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Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.82700 @ 25.00 °C.
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| Refractive Index: | 1.43100 @ 20.00 °C.
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| Boiling Point: | 120.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 15.548000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 73.00 °F. TCC ( 22.78 °C. )
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| logP (o/w): | -0.620 |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 200 mg/kg
European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 17, Pg. 235, 1982.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for N,N'-dimethyl ethylene diamine usage levels up to: | | | not for fragrance use.
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| Recommendation for N,N'-dimethyl ethylene diamine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| N,N'- | dimethylethane-1,2-diamine | | N,N'- | dimethylethylenediamine | | 1,2- | ethanediamine, N,N'-dimethyl- |
Articles:
| PubMed:A novel brain targeted 5-fU derivative with potential antitumor efficiency and decreased acute toxicity: synthesis, in vitro and in vivo evaluation. |
| PubMed:Observations on transition metal free biaryl coupling: potassium tert-butoxide alone promotes the reaction without diamine or phenanthroline catalysts. |
| PubMed:Hemocompatibility improvement of poly(ethylene terephthalate) via self-polymerization of dopamine and covalent graft of zwitterions. |
| PubMed:Palladium-catalyzed amination of meso-(bromophenyl)porphyrins with diamines and azamacrocycles. |
| PubMed:Probing adsorption interactions in metal-organic frameworks using X-ray spectroscopy. |
| PubMed:Novel mixed-valence Cu compounds formed by Cu(II) dimers with double oximato bridges: in situ formation of anionic layer [Cu2(SCN)3]n(n-). |
| PubMed:Theoretical analysis of the influence of chelate-ring size and vicinal effects on electronic circular dichroism spectra of cobalt(III) EDDA-type complexes. |
| PubMed:The mechanism of carbon dioxide adsorption in an alkylamine-functionalized metal-organic framework. |
| PubMed:One-step synthesis of 6-acetamido-3-(N-(2-(dimethylamino) ethyl) sulfamoyl) naphthalene-1-yl 7-acetamido-4-hydroxynaphthalene-2-sulfonate and its characterization with 1D and 2D NMR techniques. |
| PubMed:Solution properties of tadpole-type cationic amphiphilic dendrimers consisting of an alkyl chain, a quaternary ammonium, and a poly(amidoamine) dendron. |
| PubMed:Aminated poly(glycidyl methacrylate)s for constructing efficient gene carriers. |
| PubMed:Discrete dinuclear complex to extended 2D compound in a Cu-azido system by controlling coligand stoichiometry: synthesis and magneto-structural correlations. |
| PubMed:Photohydrate-mediated reactions of uridine, 2'-deoxyuridine and 2'-deoxycytidine with amines at near neutral pH. |
| PubMed:Transport of nanoparticles in cystic fibrosis sputum and bacterial biofilms by single-particle tracking microscopy. |
| PubMed:The weakly coordinating perchlorate group in bis(N,N'-dimethylethylenediamine-κ2N,N')bis(perchlorato-κO)copper(II) studied at 100, 250 and 400 K. |
| PubMed:Effects of branched or linear architecture of bioreducible poly(amido amine)s on their in vitro gene delivery properties. |
| PubMed:Density functional theory study on the reaction mechanism of synthesizing 1,3-dimethyl-2-imidazolidinone by urea method. |
| PubMed:Copper-catalyzed synthesis of quinazolines in water starting from o-bromobenzylbromides and benzamidines. |
