acetyl glutamic acid
N-acetyl glutamate
 
Notes:
N-Acetylglutamic acid (abbreviated NAcGlu) is biosynthesized from glutamic acid and acetyl-CoA by the enzyme NAGS. The reverse reaction, hydrolysis of the acetyl group, is catalyzed by a specific hydrolase. [HMDB]
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      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
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      Product(s):
      01-07725 N-ACETYL-L-GLUTAMIC ACID USP, Kosher
       
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(2S)-2-acetamidopentanedioic acid (Click)
CAS Number: 1188-37-0Picture of molecule
Other: 7728-87-2
ECHA EINECS - REACH Pre-Reg: 214-708-4
FDA UNII: MA61H539YZ
Nikkaji Web: J37.497K
Beilstein Number: 1727473
MDL: MFCD00002802
XlogP3: -1.80 (est)
Molecular Weight: 189.16767000
Formula: C7 H11 N O5
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor enhancers, umami taste enhancer
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
FEMA Number: 4752  N-acetyl glutamate
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 495.00 to  496.00 °C. @ 760.00 mm Hg
Flash Point: 488.00 °F. TCC ( 253.33 °C. )
logP (o/w): -2.131 (est)
Soluble in:
 water, 8.524e+005 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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Suppliers:
Carbosynth
For experimental / research use only.
N-Acetyl-L-glutamic acid
Glentham Life Sciences
N-Acetyl-L-glutamic acid
Penta International
N-ACETYL-L-GLUTAMIC ACID USP, Kosher
Santa Cruz Biotechnology
For experimental / research use only.
N-Acetyl-L-glutamic acid
Sigma-Aldrich: Aldrich
For experimental / research use only.
N-Acetyl-L-glutamic acid, ReagentPlus®, 99%
TCI AMERICA
For experimental / research use only.
N-Acetyl-L-glutamic Acid >98.0%(HPLC)(T)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  711 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toksikologicheskii Vestnik. Vol. (3), Pg. 36, 1995.

oral-mouse LD50  6838 mg/kg
BRAIN AND COVERINGS: "CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.)" LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: HEMORRHAGE
Toksikologicheskii Vestnik. Vol. (3), Pg. 36, 1995.

oral-rat LD50  > 7000 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BRAIN AND COVERINGS: "CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.)" BLOOD: HEMORRHAGE
Toksikologicheskii Vestnik. Vol. (3), Pg. 36, 1995.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor enhancers, umami taste enhancer
Recommendation for acetyl glutamic acid usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 26
Click here to view publication 26
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): 50.00000150.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: 50.00000150.00000
chewing gum: --
condiments / relishes: 20.00000100.00000
confectionery froastings: --
egg products: --
fats / oils: 25.00000100.00000
fish products: 50.00000150.00000
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: 50.00000150.00000
hard candy: --
imitation dairy: 50.00000150.00000
instant coffee / tea: 50.00000150.00000
jams / jellies: --
meat products: 50.00000150.00000
milk products: 50.00000200.00000
nut products: --
other grains: --
poultry: 50.00000150.00000
processed fruits: --
processed vegetables: 25.00000100.00000
reconstituted vegetables: 25.00000100.00000
seasonings / flavors: 50.00000500.00000
snack foods: 50.00000200.00000
soft candy: --
soups: 50.00000150.00000
sugar substitutes: --
sweet sauces: 50.00000150.00000
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Safety References:
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 1188-37-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 70914
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 (2S)-2-acetamidopentanedioic acid
Chemidplus: 0001188370
RTECS: LZ9725000 for cas# 1188-37-0
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References:
 (2S)-2-acetamidopentanedioic acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 70914
Pubchem (sid): 135028765
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
Metabolomics Database: Search
KEGG (GenomeNet): C00624
HMDB (The Human Metabolome Database): HMDB01138
FooDB: FDB022447
YMDB (Yeast Metabolome Database): YMDB00066
Export Tariff Code: 2924.19.1150
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 additives 
 skin conditioning 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
(2S)-2-acetamidopentanedioic acid
N-acetyl glutamate
N-acetyl-L-glutamic acid
N-acetyl-laevo-glutamic acid
L-acetylglutamic acid
L-glutamic acid, N-acetyl-
laevo-glutamic acid, N-acetyl-
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