EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

pyridoxine hydrochloride
3,4-pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride (1:1)

Supplier Sponsors

Name:4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
CAS Number: 58-56-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-386-2
Beilstein Number:3632435
Molecular Weight:205.64024000
Formula:C8 H12 Cl N O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:special dietary and nutritional additives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Pubchem Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1676 Pyridoxine hydrochloride View - review
FDA Regulation:
Subpart A--General Provisions
Sec. 101.9 Nutrition labeling of food.

Subpart D--Nutrient Requirements
Sec. 107.100 Nutrient specifications.

Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1676 Pyridoxine hydrochloride.
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 207.00 °C. @ 760.00 mm Hg
Boiling Point: 491.90 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000000 mmHg @ 25.00 °C. (est)
Flash Point: 484.00 °F. TCC ( 251.30 °C. ) (est)
logP (o/w): -1.098 (est)
Soluble in:
 water, 220000 mg/L @ 25 °C (exp)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antistatic agents
hair conditioning
skin conditioning
American International Chemical, LLC.
Pyridoxine HCl
Atlantic Chemicals
Pyridoxine HCL (Vitamin B6)
BOC Sciences
For experimental / research use only.
Pyridoxine Hydrochloride > 95%
Odor: characteristic
Use: Pyridoxine is a form of vitamin B6 found commonly in food and used as dietary supplement. It can be used to treat and prevent pyridoxine deficiency, sideroblastic anaemia, pyridoxine-dependent epilepsy, certain metabolic disorders,
Charkit Chemical
Charkit Chemical
ECSA Chemicals
Farbest-Tallman Foods
Pyridoxine HCL USP
Flavor: bland
It is used in dietary supplement applications including tablets and hard shell capsules.
Glentham Life Sciences
Pyridoxine hydrochloride, EP, USP grade
Penta International
Penta International
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
Pyridoxine Hydrochloride ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Pyridoxine hydrochloride, cell culture tested, insect cell culture tested
For experimental / research use only.
Pyridoxine Hydrochloride >98.0%(LC)(T)
Tianjin Talent Chemical
VB6 (Pyridoxine Hydrochloride)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 4000 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.

intravenous-rat LD50 530 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.

intramuscular-cat LD50 500 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.

intravenous-cat LD50 560 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.

oral-cat LD50 1000 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.

oral-dog LD50 > 500 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.

intravenous-mouse LD50 660 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.

oral-mouse LD50 5500 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.

intravenous-rabbit LD50 464 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.

Dermal Toxicity:
subcutaneous-rat LD50 3000 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.

subcutaneous-mouse LD50 2450 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.

Inhalation Toxicity:
Not determined
Safety in Use Information:
special dietary and nutritional additives
Recommendation for pyridoxine hydrochloride usage levels up to:
 not for fragrance use.
Recommendation for pyridoxine hydrochloride flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Assessment of the application for renewal of authorisation of pyridoxine hydrochloride (vitamin B6) as a feed additive for all animal species
View page or View pdf

Assessment of a feed additive consisting of vitamin B (pyridoxine hydrochloride) for all animal species for the renewal of its authorisation (Kaesler Nutrition GmbH)
View page or View pdf

EPI System: View
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):58-56-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6019
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
RTECS:UV1350000 for cas# 58-56-0
 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:58-56-0
Pubchem (cid):6019
Pubchem (sid):134971801
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
KEGG (GenomeNet):D02179
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2936.25.0000
FDA Listing of Food Additive Status:View
•bonadoxin an anti-emetic; antispasmodic is mixture of meclizine & pyridoxine hcl. from table •dosage forms: injection usp: 50 & 100 mgml, 500 mg & 1 g10 ml, 3 g30 ml; tablets usp: 10, 25, 50, & 100 mg. •oral capsules, 500 mg, vitamin b-6 capsules, solgar; capsules, extended release, 100 mg, vitamin b-6 t.r. capsules, scherer; 150 mg, rodex(r) t.d., legere; tablets, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 250 mg, 500 mg, and tablets extended release, vitamin b-6 timed tablets, interstate. •parenteral injection, 100 mgml, beesix (r) (with benzyl alcohol), forest; hexa-betalin (r) (with chlorobutanol), lilly; rodex (r), legere. •pyridoxine hydrochloride is also commercially available in combination with other vitamins, minerals, amino acids, antihistamines, cerebral stimulants, enzymes, infant formulas, hormones, laxatives, protein supplements, sedatives, unsaturated fatty acids, and antituberculars. for iv infusion, pyridoxine hydrochloride is also commercially available in combination with other vitamins in caloric and electrolyte solutions.
Potential Blenders and core components note
None Found
Potential Uses:
 antistatic agents
Occurrence (nature, food, other):note
 not found in nature
 adermine hydrochloride
 aderomine hydrochloride
3-hydroxy-4,5-dihydroxymethyl-2-methylpyridine hydrochloride
3-hydroxy-4,5-dimethylol-a-picoline hydrochloride
5-hydroxy-6-methyl-3,4-pyridine dimethanol hydrochloride
5-hydroxy-6-methyl-3,4-pyridinedicarbinol hydrochloride
5-hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
(5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol hydrochloride
4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride
4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride (1:1)
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride (1:1)
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, chloride
4,5-bis(hydroxymethyl)-3-hydroxy-2-methylpyridine hydrochloride
2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine hydrochloride
3,4-pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride
3,4-pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride (1:1)
 pyridoxine hydrogen chloride
 pyridoxine, hydrochloride
 vitamin B6 hydrochloride


