phenolsulfonphthalein
3H-2,1-benzoxathiole, 3,3-bis(4-hydroxyphenyl)-, 1,1-dioxide
 
Notes:
red dye, ph indicator, and diagnostic aid for determination of renal function. it is used also for studies of the gastrointestinal and other systems.
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Synonyms   Articles   Notes   Search
4-[3-(4-hydroxyphenyl)-1,1-dioxo-2,1lamda6-benzoxathiol-3-yl]phenol (Click)
CAS Number: 143-74-8Picture of molecule
Other: 2877-88-5
ECHA EINECS - REACH Pre-Reg: 205-609-7
FDA UNII: I6G9Y0J1OJ
Nikkaji Web: J5.823H
Beilstein Number: 0326470
MDL: MFCD00003552
XlogP3: 3.00 (est)
Molecular Weight: 354.38158000
Formula: C19 H14 O5 S
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: buffering agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 562.80 °C. @ 760.00 mm Hg (est)
Flash Point: 562.00 °F. TCC ( 294.20 °C. ) (est)
logP (o/w): 3.020
Soluble in:
 water, 770 mg/L @ 100C (exp)
 water, 58.41 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: buffering agents
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Suppliers:
Abbey Color
Phenol Red Dye
Odor: characteristic
Use: Abbey Color is a leading manufacturer of phenol red dye. Phenol red is a water-soluble dye used as a pH indicator, changing from yellow to red over pH 6.6 to 8.0, and then turning a bright pink color above pH 8.1. As such, phenol red can be used as a pH indicator dye in various medical and cell biology tests.
EMD Millipore
For experimental / research use only.
Phenol Red
Santa Cruz Biotechnology
For experimental / research use only.
Phenol Red ≥95%
Sigma-Aldrich
For experimental / research use only.
Phenol Red powder, BioReagent, suitable for cell culture
TCI AMERICA
For experimental / research use only.
Phenol Red
Universal Preserv-A-Chem Inc.
PHENOL RED
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50  1368 mg/kg
Drugs in Japan Vol. -, Pg. 930, 1990.

intravenous-rat LD50  752 mg/kg
Drugs in Japan Vol. -, Pg. 930, 1990.

Dermal Toxicity:
subcutaneous-rat LD50 > 600 mg/kg
Clinical Toxicology. Vol. 4(2), Pg. 185, 1971.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: buffering agents
Recommendation for phenolsulfonphthalein usage levels up to:
 not for fragrance use.
 
Recommendation for phenolsulfonphthalein flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA GENetic TOXicology: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 143-74-8
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 4766
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 4-[3-(4-hydroxyphenyl)-1,1-dioxo-2,1lamda6-benzoxathiol-3-yl]phenol
Chemidplus: 0000143748
RTECS: SJ7490000 for cas# 143-74-8
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References:
 4-[3-(4-hydroxyphenyl)-1,1-dioxo-2,1lamda6-benzoxathiol-3-yl]phenol
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 143-74-8
Pubchem (cid): 4766
Pubchem (sid): 134973933
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C12600
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2930.90.2900
Haz-Map: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
4,4'-(3H-2,1-benzoxathiol-3-ylidene)bisphenol S,S-dioxide
4,4'-(3H,2,1-benzoxathiol-3-ylidene)bisphenol S,S-dioxide
4,4'-(3H-2,1-benzoxathiol-3-ylidene)diphenol S,S-dioxide
3H-2,1-benzoxathiole, 3,3-bis(4-hydroxyphenyl)-, 1,1-dioxide
4,4'-(1,1-dioxido-3H-2,1-benzoxathiole-3,3-diyl)diphenol
 fenolipuna
a-hydroxy-a,a-bis(p-hydroxyphenyl)-o-toluenesulfonic acid g-sultone
4-[3-(4-hydroxyphenyl)-1,1-dioxo-2,1lamda6-benzoxathiol-3-yl]phenol
3,3-bis(p-hydroxyphenyl)-3H-2,1-benzoxathiole 1,1-dioxide
3,3-bis(4-hydroxyphenyl)-3H-2,1l6-benzoxathiole-1,1-dione
3,3-bis(4-hydroxyphenyl)benzo[c]1,2-oxathiolene-1,1-dione
 phenol red
 phenol, 4,4-(3H-2, 1-benzoxathiol-3-ylidene)di-, S-S-dioxide
 phenol, 4,4-(3H-2, 1-benzoxathiol-3-ylidene)di-, S,S-dioxide
 phenol, 4,4-(3H-2,1-benzoxathiol-3-ylidene)di-, S-S-dioxide
 phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis-
 phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis-, (S,S-dioxide)
 phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis-, S,S-dioxide
 phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis-,S,S-dioxide (9CI)
 phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)di-, S,S-dioxide
 phenolsulfonephthalein
 phenolsulphonephthalein
 phenosulfophthalein
 phenylsulfonephthalein
 PSP
 sulfonphthal
 sulphental
 sulphonthal
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Articles:
PubMed: Expression of gastrointestinal nesfatin-1 and gastric emptying in ventromedial hypothalamic nucleus- and ventrolateral hypothalamic nucleus-lesioned rats.
