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precocene I
2H-1-benzopyran, 7-methoxy-2,2-dimethyl-

Supplier Sponsors

CAS Number:	17598-02-6	3D/inchi
ECHA EINECS - REACH Pre-Reg:	241-566-0
FDA UNII:	25HLF91DGR
Nikkaji Web:	J4.080K
Beilstein Number:	0133917
MDL:	MFCD00006818
XlogP3:	3.30 (est)
Molecular Weight:	190.24198000
Formula:	C12 H14 O2
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:natural substances and extractives

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
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Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Specific Gravity:	1.05200 @ 25.00 °C.
Refractive Index:	1.56000 @ 20.00 °C.
Boiling Point:	292.74 °C. @ 760.00 mm Hg (est)
Flash Point:	> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w):	3.350
Soluble in:
	water, 67.52 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

Santa Cruz Biotechnology

For experimental / research use only.

7-Methoxy-2,2-dimethylchromene

Sigma-Aldrich: Sigma

For experimental / research use only.

Precocene I 99%

Safety Information:

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
natural substances and extractives
Recommendation for precocene I usage levels up to:
	not for fragrance use.

Recommendation for precocene I flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :28619

National Institute of Allergy and Infectious Diseases:Data

7-methoxy-2,2-dimethylchromene

Chemidplus:0017598026

RTECS:DJ2529000 for cas# 17598-02-6

References:

	7-methoxy-2,2-dimethylchromene
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	28619
Pubchem (sid):	134993483
Pherobase:	View

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
CHEMBL:	View
Metabolomics Database:	Search
KEGG (GenomeNet):	C09017
HMDB (The Human Metabolome Database):	Search
Export Tariff Code:	2932.90.4100
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

found in nature

Synonyms:

2H-1-	benzopyran, 2,2-dimethyl-7-methoxy-
2H-1-	benzopyran, 7-methoxy-2,2-dimethyl-
	demethoxyageratochromene
6-	demethoxyageratochromene
2,2-	dimethyl-2H-chromen-7-yl methyl ether
2,2-	dimethyl-7-methoxy-2H-1-benzopyran
7-	methoxy-2,2-dimethyl chromene
7-	methoxy-2,2-dimethyl-2H-1-benzopyran
7-	methoxy-2,2-dimethyl-2H-chromen
7-	methoxy-2,2-dimethyl-2H-chromene
7-	methoxy-2,2-dimethyl-3-chromene
7-	methoxy-2,2-dimethylchromene

Articles:

PubMed:Ecocatalysis for 2H-chromenes synthesis: an integrated approach for phytomanagement of polluted ecosystems.

PubMed:Precocene-I inhibits juvenile hormone biosynthesis, ovarian activation, aggression and alters sterility signal production in bumble bee (Bombus terrestris) workers.

PubMed:Potential of essential oils for protection of grains contaminated by aflatoxin produced by Aspergillus flavus.

PubMed:Early manipulation of juvenile hormone has sexually dimorphic effects on mature adult behavior in Drosophila melanogaster.

PubMed:Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices.

PubMed:Volatile oils from the plant and hairy root cultures of Ageratum conyzoides L.

PubMed:Schistosomicidal activity of the essential oil of Ageratum conyzoides L. (Asteraceae) against adult Schistosoma mansoni worms.

PubMed:Chemical composition and antibacterial activity of essential oils of Lantana camara, Ageratum houstonianum and Eupatorium adenophorum.

PubMed:Ageratum conyzoides essential oil as aflatoxin suppressor of Aspergillus flavus.

PubMed:New synthetic precocenoids as potential insect control agents.

PubMed:Isolation and identification of precocenes and piperitone from essential oils as specific inhibitors of trichothecene production by Fusarium graminearum.

PubMed:Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety.

PubMed:Photochromic agents as tools for protein structure study: lapachenole is a photoaffinity ligand of cytochrome P450 3A4.

PubMed:Toxicological efficacy of some indigenous dill compounds against the flesh fly, Parasarcophaga dux Thomson.

PubMed:[Effect of plants synthesizing biologically active substances-precocenes on insects].

PubMed:Synthesis of new heterocycles through a cation-driven tandem ring-enlargement-annulation reaction.

PubMed:Analysis of precocenes in the essential oil of Ageratum spp. by reverse-phase high-performance liquid chromatography.

PubMed:An ion exchange liquid chromatography/mass spectrometry method for the determination of reduced and oxidized glutathione and glutathione conjugates in hepatocytes.

PubMed:Role of juvenile hormone in the synthesis and sequestration of vitellogenins in the red cotton stainer, Dysdercus koenigii (Heteroptera: Pyrrhocoridae).

PubMed:[The effect of antihormones on the susceptibility of Anopheles sacharovi Favre. mosquitoes to the causative agent of malaria Plasmodium gallinaceum Brumpt].

PubMed:Cloning of the cDNA encoding Scg-SPRP, an unusual Ser-protease-related protein from vitellogenic female desert locusts (Schistocerca gregaria).

PubMed:Cloning of two cDNAs encoding three small serine protease inhibiting peptides from the desert locust Schistocerca gregaria and analysis of tissue-dependent and stage-dependent expression.

PubMed:Structural requirements for the direct and cytochrome P450-dependent reaction of cyclic alpha,beta-unsaturated carbonyl compounds with glutathione: a study with coumarin and related compounds.

PubMed:Effect of serum-free medium on cytochrome P450-dependent metabolism and toxicity in rat cultured hepatocytes.

PubMed:Effects of precocenes on vitellogenesis in the adult female tick, Ornithodoros moubata (Acari: Argasidae).

PubMed:Maintenance of monooxygenase activities and detection of cytochrome P-450-mediated cytotoxicity in Mongolian gerbil hepatocyte cultures.

PubMed:Effects of proallatotoxins (precocenes) on the development and reproduction of Rhodnius prolixus: some data.

PubMed:Precocene I and Other Constituents of the Essential Oil of Platostoma africanum.

PubMed:Effects of precocene analogs on the nematode Caenorhabditis remanei (var. Bangaloreiensis). II. Competitions with a juvenile hormone analog (Methoprene).

PubMed:Effects of precocene analogs on the nematode Caenorhabditis remanei (var. Bangaloreiensis). I. Structure/activity relations.

PubMed:The antiallatal effects on locusts and lethal effects on nematodes of synthetic precocene-1 derivatives differing at the carbon 7 position.

PubMed:Structure-activity studies of the hepatocarcinogenicities of alkenylbenzene derivatives related to estragole and safrole on administration to preweanling male C57BL/6J x C3H/HeJ F1 mice.

PubMed:Hepatotoxicity of precocene I in rats. Role of metabolic activation in vivo.

PubMed:Effects of precocenes on ovarian development of the seed bug, Oxycarenus lavaterae (F.).

PubMed:Metabolism and hepatotoxicity of the naturally occurring benzo[b]pyran precocene I.

PubMed:The absolute configuration of precocene I dihydrodiols produced by metabolism of precocene I by corpora allata of Locusta migratoria, in vitro.

PubMed:[Action of development inhibitors on Aedes aegypti L. mosquitoes and Rhodnius prolixus Stal. bugs. IV. The activity of precocenes].

PubMed:Activity of precocenes on the Chagas's disease vector, Panstrongylus megistus.

Notes:

inhibits juvenille hormones.

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