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N,N-dimethyl formamide
formic acid, amide, N,N-dimethyl-

Supplier Sponsors

Name:dimethylformamide
CAS Number: 68-12-2Picture of molecule3D/inchi
Other(deleted CASRN):114057-15-7
ECHA EINECS - REACH Pre-Reg:200-679-5
FDA UNII: 8696NH0Y2X
Nikkaji Web:J1.923B
MDL:MFCD00003284
XlogP3:-1.00 (est)
Molecular Weight:73.09499000
Formula:C3 H7 N O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:indirect food additives: adhesives and components of coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (IAUFC):68-12-2 ; N,N-DIMETHYLFORMAMIDE
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.94700 to 0.95200 @ 20.00 °C.
Pounds per Gallon - (est).: 7.889 to 7.931
Refractive Index:1.42800 to 1.43200 @ 20.00 °C.
Melting Point: -60.40 °C. @ 760.00 mm Hg
Boiling Point: 153.00 °C. @ 760.00 mm Hg
Vapor Pressure:3.870000 mmHg @ 25.00 °C.
Flash Point: 136.00 °F. TCC ( 57.78 °C. )
logP (o/w): -1.010
Soluble in:
 water, 1.00E+06 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BASF
Dimethylformamide
Covalent Chemical
Dimethyl Formamide
Eastman Chemical
Dimethylformamide
Odor: characteristic
Use: Dimethylformamide (DMF) is a clear, colorless, hygroscopic liquid with a slight amine odor. The solvent properties of DMF are particularly attractive because of the high dielectric constant, the aprotic nature of the solvent, its wide liquid range and low volatility. It is frequently used for chemical reactions and other applications, which require a high solvency power. The product is known as a universal solvent. The high solubility of polyacrylonitrile in DMF, together with the good miscibility of DMF in water makes DMF the preferred solvent for the production of acrylic fibers. Also the spinning of polyurethane based elastomers is performed from DMF based solutions. Another significant application is the use of DMF as a solvent for polyurethane-based coatings on leather and artificial leather fabrics.
ECSA Chemicals
DIMETHYLFORMAMIDE
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
N,N-DIMETHYLFORMAMIDE ANHYDROUS RE-PURE, ML
ECSA Chemicals
N,N-DIMETHYLFORMAMIDE ANHYDROUS RPE-ACS-FOR
EMD Millipore
For experimental / research use only.
N,N-Dimethylformamide
Glentham Life Sciences
N,N,Dimethylformamide, 99.5%
Santa Cruz Biotechnology
For experimental / research use only.
N,N-Dimethylformamide ≥99%
Shiva Chemicals and Pharmaceuticals
Dimethyl Formamide
Sigma-Aldrich
For experimental / research use only.
N,N-Dimethylformamide anhydrous, 99.8%
Silver Fern Chemical
Dimethyl Formamide (DMF)
Odor: characteristic
Use: Dimethyl formamide (DMF) is a common solvent and used for vinyl resins and acetylene, acid gases, polyacrylic fibers, and as a catalyst in certain chemical reactions.
Taminco (Eastman)
dimethylformamide
TCI AMERICA
For experimental / research use only.
N,N-Dimethylformamide [for Spectrophotometry] >99.5%(GC)
Wedor Corporation
DIMETHYL FORMAMIDE
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-cat LD50 500 mg/kg
BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED) KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION LIVER: OTHER CHANGES
British Journal of Industrial Medicine. Vol. 13, Pg. 51, 1956.

intravenous-dog LD50 470 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965.

intravenous-guinea pig LD50 1050 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965.

intraperitoneal-guinea pig LDLo 4000 mg/kg
LIVER: FATTY LIVER DEGERATION
American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974.

intramuscular-mouse LD50 3900 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965.

intraperitoneal-mouse LD50 650 mg/kg
Cancer Chemotherapy Reports. Vol. 30, Pg. 9, 1963.

intravenous-mouse LD50 2500 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965.

oral-mouse LD50 2900 mg/kg
National Technical Information Service. Vol. OTS0521148

intraperitoneal-rabbit LD50 1000 mg/kg
BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED) LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
British Journal of Industrial Medicine. Vol. 13, Pg. 51, 1956.

intravenous-rabbit LD50 1800 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965.

oral-rabbit LD50 5000 mg/kg
National Technical Information Service. Vol. OTS0520699

intraperitoneal-rat LD50 1400 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
British Journal of Industrial Medicine. Vol. 13, Pg. 51, 1956.

intravenous-rat LD50 2000 mg/kg
Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967.

oral-rat LD50 2800 mg/kg
Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967.

unreported-rat LD50 > 3000 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 645, 1968.

