EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

glycine, N-(2-(bis(carboxymethyl)amino)ethyl)-N-(2-hydroxyethyl)-

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Name:2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid
CAS Number: 150-39-0Picture of molecule3D/inchi
Other(deleted CASRN):125317-19-3
ECHA EINECS - REACH Pre-Reg:205-759-3
FDA UNII: R79J91U341
Nikkaji Web:J23.203C
Beilstein Number:1804795
XlogP3-AA:-6.20 (est)
Molecular Weight:278.26186000
Formula:C10 H18 N2 O7
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 4.31e+005 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: absorbents
bulking agents
chelating agents
opacifying agents
viscosity controlling agents
BOC Sciences
For experimental / research use only.
N-(2-Hydroxyethyl)ethylenediamine-N,N,N-triacetic acid 95%
Dow Chemical
VERSENOL™ HEDTA-based Chelating Agents
Sigma-Aldrich: Aldrich
For experimental / research use only.
N-(2-Hydroxyethyl)ethylenediamine-N,N',N'-triacetic acid ∼98%
For experimental / research use only.
N-(2-Hydroxyethyl)ethylenediamine-N,N',N'-triacetic Acid >98.0%(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 259 mg/kg
Archives of Toxicology. Vol. 57, Pg. 212, 1985.

intraperitoneal-rat LD50 337 mg/kg
Arhiv za Higijenu Rada i Toksikologiju. Archives of Industrial Hygiene and Toxicology. Vol. 13, Pg. 295, 1962.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for HEDTA usage levels up to:
 not for fragrance use.
Recommendation for HEDTA flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):150-39-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8773
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid
RTECS:MB9185000 for cas# 150-39-0
 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:150-39-0
Pubchem (cid):8773
Pubchem (sid):134973075
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2922.49.8000
Potential Blenders and core components note
None Found
Potential Uses:
 chelating agents
Occurrence (nature, food, other):note
 not found in nature
2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid
 CHEL DM acid
 glycine, N-(2-(bis(carboxymethyl)amino)ethyl)-N-(2-hydroxyethyl)-
 glycine, N-(carboxymethyl)-N'-(2-hydroxyethyl)-N,N'-ethylenedi-
N-(2-hydroxyethyl) ethylene diamine triacetic acid
(hydroxyethyl)ethylenediaminetriacetic acid
(2-hydroxyethyl)ethylenediaminetriacetic acid
N-(hydroxyethyl)ethylenediaminetriacetic acid
N-(2-hydroxyethyl)ethylenediaminetriacetic acid
2-hydroxyethylenediamine triacetate
N-(beta-hydroxyethylethylenediamine)-n,n',n'-triacetic acid
(N-hydroxyethylethylenedinitrilo)triacetic acid


PubMed:Synthesis of silver nanoparticles in aqueous aminopolycarboxylic acid solutions via γ-irradiation and hydrogen reduction.
PubMed:The ruthenium nitric oxide donor, [Ru(HEDTA)NO], inhibits acute nociception in mice by modulating oxidative stress, cytokine production and activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway.
PubMed:Synthesis and Crystal Structure of the Bioinorganic Complex [Sb(Hedta)]·2H2O.
PubMed:In vivo epithelial wound repair requires mobilization of endogenous intracellular and extracellular calcium.
PubMed:trans-[Ru(NO)Cl(cyclam)](PF6)2 and [Ru(NO)(Hedta)] incorporated in PLGA nanoparticles for the delivery of nitric oxide to B16-F10 cells: cytotoxicity and phototoxicity.
PubMed:Calculated and measured [Ca(2+)] in buffers used to calibrate Ca(2+) macroelectrodes.
PubMed:High performance ion chromatography of transition metal chelate complexes and aminopolycarboxylate ligands.
PubMed:Synthesis and structural characterization of heterometallic thorium aluminum polynuclear molecular clusters.
PubMed:Synthesis, spectroscopic analysis and photolabilization of water-soluble ruthenium(III)-nitrosyl complexes.
PubMed:Combined effect of HEDTA and selenium against aluminum induced oxidative stress in rat brain.
PubMed:Simultaneous extraction of Cr(VI) and Cu(II) from humic acid with new synthesized EDTA derivatives.
PubMed:Combined treatment of HEDTA and propolis prevents aluminum induced toxicity in rats.
PubMed:New coordination modes in potassium edta salts: K2[H2edta]2H2O, K3[Hedta]2H2O and K4[edta]·3.92H2O.
PubMed:Chelator-buffered nutrient solution is ineffective in extracting Ni from seeds of Alyssum.
PubMed:Identification of Fe-polycarboxylic complexes by electrospray ionization mass spectrometry and reduction of interferences by ion chromatography/inductively coupled plasma mass spectrometry with an octopole reaction system.
PubMed:Antileishmanial activity of ruthenium(II)tetraammine nitrosyl complexes.
PubMed:Study of solid-phase extraction for the determination of sequestering agents in river water by high-performance liquid chromatography.
PubMed:Speciation of Zn-aminopolycarboxylic complexes by electrospray ionization mass spectrometry and ion chromatography with inductively coupled plasma mass spectrometry.
