pyridoxine
3,4-pyridinedimethanol, 5-hydroxy-6-methyl-
 
Notes:
the 4-methanol form of vitamin b 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. although pyridoxine and vitamin b 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (ee snell; ann ny acad sci, vol 585 pg 1, 1990). Found in rice husks, cane molasses, yeast, wheat germ and cod liver oils. Vitamin, dietary supplement, nutrient Pyridoxine is one of the compounds that can be called vitamin B6, along with pyridoxal and pyridoxamine. It differs from pyridoxamine by the substituent at the '4' position. It is often used as 'pyridoxine hydrochloride'. (Wikipedia)
  • ECSA Chemicals
    • ECSA Chemicals
      International trading and distribution
      ECSA Group offers its customers in these business segments a complete 'one-stop shopping' solution.
      A hundred years on from its establishment, the Emanuele Centonze Holding SA has developed a solid presence in Switzerland and in Europe. The Group currently includes: ECSA Chemicals AG/ECSA Italia SRL SocietÓ con Unico Socio – ECSA Maintenance AG – ECSA Energy SA – Porta Ticino Easy Stop SA. The Group operates in the distribution of chemical and petroleum products, in the international trading of commodities, and in the distribution of maintenance systems. With 285 employees, a consolidated turnover of 335 million Swiss Francs in 2015, and more than 15,000 active customers, the Group ranks among the top 500 companies in Switzerland. ECSA operates in Switzerland and the EU, and in particular has consolidated its geographical position on the main axis linking northern and southern Europe, thus creating a competitive and privileged logistical hub.
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      Vitamin B6
       
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co.
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
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      127959 Vitamin B6
       
  • OQEMA
    • OQEMA
      With a focus on providing the highest level of service
      OQEMA has established itself at the forefront of the global chemical industry.
      The guiding principles of OQEMA have always been to establish long term relationships with customers and suppliers alike to build sustainable and profitable business for all parties. Through OQEMA’s business divisions the company tailors products and services to better support and service our customers requirements. This structure also allows the company to focus its marketing campaigns more effectively to certain industries. Over the last decade OQEMA has achieved strong growth as a result of the expansion of our business model. Going forward, the company will be expanding this business model into existing and new strategic territories.
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Synonyms   Articles   Notes   Search
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol (Click)
CAS Number: 65-23-6Picture of molecule
ECHA EINECS - REACH Pre-Reg: 200-603-0
FDA UNII: KV2JZ1BI6Z
Nikkaji Web: J2.356F
Beilstein Number: 139854
MDL: MFCD00006335
XlogP3: -0.80 (est)
Molecular Weight: 169.18027000
Formula: C8 H11 N O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
1977 Pyridoxine View-review
FDA Mainterm: PYRIDOXINE
FDA Regulation:
FDA PART 101 -- FOOD LABELING
Subpart A--General Provisions
Sec. 101.9 Nutrition labeling of food.
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: white crystalline powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 159.00 to  162.00 °C. @ 760.00 mm Hg
Boiling Point: 491.93 °C. @ 760.00 mm Hg (est)
Flash Point: 484.00 °F. TCC ( 251.30 °C. ) (est)
logP (o/w): -0.770
Soluble in:
 water, 2.82e+005 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antistatic agents
hair conditioning
skin conditioning
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Suppliers:
BOC Sciences
For experimental / research use only.
Pyridoxine >98%
DSM Nutritional
Vitamin B6
ECSA Chemicals
Vitamin B6
Company Profile
EMD Millipore
For experimental / research use only.
Pyridoxine
Farbest-Tallman Foods
Pyridoxine 97-98% for DC
Foodchem International
Vitamin B6
Graham Chemical
Vitamine B6
Jiangyin Healthway
Vitamin B6
New functional food ingredients
Kraft Chemical
Vitamin B6
OQEMA
Vitamin B6
Prinova
Vitamin B6 USP; FCC
Sigma-Aldrich: Sigma
For experimental / research use only.
Pyridoxine ≥98%
Silver Fern Chemical
Vitamin B 6
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  4000 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 116, 1940.

intravenous-rat LD50  657 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Proceedings of the Society for Experimental Biology and Medicine. Vol. 44, Pg. 147, 1940.

oral-man TDLo  5143 mg/kg/17W
PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC
New England Journal of Medicine. Vol. 309, Pg. 445, 1983.

intraperitoneal-mouse LD50  966 mg/kg
Farmakologiya i Toksikologiya Vol. 40, Pg. 371, 1977.

intravenous-mouse LD50  545 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 683, 1960.

intraperitoneal-rat LD50  1500 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Proceedings of the European Society for the Study of Drug Toxicity. Vol. 4, Pg. 179, 1964.

Dermal Toxicity:
subcutaneous-rat LD50 3100 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 116, 1940.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: special dietary and nutritional additives
Recommendation for pyridoxine usage levels up to:
 not for fragrance use.
 
