EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

heliotropic acid
3,4-methylenedioxybenzoic acid

Supplier Sponsors

CAS Number: 94-53-1Picture of molecule3D/inchi
Other(deleted CASRN):1160950-49-1
ECHA EINECS - REACH Pre-Reg:202-342-8
FDA UNII: QX3V1NO0KH
Nikkaji Web:J4.700G
Beilstein Number:150206
MDL:MFCD00005830
XlogP3:0.40 (est)
Molecular Weight:166.13262000
Formula:C8 H6 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 227.00 to 228.00 °C. @ 760.00 mm Hg
Boiling Point: 324.59 °C. @ 760.00 mm Hg (est)
Flash Point: 283.00 °F. TCC ( 139.60 °C. ) (est)
logP (o/w): 0.810 (est)
Soluble in:
 water, 1424 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Piperonylic acid 98%
BOC Sciences
For experimental / research use only.
Piperonylic acid 97%
EMD Millipore
For experimental / research use only.
Piperonylic acid
sds
Penta International
PIPERONYLIC ACID
Santa Cruz Biotechnology
For experimental / research use only.
Piperonylic acid
Sigma-Aldrich: Aldrich
For experimental / research use only.
Piperonylic acid 99%
sds
TCI AMERICA
For experimental / research use only.
Heliotropic Acid >98.0%(GC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 > 800 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 196, Pg. 478, 1976.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for heliotropic acid usage levels up to:
 not for fragrance use.
 
Recommendation for heliotropic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):94-53-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7196
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
1,3-benzodioxole-5-carboxylic acid
Chemidplus:0000094531
RTECS:DF4912765 for cas# 94-53-1
 
References:
 1,3-benzodioxole-5-carboxylic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):7196
Pubchem (sid):134971290
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB32613
FooDB:FDB010554
Export Tariff Code:2918.99.4700
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 camphor
Search PMC Picture
 pha-chium
Search PMC Picture
 
Synonyms:
 benzo[1,3]dioxole-5-carboxylic acid
 benzo[d][1,3]dioxole-5-carboxylic acid
2H-benzo[d]1,3-dioxolene-5-carboxylic acid
1,3-benzodioxole-5-carboxylic acid
 benzoic acid, 3,4-(methylenedioxy)-
3,4-dioxymethylenebenzoic acid
3,4-methylene dioxybenzoic acid
3,4-(methylenedioxy)benzoic acid
3,4-methylenedioxybenzoic acid
 piperonylic acid
 piperonylicacid
 protocatechuic acid methylene ether
 

Articles:

PubMed:Antifungal activity of compounds extracted from Cortex Pseudolaricis against Colletotrichum gloeosporioides.
PubMed:Enhanced lignin monomer production caused by cinnamic Acid and its hydroxylated derivatives inhibits soybean root growth.
PubMed:Phenolic esters of O-desmethylvenlafaxine with improved oral bioavailability and brain uptake.
PubMed:Cinnamic acid increases lignin production and inhibits soybean root growth.
PubMed:Non-cell-autonomous postmortem lignification of tracheary elements in Zinnia elegans.
PubMed:Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli.
PubMed:[Study on the bioactive constituents of Piper wallichii].
PubMed:Exogenous caffeic acid inhibits the growth and enhances the lignification of the roots of soybean (Glycine max).
PubMed:Accumulation of p-hydroxybenzoic acid in hairy roots of Daucus carota 2: confirming biosynthetic steps through feeding of inhibitors and precursors.
PubMed:Soybean (Glycine max) root lignification induced by ferulic acid. The possible mode of action.
PubMed:Metabolites from the Lichen Ochrolechia parella growing under two different heliotropic conditions.
PubMed:8-Bromo-7-hydroxyquinoline as a photoremovable protecting group for physiological use: mechanism and scope.
PubMed:Study of cis-cinnamic acid in Arabidopsis thaliana.
PubMed:Synthesis and evaluation of the antitrypanosomal and antiplasmodial activities of new 4-aminobicyclo[2.2.2]octane derivatives.
PubMed:Thermodynamic study of sesamol, piperonyl alcohol, piperonylic acid and homopiperonylic acid: a combined experimental and theoretical investigation.
PubMed:Biotransformations of propenylbenzenes by an Arthrobacter sp. and its t-anethole blocked mutants.
PubMed:Chemical inactivation of the cinnamate 4-hydroxylase allows for the accumulation of salicylic acid in elicited cells.
PubMed:Free and conjugated benzoic acid in tobacco plants and cell cultures. Induced accumulation upon elicitation of defense responses and role as salicylic acid precursors.
PubMed:Piperonylic acid, a selective, mechanism-based inactivator of the trans-cinnamate 4-hydroxylase: A new tool to control the flux of metabolites in the phenylpropanoid pathway
PubMed:[New data on heliotropic dystrophy of the liver].
PubMed:Metabolic disposition of piperine in the rat.
PubMed:The metabolism of some food additives related to piperonal in the rabbit.
PubMed:Heterocyclic and piperonylic acid esters of 1-methyl-4-piperidinol as analgesics.
PubMed:Biologically active substances in oak gall extracts. Part 1: Isolation and chemical identification of a substance exerting antihistamine-like activity (KC-18).
PubMed:Microbial degradation of piperonylic acid.
PubMed:Microbial degradation of piperonylic acid by Pseudomonas fluorescens.
PubMed:Piperonylic acid conjugates with alanine, glutamate, glutamine, glycine, and serine in living houseflies.
 
Notes:
Isol. from Piper longum (long pepper)
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