EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

sodium palmitate
hexadecanoic acid, sodium salt (1:1)

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CAS Number: 408-35-5Picture of molecule3D/inchi
Other(deleted CASRN):155215-74-0
ECHA EINECS - REACH Pre-Reg:206-988-1
Nikkaji Web:J43.197D
Beilstein Number:3575882
Molecular Weight:278.41123928
Formula:C16 H31 Na O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:food-contact surface of paper and paperboard
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
186.1771 Sodium palmitate (packaging) View - review
FDA Mainterm (SATF):408-35-5 ; SODIUM PALMITATE
FDA Regulation:
Subpart I--Multipurpose Additives
Sec. 172.863 Salts of fatty acids.

Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 186.1771 Sodium palmitate.
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 286.00 to 287.00 °C. @ 760.00 mm Hg
Boiling Point: 340.60 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000033 mmHg @ 25.00 °C. (est)
Flash Point: 309.00 °F. TCC ( 154.10 °C. ) (est)
logP (o/w): 7.154 (est)
Soluble in:
 water, 33.32 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: cleansing agents
surfactant - emulsifying
viscosity controlling agents
BOC Sciences
For experimental / research use only.
sodium palmitate 75%
Odor: characteristic
Use: sodium palmitate is commonly used to produce cosmetics, soaps and release agents.
Santa Cruz Biotechnology
For experimental / research use only.
Sodium Palmitate ≥98.5
Sigma-Aldrich: Sigma
For experimental / research use only.
Sodium Palmitate ≥98.5%
For experimental / research use only.
Sodium Palmitate >97.0%(GC)(T)
Viva Corporation
Sodium Palmitate
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LDLo 10 mg/kg
Journal of Clinical Investigation. Vol. 42, Pg. 860, 1963.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
food-contact surface of paper and paperboard
Recommendation for sodium palmitate usage levels up to:
 not for fragrance use.
Recommendation for sodium palmitate flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Re-evaluation of sodium, potassium and calcium salts of fatty acids (E 470a) and magnesium salts of fatty acids (E 470b) as food additives
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):408-35-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :2735111
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
sodium hexadecanoate
RTECS:RT4945000 for cas# 408-35-5
 sodium hexadecanoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:408-35-5
Pubchem (cid):2735111
Pubchem (sid):134973648
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2915.70.0150
FDA Listing of Food Additive Status:View
Potential Blenders and core components note
None Found
Potential Uses:
 emulsifying agents
 viscosity controlling agents
Occurrence (nature, food, other):note
 not found in nature
 hexadecanoic acid sodium salt
 hexadecanoic acid sodium salt (1:1)
 hexadecanoic acid, sodium salt
 hexadecanoic acid, sodium salt (1:1)
 palmitic acid sodium salt
 palmitic acid, sodium salt
 sodium hexadecanoate
 sodium pentadecane carboxylate
 sodium pentadecanecarboxylate


