cassic acid
chrysazin-3-carboxylic acid

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  CODE128036 CODE128036
  Product(s):
  478-43-3 Rhein >98%
  Rhein (Monorhein; NSC 38629; Rheic acid; Rheinic acid) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities.

Name: 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid CAS Number: 478-43-3 3D/inchi ECHA EINECS - REACH Pre-Reg: 207-521-4 FDA UNII: YM64C2P6UX Nikkaji Web: J12.584I Beilstein Number: 2222155 MDL: MFCD00009618 XlogP3-AA: 2.20 (est) Molecular Weight: 284.22396000 Formula: C15 H8 O6 BioActivity Summary: listing NMR Predictor: Predict (works with chrome, Edge or firefox) Category:natural substances and extractives   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Appearance: white powder (est) Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Melting Point: 321.00 °C. @ 760.00 mm Hg Boiling Point: 597.00 to 598.00 °C. @ 760.00 mm Hg (est) Flash Point: 625.00 °F. TCC ( 329.40 °C. ) (est) logP (o/w): 4.290 (est) Soluble in:   water, 2.448 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: Alfa Biotechnology For experimental / research use only. Rhein 98% BOC Sciences For experimental / research use only. Rhein >98% Odor: characteristic Use: Rhein (Monorhein; NSC 38629; Rheic acid; Rheinic acid) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Coompo For experimental / research use only. Rhein from Plants ≥95% Odor: characteristic Use: Rhein, also known as cassic acid, is a substance in the anthraquinone group. Rhein has been reevaluated as an antibacterial agent against Staphylococcus aureus in 2008. Synergy or partial synergy has been demonstrated between rhein and the antibiotics oxacillin and ampicillin. The pharmacokinetics of rhein have not been intensively studied in humans, but at least one study in healthy male volunteers found that rhein was better absorbed from oral administration of rhubarb than from a retention enema. Rhein (at an oral dose of 50 mg twice per day) was shown to be safe when administered for five days to elderly patients with chronic congestive heart failure. ExtraSynthese For experimental / research use only. Rhein (HPLC) ≥99% Sigma-Aldrich: Aldrich For experimental / research use only. Rhein technical grade sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: intravenous-mouse LD50 > 25 mg/kg Pharmacology and Toxicology Vol. 61, Pg. 153, 1987. oral-mouse LD50 > 5000 mg/kg Pharmacology and Toxicology Vol. 61, Pg. 153, 1987. Dermal Toxicity: Not determined Inhalation Toxicity: Not determined   Safety in Use Information: Category: natural substances and extractives Recommendation for cassic acid usage levels up to:   not for fragrance use.   Recommendation for cassic acid flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View Chemical Carcinogenesis Research Information System:Search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :10168 National Institute of Allergy and Infectious Diseases:Data WGK Germany:2 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid Chemidplus:0000478433 EPA/NOAA CAMEO:hazardous materials RTECS:CA9516000 for cas# 478-43-3   References:   4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid NIST Chemistry WebBook: Search Inchi Pubchem (cid): 10168 Pubchem (sid): 134973996   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View KEGG (GenomeNet): C10401 HMDB (The Human Metabolome Database): HMDB32876 FooDB: FDB010856 Export Tariff Code: 2918.90.4000 VCF-Online: VCF Volatile Compounds in Food ChemSpider: View Wikipedia: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   rhubarb root Search Trop Picture   rubus spp. Search Trop Picture   Synonyms: 2- anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9, 10-dioxo- 2- anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- 2- anthroic acid, 9,10-dihydro-4,5-dihydroxy-9, 10-dioxo- 2- anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-   chrysazin-3-carboxylic acid 9,10- dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracene carboxylic acid 9,10- dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid 9,10- dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid 4,5- dihydroxy-2-anthraquinonecarboxylic acid 1,8- dihydroxy-3-carboxyanthraquinone 1,8- dihydroxy-3-carboxyl anthraquinone 1,8- dihydroxy-3-carboxyl-9,10-anthraquinone 4,5- dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenecarboxylic acid 4,5- dihydroxy-9,10-dioxo-9,10-dihydro-anthracene-2-carboxylic acid 4,5- dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid 4,5- dihydroxy-9,10-dioxoanthracene-2-carboxylic acid 4,5- dihydroxyanthraquinone-2-carboxylic acid 1,8- dihydroxyanthraquinone-3-carboxylic acid   parietic acid   rheic acid   rhein   rhubarb yellow   Articles:   None found yet. Try the PubMed Search.

Notes: Present in Rheum palmatum (Chinese rhubarb)