PubMed:Stability of hydrophilic vitamins mixtures in the presence of electrolytes and trace elements for parenteral nutrition: A nuclear magnetic resonance spectroscopy investigation.
PubMed:[The effect of a water-soluble vitamins on the activity of some enzymes in diabetes.]
PubMed:Oral exposure to the anti-pyridoxine compound 1-amino d-proline further perturbs homocysteine metabolism through the transsulfuration pathway in moderately vitamin B6 deficient rats.
PubMed:Validated stability-indicating liquid chromatographic method for the determination of ribavirin in the presence of its degradation products: application to degradation kinetics.
PubMed:Modified Eu-doped Y2 O3 nanoparticles as turn-off luminescent probes for the sensitive detection of pyridoxine.
PubMed:Effect of potassium magnesium citrate and vitamin B-6 prophylaxis for recurrent and multiple calcium oxalate and phosphate urolithiasis.
PubMed:Doxylamine succinate-pyridoxine hydrochloride (Diclegis) for the management of nausea and vomiting in pregnancy: an overview.
PubMed:Development and validation of a liquid chromatography method for the simultaneous determination of eight water-soluble vitamins in multivitamin formulations and human urine.
PubMed:A new pharmacologic treatment for nausea and vomiting of pregnancy.
PubMed:The pharmacologic management of nausea and vomiting of pregnancy.
PubMed:Doxylamine succinate/pyridoxine hydrochloride.
PubMed:[Alkalimetric titrations of salts of organic bases in the Pharmacopoeia].
PubMed:A novel method aimed at counteracting the side effects caused by prostaglandin e2 deficiency during non-steroidal anti-inflammatory drug therapy.
PubMed:[Ion-pair HPLC analysis of B vitamins in syrup products in Indonesia].
PubMed:Sex differences in the pharmacokinetics and bioequivalence of the delayed-release combination of doxylamine succinate-pyridoxine hydrochloride; implications for pharmacotherapy in pregnancy.
PubMed:Nausea and vomiting in pregnancy: a review of the pathology and compounding opportunities.
PubMed:Development of a Raman method to follow the evolution of coating thickness of pellets.
PubMed:Vitamin B-6 vitamer levels in plasma and related symptoms in hemodialysis subjects taking low- and high-dose renal multivitamin supplements.
PubMed:Fractional-continuous wavelet transforms and ultra-performance liquid chromatography for the multicomponent analysis of a ternary mixture containing thiamine, pyridoxine, and lidocaine in ampules.
PubMed:Purification and some properties of rose (Fructus cynosbati) hips invertase.
PubMed:Measurement of plasma B6 vitamer profiles in children with inborn errors of vitamin B6 metabolism using an LC-MS/MS method.
PubMed:Application of CZE Method in Routine Analysis for Determination of B-Complex Vitamins in Pharmaceutical and Veterinary Preparations.
PubMed:Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectoris.
PubMed:B vitamin and/or ω-3 fatty acid supplementation and cancer: ancillary findings from the supplementation with folate, vitamins B6 and B12, and/or omega-3 fatty acids (SU.FOL.OM3) randomized trial.
PubMed:Review of NVP and HG and Early Pharmacotherapeutic Intervention.
PubMed:Vitamin B₆ supplementation in pregnant women with nausea and vomiting.
PubMed:Determination of vitamin B6 by means of differential spectrophotometry in pharmaceutical preparations in the presence of magnesium compounds.
PubMed:[Effects of magnesium salts on the course of experimental calcium-oxalate urolithiasis].
PubMed:Non-occupational allergic contact dermatitis from pyridoxine hydrochloride and ranitidine hydrochloride.
PubMed:Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine, d-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan.
PubMed:Simultaneous controlled vitamin release from multiparticulates: theory and experiment.
PubMed:The use of B vitamins for cutaneous ulcerations mimicking pyoderma gangrenosum in patients with MTHFR polymorphism.
PubMed:Stability of an extemporaneous alcohol-free melatonin suspension.
PubMed:Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation.
PubMed:Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin).
PubMed:Preparation and investigation of vitamin B6-derived aminopyridinol antioxidants.
PubMed:Development and validation of PCR, PLS, and TLC densitometric methods for the simultaneous determination of vitamins B(1), B(6) AND B(12) in pharmaceutical formulations.
PubMed:Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
PubMed:Hepatoprotective treatment attenuates oxidative damages induced by carbon tetrachloride in rats.
PubMed:Simultaneous chemometric determination of pyridoxine hydrochloride and isoniazid in tablets by multivariate regression methods.
PubMed:Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing age.
PubMed:Montmorillonite-alginate nanocomposites as a drug delivery system: intercalation and in vitro release of vitamin B1 and vitamin B6.
PubMed:[Effects of mangesium salts and their combinations with vitamin B6 on oxalates crystalluria in rats fed with pyridoxine-deficient diet].