PubMed:Separation of yttrium from heavy lanthanide by CA-100 using the complexing agent.
PubMed:Leaching and efficiency of six organic zinc fertilizers applied to navy bean crop grown in a weakly acidic soil of Spain.
PubMed:Solubility and accumulation of metals in Chinese brake fern, vetiver and rostrate sesbania using chelating agents.
PubMed:Kosmotropes enhance the yield of antibody purified by affinity chromatography using immobilized bacterial immunoglobulin binding proteins.
PubMed:Determination of sequestering agents in cosmetics and synthetic detergents by high-performance liquid chromatography with ultraviolet detection.
PubMed:Confirmation of lead aminocarboxylic complex formation using electrospray ionization mass spectrometry and speciation by anion-exchange chromatography coupled with ICP-MS.
PubMed:Separation of chelating agents as copper complexes by capillary zone electrophoresis using quaternary ammonium bromides as additives in N-methylformamide.
PubMed:Behavior of zinc from six organic fertilizers applied to a navy bean crop grown in a calcareous soil.
PubMed:Influence of soil type on the mobility and bioavailability of chelated zinc.
PubMed:Confirmation of vanadium complex formation using electrospray mass spectrometry and determination of vanadium speciation by sample stacking capillary electrophoresis.
PubMed:Determination of alternative and conventional chelating agents as copper(II) complexes by capillary zone electrophoresis--the first use of didecyldimethylammonium bromide as a flow reversal reagent.
PubMed:Iron acquisition by phytosiderophores contributes to cadmium tolerance.
PubMed:Effect of the methionine ligand on the reorganization energy of the type-1 copper site of nitrite reductase.
PubMed:Determination of synthetic ferric chelates used as fertilizers by liquid chromatography-electrospray/mass spectrometry in agricultural matrices.
PubMed:Effects of lead and chelators on growth, photosynthetic activity and Pb uptake in Sesbania drummondii grown in soil.
PubMed:Improving sensitivity in simultaneous determination of copper carboxylates by nonaqueous capillary electrophoresis.
PubMed:Equilibrium, kinetic and solvent effect studies on the reactions of [RuIII(Hedta)(H2O)] with thiols.
PubMed:Inhibition of the Fenton reaction by nitrogen monoxide.
PubMed:Macrocyclic lanthanide complexes as artificial nucleases and ribonucleases: effects of pH, metal ionic radii, number of coordinated water molecules, charge, and concentrations of the metal complexes.
PubMed:Antioxidant defense in a lead accumulating plant, Sesbania drummondii.
PubMed:Potential of Hemidesmus indicus for phytoextraction of lead from industrially contaminated soils.
PubMed:The [Ru(Hedta)NO](0.1-) system: structure, chemical reactivity and biological assays.
PubMed:Preparation of Gd3+-containing polymer complex as a novel magnetic resonance signal-enhancing coating material.
PubMed:Protons block BK channels by competitive inhibition with K+ and contribute to the limits of unitary currents at high voltages.
PubMed:Biogeochemistry of fluoride in a plant-solution system.
PubMed:Functional and structural study on chelator-induced suppression of S2/S1 FTIR spectrum in photosynthetic oxygen-evolving complex.
PubMed:Immobilization of Fe chelators on sepharose gel and its effect on their chemical properties.
PubMed:Effect of N-hydroxyethyl-ethylenediamine-triacetic acid (HEDTA) on Cr(VI) reduction by Fe(II).
PubMed:Isothermal titration calorimetric procedure to determine protein-metal ion binding parameters in the presence of excess metal ion or chelator.
PubMed:Aluminum-induced oxidative stress in rat brain: response to combined administration of citric acid and HEDTA.
PubMed:Lead phytoextraction from contaminated soil with high-biomass plant species.
PubMed:Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA.
PubMed:On-column complexation and simultaneous separation of vanadium(IV) and vanadium(V) by capillary electrophoresis with direct UV detection.
PubMed:Ruthenium(III) readily abstracts NO from L-arginine, the physiological precursor to NO, in the presence of H2O2. A remarkably simple model system for NO synthases.
PubMed:Direct modulation of volume-regulated anion channels by Ca(2+) chelating agents.
PubMed:Beneficial effects of humic acid on micronutrient availability to wheat.
PubMed:Determination of strong binding chelators and their metal complexes by anion-exchange chromatography and inductively coupled plasma mass spectrometry.
PubMed:Phytosiderophores influence on cadmium mobilization and uptake by wheat and barley plants.
PubMed:15N NMR and Electrochemical Studies of [Ru(II)(hedta)](-) Complexes of NO, NO(+), NO(2)(-), and NO(-).
PubMed:A Proton-Induced N-1 to eta(2) Migration of the Fluxional Pyrazine in the [Ru(II)(hedta)(pz)](-) Complex.
PubMed:EDTA and HEDTA effects on Cd, Cr, and Ni uptake by Helianthus annuus.
PubMed:High-pressure pulse-radiolysis study of the formation and decomposition of complexes with iron-carbon sigma bonds: mechanistic comparison for different metal centers.
