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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 340 mg/L @ 25 °C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 916 mg/kg
CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1893, 1978.
oral-mouse LD50 2340 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1893, 1978.
intraperitoneal-rat LD50 874 mg/kg
CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1893, 1978.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for para-toluic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for para-toluic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf
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| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):99-94-5 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :7470 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:1 |
| 4-methylbenzoic acid |
| Chemidplus:0000099945 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:XU1575000 for cas# 99-94-5 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzoic acid, 4-methyl- | | | crithminic acid | | 4- | methyl benzoic acid | | 4- | methylbenzoic acid | | p- | methylbenzoic acid | | | toluene carboxylic acid | | 4- | toluic acid | | p- | toluic acid |
Articles:
| PubMed:Biotransformation of p-xylene into terephthalic acid by engineered Escherichia coli. |
| PubMed:Supported C-Scorpionate Vanadium(IV) Complexes as Reusable Catalysts for Xylene Oxidation. |
| PubMed:Supramolecular hydrogen-bonding patterns in 1:1 cocrystals of 5-fluorouracil with 4-methylbenzoic acid and 3-nitrobenzoic acid. |
| PubMed:Synthesis, characterization and antifungal efficacy of C-coordinated O-carboxymethyl chitosan Cu(II) complexes. |
| PubMed:A Sustainable Route to a Terephthalic Acid Precursor. |
| PubMed:Fast and efficient synthesis of Zorro-LNA type 3'-5'-5'-3' oligonucleotide conjugates via parallel in situ stepwise conjugation. |
| PubMed:Degradation pathway and kinetic analysis for p-xylene removal by a novel Pandoraea sp. strain WL1 and its application in a biotrickling filter. |
| PubMed:Insight into luminescence enhancement of coordinated water-containing lanthanide metal-organic frameworks by guest molecules. |
| PubMed:Synthesis of carbon-11-labeled 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine derivatives as new potential PET tracers for imaging of p38α mitogen-activated protein kinase. |
| PubMed:Synthesis of a new fluorine-18-labeled bexarotene analogue for PET imaging of retinoid X receptor. |
| PubMed:Effect of functionalized groups on gas-adsorption properties: syntheses of functionalized microporous metal-organic frameworks and their high gas-storage capacity. |
| PubMed:Organoimido-derivatized hexamolybdates with a remote carboxyl group: syntheses and structural characterizations. |
| PubMed:Spiroketals of Pestalotiopsis fici provide evidence for a biosynthetic hypothesis involving diversified Diels-Alder reaction cascades. |
| PubMed:Molecular structure, spectroscopic (FT-IR, FT-Raman) studies and first-order molecular hyperpolarizabilities, HOMO-LUMO, NBO analysis of 2-hydroxy-p-toluic acid. |
| PubMed:Bimodal electricity generation and aromatic compounds removal from purified terephthalic acid plant wastewater in a microbial fuel cell. |
| PubMed:Simultaneous determination of nine related substances in p-phthalic acid residue by RP-HPLC. |
| PubMed:Degradation pathways of 4-methylmethcathinone in alkaline solution and stability of methcathinone analogs in various pH solutions. |
| PubMed:Synthesis, growth, thermal, optical and mechanical properties of 2-Aminopyridinium 4-methylbenzoate Dihydrate. |
| PubMed:Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae. |
| PubMed:Effect of substitution and planarity of the ligand on DNA/BSA interaction, free radical scavenging and cytotoxicity of diamagnetic Ni(II) complexes: a systematic investigation. |