PubMed: L-lysine dose dependently delays gastric emptying and increases intestinal fluid volume in humans and rats.
PubMed: A comparative rapid and sensitive method to screen l-asparaginase producing fungi.
PubMed: Mn(2+)-deficiency reveals a key role for the Pleurotus ostreatus versatile peroxidase (VP4) in oxidation of aromatic compounds.
PubMed: The Puzzling Issue of 'Vehicle-Treated Control' when Using Ethanol as Drug Carrier for MCF-7 Cells.
PubMed: [Investigation of antimicrobial and antibiofilm effects of some preservatives used in drugs, cosmetics and food products].
PubMed: Protective effect of an immune-modulating diet comprising whey peptides and fermented milk products on indomethacin-induced small-bowel disorders in rats.
PubMed: Caffeic acid inhibits organic anion transporters OAT1 and OAT3 in rat kidney.
PubMed: PrfA-like transcription factor gene lmo0753 contributes to L-rhamnose utilization in Listeria monocytogenes strains associated with human food-borne infections.
PubMed: The effect of Taraxacum officinale on gastric emptying and smooth muscle motility in Rodents.
PubMed: Pharmacological evaluation of Alstonia scholaris: anti-tussive, anti-asthmatic and expectorant activities.
PubMed: Serogroup distribution and virulence characteristics of sorbitol-negative Escherichia coli from food and cattle stool.
PubMed: Responses of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in MCF-7 cells are culture condition dependent.
PubMed: Bovine colostrum prevents bacterial translocation in an intestinal ischemia/reperfusion-injured rat model.
PubMed: Prevalence of methicillin-resistant Staphylococcus aureus in meat.
PubMed: A simple and rapid Hepatitis A Virus (HAV) titration assay based on antibiotic resistance of infected cells: evaluation of the HAV neutralization potency of human immune globulin preparations.
PubMed: Gastric emptying in response to IAPP and CCK in rats with subdiaphragmatic afferent vagotomy.
PubMed: The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet.
PubMed: Resveratrol modulates roscovitine-mediated cell cycle arrest of human MCF-7 breast cancer cells.
PubMed: Determination of inorganic bromide content in several vegetable foods.
PubMed: Effect of Prototheca zopfii on neutrophil function from bovine milk.
PubMed: Leptin inhibits gastric emptying in rats: role of CCK receptors and vagal afferent fibers.
PubMed: [Gastric emptying of liquids in rats submitted to acute myocardial infarction].
PubMed: A conscious mouse model of gastric ileus using clinically relevant endpoints.
PubMed: Gastric emptying in premature newborns with acute respiratory distress.
PubMed: Quantifying individual fruit fly consumption with Anastrepha suspensa (Diptera: Tephritidae).
PubMed: Intestinal electric stimulation decreases fat absorption in rats: therapeutic potential for obesity.
PubMed: Gastric emptying and gastrointestinal transit of liquid in awake rats is delayed after acute myocardial infarction.
PubMed: [Comparison on dissolving sputum and anti-inflammation of "mao ju hong" and "guang ju hong"].
PubMed: [Effects of environmental estrogens on apoptosis induced by estrogen depletion in T47D cells].
PubMed: Assessment of the presence of Salmonella spp. in Egyptian dairy products using various detection media.
PubMed: Spread of bacterial pathogens during preparation of freshly squeezed orange juice.
PubMed: Evaluation of consumer-style cooking methods for reduction of Escherichia coli O157:H7 in ground beef.
PubMed: The addition of soybean phosphatidylcholine to triglyceride increases suppressive effects on food intake and gastric emptying in rats.
PubMed: Inhibitory effect of Eucommia ulmoides Oliv. on oxidative DNA damage in lymphocytes induced by H2O2.
PubMed: Bilateral nephrectomy delays gastric emptying of a liquid meal in awake rats.
PubMed: Fast Green FCF (Food Green 3) inhibits synaptic activity in rat hippocampal interneurons.
PubMed: Effects of continuous microchip (MC) vagal neuromodulation on gastrointestinal function in rats.
PubMed: Small amount of low-residue diet with parenteral nutrition can prevent decreases in intestinal mucosal integrity.
PubMed: Gastric response to increased meal viscosity assessed by echo-planar magnetic resonance imaging in humans.
PubMed: Occurrence of Escherichia coli O157:H7 in hamburgers produced in Brazil.
PubMed: Postprandial normal saline intake delays gastric emptying of solids in conscious dogs: partial involvement of CCK in its mechanism.
PubMed: Development of a medium for differentiation between Escherichia coli and Escherichia coli O157:H7.
PubMed: Identification of Listeria monocytogenes from unpasteurized apple juice using rapid test kits.
PubMed: Thermal inactivation of Escherichia coli O157:H7, Salmonella senftenberg, and enzymes with potential as time-temperature indicators in ground turkey thigh meat.
PubMed: Amino acid decarboxylase capability of microorganisms isolated in Spanish fermented meat products.
PubMed: Estrogen affects development of alveolar structures in whole-organ culture of mouse mammary glands.
