EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

N-methyl aniline
benzeneamine, N-methyl-

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CAS Number: 100-61-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:202-870-9
FDA UNII: TH45GK410O
Nikkaji Web:J3.591B
Beilstein Number:0741982
MDL:MFCD00008283
XlogP3:1.70 (est)
Molecular Weight:107.15573000
Formula:C7 H9 N
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:colorless to brown viscous liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.98900 @ 25.00 °C.
Boiling Point: 194.00 to 195.00 °C. @ 760.00 mm Hg
Boiling Point: 112.00 to 113.00 °C. @ 50.00 mm Hg
Vapor Pressure:0.402000 mmHg @ 25.00 °C. (est)
Flash Point: 174.00 °F. TCC ( 78.89 °C. )
logP (o/w): 1.660
Soluble in:
 water, 4249 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Azelis UK
N-Methylaniline
Connect Chemicals
Monomethylaniline or N-Methylaniline (NMA)
Odor: characteristic
Use: N-Methylaniline (NMA) is an organic compound, aniline derivative. N-Methyl Aniline is a colorless, slightly yellow viscous liquid which turns to brown when exposed to air.
Santa Cruz Biotechnology
For experimental / research use only.
N-Methylaniline
Sigma-Aldrich: Aldrich
For experimental / research use only.
N-Methylaniline ≥99%
sds
TCI AMERICA
For experimental / research use only.
N-Methylaniline >98.0%(GC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-cat LDLo 24 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 1, 1949.

oral-guinea pig LDLo 1200 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
U.S. Public Health Service, Public Health Bulletin. Vol. 271, Pg. 16, 1941.

intravenous-rabbit LDLo 24 mg/kg
LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 1, 1949.

oral-rabbit LDLo 280 mg/kg
LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 1, 1949.

Dermal Toxicity:
subcutaneous-guinea pig LDLo 1200 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
U.S. Public Health Service, Public Health Bulletin. Vol. 271, Pg. 16, 1941.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for N-methyl aniline usage levels up to:
 not for fragrance use.
 
Recommendation for N-methyl aniline flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):100-61-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7515
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
N-methylaniline
Chemidplus:0000100618
EPA/NOAA CAMEO:hazardous materials
RTECS:100-61-8
 
References:
 N-methylaniline
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:100-61-8
Pubchem (cid):7515
Pubchem (sid):134972715
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C02299
HMDB (The Human Metabolome Database):Search
FooDB:FDB012647
Export Tariff Code:2921.42.1800
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
technical
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 anaxagorea brevipes
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 anaxagorea dolichocarpa
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 cabbage leaf
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 carrot root
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 celery plant
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 celery stem
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 duguetia asterotricha
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 orange pericarp oil
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 pepper bell pepper fruit
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 rollinia insignis
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 spinach leaf
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 tea leaf
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 xylopia aromatica
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 xylopia benthamii
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Synonyms:
 aniline, N-methyl-
 benzenamine, N-methyl-
 benzeneamine, N-methyl-
N-methlaniline
N-methyl-N-phenylamine
(methylamino)benzene
N-methylaminobenzene
N-methylaniline
N-monomethylaniline
N-methylbenzenamine
N-methylbenzeneamine
N-methylbenzylamine
N-methylphenylamine
 

Articles:

PubMed:Mutational and crystallographic analysis of l-amino acid oxidase/monooxygenase from Pseudomonas sp. AIU 813: Interconversion between oxidase and monooxygenase activities.
PubMed:CYP-450 isoenzymes catalyze the generation of hazardous aromatic amines after reaction with the azo dye Sudan III.
PubMed:Efficacy of European starling control to reduce Salmonella enterica contamination in a concentrated animal feeding operation in the Texas panhandle.
PubMed:Determination of aromatic amines in environmental water sample by hollow fiber-liquid phase microextraction and microemulsion electrokinetic chromatography.
PubMed:Decolorization of water and oil-soluble azo dyes by Lactobacillus acidophilus and Lactobacillus fermentum.
PubMed:A sweeping-micellar electrokinetic chromatography method for direct detection of some aromatic amines in water samples.
PubMed:Facile and sensitive spectrophotometric determination of carbosulfan in formulations and environmental samples.
PubMed:Development of simple and sensitive spectrophotometric method for the determination of bendiocarb in its formulations and environmental samples.
PubMed:Direct trapping of formaldehyde formed via oxidative N-demethylation of N,N-dialkylarylamines by Bacillus megaterium using cysteamine derivatization.
PubMed:Absorption, distribution, and excretion of [14C]-3-chloro-4-methylaniline hydrochloride in two species of birds following a single oral dose.
PubMed:Recent studies in Canada on the occurrence and formation of N-nitroso compounds in foods and food contact materials.
PubMed:Nucleic acid binding of arylamines during the respiratory burst of human granulocytes.
PubMed:Model system studies on N-nitrosamine formation in relation to cured meat: the non-polar phase and S-nitroso peptides.
 
Notes:
None found
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