| PubMed:Seven hexamethylenetetramine (HMTA) complexes with mono- and dicarboxylic acids: analysis of packing modes of HMTA complexes in the literature. |
| PubMed:The influence of dye structure on charge recombination in dye-sensitized solar cells. |
| PubMed:Chloropupukeanolides C-E: cytotoxic pupukeanane chlorides with a spiroketal skeleton from Pestalotiopsis fici. |
| PubMed:Isoflavones from the mangrove endophytic fungus Fusarium sp. (ZZF41). |
| PubMed:Pharmacological evaluation and characterizations of newly synthesized 1,2,4-triazoles. |
| PubMed:N-[2-(2-Chloro-phen-yl)-2-hy-droxy-eth-yl]propan-2-aminium 4-methyl-benzoate. |
| PubMed:Spectroscopic investigation of the species involved in the rhodium-catalyzed oxidative carbonylation of toluene to toluic acid. |
| PubMed:Modified epidermal growth factor receptor (EGFR)-bearing liposomes (MRBLs) are sensitive to EGF in solution. |
| PubMed:Preparation and characterization of mu-nitrido diiron phthalocyanines with electron-withdrawing substituents: application for catalytic aromatic oxidation. |
| PubMed:[Biotransformation of p-toluic acid by bacterium Rhodococcus ruber P25]. |
| PubMed:Transition state-finding strategies for use with the growing string method. |
| PubMed:Chloropestolide A, an antitumor metabolite with an unprecedented spiroketal skeleton from Pestalotiopsis fici. |
| PubMed:Mono-, di- and polynuclear copper(II) compounds derived from N-butyldiethanolamine: structural features, magnetism and catalytic activity for the mild peroxidative oxidation of cyclohexane. |
| PubMed:Determining organic impurities in mother liquors from oxidative terephthalic acid synthesis by microemulsion electrokinetic chromatography. |
| PubMed:Sample stacking for determination of aromatic acid impurities by microemulsion electrokinetic chromatography. |
| PubMed:Development and application of a hybrid method involving interpolation and ab initio calculations for the determination of transition states. |
| PubMed:Screening of toxicological properties of 4-methylbenzoic acid by oral administration to rats. |
| PubMed:Multivariate analysis of homogeneous nucleation rate measurements. Nucleation in the p-toluic acid/sulfuric acid/water system. |
| PubMed:Biodegradability enhancement of purified terephthalic acid wastewater by coagulation-flocculation process as pretreatment. |
| PubMed:Synthesis of novel trifluoromethyl-bearing bifunctional acyl-acceptant arenes: 2,2'-bis(trifluoromethylated aryloxy)biphenyls. |
| PubMed:Toward a magnetostructural correlation for a family of Mn6 SMMs. |
| PubMed:Rubralactone, rubralides A, B and C, and rubramin produced by Penicillium rubrum. |
| PubMed:Chromatographic fingerprints of industrial toluic acids established for their quality control. |
| PubMed:Hydrogen bond mediated open-frame networks in coordination polymers: supramolecular assemblies of Pr(III) and 3,5-dinitro-4-methylbenzoic acid with aza-donor compounds. |
| PubMed:Pd-catalyzed carbonylative lactamization: a novel synthetic approach to FR900482. |
| PubMed:Combined application of stable carbon isotope analysis and specific metabolites determination for assessing in situ degradation of aromatic hydrocarbons in a tar oil-contaminated aquifer. |
| PubMed:Solvent-dependent coordination polymers: cobalt complexes of 3,5-dinitrobenzoic acid and 3,5-dinitro-4-methylbenzoic acid with 4,4'-bipyrdine. |
| PubMed:Capillary electrophoretic analysis of the derivatives and isomers of benzoate and phthalate. |
| PubMed:Effects of the headspace gas composition on anaerobic biotransformation of o-, m-, and p-toluic acid in sediment slurries. |
| PubMed:A correlative study between 99mTc-ESTCPTA and 99mTc-MIBI in rats. |
| PubMed:Structural basis and mechanism of the inhibition of the type-3 copper protein tyrosinase from Streptomyces antibioticus by halide ions. |
| PubMed:Transport across 1,9-decadiene precisely mimics the chemical selectivity of the barrier domain in egg lecithin bilayers. |
