carbocysteine
L-cysteine, S-(carboxymethyl)-, monosodium salt

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Name: (2R)-2-amino-3-(carboxymethylsulfanyl)propanoic acid
CAS Number: 638-23-3Picture of molecule3D/inchi
Other: 11139-64-3
ECHA EINECS - REACH Pre-Reg: 211-327-5
FDA UNII: 740J2QX53R
Nikkaji Web: J2.289F
Beilstein Number: 1725012
MDL: MFCD00002614
XlogP3-AA: -3.10 (est)
Molecular Weight: 179.19553000
Formula: C5 H9 N O4 S
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antiseborrhoeic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 206.00 °C. @ 760.00 mm Hg
Boiling Point: 417.33 °C. @ 760.00 mm Hg (est)
Flash Point: 403.00 °F. TCC ( 206.20 °C. ) (est)
logP (o/w): 0.204 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antiseborrhoeic agents
skin conditioning
 
Suppliers:
Aceto
S-Carboxymethyl -L- Cysteine
BOC Sciences
For experimental / research use only.
Carbocisteine > 95%
Odor: characteristic
Use: Carbocisteine (INN), also called carbocysteine (USAN), is a mucolytic that reduces the viscosity of sputum and so can be used to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis
Glentham Life Sciences
Carbocisteine
Sigma-Aldrich: Sigma
For experimental / research use only.
S-Carboxymethyl-L-cysteine
TCI AMERICA
For experimental / research use only.
S-(Carboxymethyl)-L-cysteine >98.0%(HPLC)(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 1433 mg/kg
Yakugaku Zasshi. Journal of Pharmacy. Vol. 94, Pg. 1419, 1974.

oral-mouse LD50 8400 mg/kg
Drugs in Japan Vol. 6, Pg. 190, 1982.

intraperitoneal-rat LD50 7800 mg/kg
Drugs in Japan Vol. 6, Pg. 190, 1982.

oral-rat LD50 > 15000 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 1705, 1982.

Dermal Toxicity:
subcutaneous-mouse LD50 9000 mg/kg
Drugs in Japan Vol. 6, Pg. 190, 1982.

subcutaneous-rat LD50 10300 mg/kg
BEHAVIORAL: ATAXIA
Yakkyoku. Pharmacy. Vol. 32, Pg. 993, 1981.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: antiseborrhoeic agents
Recommendation for carbocysteine usage levels up to:
 not for fragrance use.
 
Recommendation for carbocysteine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 638-23-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 193653
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 (2R)-2-amino-3-(carboxymethylsulfanyl)propanoic acid
Chemidplus: 0000638233
RTECS: AY4342000 for cas# 638-23-3
 
References:
 (2R)-2-amino-3-(carboxymethylsulfanyl)propanoic acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 193653
Pubchem (sid): 134978717
 
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C03727
HMDB (The Human Metabolome Database): HMDB29415
FooDB: FDB000507
Export Tariff Code: 2922.49.4050
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other): note
 radish
Search Trop Picture
 
Synonyms:
 alanine, 3-((carboxymethyl)thio)-, L-
(2R)-2-amino-3-(carboxymethylthio)propanoic acid
(2R)-2-amino-3-[(carboxymethyl)sulfanyl]propanoic acid
S-carboxymethyl-L-cysteine
S-carboxymethyl-laevo-cysteine
S-(carboxymethyl)-(R)-cysteine
S-(carboxymethyl)-L-cysteine
L-3-((carboxymethyl)thio)alanine
L-cysteine, S-(carboxymethyl)-
L-cysteine, S-(carboxymethyl)-, monosodium salt
 

Articles:

PubMed: S-Carboxyethylcysteine (a constituent of Acacia seed) negatively affects casein protein utilization by rats.
PubMed: Spectrophotometric determination of cysteine and/or carbocysteine in a mixture of amino acids, shampoo, and pharmaceutical products using p-benzoquinone.
PubMed: Phenotypic variation in xenobiotic metabolism and adverse environmental response: focus on sulfur-dependent detoxification pathways.
PubMed: Poor sulphoxidation ability in patients with food sensitivity.
 
Notes:
a compound formed when iodoacetic acid reacts with sulfhydryl groups in proteins. it has been used as an anti-infective nasal spray with mucolytic and expectorant action. Isol. from radish seedlings
 
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