Dermal Toxicity:
subcutaneous-mouse LD50 4500 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965.

skin-rabbit LD50 4720 mg/kg
American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.

skin-rat LD > 3160 mg/kg
National Technical Information Service. Vol. OTS0516779

subcutaneous-rat LD50 3800 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965.

Inhalation Toxicity:
inhalation-mouse LC50 9400 mg/m3/2H
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE WEAKNESS
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 1, Pg. 54, 1961.

inhalation-rat LCLo 5000 ppm/6H
United States Patent Document. Vol. #5122301

 
Safety in Use Information:
Category:
indirect food additives: adhesives and components of coatings
Recommendation for N,N-dimethyl formamide usage levels up to:
 not for fragrance use.
 
Recommendation for N,N-dimethyl formamide flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):68-12-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6228
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
dimethylformamide
Chemidplus:0000068122
EPA/NOAA CAMEO:hazardous materials
RTECS:68-12-2
 
References:
 dimethylformamide
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:68-12-2
Pubchem (cid):6228
Pubchem (sid):134971046
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
KEGG (GenomeNet):C03134
HMDB (The Human Metabolome Database):HMDB01888
FooDB:FDB004724
YMDB (Yeast Metabolome Database):YMDB01396
Export Tariff Code:2924.19.1120
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 papaya fruit
Search Trop Picture
 
Synonyms:
 dimethyl formamide
N,N-dimethyl methanamide
 dimethylformamide
N,N-dimethylformamide
N,N'-dimethylformamide
N,N-dimethylformamide [UN2265] [Flammable liquid]
 dimethylformamide, N,N-
N,N-dimethylmethanamide
 formamide, dimethyl-
 formamide, N,N-dimethyl-
 formic acid, amide, N,N-dimethyl-
N-formyldimethylamine
 
 
Notes:
Dimethylformamide is a polar (hydrophilic) Aprotic solvent with a high boiling point. It facilitates reactions that follow polar mechanisms, such as SN2 reactions. Dimethylformamide can be synthesized from methyl formate and dimethyl amine or reaction of dimethyl amine and carbon monoxide. Dimethylformamide is not stable in the presence of strong bases like sodium hydroxide or strong acids such as hydrochloric acid or sulfuric acid and is hydrolyzed back into formic acid and dimethylamine, especially at elevated temperatures.; Dimethylformamide is the organic compound with the formula (CH3)2NC(O)H. Commonly abbreviated DMF (though this acronym is sometimes used for dimethylfuran), this colourless liquid is miscible with water and the majority of organic liquids. DMF is a common solvent for chemical reactions. Pure dimethylformamide is odorless whereas technical grade or degraded dimethylformamide often has a fishy smell due to impurity of dimethylamine. Its name is derived from the fact that it is a derivative of formamide, the amide of formic acid.; N,N-Dimethylformamide (DMF) is a clear liquid that has been widely used in industries as a solvent, an additive, or an intermediate because of its extensive miscibility with water and most common organic solvents. Its health effects include hepatotoxicity and male reproductoxicity, possibly linked with mitochondrial DNA (mtDNA) alterations including mtDNA common deletion (delta-mtDNA4977) and mtDNA copy number; during the biotransformation of DMF in the body, free radicals are formed, including hydroxyl radicals.; The world-wide consumption of DMF in 2001 was approximately 285,000 metric tonnes and most of that was used as an industrial solvent. Overexposure to DMF could result in hepatotoxicity, alcohol intolerance, possible embryotoxicity and teratogenicity in humans and animals, and decline of human sperm motility. Based on its wide application and a wide range of toxic effects, DMF has been selected as one of the four priority compounds for human field studies by the National Toxicology Program (NTP) of the US National Institute of Environmental Health Sciences (NIEHS). The current permissible exposure limit for DMF in the working environment is 10 ppm in both USA and Taiwan. The concentrations of two major DMF metabolites in urine, N-methylformamide (U-NMF) of 15 mg/L and N-acetyl-S-(N-methylcarbamoyl) cysteine (U-AMCC) of 40 mg/L, were recommended as the biological exposure indices (BEIs) by the American Conference of Governmental Industrial Hygienists for DMF exposure in workplace. (PMID: 17254560)
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