| PubMed:A computer simulation of functional group contributions to free energy in water and a DPPC lipid bilayer. |
| PubMed:Pure bacterial isolates that convert p-xylene to terephthalic acid. |
| PubMed:Biotransformation of p-toluic acid in anoxic estuarine sediments under a CO2 or N2/H2 atmosphere. |
| PubMed:A polar substituent-containing acylation agent for the radioiodination of internalizing monoclonal antibodies: N-succinimidyl 4-guanidinomethyl-3-[131I]iodobenzoate ([131I]SGMIB). |
| PubMed:Repellent and antifeedant activity of salicylic acid and related compounds against the biting midge, Culicoides impunctatus (Diptera: Ceratopogonidae). |
| PubMed:Molecular characterization of the genes of actinomycin synthetase I and of a 4-methyl-3-hydroxyanthranilic acid carrier protein involved in the assembly of the acylpeptide chain of actinomycin in Streptomyces. |
| PubMed:The barrier domain for solute permeation varies with lipid bilayer phase structure. |
| PubMed:Bufadienolides and other constituents of Urginea sanguinea. |
| PubMed:Degradation of chloro- and methyl-substituted benzoic acids by a genetically modified microorganism. |
| PubMed:[Effect of human serum albumin on transport of drugs through human erythrocyte membranes]. |
| PubMed:Stability and Structure of Activated Macrocycles. Ligands with Biological Applications. |
| PubMed:Isolation and characterization of a novel toluene-degrading, sulfate-reducing bacterium. |
| PubMed:Separation and determination of some stereoisomers by capillary gel electrophoresis with cyclodextrin incorporated in polyacrylamide gel. |
| PubMed:[Comparative characteristics of membrane forms of aldehyde dehydrogenase]. |
| PubMed:Cyclodextrin-enhanced degradation of toluene and p-toluic acid by Pseudomonas putida. |
| PubMed:Mathematical models of antisickling activities of benzoic acid derivatives on red blood cells of sicklers. |
| PubMed:Substituent contributions to the transport of substituted p-toluic acids across lipid bilayer membranes. |
| PubMed:Epimerization of the D-valine portion in the biosynthesis of actinomycin D. |
| PubMed:Simultaneous determination of (R)- and (S)-brefanolol in human plasma: high-performance liquid chromatographic assay on a chiral stationary phase. |
| PubMed:[Inhibition of aldehyde dehydrogenase activity in rat liver by cyclopropylethyl-containing benzoic acid amides]. |
| PubMed:The initiation of peptide formation in the biosynthesis of actinomycin. |
| PubMed:Transport methods for probing the barrier domain of lipid bilayer membranes. |
| PubMed:Ligand specificity of human plasminogen kringle 4. |
| PubMed:Skin permeability to aromatic carboxylic acids: an in vitro comparison in pig ear, white mouse and brown mouse. |
| PubMed:Morphological and cytogenetical changes in HR-18 rat ascites cells after in vitro 3-[bis(2-chloroethyl)amino]-4-methylbenzoic acid (NSC-146171; IOB-82) administration. |
| PubMed:Bacterial metabolism of para- and meta-xylene: oxidation of a methyl substituent. |
| PubMed:In vitro and in vivo cytogenetic effects of 3-(bis(2-chloroethyl)amino)-4-methylbenzoic acid (NSC-146171; IOB 82) in human peripheral leukocytes. |
| PubMed:Gentisic acid and its 3- and 4-methyl-substituted homologoues as intermediates in the bacterial degradation of m-cresol, 3,5-xylenol and 2,5-xylenol. |
| PubMed:3-N,N-bis(2-chloroethylamino)p-toluic acid, a new cytostatic drug active in cancer. |
| PubMed:Microbial Hydrocarbon Co-oxidation. III. Isolation and Characterization of an alpha, alpha'-Dimethyl-cis, cis-Muconic Acid-producing Strain of Nocardia corallina. |
| PubMed:Potential anticancer agents. V. New aromatic nitrogen mustards related to 3-[N,N-bis(2-chloroethyl)amino]-4-methylbenzoic acid. |
| PubMed:Microbial hydrocarbon co-oxidation. I. Oxidation of mono- and dicyclic hydrocarbons by soil isolates of the genus Nocardia. |
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3D/inchi