santonin. |
| PubMed:A new sensitive isotropic-anisotropic separation experiment-SPEED MAS. |
| PubMed:Synthesis of phytuberin. 4-endo-tet acid-catalyzed cyclization of alpha-hydroxy epoxides. |
| PubMed:Convenient method for determining the absolute configuration of chiral alcohols with racemic 1H NMR anisotropy reagent, M(alpha)NP acid: use of HPLC-CD detector. |
| PubMed:Biotransformation of two cytotoxic terpenes, alpha-santonin and sclareol by Botrytis cinerea. |
| PubMed:Santonin-related compound 2 inhibits the expression of ICAM-1 in response to IL-1 stimulation by blocking the signaling pathway upstream of I kappa B degradation. |
| PubMed:Guaianolides as immunomodulators. Synthesis and biological activities of dehydrocostus lactone, mokko lactone, eremanthin, and their derivatives. |
| PubMed:Synthetic studies of sesquiterpenes with a cis-fused decalin system, 5. A synthetic approach to the study of structure-activity relationships of the termiticidal norsesquiterpenoids, chamaecynone and related compounds. |
| PubMed:Use of high-performance liquid chromatographic peak deconvolution and peak labelling to identify antiparasitic components in plant extracts. |
| PubMed:Elimination of broad-host range plasmid vectors in Escherichia coli by curing agents. |
| PubMed:Studies on the synthesis of sesquiterpene lactones, 12. Synthesis of (+)-colartin, (+)-arbusculin A, and their C-4 epimers and their biological activities. |
| PubMed:Growth, terpenoid production and antibacterial activity of an in vitro culture of the liverwort Fossombronia pusilla. |
| PubMed:Elimination of ColE1 group (pBR322 and pBR329) plasmids in Escherichia coli by alpha-santonin. |
| PubMed:Antipyretic activity of alpha- and beta-santonin. |
| PubMed:Mechanism of uptake of alpha-santonin by Pseudomonas cichorii strain S. |
| PubMed:alpha-Santonin 1,2-reductase and its role in the formation of dihydrosantonin and lumisantonin by Pseudomonas cichorii S. |
| PubMed:Antimalarial agents. 1. alpha-Santonin-derived cyclic peroxide as potential antimalarial agent. |
| PubMed:Studies on microbial transformations. XVIII. Microbiological transformation of 1-alpha-santonin. |
| PubMed:[Studies on the microbiological transformation of alpha-santonin and its analogues (author's transl)]. |
| PubMed:Sesquiterpenoids. 3. The stereochemistry of santonin: x-ray analysis of 2-bromo-alpha-santonin. |
|
3D/inchi