EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

propylene oxide
1,2-epoxypropane

Supplier Sponsors

CAS Number: 75-56-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-879-2
FDA UNII:Y4Y7NYD4BK
Nikkaji Web:J1.171A
Beilstein Number:0079763
MDL:MFCD00005126
Molecular Weight:58.08002000
Formula:C3 H6 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:food starch-modified, preservative
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Pubchem Patents:Search
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NCBI:Search
JECFA Food Additive: Propylene Oxide
DG SANTE Food Contact Materials:propylene oxide
FDA Mainterm (SATF):75-56-9 ; PROPYLENE OXIDE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.892 Food starch-modified.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.210 Defoaming agents used in the manufacture of paper and paperboard.
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.82500 to 0.83500 @ 20.00 °C.
Pounds per Gallon - (est).: 6.873 to 6.956
Refractive Index:1.36500 to 1.36700 @ 20.00 °C.
Boiling Point: 35.00 °C. @ 760.00 mm Hg
Vapor Pressure:572.478027 mmHg @ 25.00 °C. (est)
Flash Point: -35.00 °F. TCC ( -37.22 °C. )
logP (o/w): 0.030
Soluble in:
 water, 590000 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor Description:at 100.00 %. ethereal sweet
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses:
 
Suppliers:
Balchem
Propylene Oxide
Odor: characteristic
Use: Propylene Oxide is used principally as a chemical intermediate in the manufacturing of items such as flexible and rigid foams, elastomers, coatings, adhesives, and injection moldings, which are ultimately used in many industrial and consumer products such as tub-shower combinations, gasoline tanks, boat hulls, etc.
Charkit Chemical
PROPYLENE OXIDE
Dow Chemical
Propylene Oxide
LyondellBasell Industries
Propylene Oxide
Sigma-Aldrich: Aldrich
For experimental / research use only.
(±)-Propylene oxide puriss. p.a., ≥99.5% (GC)
TCI AMERICA
For experimental / research use only.
Propylene Oxide >99.0%(GC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 380 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ATAXIA BEHAVIORAL: EXCITEMENT
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(11), Pg. 55, 1970.

oral-guinea pig LD50 660 mg/kg
KIDNEY, URETER, AND BLADDER: OTHER CHANGES LIVER: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(7), Pg. 76, 1981.

oral-mammal (species unspecified) LD50 440 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.

intraperitoneal-mouse LD50 175 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 103, 1982.

oral-mouse LD50 440 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(11), Pg. 55, 1970.

intraperitoneal-rat LD50 150 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 103, 1982.

Dermal Toxicity:
skin-rabbit LD50 1500 ul/kg
American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.

Inhalation Toxicity:
inhalation-rat LC50 4000 ppm/4H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
AMA Archives of Industrial Health. Vol. 13, Pg. 237, 1956.

inhalation-dog LCLo 2005 ppm/4H
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: NAUSEA OR VOMITING
AMA Archives of Industrial Health. Vol. 13, Pg. 237, 1956.

inhalation-guinea pig LCLo 4000 ppm/4H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE WEAKNESS SENSE ORGANS AND SPECIAL SENSES: IRITIS: EYE
AMA Archives of Industrial Health. Vol. 13, Pg. 228, 1956.

inhalation-man TCLo 1400000 mg/m3/10M
GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: HEADACHE
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 15(2), Pg. 48, 1971.

inhalation-mouse LC50 1740 ppm/4H
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
AMA Archives of Industrial Health. Vol. 13, Pg. 237, 1956.

 
Safety in Use Information:
Category: food starch-modified, preservative
Recommendation for propylene oxide usage levels up to:
 not for fragrance use.
 
Recommendation for propylene oxide flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ECHA (ESR):View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):75-56-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6378
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:3
2-methyloxirane
Chemidplus:0000075569
EPA/NOAA CAMEO:hazardous materials
RTECS:75-56-9
 
References:
 2-methyloxirane
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:75-56-9
Pubchem (cid):6378
Pubchem (sid):134970908
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
UM BBD:Search
KEGG (GenomeNet):C15508
HMDB (The Human Metabolome Database):HMDB31558
FooDB:FDB008171
Export Tariff Code:2910.20.0000
FDA Listing of Food Additive Status:View
Haz-Map:View
Household Products:Search
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 epoxypropane
1,2-epoxypropane
 methyl ethylene oxide
 methyl oxirane
 methyloxacyclopropane
 methyloxirane
(±)-methyloxirane
2-methyloxirane
 oxirane, 2-methyl-
 propylene epoxide
(±)-propylene oxide
1,2-propylene oxide
 propyleneoxide
 

