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zinc protoporphyrin
protoporphyrin IX, zinc chelate

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Name:zinc;3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid
CAS Number: 15442-64-5Picture of molecule3D/inchi
Other(deleted CASRN):15278-20-3
ECHA EINECS - REACH Pre-Reg:239-455-7
FDA UNII: Search
MDL:MFCD00011612
Molecular Weight:626.03384000
Formula:C34 H32 N4 O4 Zn
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Zinc protoporphyrin IX
Odor: characteristic
Use: Zinc protoporphyrin IX is an endogenous metabolite formed during heme biosynth
Santa Cruz Biotechnology
For experimental / research use only.
Zinc Protoporphyrin-9 ≥95%
Sigma-Aldrich
For experimental / research use only.
Protoporphyrin IX zinc(II) guanylate cyclase inhibitor
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for zinc protoporphyrin usage levels up to:
 not for fragrance use.
 
Recommendation for zinc protoporphyrin flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):15442-64-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :455799
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
zinc;3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid
Chemidplus:0015442645
 
References:
 zinc;3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):455799
Pubchem (cas):15442-64-5
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.90.9500
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 dihydrogen (3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionato(4-)-N21,N22,N23,N24)zincate(4-)
 protoporphyrin IX zinc
 protoporphyrin IX, zinc chelate
 zinc;3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid
 

Articles:

PubMed:Influence of meat source, pH and production time on zinc protoporphyrin IX formation as natural colouring agent in nitrite-free dry fermented sausages.
PubMed:Subcritical water-hydrolyzed fish collagen ameliorates survival of endotoxemic mice by inhibiting HMGB1 release in a HO-1-dependent manner.
PubMed:Lotus Root Extract Stimulates BDNF Gene Expression Through Potential Mechanism Depending on HO-1 Activity in C6 Glioma Cells.
PubMed:Daily home fortification with iron as ferrous fumarate versus NaFeEDTA: a randomised, placebo-controlled, non-inferiority trial in Kenyan children.
PubMed:15-Deoxy-Δ(12,14)-prostaglandin J2 stabilizes hypoxia inducible factor-1α through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2.
PubMed:Fermented Brown Rice Extract Stimulates BDNF Gene Transcription in C6 Glioma Cells: Possible Connection with HO-1 Expression.
PubMed:4-Hydroxyestradiol induces mammary epithelial cell transformation through Nrf2-mediated heme oxygenase-1 overexpression.
PubMed:Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation of Nrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells.
PubMed:Impact of small-quantity lipid-based nutrient supplement on hemoglobin, iron status and biomarkers of inflammation in pregnant Ghanaian women.
PubMed:Baicalein protects C6 glial cells against hydrogen peroxide-induced oxidative stress and apoptosis through regulation of the Nrf2 signaling pathway.
PubMed:Antioxidant, Anti-Tyrosinase and Anti-Inflammatory Activities of Oil Production Residues from Camellia tenuifloria.
PubMed:Formation of naturally occurring pigments during the production of nitrite-free dry fermented sausages.
PubMed:An exploration of the antioxidant effects of garlic saponins in mouse-derived C2C12 myoblasts.
PubMed:Antagonistic effects of acetylshikonin on LPS-induced NO and PGE2 production in BV2 microglial cells via inhibition of ROS/PI3K/Akt-mediated NF-κB signaling and activation of Nrf2-dependent HO-1.
PubMed:The Cytoprotective Effect of Petalonia binghamiae Methanol Extract against Oxidative Stress in C2C12 Myoblasts: Mediation by Upregulation of Heme Oxygenase-1 and Nuclear Factor-Erythroid 2 Related Factor 2.
PubMed:Blood pressure and occupational exposure to noise and lead (Pb): A cross-sectional study.
PubMed:[Prevalence of deficiency and dietary intake of iron, zinc and copper in Chilean childbearing age women].
PubMed:Anti-Inflammatory Activity of Butein and Luteolin Through Suppression of NFκB Activation and Induction of Heme Oxygenase-1.
PubMed:Sargassum horneri methanol extract rescues C2C12 murine skeletal muscle cells from oxidative stress-induced cytotoxicity through Nrf2-mediated upregulation of heme oxygenase-1.
PubMed:Highly sensitive fluorescence assay of DNA methyltransferase activity by methylation-sensitive cleavage-based primer generation exponential isothermal amplification-induced G-quadruplex formation.
PubMed:A comparative study of zinc protoporphyrin IX-forming properties of animal by-products as sources for improving the color of meat products.
PubMed:In-home fortification with 2.5 mg iron as NaFeEDTA does not reduce anaemia but increases weight gain: a randomised controlled trial in Kenyan infants.
PubMed:Anti-inflammatory effect and mechanism of the green fruit extract of Solanum integrifolium Poir.
PubMed:Anti-inflammatory effect of methanol extract from Erigeron Canadensis L. may be involved with upregulation of heme oxygenase-1 expression and suppression of NFκB and MAPKs activation in macrophages.
PubMed:Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells.
PubMed:Ultrasensitive fluorescence detection of nucleic acids using exonuclease III-induced cascade two-stage isothermal amplification-mediated zinc (II)-protoporphyrin IX/G-quadruplex supramolecular fluorescent nanotags.
PubMed:Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid.
PubMed:Iron status biomarkers and C-reactive protein in children aged 19 to 72 months in Chile.
PubMed:5-Hydroxy-3,6,7,8,3'4'-hexamethoxyflavone inhibits nitric oxide production in lipopolysaccharide-stimulated BV2 microglia via NF-κB suppression and Nrf-2-dependent heme oxygenase-1 induction.
PubMed:Curcumin ameliorates the permeability of the blood-brain barrier during hypoxia by upregulating heme oxygenase-1 expression in brain microvascular endothelial cells.
PubMed:Iron status and systemic inflammation, but not gut inflammation, strongly predict gender-specific concentrations of serum hepcidin in infants in rural Kenya.
PubMed:Bilirubin participates in protecting of heme oxygenase-1 induction by quercetin against ethanol hepatotoxicity in cultured rat hepatocytes.
PubMed:Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells.
PubMed:Iron fortification of whole wheat flour reduces iron deficiency and iron deficiency anemia and increases body iron stores in Indian school-aged children.
PubMed:Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways.
PubMed:Effects of different storage conditions on quality related porphyrin fluorescence signatures of pork slices.
PubMed:[Acute lead poisoning: a singular case of hemolytic anemia and lead colic].
PubMed:Hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction.
PubMed:Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women.
PubMed:In vivo uptake of a haem analogue Zn protoporphyrin IX by the human malaria parasite P. falciparum-infected red blood cells.
PubMed:Efficacy of pandesal baked from wheat flour fortified with iron and vitamin a in improving the iron and anthropometric status of anemic schoolchildren in the Philippines.
PubMed:Nitric oxide inhibits the formation of zinc protoporphyrin IX and protoporphyrin IX.
PubMed:Neurotrophic and cytoprotective action of luteolin in PC12 cells through ERK-dependent induction of Nrf2-driven HO-1 expression.
PubMed:Formation of zinc protoporphyrin IX in Parma-like ham without nitrate or nitrite.