PubMed: Antibacterial activity of formic and propionic acids in the diet of hens on Salmonellas in the crop.
PubMed: Recovery of thermally-stressed Escherichia coli O157:H7 by media supplemented with pyruvate.
PubMed: Influence of aging on gastric emptying of liquids, small intestine transit, and fecal output in rats.
PubMed: Gastric emptying of ingested fat emulsion in rats: implications for studies of fat-induced satiety.
PubMed: Chronic effects of misoprostol in combination with the NSAID, diclofenac, on gastrointestinal tract of pigs. Relation to diarrheagenic activity, leukocyte infiltration, and mucosal leukotrienes.
PubMed: Effects of nutrient solutions on concentration analysis of non-absorbable dilution markers--implications for studies of gastric emptying.
PubMed: Elemental diet and IV-TPN-induced bacterial translocation is associated with loss of intestinal mucosal barrier function against bacteria.
PubMed: On the absorption of alendronate in rats.
PubMed: Evaluation of the effects of varying solute content on the efficacy of oral rehydration solutions in a rat model of secretory diarrhoea.
PubMed: [The detection of salmonellas using Rambach agar].
PubMed: Pharmacokinetics and excretion of phenol red in the channel catfish.
PubMed: Evidence for a new extracellular peroxidase. Manganese-inhibited peroxidase from the white-rot fungus Bjerkandera sp. BOS 55.
PubMed: Inhibitory effect of ileal oleate on postprandial motility of the upper gut.
PubMed: Effects of a histamine type-2 receptor antagonist (BMY-25368) on gastric secretion in horses.
PubMed: Analysis of hydrogen peroxide in freshly prepared coffees.
PubMed: Liquid and solid selective differential media for the detection and enumeration of L. monocytogenes and other Listeria spp.
PubMed: Effects of drinking water acidification, restriction of water supply and individual caging on parameters of toxicological studies in rats.
PubMed: Determination of total gastric volume, gastric secretion and residual meal using the double sampling technique of George.
PubMed: Use of MRSD medium and the hydrophobic grid membrane filter technique to differentiate between pediococci and lactobacilli in fermented meat and starter cultures.
PubMed: A selective and diagnostic medium for use in the enumeration of Listeria spp. in foods.
PubMed: Food restriction and recovery of nonabsorbed indicators from the small intestine of the rat.
PubMed: Desferrioxamine as an electron donor. Inhibition of membranal lipid peroxidation initiated by H2O2-activated metmyoglobin and other peroxidizing systems.
PubMed: The effect of an oral evening dose of nizatidine on nocturnal and peptone-stimulated gastric acid and gastrin secretion.
PubMed: Effects of certain dietary fibers on apparent permeability of the rat intestine.
PubMed: In vivo metabolism and disposition of drugs by aquatic species.
PubMed: Intragastric feeding differentially affects apparent rate of gastric emptying of phenol red and carbohydrate.
PubMed: Starch-Ampicillin Agar for the Quantitative Detection of Aeromonas hydrophila.
PubMed: The influence of a chronic subclinical infection of Trichostrongylus colubriformis on gastrointestinal motility and digesta flow in sheep.
PubMed: The relation between food intake and abomasal emptying and small intestinal transit time in sheep.
PubMed: Post-prandial changes of osmolality and electrolyte concentration in the upper jejunum of normal man.
PubMed: [Salmonella in eviscerated chickens from processing plants of greater Buenos Aires].
PubMed: Parallel gastric emptying of nonhydrolyzable fat and water after a solid-liquid meal in humans.
PubMed: Relationship of motility to flow of contents in the human small intestine.
PubMed: Measurement of gastrointestinal transit of solid food using a colestipol-phenol red complex as a marker.
PubMed: Gastric emptying of lipids after ingestion of a solid-liquid meal in humans.
PubMed: Action of caerulein on gastric emptying of the conscious rat.
PubMed: Vagally induced gastric antral contractions and gastric emptying of a liquid test meal.
PubMed: [The extent to which ethanol absorption is influenced by an alteration of gastric emptying (author's transl)].
PubMed: The effect of different diets including those containing soya-bean products, on digesta movement and water and nitrogen absorption in the small intestine of the pre-ruminant calf.
PubMed: Hydrogen sulphide production as an aid to the identification of Vibrio parahaemolyticus.
PubMed: Control of gastric emptying by osmolality of duodenal contents in man.
PubMed: Disappearance of nitrite from the rat stomach: contribution of emptying and other factors.
PubMed: [Official inquiry into the presence of salmonella in frozen slaughtered poultry on the German market (author's transl)].
PubMed: Gastric emptying and secretion in the milk-fed calf.
PubMed: A comparison between phenol red and 51 Cr-EDTA as reference substances in rats by a test meal technique.
PubMed: Enumeration of Bacillus cereus in foods.
PubMed: Effects of xylitol on carbohydrate digesting enzymes activity, intestinal glucose absorption and muscle glucose uptake: a multi-mode study.
PubMed: Label-free, non-invasive light scattering sensor for rapid screening of Bacillus colonies.
PubMed: Development of a food spoilage indicator for monitoring freshness of skinless chicken breast.
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