EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sanguinarine chloride
(1,3)benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium, 13-methyl-, chloride

Supplier Sponsors

CAS Number: 5578-73-4Picture of molecule3D/inchi
FDA UNII: B8Z8J4400H
MDL:MFCD00012126
Molecular Weight:367.78738000
Formula:C20 H14 Cl N O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 140.8 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Sanguinarium chloride?Sanguinarine 98%
BOC Sciences
For experimental / research use only.
Sanguinarine chloride hydrate
ExtraSynthese
For experimental / research use only.
Sanguinarine Chloride (HPLC) ≥90%
Glentham Life Sciences
Sanguinarine chloride hydrate
Santa Cruz Biotechnology
For experimental / research use only.
Sanguinarine Chloride ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Sanguinarine chloride hydrate ≥98% (HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 15900 ug/kg
Planta Medica. Vol. 43, Pg. 161, 1981.

intravenous-rat LD50 29 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: ATAXIA
Journal of Toxicology and Environmental Health. Vol. 20, Pg. 199, 1987.

oral-rat LD50 1658 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Journal of Toxicology and Environmental Health. Vol. 20, Pg. 199, 1987.

intraperitoneal-rat LDLo 20 mg/kg
Nature. Vol. 162, Pg. 265, 1948.

Dermal Toxicity:
subcutaneous-mouse LD50 102 mg/kg
Planta Medica. Vol. 43, Pg. 161, 1981.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for sanguinarine chloride usage levels up to:
 not for fragrance use.
 
Recommendation for sanguinarine chloride flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :68635
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0005578734
RTECS:VP5220000 for cas# 5578-73-4
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):68635
Pubchem (sid):135026667
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D05799
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2939.90.5000
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
(1,3)benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium, 13-methyl-, chloride
 sanguinarine hydrochloride
 sanguinarium chloride
 viadent
 

Articles:

PubMed:Combination analyses of anti-cancer drugs on human neuroendocrine tumor cell lines.
PubMed:Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1.
PubMed:Micronucleus formation in human lymphocytes and in the metabolically competent human hepatoma cell line Hep-G2: results with 15 naturally occurring substances.
PubMed:SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest).
PubMed:In vitro activities of antimicrobial agents against Candida species.
PubMed:The use of locally delivered doxycycline in the treatment of periodontitis. Clinical results.
PubMed:Cytotoxicity of sanguinarine chloride to cultured human cells from oral tissue.
PubMed:Sanguinarine, a phototoxic H2O2-producing alkaloid.
PubMed:Lacking anti-plaque efficacy of 2 sanguinarine mouth rinses.
PubMed:Clinical experiments with a mouthrinse containing sanguinarine chloride.
PubMed:Evaluation of sanguinarine chloride in control of plaque in the dental practice.
 
Notes:
None found
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