EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

procaine hydrochloride
4-aminobenzoic acid 2-(diethylamino)ethyl ester monohydrochloride

Supplier Sponsors

CAS Number: 51-05-8Picture of molecule3D/inchi
Other(deleted CASRN):12663-50-2
ECHA EINECS - REACH Pre-Reg:200-077-2
FDA UNII: 95URV01IDQ
Beilstein Number:3917802
MDL:MFCD00013000
Molecular Weight:272.77477000
Formula:C13 H21 Cl N2 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 155.50 °C. @ 760.00 mm Hg
Boiling Point: 373.60 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000009 mmHg @ 25.00 °C. (est)
Flash Point: 356.00 °F. TCC ( 179.80 °C. ) (est)
logP (o/w): 2.364 (est)
Soluble in:
 water, 9.404e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Procaine HCl >98%
Odor: characteristic
Use: Procaine hydrochloride is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry.
Glentham Life Sciences
Procaine hydrochloride
Santa Cruz Biotechnology
For experimental / research use only.
Procaine Hydrochloride
Sigma-Aldrich: Sigma
For experimental / research use only.
Procaine hydrochloride ≥97%
sds
TCI AMERICA
For experimental / research use only.
Procaine Hydrochloride >98.0%(HPLC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-cat LDLo 10 mg/kg
CARDIAC: CHANGE IN RATE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 8, Pg. 385, 1916.

intravenous-dog LD50 63 mg/kg
CARDIAC: OTHER CHANGES VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Dental Research. Vol. 20, Pg. 425, 1941.

intravenous-guinea pig LD50 51 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958.

intramuscular-mouse LD50 500 mg/kg
Therapie. Vol. 9, Pg. 332, 1954.

intraperitoneal-mouse LD50 165 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 793, 1976.

intravenous-mouse LD50 33 mg/kg
Anesthesia Progress. Vol. 36, Pg. 79, 1989.

oral-mouse LD50 175 mg/kg
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951.

parenteral-mouse LD50 192 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Antibiotics and Chemotherapy Vol. 4, Pg. 633, 1954.

intravenous-rabbit LD50 43 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.

unreported-rabbit LD50 41 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1957, 1974.

intraperitoneal-rat LD50 160 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.

intravenous-rat LD50 38 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Anesthesiology. Vol. 3, Pg. 398, 1942.

oral-rat LD50 200 mg/kg
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951.

unreported-rat LD50 150 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1012, 1967.

Dermal Toxicity:
subcutaneous-guinea pig LD50 407 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 388, 1948.

subcutaneous-mammal (species unspecified) LD50 630 mg/kg
Ceska a Slovenska Farmacie. Vol. 44, Pg. 210, 1995.

subcutaneous-mouse LD50 339 mg/kg
Bollettino Chimico Farmaceutico. Vol. 107, Pg. 310, 1968.

subcutaneous-rabbit LD50 687 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 388, 1948.

subcutaneous-rat LD50 597 mg/kg
Pharmaceutical Archives. Vol. 11, Pg. 81, 1940.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for procaine hydrochloride usage levels up to:
 not for fragrance use.
 
Recommendation for procaine hydrochloride flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):51-05-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5795
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride
Chemidplus:0000051058
RTECS:DG2275000 for cas# 51-05-8
 
References:
 2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:51-05-8
Pubchem (cid):5795
Pubchem (sid):134972096
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C07894
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2922.49.3700
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 allocaine
4-aminobenzoic acid 2-(diethylamino)ethyl ester hydrochloride
4-aminobenzoic acid 2-(diethylamino)ethyl ester monohydrochloride
4-aminobenzoic acid 2-diethylaminoethyl ester
p-aminobenzoic acid 2-diethylaminoethyl ester hydrochloride
p-aminobenzoic acid diethylaminoethyl ester hydrochloride
p-aminobenzoyldiethylaminoethanol hydrochloride
 aminocaine
 anadolor
 atoxicocaine
 benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, hydrochloride (1:1)
 benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, monohydrochloride
 benzoic acid, p-amino-, 2-(diethylamino)ethyl ester, monohydrochloride
 bernacaine
 bernocaine
 chlorocaine
2-(diethylamino)ethyl 4-aminobenzoate hydrochloride
2-(diethylamino)ethyl 4-aminobenzoate hydrochloride (1:1)
2-(diethylamino)ethyl 4-aminobenzoate, chloride
2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride
2-(diethylamino)ethyl p-aminobenzoate monohydrochloride
2-diethylaminoethyl p-aminobenzoate hydrochloride
 ethocaine
 geriocaine
 herocaine
 irocaine
 jenacaine
 juvocaine
 kerocaine
 lactocaine
 naucaine
 neocaine
 neotonocaine
 novocaine
 novocaine hydrochloride
 omnicain
 planocaine
 procaine HCl
 procaine, hydrochloride
 procainehydrochloride
 scurocaine
 sevicaine
 syncaine
 topokain
 westocaine
 

Articles:

PubMed:Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research.
PubMed:[Intermediary effectiveness of procaine and procaine metabolites following oral administration].
PubMed:Stoichiometric ratio and stability constants of complexes of some aromatic amino acids with caffeine and procaine hydrochloride.
PubMed:Reinforcing properties of intravenous procaine in rhesus monkeys.
PubMed:Effect of ventromedial hypothalamic procaine injections on feeding, lever pressing, and other behavior in rats.
PubMed:Safety of administration of procaine hydrochloride-hematoporphyrin (KH3) to beagle dogs.
 
Notes:
a local anesthetic of the ester type that has a slow onset and a short duration of action. it is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (from martindale, the extra pharmacopoeia, 30th ed, p1016). contains mainly procaine & small amounts of benzoic acid, potassium metabisulfite & disodium phosphate.
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