| PubMed:Synthesis of new β-amidodehydroaminobutyric acid derivatives and of new tyrosine derivatives using copper catalyzed C-N and C-O coupling reactions. |
| PubMed:Capture of carbon dioxide from air and flue gas in the alkylamine-appended metal-organic framework mmen-Mg2(dobpdc). |
| PubMed:Transition-metal-free intramolecular N-arylations. |
| PubMed:Thermodynamics of the interaction of Pd(dmen)(H₂O)₂²⁺ with bio-relevant ligands with reference to the deactivation of metal-based drug by thiol ligands. |
| PubMed:Nitric oxide reactivity of copper(II) complexes of bidentate amine ligands: effect of substitution on ligand nitrosation. |
| PubMed:Synthesis of ternary and quaternary graphite intercalation compounds containing alkali metal cations and diamines. |
| PubMed:Cu(II)-azide polymers with various molar equivalents of blocking diamine ligands: synthesis, structures, magnetic properties with DFT studies. |
| PubMed:Metal-organic niccolite: synthesis, structures, phase transition, and magnetic properties of [CH3NH2(CH2)2NH2CH3][M2(HCOO)6] (M=divalent Mn, Fe, Co, Ni, Cu and Zn). |
| PubMed:Tridentate N(2)S ligand from 2,2'-dithiodibenzaldehyde and N,N-dimethylethylenediamine: Synthesis, structure, and characterization of a Ni(II) complex with relevance to Ni Superoxide Dismutase. |
| PubMed:Erbium-formate frameworks templated by diammonium cations: syntheses, structures, structural transition and magnetic properties. |
| PubMed:A missing high-spin molecule in the family of cyanido-bridged heptanuclear heterometal complexes, [(LCu(II))₆Fe(III)(CN)₆]3+, and its Co(III) and Cr(III) analogues, accompanied in the crystal by a novel octameric water cluster. |
| PubMed:Active participation of cellular chaperone Hsp90 in regulating the function of rotavirus nonstructural protein 3 (NSP3). |
| PubMed:Synthesis, structures, and magnetic behavior of a series of copper(II) azide polymers of Cu4 building clusters and isolation of a new hemiaminal ether as the metal complex. |
| PubMed:Delivery of plasmid DNA encoding bone morphogenetic protein-2 with a biodegradable branched polycationic polymer in a critical-size rat cranial defect model. |
| PubMed:A series of Cu(II)-azide polymers of Cu6 building units and the role of chelating diamine in controlling their dimensionality: synthesis, structures, and magnetic behavior. |
| PubMed:Copper-catalyzed synthesis of N-fused heterocycles through regioselective 1,2-aminothiolation of 1,1-dibromoalkenes. |
| PubMed:A unique example of structural and magnetic diversity in four interconvertible copper(II)-azide complexes with the same schiff base ligand: a monomer, a dimer, a chain, and a layer. |
| PubMed:Synthesis of 17 alpha-substituted ethynylestradiols: potential ligands for drug vectors. |
| PubMed:Copper/alpha-ketocarboxylate chemistry with supporting peralkylated diamines: reactivity of copper(I) complexes and dicopper-oxygen intermediates. |
| PubMed:Altering amine basicities in biodegradable branched polycationic polymers for nonviral gene delivery. |
| PubMed:A cascade biodegradable polymer based on alternating cyclization and elimination reactions. |
| PubMed:Preparation and characterization of bisphenolato magnesium derivatives: an efficient catalyst for the ring-opening polymerization of epsilon-caprolactone and L-lactide. |
| PubMed:Selective formation of cis-diacyl, cis-PPh(2)R rhodium(III) complexes by the reaction of rhodium(III) cis-diacyl, trans-PPh(2)R complexes with aliphatic diamines. |
| PubMed:In situ diffuse reflectance infrared Fourier transform spectroscopy of MCM-41 mesoporous silica: mechanistic consideration on the chemical fixation of CO2 with N,N'-dimethylethylenediamine to 1,3-dimethyl-2-imidazolidinone. |