PubMed:Simultaneous determination of chondroitin sulfate sodium, allantoin and pyridoxine hydrochloride in pharmaceutical eye drops by an ion-pair high-performance liquid chromatography.
PubMed:Impairments in pyridoxine-dependent sulphur amino acid metabolism are highly sensitive to the degree of vitamin B6 deficiency and repletion in the pig.
PubMed:Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study.
PubMed:[The role of alimentary magnesium deficiency in development of nephrolithiasis and its correction with magnesium salts in rats].
PubMed:Simultaneous determination of a ternary mixture of doxylamine succinate, pyridoxine hydrochloride, and folic acid by the ratio spectra-zero-crossing, double divisor-ratio spectra derivative, and column high-performance liquid chromatographic methods.
PubMed:Multidetermination of thiamine HCl and pyridoxine HCl in their mixture using continuous daubechies and biorthogonal wavelet analysis.
PubMed:Chemiluminescent determination of pyridoxine hydrochloride in pharmaceutical samples using flow injection.
PubMed:Polarographic behavior of nicotinamide in surfactant media and its determination in cetyltrimethylammonium bromide surfactant system.
PubMed:Simultaneous determination of some water-soluble vitamins and preservatives in multivitamin syrup by validated stability-indicating high-performance liquid chromatography method.
PubMed:Simultaneous derivative spectrophotometric analysis of doxylamine succinate, pyridoxine hydrochloride and folic Acid in combined dosage forms.
PubMed:Spectroscopic and thermodynamic study of charge transfer interaction between vitamin B6 and p-chloranil in aqueous ethanol mixtures of varying composition.
PubMed:Determination of pyridoxine hydrochloride in pharmaceutical preparations by calixarene based potentiometric sensor.
PubMed:Spectral diagnostics of the interaction between pyridoxine hydrochloride and bovine serum albumin in vitro.
PubMed:Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial.
PubMed:The role of nitric oxide in the anticonvulsant effects of pyridoxine on penicillin-induced epileptiform activity in rats.
PubMed:Validation of a rapid micellar electrokinetic capillary chromatographic method for the simultaneous determination of isoniazid and pyridoxine hydrochloride in pharmaceutical formulation.
PubMed:Spectrophotometric methods for the simultaneous analysis of meclezine hydrochloride and pyridoxine hydrochloride in bulk drug and pharmaceutical formulations.
PubMed:Stability of cyanocobalamin in sugar-coated tablets.
PubMed:Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials.
PubMed:Relation of higher folate intake to lower risk of Alzheimer disease in the elderly.
PubMed:Chemical Stability of Pyridoxine Hydrochloride 100-mg/mL Injection, Preservative Free.
PubMed:[The determination of pyridoxine hydrochloride (vitamin B6) according to European Pharmacopoeia 4.0].
PubMed:Spectral study of photolysis of aqueous cyanocobalamin solutions in presence of vitamins B and C.
PubMed:High-performance liquid chromatography method for the simultaneous determination of thiamine hydrochloride, pyridoxine hydrochloride and cyanocobalamin in pharmaceutical formulations using coulometric electrochemical and ultraviolet detection.
PubMed:Protective effect of vitamin B6 in chromium-induced oxidative stress in liver.
PubMed:Prophylactic Diclectin reduces the incidence of postoperative vomiting.
PubMed:Determination of thiamine HCl and pyridoxine HCl in pharmaceutical preparations using UV-visible spectrophotometry and genetic algorithm based multivariate calibration methods.
PubMed:HPLC and chemometric methods for the simultaneous determination of cyproheptadine hydrochloride, multivitamins, and sorbic acid.
PubMed:Multicomponent quantitative resolution of binary mixtures by using continuous wavelet transform.
PubMed:Pyridoxine hydrochloride treatment of carpal tunnel syndrome: a review.
PubMed:A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy.
PubMed:[Study of pharmacological activity of complex magnesium-containing preparation based on mineral bishofit and pyridoxine hydrochloride in a rat model of chronic alcoholic intoxication].
PubMed:Vitamin B6 metabolites in idiopathic calcium stone formers: no evidence for a link to hyperoxaluria.
PubMed:Crosslinked poly(methyl vinyl ether-co-maleic anhydride) as topical vehicles for hydrophilic and lipophilic drugs.
PubMed:The effect of vitamin B6 on cognition.
PubMed:Diclectin therapy for nausea and vomiting of pregnancy: effects of optimal dosing.
PubMed:Determination of water-soluble vitamins in soft drinks and vitamin supplements using capillary electrophoresis.
PubMed:Potentiometric membrane sensors for the selective determination of pyridoxine hydrochloride (vitamin B6) in some pharmaceutical formulations.
PubMed:Spectrophotometric and LC determination of two binary mixtures containing pyridoxine hydrochloride.