PubMed:Biodegradability of ethylenediamine-based complexing agents and related compounds.
PubMed:Biodegradability of ethylenediamine-based complexing agents.
PubMed:Characterization of Fe(III)-deferoxamine and Mn(II)-pectin as magnetic resonance imaging contrast agents.
PubMed:Fully automated measurement of total iron-binding capacity in serum.
PubMed:Wanderlust kinetics and variable Ca(2+)-sensitivity of dSlo [correction of Drosophila], a large conductance CA(2+)-activated K+ channel, expressed in oocytes.
PubMed:Wanderlust kinetics and variable Ca(2+)-sensitivity of Drosophila, a large conductance Ca(2+)-activated K+ channel, expressed in oocytes.
PubMed:Volume Profile for Substitution in Labile Chromium(III) Complexes: Reactions of Aqueous [Cr(Hedta)OH(2)] and [Cr(edta)](-) with Thiocyanate Ion.
PubMed:Labeling a hydrazino nicotinamide-modified cyclic IIb/IIIa receptor antagonist with 99mTc using aminocarboxylates as coligands.
PubMed:Spectrophotometric determination of tin in copper-based alloys using pyrocatechol violet.
PubMed:Reactions of low valent transition metal complexes with hydrogen peroxide. Are they "Fenton-like" or not? 4. The case of Fe(II)L, L = edta; hedta and tcma.
PubMed:Relative efficacy of chelating agents on excretion and tissue distribution of manganese in mice.
PubMed:In vitro and in vivo comparative studies on chelation of aluminum by some polyaminocarboxylic acids.
PubMed:Mobilization and distribution of beryllium over the course of chelation therapy with some polyaminocarboxylic acids in the rat.
PubMed:Iron assimilation in Cryptococcus neoformans.
PubMed:Separation of yttrium and neodymium from samarium and the heavier lanthanides by cation-exchange chromatography with hydroxyethylenediaminetriacetate in monochloroacetate buffer.
PubMed:Determination of lead by selective chelatometric titration with HEDTA after separation as its sulphate by an improved method of precipitation.
PubMed:Na+-Ca2+ exchange in squid optic nerve membrane vesicles is activated by internal calcium.
PubMed:Alleviation of nickel-induced biochemical alterations by chelating agents.
PubMed:Correlation between calpain-mediated cytoskeletal degradation and expression of platelet procoagulant activity. A role for the platelet membrane-skeleton in the regulation of membrane lipid asymmetry?
PubMed:The reaction between ferrous polyaminocarboxylate complexes and hydrogen peroxide: an investigation of the reaction intermediates by stopped flow spectrophotometry.
PubMed:Samarium-153 chelate localization in malignant melanoma.
PubMed:Calcium-dependent chloride currents in isolated cells from rat lacrimal glands.
PubMed:Evaluation of LD50 of some polyaminocarboxylic acids used as chelating drugs in metal intoxication.
PubMed:Screening of chelating agents for chemolysis.
PubMed:Ascorbate autoxidation in the presence of iron and copper chelates.
PubMed:Chelatometric titration of tin in non-ferrous alloys with hedta.
PubMed:Chelatometric titration of bismuth with hedta.
PubMed:Rapid and selective chelatometric titration of aluminium in non-ferrous alloys.
PubMed:Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria.
PubMed:157Dy-HEDTA for skeletal imaging. By G. Subramanian, J.G. McAfee, R.J. Blair, R.E. O'Mara, M.W. Greene and E. Lebowitz. 1971.
PubMed:The effect of EDTA and related chelating agents on the oxidation of methanol by the methylotrophic bacterium, Methylophilus methylotrophus.
PubMed:Rapid and selective chelatometric titration of zinc in non-ferrous alloys.
PubMed:The kinetics of the reaction of superoxide radical with Fe(III) complexes of EDTA, DETAPAC and HEDTA.
PubMed:A survey of readily available chelators for buffering calcium ion concentrations in physiological solutions.
PubMed:The effects of thiosalicylic and hydroxyethylethylenediaminetriacetic acids on the absorption and excretion of 54Mn and 65Zn in the duodenally dosed sheep.
PubMed:Chelation in metal intoxication X: Influence of different polyaminocarboxylic acids and thiol chelators in the excretion and tissue distribution of 54Mn in rat.
PubMed:Effect of chelating agents on the stability of injectable isoniazid solutions.
PubMed:The effects of Ca2+ and Sr2+ on Ca2+-sensitive biochemical changes in human erythrocytes and their membranes.
PubMed:Rat mast cells permeabilized with ATP secrete histamine in response to calcium ions buffered in the micromolar range.
PubMed:Chelation in metal intoxication. IX. Influence of amino and thiol chelators on excretion of manganese in poisoned rabbits.
PubMed:Stability of injection solutions of vitamin B1 Part 1: Influence of chelating agents.
PubMed:Studies on the stability of injectable solutions of some phenothiazines. Part 2: Effect of chelating agents and antioxidants.
PubMed:Evaluation of 167Tm HEDTA as a bone scanning agent in humans and its comparison with 18F.
PubMed:157 Dy-HEDTA for skeletal imaging.
None found
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