| PubMed:CuI-catalyzed amination of arylhalides with guanidines or amidines: a facile synthesis of 1-H-2-substituted benzimidazoles. |
| PubMed:Polysubstituted pyridazinones from sequential nucleophilic substitution reactions of tetrafluoropyridazine. |
| PubMed:Bisquinoline-based fluorescent zinc sensors. |
| PubMed:Deprotection of N(in)-formyl group on tryptophan by application of new reagent, 1,2-dimethylethylendiamine in aqueous solution. |
| PubMed:Mild immobilization of diverse macromolecular bioactive agents onto multifunctional fibrous membranes prepared by coaxial electrospinning. |
| PubMed:Mesoporous silica-catalysed continuous chemical fixation of CO(2) with N,N'-dimethylethylenediamine in supercritical CO(2): the efficient synthesis of 1,3-dimethyl-2-imidazolidinone. |
| PubMed:Deprotection of the indole (N(ind))-formyl (For) group on tryptophan employing a new reagent, N,N'-dimethylethylendiamine (DMEDA) in an aqueous solution. |
| PubMed:Synthesis and biodistribution of lipophilic and monocationic gallium radiopharmaceuticals derived from N,N'-bis(3-aminopropyl)-N,N'-dimethylethylenediamine: potential agents for PET myocardial imaging with 68Ga. |
| PubMed:Synthesis, structure, spectra and reactivity of iron(III) complexes of facially coordinating and sterically hindering 3N ligands as models for catechol dioxygenases. |
| PubMed:Theoretical study of the hydroxylation of phenolates by the Cu(2)O (2)(N,N'-dimethylethylenediamine) (2) (2+) complex. |
| PubMed:SOLVERSTAT: a new utility for multipurpose analysis. An application to the investigation of dioxygenated Co(II) complex formation in dimethylsulfoxide solution. |
| PubMed:Copper-catalyzed intramolecular N-vinylation of sulfonamides: general and efficient synthesis of heterocyclic enamines and macrolactams. |
| PubMed:Harnessing a ratiometric fluorescence output from a sensor array. |
| PubMed:A flexible coordination polymer crystal providing reversible structural and magnetic conversions. |
| PubMed:Synthesis of a biocleavable polyrotaxane-plasmid DNA (pDNA) polyplex and its use for the rapid nonviral delivery of pDNA to cell nuclei. |
| PubMed:Hydrogen bonding and cation coordination effects in primary and secondary amines dissolved in carbon tetrachloride. |
| PubMed:EPR spectra of Cu(2+) doped [Zn(sac)2(dmen)] and [Zn(sac)2(paen)] single crystals. |
| PubMed:Multiple photochemical reaction pathways in a Ni(II) coordination compound. |
| PubMed:General and highly efficient synthesis of 2-alkylideneazetidines and beta-lactams via copper-catalyzed intramolecular N-vinylation. |
| PubMed:Adsorption and aggregation properties of heterogemini surfactants containing a quaternary ammonium salt and a sugar moiety. |
| PubMed:Coordination chemistry of amine bis(phenolate) cobalt(II), nickel(II), and copper(II) complexes. |
| PubMed:An activity-dependent assay for ricin and related RNA N-glycosidases based on electrochemiluminescence. |
| PubMed:O-arylation versus C-arylation: copper-catalyzed intramolecular coupling of aryl bromides with 1,3-dicarbonyls. |
| PubMed:Crystalline and solution phases of N,N-dimethylethylenediamine complexed with lithium triflate and sodium triflate: intramolecular and intermolecular hydrogen bonding. |
| PubMed:Amine mediated proton transfer reaction and C-Cl bond activation of solvent chloroform by a trinuclear copper(II) complex of a glucopyranosylamine derived ligand. |
| PubMed:Preparation of platinum(IV) complexes with dipeptide and diimine. X-ray crystal structure and 195Pt NMR spectra. |
| PubMed:Perturbation of the PET process in fluorophore-spacer-receptor systems through structural modification: transition metal induced fluorescence enhancement and selectivity. |