PubMed:Improvement in 5'-position-selective glucosylation of pyridoxine by Verticillium dahliae TPU 4900.
PubMed:Effect of magnesium supplementation containing mineral bishofit (MgCl2 x 6H2O) solution and pyridoxine hydrochloride on erythrocyte magnesium depletion and behaviour of rats after three-month alcoholization.
PubMed:Simultaneous determination of water-soluble vitamins in a vitamin-enriched drink by an in-capillary enzyme reaction method.
PubMed:Simultaneous determination of nicotinamide, pyridoxine hydrochloride, thiamine mononitrate and riboflavin in multivitamin with minerals tablets by reversed-phase ion-pair high performance liquid chromatography.
PubMed:An optimized method for the simultaneous determination of vitamins B1, B6, B12 in multivitamin tablets by high performance liquid chromatography.
PubMed:Possible adverse reactions to preservatives in high-dose pyridoxine hydrochloride i.v. injection.
PubMed:Simultaneous determination of ingredients in a vitamin-enriched drink by micellar electrokinetic chromatography.
PubMed:Effect of thiamine hydrochloride, pyridoxine hydrochloride and calcium-d-pantothenate on the patulin content of apple juice concentrate.
PubMed:Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial.
PubMed:Effect of amino acids and vitamins on laccase production by the bird's nest fungus Cyathus bulleri.
PubMed:Simultaneous determination of riboflavin phosphate and other ingredients in a multivitamin pharmaceutical preparation by on-line automated LC coupled with pre-column immobilized enzyme reactor.
PubMed:Simple spectrophotometric determination of cinnarizine in its dosage forms.
PubMed:Simultaneous determination of melatonin and pyridoxine in tablet formulations by differential pulse voltammetry.
PubMed:Bioavailability and antioxidant activity of some food supplements in men and women using the D-Roms test as a marker of oxidative stress.
PubMed:Homocysteine levels in patients treated with lipid apheresis: effect of a vitamin therapy.
PubMed:Intravenous pyridoxine-induced metabolic acidosis.
PubMed:Use of bioimpedance spectroscopy to estimate body water distribution in rats fed high dietary sulfur amino acids.
PubMed:[Significance of lacrimal fluid peroxidation and anti-radical defense parameters for prediction and treatment of complicated myopia].
PubMed:Effects of glucose, vitamins, and DO concentrations on pyruvate fermentation using Torulopsis glabrata IFO 0005 with metabolic flux analysis.
PubMed:Pyridoxine-induced photosensitivity and hypophosphatasia.
PubMed:Water-soluble vitamin levels in patients undergoing high-flux hemodialysis and receiving long-term oral postdialysis vitamin supplementation.
PubMed:Homocysteine and neurologic disease.
PubMed:A gene for pyridoxine-dependent epilepsy maps to chromosome 5q31.
PubMed:A comparison of matrix resolution method, ratio spectra derivative spectrophotometry and HPLC method for the determination of thiamine HCl and pyridoxine HCl in pharmaceutical preparation.
PubMed:Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial. Terry Beirn Community Programs for Clinical Research on AIDS, the Adult AIDS Clinical Trials Group, the Pan American Health Organization, and the Centers for Disease Control and Prevention Study Group.
PubMed:Determination of eight water- and fat-soluble vitamins in multi-vitamin pharmaceutical formulations by high-performance liquid chromatography.
PubMed:Simultaneous determination of pyridoxine hydrochloride and doxylamine succinate from tablets by ion pair reversed-phase high-performance liquid chromatography (RP-HPLC).
PubMed:[Effect of mexidol and its structural components on carbohydrate level and lipid peroxidation in acute stress].
PubMed:Plasma total homocysteine response to oral doses of folic acid and pyridoxine hydrochloride (vitamin B6) in healthy individuals. Oral doses of vitamin B6 reduce concentrations of serum folate.
PubMed:Simultaneous determination of ascorbic acid, pyridoxine hydrochloride, and tyrosine by derivative UV spectrophotometry.
PubMed:Assessment of efficacy of pyridoxine in control of radiation induced sickness.
PubMed:Photosensitive dermatitis caused by pyridoxine hydrochloride.
PubMed:Energetics of the adsorption of some drug onto the sclerotium of Pleurotus tuber-regium.
PubMed:Simultaneous determination of melatonin-pyridoxine combination in tablets by zero-crossing derivative spectrophotometry and spectrofluorimetry.
PubMed:Spectrophotometric determination of pyridoxine hydrochloride [correction of hydrochlorine] pharmaceutical preparations and foods.
PubMed:Coma from long-term overingestion of isoniazid.
PubMed:Effects of salinomycin and vitamin B(6) on the in vitro synthesis of lysine from the stereoisomers of 2,6-diaminopimelic acid by mixed rumen protozoa, bacteria, and their mixture.
PubMed:Zinc, copper and iron levels in tissues of the vitamin B6 deficient rat.
PubMed:The effect of a subnormal dose of vitamin B6 on plasma lipid in the rat.
PubMed:Zinc status in vitamin B6 deficiency.
