EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

N-acetyl histamine
N-(2-(imidazol-4-yl)ethyl)acetamide

Supplier Sponsors

CAS Number: 673-49-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:211-610-3
FDA UNII: E65S46EBQ6
Nikkaji Web:J205.971A
MDL:MFCD00005209
XlogP3:-0.40 (est)
Molecular Weight:153.18487000
Formula:C7 H11 N3 O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 8408 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
N-acetyl histamine ≥95%
Odor: characteristic
Use: N-acetyl histamine is a histamine metabolite that can be used as a biomarker of histidine metabolism for anaphylactoid reaction
Santa Cruz Biotechnology
For experimental / research use only.
N-Acetylhistamine
Sigma-Aldrich: Aldrich
For experimental / research use only.
N-Acetylhistamine 98%
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for N-acetyl histamine usage levels up to:
 not for fragrance use.
 
Recommendation for N-acetyl histamine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :69602
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
N-[2-(1H-imidazol-5-yl)ethyl]acetamide
Chemidplus:0000673494
 
References:
 N-[2-(1H-imidazol-5-yl)ethyl]acetamide
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):69602
Pubchem (cas):673-49-4
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C05135
HMDB (The Human Metabolome Database):HMDB13253
FooDB:FDB012595
Export Tariff Code:2933.29.5000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 spinach leaf
Search Trop Picture
 
Synonyms:
 acetamide, N-(2-(1H-imidazol-4-yl)ethyl)- (9CI)
N-omega-acetyl histamine
N-acetylhistamine
N-(2-(imidazol-4-yl)ethyl)acetamide
N-[2-(1H-imidazol-5-yl)ethyl]acetamide
 

Articles:

PubMed:Metabolomics analysis of anaphylactoid reaction reveals its mechanism in a rat model.
PubMed:[Active sites of N-acetylhexosamine 1-kinase from Bifidobacterium longum].
PubMed:Mechanistic and Structural Analysis of a Drosophila melanogaster Enzyme, Arylalkylamine N-Acetyltransferase Like 7, an Enzyme That Catalyzes the Formation of N-Acetylarylalkylamides and N-Acetylhistamine.
PubMed:Algicidal metabolites produced by Bacillus sp. strain B1 against Phaeocystis globosa.
PubMed:NaxD is a deacetylase required for lipid A modification and Francisella pathogenesis.
PubMed:Transport of the anti-diabetic VO2+ complexes formed by pyrone derivatives in the blood serum.
PubMed:Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain.
PubMed:Effects of intracerebroventricular administration of N-acetylhistamine on body temperature in mice.
PubMed:Histamine: a neurotransmitter candidate for Drosophila photoreceptors.
PubMed:Histidines, histamines and imidazoles as glycosidase inhibitors.
PubMed:Histamine inhibition of mixed function oxidase activity in rat and human liver microsomes and in the isolated perfused rat liver.
PubMed:Monooxygenation of N-acetylhistamine mediated by L-ascorbate.
PubMed:Inhibition of in vivo histamine metabolism in rats by foodborne and pharmacologic inhibitors of diamine oxidase, histamine N-methyltransferase, and monoamine oxidase.
PubMed:Properties of N-acetylhistamine deacetylase in mammalian brain.
PubMed:[Molecular mechanism of the interaction of histamine with hyaluronic acid].
PubMed:Histamine receptors on human peripheral blood leucocytes.
PubMed:[Oscillographic polarography of the alkaloid dolicotheline and several related imidazole derivatives].
PubMed:Model studies on the coordination of copper in biological systems. The deprotonated peptide nitrogen as a potential binding site for copper(II).
PubMed:Elevation of histamine levels in rat and mouse tissues by the deacetylation of administered N-acetylhistamine.
PubMed:The metabolism of exogenous histamine by aortic tissues.
PubMed:Chemotactic activity of guinea pig eosinophils for the ECF-A acidic tetrapeptides, histamine, histamine metabolites, and the effect of H1- and H2-receptor antagonists.
PubMed:Eosinophils and mediators of anaphylaxis. Histamine and imidazole acetic acid as chemotactic agents for human eosinophil leucocytes.
PubMed:Partial purification and properties of N-acetylhistamine deacetylase.
PubMed:New and uncommon indole- and imidazole-alkylamines in skins of amphibians from Australia and Papua New Guinea.
PubMed:Effect of pharmacologic agents on human keratinocyte mitosis in vitro. III. Inhibition by histamine and methylated analogs.
PubMed:Proceedings: Enzymatic deacetylation of N-acetylhistamine in the brain of rats.
PubMed:Increased urinary imidazolepropionic acid, N-acetylhistamine and other imidazole compounds in patients with intestinal disorders.
PubMed:Rupture of the imidazole ring of histamine and N-acetylhistamine by human intestinal contents.
PubMed:Ionization of histamine, N-acetylhistamine, and their iodinated derivatives.
PubMed:Iodinated derivatives of histamine and N-acetylhistamine.
PubMed:Possible in vivo de-acetylation of N-acetylhistamine in man.
PubMed:Fate of histamine and N-acetylhistamine administered into the human gut.
PubMed:[Determination of histamine, N-dimethylhistamine, N-acetylhistamine and acetylcholine in Spinacia oleracea].
PubMed:A method of estimating histamine in plasma.
 
Notes:
Isol. from leaves of Spinacia oleracea (spinach)
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