| PubMed:Ionic (liquid) matrices for matrix-assisted laser desorption/ionization mass spectrometry-applications and perspectives. |
| PubMed:Spectroscopy and structures of copper complexes with ethylenediamine and methyl-substituted derivatives. |
| PubMed:Axial coordination changes the morphology of porphyrin assemblies in an organogel system. |
| PubMed:Characterization of modified antisense oligonucleotides in Xenopus laevis embryos. |
| PubMed:Parallel synthesis of a library of benzoxazoles and benzothiazoles using ligand-accelerated copper-catalyzed cyclizations of ortho-halobenzanilides. |
| PubMed:Synthesis of lipopolyhydroxylalkyleneamines for gene delivery. |
| PubMed:Fixing the conformations of diamineplatinum(II)-GpG chelates: NMR and CD signatures of individual rotamers. |
| PubMed:Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C. |
| PubMed:Synthesis of biodegradable cross-linked poly(beta-amino ester) for gene delivery and its modification, inducing enhanced transfection efficiency and stepwise degradation. |
| PubMed:Total spontaneous resolution of chiral covalent networks from stereochemically labile metal complexes. |
| PubMed:Magneto-structural correlations in binuclear copper(II) compounds bridged by a ferrocenecarboxylato(-1) and an hydroxo- or methoxo-ligands. |
| PubMed:Organoaluminium complexes incorporating an amido phosphine chelate with a pendant amine arm. |
| PubMed:Synthesis of lactams via copper-catalyzed intramolecular vinylation of amides. |
| PubMed:Zwitterionic heterogemini surfactants containing ammonium and carboxylate headgroups. 1. Adsorption and micellization. |
| PubMed:Is delayed micro-graft hair transplantation possible?--evaluation of viabilities of hair follicles preserved in two storage media. |
| PubMed:Modification of ion-exchange membrane used for separation of protons and metallic cations and characterization of the membrane by current-voltage curves. |
| PubMed:A family of oxorhenium(v) complexes incorporating chelated monoanionic ONN reduced Schiff base and dianionic ONNO tetradentate ligands: synthesis, spectroscopic and electrochemical studies. |
| PubMed:The one-dimensional structure of Cu(dmen)2Pd(CN)4 (dmen is N,N-dimethylethylenediamine). |
| PubMed:Platelet adhesive resistance of polyurethane surface grafted with zwitterions of sulfobetaine. |
| PubMed:Synthesis and oxygenation of a nickel(II) and zinc(II) dithiolate: an experimental and theoretical comparison. |
| PubMed:Bis(acetone-kappaO)bis(N,N'-dimethylethylenediamine-kappa(2)N,N')copper(II) diperchlorate. |
| PubMed:Synthesis and characterization of three novel amphiphilic aminated hypocrellins as photodynamic therapeutic agents. |
| PubMed:Exploration of composition space in templated uranium sulfates. |
| PubMed:The effect of shear on the desorption of liposomes adsorbed to bacterial biofilms. |
| PubMed:Copper-catalyzed C-P bond construction via direct coupling of secondary phosphines and phosphites with aryl and vinyl halides. |
| PubMed:Photolytic control of peptide self-assembly. |
| PubMed:[Au(CN)4]- as a supramolecular building block for heterobimetallic coordination polymers. |
| PubMed:Copper-catalyzed domino halide exchange-cyanation of aryl bromides. |
| PubMed:Molecular motions in the solid state: the thermochromic nitro-nitrito Interconversion in nickel(II) bis(diamine) complexes. |
| PubMed:Synthesis and estrogen receptor affinity of a 4-hydroxytamoxifen-labeled ligand for diagnostic imaging. |
| PubMed:Architecture dependence on the steric constrains of the ligand in cyano-bridged copper(I) and copper(II)-copper(I) mixed-valence polymer compounds containing diamines: crystal structures and spectroscopic and magnetic properties. |