PubMed:Insufficient stocking of poisoning antidotes in hospital pharmacies.
PubMed:Effect of vitamins on the aerobic degradation of 2-chlorophenol, 4-chlorophenol, and 4-chlorobiphenyl.
PubMed:Photoallergic drug eruption due to pyridoxine hydrochloride.
PubMed:Vitamin B6 and cancer: synthesis and occurrence of adenosine-N6-diethylthioether-N-pyridoximine-5'-phosphate, a circulating human tumor marker.
PubMed:Photosensitivity from pyridoxine hydrochloride (vitamin B6).
PubMed:Risk of low vitamin B6 status in infants breast-fed exclusively beyond six months.
PubMed:Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension.
PubMed:Pyridoxine in atopic dermatitis.
PubMed:Vitamin B-6 adequacy in neonatal nutrition: associations with preterm delivery, type of feeding, and vitamin B-6 supplementation.
PubMed:Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial.
PubMed:Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with positron emission tomography.
PubMed:Effect of oral pyridoxine hydrochloride supplementation on in vitro platelet sensitivity to different agonists.
PubMed:Effect of pyrrolidone carboxylate (PCA) and pyridoxine on liver metabolism during chronic ethanol intake in rats.
PubMed:The utilization of intravenously infused pyridoxine in humans.
PubMed:Zinc, copper and iron balance in the vitamin B-6-deficient rat.
PubMed:Water soluble vitamins in chronic hemodialysis patients and need for supplementation.
PubMed:[Hemodynamic effects of one administration of l-dopa in patients with left ventricular heart failure (introductory remarks)].
PubMed:[Effect of low doses of emoxipine and pyridoxine hydrochloride on the status of patients with cataract and glaucoma].
PubMed:The in vivo effect in humans of pyridoxal-5'-phosphate on platelet function and blood coagulation.
PubMed:Experimental Albizia versicolor poisoning in sheep and its successful treatment with pyridoxine hydrochloride.
PubMed:Androgen hydroxysteroid dehydrogenases under the influence of pyridoxine derivatives.
PubMed:Effects of megadoses of pyridoxine on spermatogenesis and male reproductive organs in rats.
PubMed:[Pyridoxine hydrochloride reference standard (Control 911) of the National Institute of Hygienic Sciences].
PubMed:Insensitivity of the tryptophan-load test to marginal vitamin B-6 intake in rats.
PubMed:Glutathione levels and related enzyme activities in vitamin B-6-deficient rats fed a high methionine and low cystine diet.
PubMed:Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study.
PubMed:Increasing hatchability of turkey eggs by injecting eggs with pyridoxine.
PubMed:[Pathologic processes of lumbar primary sensory neurons produced by high doses of pyridoxine in rats--morphometric and electron microscopic studies].
PubMed:Influence of age and sex on vitamin B-6 vitamer distribution and on vitamin B-6 metabolizing enzymes in Wistar rats.
PubMed:Effects of pyridoxine supplementation on blood glucocorticoids level, aspartate aminotransferase activity and glucose tolerance pattern under acute hypoxic stress.
PubMed:Sideroblastic anemia showing unique response to pyridoxine.
PubMed:Relationship between blood, liver and brain pyridoxal phosphate and pyridoxamine phosphate concentrations in mice.
PubMed:Liquid chromatographic studies of vitamin B6 metabolism in man.
PubMed:Determination of water-soluble vitamins by liquid chromatography with a parallel dual-electrode electrochemical detector.
PubMed:Lack of effect of vitamin B-6 supplementation on the lipoprotein profile of post-menopausal chronic hemodialysis patients.
PubMed:Distribution of B-6 vitamers in human milk during a 24-h period after oral supplementation with different amounts of pyridoxine.
PubMed:Effects of maternal restriction in vitamin B-6 on neocortex development in rats: neuron differentiation and synaptogenesis.
PubMed:Mutagenic activity of pyrolysates of cyanocobalamin and some other water-soluble vitamins in the model system with the Salmonella/mammalian microsomes.
PubMed:Subtle abnormalities of gait detected early in vitamin B6 deficiency in aged and weanling rats with hind leg gait analysis.
PubMed:Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Effects of pyridoxine and folic acid treatment.
PubMed:Vitamin B6 status in uremia.
PubMed:[Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study].
PubMed:Effects of oral pyridoxine upon plasma and 24-hour urinary oxalate levels in normal subjects and stone formers with idiopathic hypercalciuria.
PubMed:Testicular damage induced by megadoses of pyridoxine.
PubMed:On the formation of isopropylidenepyridoxines. A convenient method for the preparation of 2,2,8-trimethyl-4H-1,3-dioxino[4,5-c]pyridin-5-ylmethanol from pyridoxine hydrochloride.
PubMed:A simple liquid-chromatographic method for measuring vitamin B6 compounds in plasma.
PubMed:[Pyridoxine Hydrochloride Reference Standard (Control 871) of National Institute of Hygienic Sciences].
PubMed:Alteration of tissue magnesium levels in rats by dietary vitamin B6 supplementation.