PubMed:Heme induces DNA damage and hyperproliferation of colonic epithelial cells via hydrogen peroxide produced by heme oxygenase: a possible mechanism of heme-induced colon cancer.
PubMed:The plant phenolic diterpene carnosol suppresses sodium nitroprusside-induced toxicity in c6 glial cells.
PubMed:Color formation in nitrite-free dried hams as related to Zn-protoporphyrin IX and Zn-chelatase activity.
PubMed:Oral supplementation with NaFeEDTA reduces blood lead in postmenopausal but not premenopausal Korean women with anemia.
PubMed:Determinants of anemia among preschool children in the Philippines.
PubMed:Luteolin suppresses cisplatin-induced apoptosis in auditory cells: possible mediation through induction of heme oxygenase-1 expression.
PubMed:Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification.
PubMed:Intragastric administration with recombinant Lactococcus lactis producing heme oxygenase-1 prevents lipopolysaccharide-induced endotoxemia in rats.
PubMed:Evaluation of serum transferrin receptor for iron deficiency in women of child-bearing age.
PubMed:Quantification of zinc-porphyrin in dry-cured ham products by spectroscopic methods Comparison of absorption, fluorescence and X-ray fluorescence spectroscopy.
PubMed:Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1.
PubMed:Isoflavone and the heme oxygenase system in ischemic acute kidney injury in rats.
PubMed:A cohort study of haemoglobin and zinc protoporphyrin levels in term Zambian infants: effects of iron stores at birth, complementary food and placental malaria.
PubMed:Anaemia and abdominal pain due to occupational lead poisoning.
PubMed:Mild riboflavin deficiency is highly prevalent in school-age children but does not increase risk for anaemia in Côte d'Ivoire.
PubMed:Iron fortification reduces blood lead levels in children in Bangalore, India.
PubMed:Protective effects of Korean herbal remedy against oxidative stress in cardiomyocytes.
PubMed:Feeding practices and factors contributing to wasting, stunting, and iron-deficiency anaemia among 3-23-month old children in Kilosa district, rural Tanzania.
PubMed:Nutritional risk factors for iron-deficiency anaemia in children 12-24 months old in the area of Thessalia in Greece.
PubMed:Cultural and environmental barriers to adequate iron intake among northern Kenyan schoolchildren.
PubMed:Induction of heme oxygenase-1 in human hepatocytes to protect them from ethanol-induced cytotoxicity.
PubMed:[Effects of iron supplementation on human serum level of transferrin receptor].
PubMed:Processed complementary food does not improve growth or hemoglobin status of rural tanzanian infants from 6-12 months of age in Kilosa district, Tanzania.
PubMed:The protective effect of delta-aminolevulinic acid dehydratase 1-2 and 2-2 isozymes against blood lead with higher hematologic parameters.
PubMed:Iron, zinc, and copper concentrations in breast milk are independent of maternal mineral status.
PubMed:Iron deficiency and risk factors for lower iron stores in 6-24-month-old New Zealanders.
PubMed:Iron deficiency is unacceptably high in refugee children from Burma.
PubMed:Cross-sectional study of blood lead effects on iron status in Korean lead workers.
PubMed:Dual fortification of salt with iodine and microencapsulated iron: a randomized, double-blind, controlled trial in Moroccan schoolchildren.
PubMed:Iron and zinc status of women and men who followed cholesterol-lowering diets.
PubMed:Longitudinal study of diet and iron deficiency anaemia in infants during the first two years of life.
PubMed:Community-based dietary phytate reduction and its effect on iron status in Malawian children.
PubMed:Prevalence of iron deficiency with and without concurrent anemia in population groups with high prevalences of malaria and other infections: a study in Côte d'Ivoire.
PubMed:Supplemental sodium phytate and microbial phytase influence iron availability in growing rats.
PubMed:The role of prophylactic iron supplementation in pregnancy.
PubMed:Effect of calcium supplementation on daily nonheme-iron absorption and long-term iron status.
PubMed:Factors affecting iron stores in infants 4-18 months of age.
PubMed:Effects of discontinuing coffee intake on iron status of iron-deficient Guatemalan toddlers: a randomized intervention study.
PubMed:Inhibition of hemozoin formation in Plasmodium falciparum trophozoite extracts by heme analogs: possible implication in the resistance to malaria conferred by the beta-thalassemia trait.
PubMed:Lead intoxication epidemic caused by ingestion of contaminated ground paprika.
PubMed:Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen.
PubMed:Effect of lead exposure on patterns of food intake in weanling rats.
PubMed:Absorption of non-haem iron from food during normal pregnancy.
PubMed:Use of lead-glazed ceramics is the main factor associated to high lead in blood levels in two Mexican rural communities.
PubMed:[Lead and health].
PubMed:Seizures in a 10-week-old infant: lead poisoning from an unexpected source.
PubMed:Iron fortification of infant milk formula: the effect on iron status and immune function.
PubMed:Relationship between the levels of biological indicators of lead exposure in children and their mothers environmentally exposed to lead.
PubMed:Mechanisms by which lead depresses linear and ponderal growth in weanling rats.
PubMed:Indicators of lead, zinc and cadmium exposure in cattle: II. Controlled feeding and recovery.
PubMed:Low dose lead effects in calves fed a whole milk diet.
PubMed:Performance and exposure indices of rats exposed to low concentrations of lead.
PubMed:[Chronic lead exposure. Its repercussion on indicators of heme synthesis and iron metabolism].
PubMed:Exposure to lead and cadmium of the general population of Malta.
PubMed:Widening perspectives of lead toxicity. A review of health effects of lead exposure in adults.
 
Notes:
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