| PubMed:Per-6-substituted beta-cyclodextrin libraries inhibit formation of beta-amyloid-peptide (A beta)-derived, soluble oligomers. |
| PubMed:Development of multicomponent DNA delivery systems based upon poly(amidoamine)-PEG co-polymers. |
| PubMed:Tricalixarenes and pentacalixarenes: synthesis and complexation studies. |
| PubMed:A general and efficient copper catalyst for the amidation of aryl halides. |
| PubMed:Amphiphilic block copolymers as bile acid sorbents: 1. Synthesis of polystyrene-b-poly(N,N,N-trimethylammoniumethylene acrylamide chloride). |
| PubMed:Synthesis of Chiral C(2)-Symmetric Bisferrocenyldiamines. X-ray Crystal Structure of Ru(2)Cl(2).2CHCl(3) (2 = N1,N2-Bis{(R)-1-[(S)-2-(diphenylphosphino)]ferrocenylethyl}- N1,N2-dimethyl-1,2-ethanediamine). |
| PubMed:Catalysis and inhibition of ligand substitution in palladium(II) square-planar complexes: effects of DNA. |
| PubMed:Ancillary ligand effect on the properties of "Mg(thd)2" and crystal structures of [Mg(thd)2(ethylenediamine)]2, [Mg(thd)2(tmeda)], and [Mg(thd)2(trien)]. |
| PubMed:Synthesis, structure, and magnetic properties of two new ferromagnetic/antiferromagnetic one-dimensional nickel(II) complexes. Magnetostructural correlations. |
| PubMed:Mono- and dinuclear zinc complexes derived from unsymmetric binucleating ligands: synthesis, characterization, and formation of tetranuclear arrays. |
| PubMed:Enhancement of CsNO3 extraction in 1,2-dichloroethane by tris(2-aminoethyl)amine triamide derivatives via a dual-host strategy |
| PubMed:Reductions with lithium in low molecular weight amines and ethylenediamine |
| PubMed:Circular dichroism spectra of the individual rotamers of [Pt(N,N-dmen)(GpG)]+ (N,N-dmen=N,N-dimethylethylenediamine) indicate that the base-base oscillator coupling is not the main source of ellipticity in cis-PtG2L2 head-to-head complexes. |
| PubMed:The effect of lyophilization on plasmid DNA activity. |
| PubMed:The reactivity of the 2-deoxyribonolactone lesion in single-stranded DNA and its implication in reaction mechanisms of DNA damage and repair. |
| PubMed:A modular lymphographic magnetic resonance imaging contrast agent: contrast enhancement with DNA transfection potential. |
| PubMed:Voltage-dependent behavior of a "ball-and-chain" gramicidin channel. |
| PubMed:Characterization of DNA damage inflicted by free radicals from a mutagenic sunscreen ingredient and its location using an in vitro genetic reversion assay. |
| PubMed:Synthesis and antitumor properties of N-[2-(dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: a new class of putative topoisomerase inhibitors. |
| PubMed:Cationic liposome-mediated gene transfer to tumor cells in vitro and in vivo. |
| PubMed:Novel reagents for chemical cleavage at abasic sites and UV photoproducts in DNA. |
| PubMed:Bis-dithiocarbamates: effective chelating agents for mobilization of polonium-210 from rat. |
| PubMed:A new approach to the design of sigma-2-selective ligands: synthesis and evaluation of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine-related polyamines at sigma-1 and sigma-2 receptor subtypes. |
| PubMed:Carcinogenesis and mutagenesis by N-nitroso compounds having a basic center. |
| PubMed:Cytotoxicity of asymmetric platinum complexes against L-1210 cells. Effect of bulky substituents. |
| PubMed:The in vivo metabolism of methapyrilene, a hepatocarcinogen, in the rat. |
| PubMed:Species differences in the in vitro metabolism of methapyrilene. |
| PubMed:The effect of chronic methapyrilene treatment on methapyrilene metabolism in vitro. |