PubMed:Pharmacokinetics of doxylamine, a component of Bendectin, in the rhesus monkey.
PubMed:Simultaneous spectrophotometric analysis of a ternary mixture of pharmaceuticals--assay for meclozine hydrochloride, pyridoxine hydrochloride and caffeine.
PubMed:Pyridoxine in the treatment of premenstrual syndrome: a retrospective survey in 630 patients.
PubMed:[Shortening diclofenac therapy by B vitamins. Results of a randomized double-blind study, diclofenac 50 mg versus diclofenac 50 mg plus B vitamins, in painful spinal diseases with degenerative changes].
PubMed:Spectrophotometric determination of pyridoxine hydrochloride in pharmaceutical samples.
PubMed:Folic acid--an innocuous means to reduce plasma homocysteine.
PubMed:Comparative evaluation of two direct compression lactose grades for pyridoxine hydrochloride tablets.
PubMed:Hyperoxaluria type I: therapeutic effects of pyridoxine hydrochloride and inheritance patterns of the disease in a family.
PubMed:Effects of pyridoxine on implantation and pregnancy in Wistar rat.
PubMed:Evaluation of prenatal vitamin-mineral supplements.
PubMed:The effect of pyridoxine supplementation on plasma pyridoxal-5'-phosphate levels in children with the nephrotic syndrome.
PubMed:Dosage form and formulation effects on the bioavailability of vitamin E, riboflavin, and vitamin B-6 from multivitamin preparations.
PubMed:Spectrophotometric determination of pyridoxine hydrochloride.
PubMed:Identification of pyridoxine 3-sulfate, pyridoxal 3-sulfate, and N-methylpyridoxine as major urinary metabolites of vitamin B6 in domestic cats.
PubMed:[Monobloc lamellar autokeratoplasty (MLAK) and corneal cicatrization. Apropos of a comparative trial in a control group and a group treated with a L-cystine and pyridoxine hydrochloride combination].
PubMed:Isoniazid overdose in the Cambodian population of Olmsted County, Minnesota.
PubMed:Managing the premenstrual syndrome.
PubMed:Vitamin stability in a TPN mixture stored in an EVA plastic bag.
PubMed:Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy.
PubMed:The lack of effect of a pyridoxine deficiency on the utilization of the hydroxyl analogue of methionine by the chick.
PubMed:Gastrointestinal absorption of vitamin B-6 in the chicken (Gallus domesticus).
PubMed:Effects of vitamin B6 intake on nutriture and growth of young infants.
PubMed:Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): childhood cancer and the consumption of debendox and related drugs in pregnancy.
PubMed:Relationship between particle packing and the physical stability of powder mixes.
PubMed:[Peripheral sensory neuropathy produced by a megadose of vitamin B6].
PubMed:Pyridoxine megavitaminosis: an analysis of the early changes induced with massive doses of vitamin B6 in rat primary sensory neurons.
PubMed:Contact allergy to hydrocortisone 17-butyrate and pyridoxine hydrochloride.
PubMed:Effects of pyridine and some of its derivatives on prostaglandin synthesis.
PubMed:Relationship between N-acetylator phenotype and susceptibility toward hydrazine-induced lethal central nervous system toxicity in the rabbit.
PubMed:Vitamin B6 status and static muscle function. 2 case reports.
PubMed:[Comparative studies on the resorption, anti-anemic action and growth effect of FV-82 and dextrofer-100 on pigs].
PubMed:Immunologic abnormalities in hemodialysis patients: improvement after pyridoxine therapy.
PubMed:Induction of sister-chromatid exchange in human lymphocytes by vitamin B6.
PubMed:Isoniazid-induced hepatic steatosis in rabbits: an explanation for susceptibility and its antagonism by pyridoxine hydrochloride.
PubMed:Simple colorimetric method for determination of pyridoxine hydrochloride (vitamin B6) in pharmaceuticals.
PubMed:Amitriptyline-related peripheral neuropathy relieved during pyridoxine hydrochloride administration.
PubMed:Clonal propagation of Callistemon by tissue culture techniques.
PubMed:Effect of antioxidants and antitoxicants of isoniazid on the formation of lung tumours in mice by isoniazid and hydrazine sulphate.
PubMed:Maternal plasma concentration of pyridoxal phosphate during pregnancy: adequacy of vitamin B6 supplementation during isoniazid therapy.
PubMed:Effect of high dose ascorbic acid on vitamin B6 metabolism.
PubMed:Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy.
PubMed:[Pyridoxine hydrochloride reference standard (Control 801) of National Institute of Hygienic Sciences].
PubMed:Acute effects of pyridoxine hydrochloride on monomethylhydrazine seizure latency and amygdaloid kindled seizure thresholds in cats.
PubMed:Drug-pyridoxal phosphate interactions.
PubMed:Ultrastructural lesions of pyridoxine toxicity in beagle dogs.
PubMed:The influence of pyridoxine in diabetic peripheral neuropathy.
PubMed:The subacute neurotoxicity of excess pyridoxine HCl and clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) in beagle dogs. II. Pathology.
