EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sodium phenyl pyruvate
2-oxo-3-phenylpropionic acid sodium salt

Supplier Sponsors

Name:sodium 2-oxo-3-phenylpropanoate
CAS Number: 114-76-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-053-2
FDA UNII: 7528CW33WW
Nikkaji Web:J193.612C
Beilstein Number:4770978
MDL:MFCD00002590
Molecular Weight:186.14215928
Formula:C9 H7 Na O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:flavor enhancers
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1479 2-oxo-3-phenylpropionic acid sodium salt
FEMA Number:3892 2-oxo-3-phenylpropionic acid sodium salt
FDA:No longer provide for the use of these seven synthetic flavoring substances
 
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 300.00 to 302.00 °C. @ 760.00 mm Hg
Boiling Point: 299.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000546 mmHg @ 25.00 °C. (est)
Flash Point: 300.00 °F. TCC ( 148.90 °C. ) (est)
logP (o/w): 0.537 (est)
Soluble in:
 water, 6.522e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Description:honey
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Phenylpyruvic acid sodium salt monohydrate
Parchem
sodium phenyl pyruvate
Santa Cruz Biotechnology
For experimental / research use only.
Phenylpyruvic acid, sodium salt ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Sodium phenylpyruvate 98%
sds
TCI AMERICA
For experimental / research use only.
Sodium Phenylpyruvate Monohydrate >98.0%(HPLC)(T)
sds
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
flavor enhancers
Recommendation for sodium phenyl pyruvate usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 18
Click here to view publication 18
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): 0.5000010.00000
beverages(alcoholic): --
breakfast cereal: 1.000005.00000
cheese: 0.500005.00000
chewing gum: 1.000005.00000
condiments / relishes: --
confectionery froastings: 1.000005.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: 0.500005.00000
gelatins / puddings: 0.500005.00000
granulated sugar: --
gravies: --
hard candy: 1.000005.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: 0.500005.00000
nut products: --
other grains: 1.000005.00000
poultry: --
processed fruits: 0.100001.00000
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 50.00000100.00000
snack foods: --
soft candy: 1.000005.00000
soups: --
sugar substitutes: 0.500005.00000
sweet sauces: 1.000005.00000
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :23667645
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
sodium 2-oxo-3-phenylpropanoate
Chemidplus:0000114761
 
References:
 sodium 2-oxo-3-phenylpropanoate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):23667645
Pubchem (sid):135025621
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2918.30.3000
FDA Listing of Food Additive Status:View
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 benzenepropanoic acid, a-oxo-, sodium salt
 benzenepropanoic acid, a-oxo-, sodium salt (1:1)
 phenyl pyruvic acid sodium salt
 phenyl pyruvic acid sodium salt monohydrate
2-oxo-3-phenylpropionic acid sodium salt
 phenylpyruvic acid sodium salt
 phenylpyruvic acid, sodium salt
 sodium 2-oxidanylidene-3-phenyl-propanoate
 sodium 2-oxo-3-phenyl propanoate
 sodium 2-oxo-3-phenyl propionate
 sodium 2-oxo-3-phenylpropanoate
 sodium 3-phenyl pyruvate
 sodium phenylpyruvate
 sodium phenylpyruvate monohydrate
 sodiumphenylpyruvate
 

Articles:

PubMed:Differential resuscitative effect of pyruvate and its analogues on VBNC (viable but non-culturable) Salmonella.
PubMed:Study on urinary metabolic profile of phenylketonuria by micellar electrokinetic capillary chromatography with dual electrochemical detection--potential clinical application in fast diagnosis of phenylketonuria.
PubMed:Discovery and characterization of D-phenylserine deaminase from Arthrobacter sp. TKS1.
PubMed:Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K.
PubMed:Rapid one-step separation and purification of recombinant phenylalanine dehydrogenase in aqueous two-phase systems.
PubMed:Comparative studies on enzyme preparations and role of cell components for (R)-phenylacetylcarbinol production in a two-phase biotransformation.
PubMed:Antioxidants inhibit human endothelial cell functions through down-regulation of endothelial nitric oxide synthase activity.
PubMed:Strategies for neuroprotection against L-trans-2,4-pyrrolidine dicarboxylate-induced neuronal damage during energy impairment in vitro.
PubMed:Purification and characterization of pyruvate kinase from lamprey (Entosphenus japonicus) muscle.
PubMed:Some metabotropic glutamate receptor ligands reduce kynurenate synthesis in rats by intracellular inhibition of kynurenine aminotransferase II.
PubMed:Anilides of (R)-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase.
PubMed:[Effects of ultraviolet irradiation of blood and sodium hypochlorite on aromatic amino acid metabolism in phlegmons of the maxillofacial region].
PubMed:Metabolic and K(ATP) channel-independent actions of keto acid initiators of insulin secretion.
PubMed:Effects of in vivo sodium azide administration on the immunohistochemical localization of kynurenine aminotransferase in the rat brain.
PubMed:Effect of microbial siderophores on matrix metalloproteinase-2 activity.
PubMed:Quantitative determination of aromatic amino acids and related compounds in rumen fluid by high-performance liquid chromatography.
PubMed:Catalytic properties, molecular composition and sequence alignments of pyruvate: ferredoxin oxidoreductase from the methanogenic archaeon Methanosarcina barkeri (strain Fusaro).
PubMed:Alanine reverses the inhibitory effect of phenylalanine and its metabolites on Na+,K(+)-ATPase in synaptic plasma membranes from cerebral cortex of rats.
PubMed:Rapid determination of phenylalanine and its related compounds in rumen fluid by high-performance liquid chromatography.
PubMed:Stimulation of weak organic acid uptake in rat renal tubules by cadmium and nystatin.
PubMed:Age-related changes in kynurenic acid production in rat brain.
PubMed:Kynurenine aminotransferase activity in human liver: identity with human hepatic C-S lyase activity and a physiological role for this enzyme.
PubMed:Purification and characterization of kynurenine-pyruvate aminotransferase from rat kidney and brain.
PubMed:Purification and characterization of the pyruvate-ferredoxin oxidoreductase from Clostridium acetobutylicum.
PubMed:Distinct phases of the fluorescence response of the lipophilic probe N-phenyl-1-naphthylamine in intact cells and membrane vesicles of Escherichia coli.
PubMed:Purification and characterization of a high molecular weight type 1 phosphoprotein phosphatase from the human erythrocyte.
PubMed:Chemoreflexes in rabbits.
PubMed:Purification and characterization of yeast L-kynurenine aminotransferase with broad substrate specificity.
PubMed:Involvement of D-amino-acid oxidase in D-amino acid utilization in the mouse.
PubMed:Inhibition of carnitine palmitoyltransferase 1 by phenylalkyloxiranecarboxylic acid and its influence on lipolysis and glucose metabolism in isolated, perfused hearts of streptozotocin-diabetic rats.
PubMed:Transport of alpha-keto analogues of amino acids across blood-brain barrier in rats.
PubMed:Effects of phenylalanine and its deaminated metabolites on Na+,K+-ATPase activity in synaptosomes from rat brain.
PubMed:Effect of pyruvate decarboxylase activity and of pyruvate concentration on the production of 1-hydroxy-1-phenylpropanone in Saccharomyces carlsbergensis.
PubMed:Metabolic effects of L-phenyllactate in perfused kidney, liver, and muscle.
PubMed:Tryptophan and hydrogen sulfide reaction from modified trypticase soy agar.
PubMed:Characteristics of hepatic serine-pyruvate aminotransferase in different mammalian species.
PubMed:Effects of aldosterone on Na+ transport in the toad bladder. I. Glycolysis and lactate production under aerobic conditions.
PubMed:Purification and properties of chorismate mutase-prephenate dehydratase and prephenate dehydrogenase from Alcaligenes eutrophus.
PubMed:Studies on phenylpyruvic acid. I. Keto-enol tautomerism.
PubMed:Purification and properties of avian liver p-hydroxyphenylpyruvate hydroxylase.
PubMed:Effects of sodium phenylpyruvate on amino acid formation in brain.
PubMed:[STUDY OF TRYPTOPHAN METABOLISM IN MAN. APPLICATION TO 2 CASES OF D'EJ'ERINE-SOTTAS DISEASE].
PubMed:Effects of sodium phenylpyruvate on brain amino acids.
PubMed:Effects of L-phenylalanine and sodium phenylpyruvate on the formation of melanin from L-tyrosine in melanoma.
PubMed:Effects of l-phenylalanine and sodium phenylpyruvate on the formation of adrenaline from l-tyrosine in adrenal medulla in vitro.
 
Notes:
None found
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