Recommendation for pyridoxine flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the substantiation of a health claim related to a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil and maintenance of normal hair pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
Dietary Reference Values for vitamin B6
View page or View pdf
Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin B6
View page or View pdf
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 65-23-6
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 1054
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
Chemidplus: 0000065236
RTECS: UV1300000 for cas# 65-23-6
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References:
 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 65-23-6
Pubchem (cid): 1054
Pubchem (sid): 134972472
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
Metabolomics Database: Search
UM BBD: Search
KEGG (GenomeNet): C00314
HMDB (The Human Metabolome Database): HMDB00239
FooDB: FDB000574
YMDB (Yeast Metabolome Database): YMDB00037
Export Tariff Code: 2936.25.0000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
•bonadoxin an anti-emetic; antispasmodic is mixture of meclizine & pyridoxine hcl. from table •dosage forms: injection usp: 50 & 100 mgml, 500 mg & 1 g10 ml, 3 g30 ml; tablets usp: 10, 25, 50, & 100 mg. •oral capsules, 500 mg, vitamin b-6 capsules, solgar; capsules, extended release, 100 mg, vitamin b-6 t.r. capsules, scherer; 150 mg, rodex(r) t.d., legere; tablets, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 250 mg, 500 mg, and tablets extended release, vitamin b-6 timed tablets, interstate. •parenteral injection, 100 mgml, beesix (r) (with benzyl alcohol), forest; hexa-betalin (r) (with chlorobutanol), lilly; rodex (r), legere. •pyridoxine hydrochloride is also commercially available in combination with other vitamins, minerals, amino acids, antihistamines, cerebral stimulants, enzymes, infant formulas, hormones, laxatives, protein supplements, sedatives, unsaturated fatty acids, and antituberculars. for iv infusion, pyridoxine hydrochloride is also commercially available in combination with other vitamins in caloric and electrolyte solutions.
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 antistatic agents 
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Occurrence (nature, food, other): note
 almond seed
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 apple custard apple fruit
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 apple fruit
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 banana fruit
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 barley seed
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 bean asparagus bean seed
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 bean black bean fruit
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 bean black bean seed
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 bean butter bean seed
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 bean field bean fruit
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 bean field bean seed
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 bean mung bean seed
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 bean mung bean sprout
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 brussel sprout leaf
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 cabbage leaf
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 cantaloupe fruit
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 carrot root
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 cashew nut
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 cayenne fruit
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 celery leaf
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 chervil leaf
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 chive leaf
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 corn cob
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 corn seed
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 cotton seed
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 cranberry fruit
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 cress garden cress leaf
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 cucumber fruit
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 currant black currant fruit
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 currant red currant fruit
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 date palm fruit
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 eggplant fruit
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 endive leaf
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 fenugreek plant
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 fig fruit
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 ginger root
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 gooseberry fruit
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 gourd calabash gourd fruit
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 grape fruit
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 guava fruit
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 hazelnut seed
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 jackfruit fruit
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 kohlrabi stem
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 lentil seed
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 lentil sprout
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 lettuce leaf
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 mallow jew's mallow leaf
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 mandarin fruit
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 mango fruit
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 marango fruit
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 marango shoot
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 oat plant
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 oat seed
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 okra fruit
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 onion bulb
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 orange fruit
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 papaya fruit
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 parsley plant
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 parsnip root
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 pea black-eyed pea seed
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 pea fruit
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 pea pigeon pea seed
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 pea seed
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 peach fruit
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 peanut seed
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 pear fruit
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 pepper bell pepper fruit
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 peppermint leaf
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 pineapple fruit
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 plum fruit
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 pomegranate fruit
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 poppy opium poppy seed
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 potato sweet potato root
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 potato tuber
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 purslane plant
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 radish root
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 raspberry red raspberry fruit
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 rice seed
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 rosemary leaf
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 rye seed
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 sesame seed
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 soursop fruit
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 soybean seed
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 spearmint leaf
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 spinach plant
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 squash summer squash fruit
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 tamarind fruit
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 tomato fruit
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 walnut english walnut nut
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 watercress herb
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 wheat seed
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Synonyms:
 adermine
3-hydroxy-2-picoline-4,5-dimethanol
3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
3-hydroxy-4,5-dimethylol-a-picoline
3-hydroxy-4,5-dimethylol-alpha-picoline
5-hydroxy-6-methyl-3,4-pyridine dimethanol
5-hydroxy-6-methyl-3,4-pyridinedimethanol
(5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol
4,5-bis-hydroxymethyl-2-methyl-pyridin-3-ol
4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol
4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
2-methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine
2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine
2-methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine
2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine
2-methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine
2-picoline-4,5-dimethanol, 3-hydroxy-
3,4-pyridinedimethanol, 5-hydroxy-6-methyl-
 vitamin B6
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