PubMed:The subacute neurotoxicity of excess pyridoxine HCl and clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) in beagle dogs. I. Clinical disease.
PubMed:Single high-dose pyridoxine treatment for isoniazid overdose.
PubMed:Daily requirement for pyridoxine supplements in chronic renal failure.
PubMed:Ocular findings in patients with gyrate atrophy on pyridoxine and low-protein, low-arginine diets.
PubMed:A controlled trial of pyridoxine supplementation in children with febrile convulsions.
PubMed:Effects of vitamin B-6 deficiency and 4'- deoxypyridoxine on pyridoxal phosphate concentrations, pyridoxine kinase and other aspects of metabolism in the rat.
PubMed:[2 cases of malformations of a limb in infants of mothers treated with an antiemetic in a very early phase of pregnancy].
PubMed:5-hydroxytryptophan and pyridoxine. Their effects in young children with Down's syndrome.
PubMed:Acute isoniazid poisoning in childhood.
PubMed:Prevention of isoniazid tumorigenicity by antitoxicants of isoniazid in Swiss mice.
PubMed:In vitro dissolution test and absorption study of a per oral controlled release dosage form containing pyridoxine hydrochloride or sodium riboflavin phosphate with hydroxypropyl cellulose.
PubMed:[Effects of D-penicillamine on vitamin B6 and metal ions in rats (author's transl)].
PubMed:Effects of pyridoxine on hepatic tryptophan pyrrolase activity in rat during chronic ethanol administration.
PubMed:Failure of pyridoxine to improve glucose tolerance in diabetics.
PubMed:Viridans streptococcal endocarditis: the role of various species, including pyridoxal-dependent streptococci.
PubMed:Effects of pyridoxine hydrochloride (vitamin B6) on chlorpromazine-induced serum prolactin rise in male rats.
PubMed:[Effect of motion sickness on the absorption of B group vitamins and ascorbic acid in the small intestine of dogs].
PubMed:Spectrophotometric determination of tolbutamide, thiamine hydrochloride, and pyridoxine hydrochloride in combination products.
PubMed:Primary oxalosis: clinical and biochemical response to high-dose pyridoxine therapy.
PubMed:The vitamin B6 requirement in oral contraceptive users. II. Assessment by tryptophan metabolites, vitamin B6, and pyridoxic acid levels in urine.
PubMed:The vitamin B6 requirement in oral contraceptive users. I. Assessment by pyridoxal level and transferase activity in erythrocytes.
PubMed:Exogenous hormones and other drug exposures of children with congenital heart disease.
PubMed:Pyridoxine requirements of channel catfish.
PubMed:Dangers of vitamin B6 in nursing mothers.
PubMed:Nutritional management of chronic renal failure.
PubMed:Response to pyridoxine hydrochloride in refractory anemia due to myelofibrosis.
PubMed:Vitamin B-6 absorption in children with acute celiac disease and in control subjects.
PubMed:Pyridoxine inhibition of a symbiotic streptococcus.
PubMed:[Pharmacology of several aromatic amino acid decarboxylase inhibitors].
PubMed:Studies on the nutrition of marine flatfish. The pyridoxine requirement of turbot (Scophthalmus maximus).
PubMed:A pyridoxine-dependent behavioral disorder unmasked by isoniazid.
PubMed:Subacute toxicity of pyridoxine hydrochloride in the beagle dog.
PubMed:Acute megakaryocytic leukemia. Description of a case initially seen as preleukemia syndrome.
PubMed:Primary inoculation tuberculosis of the skin. Prosector's paronychia,.
PubMed:Vitamin B6 and aspartate aminotransferase activity in chronic liver disease.
PubMed:The degradation of tryptophan in severe liver disease.
PubMed:Evidence for the role of vitamin C-6 as a cofactor of lysyl oxidase.
PubMed:Nitrofurantoin solubility in aqueous pyridoxine hydrochloride solutions.
PubMed:Metabolism of methionine in oral contraceptive users and control women receiving controlled intakes of vitamin B6.
PubMed:Reversal of the toxicity of hydrazine an analogues by pyridoxine hydrochloride.
PubMed:Vitamin B6 deficiency in chronic liver disease--evidence for increased degradation of pyridoxal-5'-phosphate.
PubMed:Plasma pyridoxal phosphate levels in fulminant hepatic failure and the effects of parenteral supplementation.
PubMed:Uptake of pyridoxine hydrochloride by the rat jejunal mucosa in vitro.
PubMed:Liquid chromatography in pharmaceutical analysis V: determination of an isoniazid-pyridoxine hydrochloride mixture.
PubMed:Effect of oral contraceptives and vitamin B6 supplements on alanine and glycine metabolism.
PubMed:Abnormal tryptophan metabolism in a family with a history of bladder cancer.
PubMed:Isoniazid-induced convulsions.
PubMed:Synthesis of site-directed chelating agents II: 2-formyl-3-hydroxy-4,5-bis (hydroxymethyl)pyridine thiosemicarbazone.
PubMed:[Photocolorimetric determination of pyridoxine hydrochloride in drug mixtures used in geriatric practice].
PubMed:Bone growth changes in pyridoxine-deficient rats.
PubMed:Vitamin B6 levels in rheumatoid arthritis: effect of treatment.
PubMed:Colorimetric determination of diazepam in pharmaceutical preparations.
PubMed:Assessment of vitamin B 6 status. Studies on pregnant women and oral contraceptive users.
