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(2R)-2-acetamido-3-sulfanylpropanoic acid

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CAS Number: 616-91-1Picture of molecule3D/inchi
Other(deleted CASRN):7696-05-1
ECHA EINECS - REACH Pre-Reg:210-498-3
Nikkaji Web:J3.309J
Beilstein Number:1724426
XlogP3:0.40 (est)
Molecular Weight:163.19633000
Formula:C5 H9 N O3 S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:special dietary and nutritional additives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 109.00 to 110.00 °C. @ 760.00 mm Hg
Boiling Point: 407.00 to 408.00 °C. @ 760.00 mm Hg (est)
Flash Point: 392.00 °F. TCC ( 200.00 °C. )
logP (o/w): -0.696 (est)
Soluble in:
 water, 2.429e+005 mg/L @ 25 °C (est)
Similar Items:note
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
skin conditioning
N-Acetyl L-Cysteine NAC 98.5%-101.0%
Ajinomoto USA
Ajinomoto USA
BOC Sciences
For experimental / research use only.
N-Acetyl-L-cysteine > 95%
Odor: characteristic
Use: N-Acetyl-L-cysteine is a metabolite of Methyl Isocyanate.
For experimental / research use only.
Charkit Chemical
EMD Millipore
For experimental / research use only.
Glentham Life Sciences
Graham Chemical
Maypro Industries
For experimental / research use only.
Penta International
Qingdao Dacon Trading
Santa Cruz Biotechnology
For experimental / research use only.
N-Acetyl-L-cysteine ≥98%
For experimental / research use only.
N-Acetyl-L-cysteine Sigma Grade, ≥99% (TLC), powder
For experimental / research use only.
N-Acetyl-L-cysteine >98.0%(HPLC)(T)
United International
N-Acetyl-L-Cysteine Nat.
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 400 mg/kg
National Technical Information Service. Vol. AD691-490

intravenous-mouse LD50 3800 mg/kg
Journal of Medicinal Chemistry. Vol. 10, Pg. 1172, 1967.

oral-mouse LD50 4400 mg/kg
European Patent Application. Vol. #0192191

intravenous-rat LD50 1140 mg/kg
European Journal of Respiratory Diseases. Vol. 61(Suppl

oral-rat LD50 5050 mg/kg
Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

intravenous-dog LD50 700 mg/kg
Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 479, 1979.

oral-dog LD50 > 1000 mg/kg
Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 479, 1979.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
special dietary and nutritional additives
Recommendation for acetyl-laevo-cysteine usage levels up to:
 not for fragrance use.
Recommendation for acetyl-laevo-cysteine flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to N-Acetyl-L-cysteine for use in foods for particular nutritional uses and in foods for special medical purposes
View page or View pdf

EPI System: View
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):616-91-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :12035
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(2R)-2-acetamido-3-sulfanylpropanoic acid
RTECS:HA1660000 for cas# 616-91-1
 (2R)-2-acetamido-3-sulfanylpropanoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:616-91-1
Pubchem (cid):12035
Pubchem (sid):134978062
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Golm Metabolome Database:Search
KEGG (GenomeNet):C06809
HMDB (The Human Metabolome Database):HMDB01890
Export Tariff Code:2930.90.9190
FDA Listing of Food Additive Status:View
parenteral: for injection concentrate, for iv infusion: 200 mgml acetadote (cumberland). oral inhalation, intratracheal instillation, and oral: solution: 100 mg (of acetylcysteine) per ml (10%), acetylcysteine sodium solution, (abbott, american regent, bedford, dey, mayne, roxane); mucomyst (sandoz); 200 mg (of acetylcysteine) per ml (20%) acetylcysteine sodium solution (abbott, american regent, bedford, dey, mayne, roxane); mucomyst (sandoz). acetylcysteine sodium
Potential Blenders and core components note
None Found
Potential Uses:
 skin conditioning
Occurrence (nature, food, other):note
 not found in nature
(R)-2-acetamido-3-mercaptopropanoic acid
(2R)-2-acetamido-3-sulfanyl-propanoic acid
(2R)-2-acetamido-3-sulfanylpropanoic acid
L-a-acetamido-b-mercaptopropionic acid
L-alpha-acetamido-beta-mercaptopropionic acid
laevo-alpha-acetamido-beta-mercaptopropionic acid
 acetyl cysteine
(R)-2-acetylamino-3-mercaptopropanoic acid
(2R)-2-acetylamino-3-sulfanylpropanoic acid
2-(acetylamino)-3-mercaptopropionic acid
(2R)-2-(acetylamino)-3-sulfanylpropanoic acid
 cysteine, N-(1-hydroxyethylidene)-, (Z)-
L-cysteine, N-acetyl-
 cysteine, N-acetyl-, L-
 fluimicil infantil
 mercapturic acid
(R)-mercapturic acid
 mucolytikum lappe


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the n-acetyl derivative of cysteine. it is used as a mucolytic agent to reduce the viscosity of mucous secretions. it has also been shown to have antiviral effects in patients with hiv due to inhibition of viral stimulation by reactive oxygen intermediates. Effective inhibitor of enzymic browning in foods [DFC] N-Acetyl-L-cysteine is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Other uses include sulfate repletion in conditions, such as autism, where cysteine and related sulfur amino acids may be depleted. N-Acetyl-L-cysteine is a precursor in the formation of the antioxidant glutathione in the body. The thiol group confers antioxidant effects and is able to reduce free radicals. [Wikipedia]
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