| PubMed:Mutagenicity studies of selected antihistamines, their metabolites and products of nitrosation. |
| PubMed:Metabolism of methapyrilene by rat-liver homogenate. |
| PubMed:Extraction and determination of anionic surfactants with copper (II)-ethylenediamine derivative complexes. |
| PubMed:Effect of hydrogen bonding on electronic spectra and reactivity of flavins. |
| PubMed:The living state and cancer. |
| PubMed:Antitumor agents. 31. Helenalin sym-dimethylethylenediamine reaction products and related derivatives. |
| PubMed:[Pharmacological studies on supersensitization. V. Augmentation of pressor response to catecholamine induced by N, N-dimethylethylenediamines (author's transl)]. |
| PubMed:The response of cell walls of Bacillus subtilis to metals and to electron-microscopic stains. |
| PubMed:Observation of a direct interaction between the carbonyl oxygen, O(6), of a N(7)-bonded 6-oxopurine and a metal center. Preparation and crystal and molecular structure of (N-3,4-benzosalicylidene-N',N'-dimethylethylenediamine)-(theophyllinato)copper (II) monohydrate. |
| PubMed:The oxidation of N,N'-bis(4-aminophenyl)-N,N'-dimethylethylenediamine (BED) by rat liver. |
| PubMed:Ultrastructural variations in N,N'-bis(4-aminophenyl)-N,N'-dimethylethylenediamine (BED) oxidase localization in rat liver and parotid gland with variation in length of fixation. |
| PubMed:[Research on changes induced by the administration of a bronchodilatory drug to healthy subjects & pneumopathic patients (silicotic, silicotuberculotic, tuberculotic & asthmatic emphysematous patients). II. Effects of treatment with dimethylethylenediamine on spirometric measurements at rest & maximum aerobic work capability]. |
| PubMed:[Research on changes induced by the administration of a bronchodilatory drug to healthy subjects & pneumopathic patients (silicotic, silicotuberculotic, tuberculotic & asthmatic emphysematous patients). I. Effect of treatment with dimethylethylenediamine on gasous metabolism at rest]. |
| PubMed:[Initial results on the effects of phenoxyethyl-dimethyl-dodecyl ammonium bromide combined with benzyl-(pyridyl)-dimethylethylenediamine in various forms of pyogenic eczematization]. |
| PubMed:Pharmacology of N-(2-furfuryl)-N-(2-pyridyl)-N',N'-dimethylethylenediamine fumarate (methafurylene fumarate II. Toxicological studies. |
| PubMed:Pharmacology of N-(2-furfuryl)-N-(2-pyridyl)-N',N'-dimethylethylenediamine fumarat (methafurylene fumarate). I. Antihistaminic properties of this compound and its 5-chloro and 5-bromo derivatives. |
| PubMed:Antihistaminic, antianaphylactic and antiallergic activity of N-(a-pyridyl)-N-(a-thenyl)-N, N -dimethylethylenediamine hydrochloride. |
| PubMed:Clinical studies with pyribenzamine (N' pyridil-N'benzyl-N-dimethylethylenediamine) in hay fever. |
| PubMed:Histamine antagonists; N-(alpha-pyridyl)-N-(alpha-thienyl)-N', N-dimethylethylenediamine, a new antihistaminic compound; experimental and clinical experiences. |
| PubMed:The symptomatic treatment of hay fever with diaminobenzopyridyl HCl (N'-pyridyl-N'-benzyl-N-dimethylethylenediamine hydrochloride)(pyribenzamine). |
| PubMed:The antihistamine action of N-(2-pyridyl)-N-(2-thenyl)-N', N'-dimethylethylenediamine hydrochloride. |
| PubMed:Pyribenzamine (n'-pyridyl-n'-benzyl-n-dimethylethylenediamine HC1), an antagonist of histamine. |
| PubMed:Some antianaphylactic and antihistaminic properties of n'pyridyl, n'benzyl, dimethylethylenediamine monohydrochloride (pyribenzamine). |
| PubMed:Adrenergic potentiation by pyribenzamine HCl (N-pyridyl N-benzyl-N-dimethylethylenediamine HCl). |
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3D/inchi