PubMed:Vitamin B6 requirements of women using oral contraceptives.
PubMed:The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children.
PubMed:[Determination of pyridoxine hydrochloride, nicotinamide and nicotinic acid by a method of differential interferometry].
PubMed:Effects of oral contraceptives on tryptophan metabolism and vitamin B6 requirements in women.
PubMed:Antagonism of the spinal action of diazepam by semicarbazide.
PubMed:Effect of pyridoxine hydrochloride (vitamin B 6 ) upon depression associated with oral contraception.
PubMed:[Effect of pyridoxine hydrochloride on oxygen and glucose uptake by several tissues of rat in vitro (author's transl)].
PubMed:Oral contraceptives and tryptophan metabolism: effects of oestrogen in low dose combined with a progestagen and of a low-dose progestagen (megestrol acetate) given alone.
PubMed:[Polarographic determination of pyridoxal hydrochloride in the presence of pyridoxine hydrochloride].
PubMed:Fluorimetric and phosphorimetric characteristics of several vitamins.
PubMed:[Results of personal experience with a sulfamide preparation associated with lysine orotate and pyridoxine hydrochloride, in the treatment of rheumatism of degenerative origin].
PubMed:Further applications of diazotized 4-amino-6-chloro-m-benzenedisulfonamide. Colorimetric determination of pyridoxine hydrochloride, 17-beta-hydroxy-7-a-alpha-dimethyl-B-homo-A-norestrane-3,6-dione and morphine sulfate.
PubMed:Treatment of radiation sickness with pyridoxine hydrochloride in outpatients of a radiotherapy unit.
PubMed:[Electroencephalographic and enzymatic studies on the protective effect of pyridoxine hydrochloride on bioelectric brain activity in rabbits poisoned with hydrazine].
PubMed:Tryptophan metabolism in women using steroid hormones for ovulation control.
PubMed:[On the use of the vitamin combination S-benzoyl-thiamine monophosphate, pyridoxine hydrochloride and hydroxocobalamin in some neurological syndromes].
PubMed:The crystal structure of pyridoxine hydrochloride. A comparison of the symbolic addition procedure and the heavy atom method.
PubMed:The absorption of tritium-labelled pyridoxine hydrochloride in the rat.
PubMed:Influence of large doses of pyridoxine hydrochloride on the convulsigenic activity of UDMH in monkeys.
PubMed:Use of pyridoxine hydrochloride to prevent isoniazid toxicity.
PubMed:[Effect of pyridoxine hydrochloride vitamin B6) and cyanocobalamin (vitamin B12) on ethyl alcohol treatment of carp].
PubMed:Pyridoxine hydrochloride (vitamin B6) need in infants and children; a study in patients with anemia, convulsions, and acute infections.
PubMed:The effect of pyridoxine hydrochloride in acute alcoholic intoxication.
PubMed:Pyridoxine hydrochloride in the treatment of acute alcoholism and delirium tremens.
PubMed:Disturbance of vitamin B6 metabolism in pregnancy. II. The influence of various amounts of pyridoxine hydrochloride upon the abnormal tryptophane load test in pregnant women.
PubMed:PYRIDOXINE hydrochloride (vitamin B6): a status report.
PubMed:[Pyridoxine hydrochloride in asthenia].
PubMed:[Pyridoxine hydrochloride (vitamin B6) in therapy; study of its action in peripheral nerve diseases].
PubMed:The use of pyridoxine hydrochloride in the treatment of radiation sickness; preliminary report.
PubMed:Agranulocytic angina treated with pyridoxine hydrochloride.
PubMed:Pyridoxine hydrochloride (vitamin B6) in the control of radiation sickness; preliminary report.
PubMed:Peroral administration of vitamin B6 (pyridoxine hydrochloride) in the treatment of radiation sickness.
PubMed:The use of pyridoxine hydrochloride in radiation sickness.
PubMed:Blood changes related to sulfonamide therapy; treatment of granulocytopenia with folic acid and pyridoxine hydrochloride.
PubMed:The effect of different concentrations of pyridoxine hydrochloride on the work output of perfused frog muscles.
PubMed:Treatment of roentgen sickness with oral administration of pyridoxine hydrochloride (vitamin B6).
the 4-methanol form of vitamin b 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. although pyridoxine and vitamin b 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (ee snell; ann ny acad sci, vol 585 pg 1, 1990). vitamin b 6 refers to several picolines (especially pyridoxine; pyridoxal; & pyridoxamine) that are efficiently converted by the body to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. during transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate. although pyridoxine and vitamin b 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (ee snell; ann ny acad sci, vol 585 pg 1, 1990). most of vitamin b6 is eventually degraded to pyridoxic acid and excreted in the urine. Pyridoxine is one of the compounds that can be called vitamin B6, along with pyridoxal and pyridoxamine. It differs from pyridoxamine by the substituent at the '4' position. It is often used as 'pyridoxine hydrochloride'. (Wikipedia)
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