Articles:

PubMed:Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity.
PubMed:A novel aqueous two phase system composed of a thermo-separating polymer and an organic solvent for purification of thermo-acidic amylase enzyme from red pitaya (Hylocereus polyrhizus) peel.
PubMed:Effects of acid-hydrolysis and hydroxypropylation on functional properties of sago starch.
PubMed:Properties and characteristics of dual-modified rice starch based biodegradable films.
PubMed:Reversal of multidrug resistance by the inhibition of ATP-binding cassette pumps employing "Generally Recognized As Safe" (GRAS) nanopharmaceuticals: A review.
PubMed:Reaction patterns of wheat starch granules substituted with an anionic propylene oxide analog (POA) revealed by confocal microscopy and 3D anaglyph imaging.
PubMed:Engineering a cyanobacterium as the catalyst for the photosynthetic conversion of CO2 to 1,2-propanediol.
PubMed:Relationship of the channels of normal maize starch to the properties of its modified products.
PubMed:Extractive fermentation for improved production and recovery of lipase derived from Burkholderia cepacia using a thermoseparating polymer in aqueous two-phase systems.
PubMed:Preparation of lignopolyols from wheat straw soda lignin.
PubMed:Effects of hydroxypropylation on the functional properties of psyllium.
PubMed:Transport across the blood-brain barrier of pluronic leptin.
PubMed:Hydroxypropylated tapioca starch retards the development of insulin resistance in KKAy mice, a type 2 diabetes model, fed a high-fat diet.
PubMed:Hydroxypropylated starches of varying amylose contents as sustained release matrices in tablets.
PubMed:An isotope dilution headspace method with gas chromatography-mass spectrometry for determination of propylene oxide in food.
PubMed:High-hydroxypropylated tapioca starch improves insulin resistance in genetically diabetic KKAy mice.
PubMed:Supercritical carbon dioxide interpolymer complexes improve survival of B. longum Bb-46 in simulated gastrointestinal fluids.
PubMed:Dual modification of starch via partial enzymatic hydrolysis in the granular state and subsequent hydroxypropylation.
PubMed:Evaluation of microwave irradiation for analysis of carbonyl sulfide, carbon disulfide, cyanogen, ethyl formate, methyl bromide, sulfuryl fluoride, propylene oxide, and phosphine in hay.
PubMed:Monte Carlo simulations assessing the risk of salmonellosis from consumption of almonds.
PubMed:Survival of Salmonella enteritidis PT 30 on inoculated almonds after commercial fumigation with propylene oxide.
PubMed:Toxicity of propylene oxide at low pressure against life stages of four species of stored product insects.
PubMed:Solubilization of Hydrophilic Compounds in Copolymer Aggregates.
PubMed:Reactions of epoxide monomers in food simulants used to test plastics for migration.
PubMed:A novel type of pyridine nucleotide-disulfide oxidoreductase is essential for NAD+- and NADPH-dependent degradation of epoxyalkanes by Xanthobacter strain Py2.
PubMed:Neurophysiological and neuropathological evaluation of primates exposed to ethylene oxide and propylene oxide.
PubMed:Effects of propylene oxide on nasal epithelial cell proliferation in F344 rats.
PubMed:Complementation of Xanthobacter Py2 mutants defective in epoxyalkane degradation, and expression and nucleotide sequence of the complementing DNA fragment.
PubMed:Effect of surface sterilization, fumigation and gamma irradiation on the microflora and germination of barley seeds.
PubMed:Inhalation developmental toxicity study of propylene oxide in Fischer 344 rats.
PubMed:Gas chromatographic determination with electron capture detection of residual ethylene oxide in intraocular lenses.
PubMed:Chronic inhalation toxicity and carcinogenicity study of propylene oxide in Wistar rats.
PubMed:Biomonitoring of exposure to potential mutagens and carcinogens in industrial populations.
PubMed:Mutagenicity of ethylene oxide and propylene oxide and of the glycols and halohydrins formed from them during the fumigation of foodstuffs.
PubMed:Mutagenic activity of propylene oxide in bacterial and mammalian systems.
PubMed:Sterilization of dehydrated potato granules with propylene oxide.
PubMed:Propylene oxide.
PubMed:Direct addition of liquid propylene oxide to dried materials for destruction of Salmonellae.
PubMed:Effect of propylene oxide treatment on the microflora of pecans.
PubMed:Gaseous sterilization: methyl bromide, propylene oxide and ozone.
PubMed:Effect of relative humidity on the bactericidal activity of propylene oxide vapor.
 
Notes:
Etherification agent for food starch
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