PubMed:PDIA3 Knockdown Exacerbates Free Fatty Acid-Induced Hepatocyte Steatosis and Apoptosis.
PubMed:Bee's honey attenuates non-alcoholic steatohepatitis-induced hepatic injury through the regulation of thioredoxin-interacting protein-NLRP3 inflammasome pathway.
PubMed:The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice.
PubMed:A novel benzenediamine derivative FC98 reduces insulin resistance in high fat diet-induced obese mice by suppression of metaflammation.
PubMed:Preparation and properties of films cast from mixtures of poly(vinyl alcohol) and submicron particles prepared from amylose-palmitic acid inclusion complexes.
PubMed:Modulation of physical properties of supramolecular hydrogels based on a hydrophobic core.
PubMed:Inhibiting CB1 receptors improves lipogenesis in an in vitro non-alcoholic fatty liver disease model.
PubMed:Bcl-2 maintains the mitochondrial membrane potential, but fails to affect production of reactive oxygen species and endoplasmic reticulum stress, in sodium palmitate-induced β-cell death.
PubMed:Cyclooxygenase-2-dependent oxidative stress mediates palmitate-induced impairment of endothelium-dependent relaxations in mouse arteries.
PubMed:Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes.
PubMed:Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells.
PubMed:Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3β activation in human liver cells.
PubMed:Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase.
PubMed:Effect of amylopectin on the rheological properties of aqueous dispersions of starch-sodium palmitate complexes.
PubMed:Preparation of starch-stabilized silver nanoparticles from amylose-sodium palmitate inclusion complexes.
PubMed:The synthesis and characterization of fatty acid salts of chitosan as novel matrices for prolonged intragastric drug delivery.
PubMed:Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways.
PubMed:Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway.
PubMed:Hydrophobically modified biomineralized polysaccharide alginate membrane for sustained smart drug delivery.
PubMed:Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2 liver cells.
PubMed:High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression.
PubMed:Ghrelin inhibits apoptosis induced by high glucose and sodium palmitate in adult rat cardiomyocytes through the PI3K-Akt signaling pathway.
PubMed:Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling.
PubMed:Preparation and characterization of a new lipid nano-emulsion containing two cosurfactants, sodium palmitate for droplet size reduction and sucrose palmitate for stability enhancement.
PubMed:Electron donor solvent effects provide biosensing with quantum dots.
PubMed:Complex formation in alkyldimethylamine oxide/sodium palmitate/water mixtures.
PubMed:Oligonucleosomal DNA fragmentation in MCF-7 cells undergoing palmitate-induced apoptosis.
PubMed:Effect of glucose and fatty acid availability on neonatal and adult heart contractility.
PubMed:Study on the lifetime and attenuation properties of microbubbles coated with carboxylic acid salts.
PubMed:Production of isopropyl cis-6-hexadecenoate by regiospecific desaturation of isopropyl palmitate by a double mutant of a Rhodococcus strain.
PubMed:Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro.
PubMed:Alterations in kidney enzyme pattern in acute hypervitaminosis A.
PubMed:Incorporation of proteins in sphingomyelin-water gel phases.
PubMed:Amplification of palmitate-induced inhibition of cholesterol biosynthesis in cultured rat hepatocytes by garlic-derived organosulfur compounds.
PubMed:Inhibition of antibacterial activity of himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus, by fatty acid sodium salts.
PubMed:Thermodynamics of binding water and solute to powdered long-chain salts of fatty acids.
PubMed:Alterations of cerebromicrovascular Na+,K(+)-ATPase activity due to fatty acids and acute hypertension.
PubMed:Arachidonic acid regulates the binding of human interferon in human skin fibroblasts.
PubMed:Chemical characterization and biologic properties of lipopolysaccharide from Bacteroides gingivalis strains W50, W83, and ATCC 33277.
PubMed:Refolding human serum albumin at relatively high protein concentration.
PubMed:Short-term effects of carbon tetrachloride on the lipoprotein secretion in isolated rat hepatocytes.
PubMed:Biosynthesis of sex pheromone components and glycerolipid precursors from sodium [1-(14)C]acetate in redbanded leafroller moth.
PubMed:Covalently linked fatty acids in gastric mucus glycoprotein of cystic fibrosis patients.
PubMed:Effects of excess free fatty acids on the electrophysiological properties of ventricular specialized conducting tissue: a comparative study between the sheep and the dog.
PubMed:Chemical and chromatographic analysis of lipopolysaccharide from an antibiotic-supersusceptible mutant of Pseudomonas aeruginosa.
PubMed:Differential thermal analysis of dipalmitoylphosphatidylcholine--fatty acid mixtures.
PubMed:[Effect of sodium palmitate on cardiac rhythm in rats].
PubMed:Selective and differential media for isolation and tentative identification of each species of Pityrosporum residing on normal or diseased human skin.
PubMed:Effect of free fatty acid concentration on furosemide binding to human serum albumin.
PubMed:Studies on new aminoglycoside antibiotics, istamycins, from an actinomycete isolated from a marine environment. II. Possible involvement of plasmid in istamycin production.
PubMed:[Release of noradrenaline and ventricular arrhythmias in the isolated perfused working rat heart in the presence of fatty acids. Effect of coronary artery occlusion and re-perfusion (author's transl)].
PubMed:Arrhythmogenic effects of sodium palmitate on canine subendocardial Purkinje fibres as evidenced by recording transmembrane action potentials [proceedings].
PubMed:Effect of fatty acids on renal ammoniagenesis in in vivo and in vitro studies.
PubMed:Influence of sodium palmitate on the cellular action of potentials of the left ventricle of isolated, perfused guinea-pig heart.
PubMed:Influence of sodium palmitate in the solubilization of cholesterol in an in vitro model of bile.
PubMed:Kinetics of the processes of desorption from fatty acid monolayers.
PubMed:[Effect of ultraviolet light on sodium palmitate in the absence of oxygen].
PubMed:Platelet adhesiveness and euglobulin lysis time in dogs given repeated infusion of sodium palmitate.
PubMed:Acylation of sn-glycerol 3-phosphate by cell fractions of rat liver.
PubMed:Incorporation of 1-C14 sodium palmitate into lipids of the ovariole of Galleria mellonella.
PubMed:Incorporation of 14-C-sodium palmitate into lipids and cell interaction in ovarioles of Galleria mellonella (Lepidoptera).
PubMed:The interaction of human erythrocytes with sodium palmitate.
PubMed:The phase nature of beta sodium palmitate.
a common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids. Used as a food additive [EAFUS]
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