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methylene blue (c.i. 52015)
methanaminium, N-[7-(dimethylamino)-3H-phenothiazin-3-ylidene]-N-methyl-, chloride (1:1)

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Name:[7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride
CAS Number: 61-73-4Picture of molecule3D/inchi
Other(deleted CASRN):105504-42-5
ECHA EINECS - REACH Pre-Reg:200-515-2
FDA UNII: 8NAP7826UB
Beilstein Number:3599847
MDL:MFCD00012111
Molecular Weight:319.85746000
Formula:C16 H18 Cl N3 S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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US Patents:Search
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NCBI:Search
FDA Mainterm (IAUFC):61-73-4 ; METHYLENE BLUE
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 105.00 °C. @ 760.00 mm Hg
Vapor Pressure:1.300000 mmHg @ 25.00 °C. (est)
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 4.36E+04 mg/L @ 25 °C (exp)
 water, 1.659e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Abbey Color
Basic Blue 9
BOC Sciences
For experimental / research use only.
Methylene Blue
ECSA Chemicals
METHYLENE BLUE SATURATED SOLUTION RPE-FOR AN
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
METHYLENE BLUE
EMD Millipore
For experimental / research use only.
Methylene Blue
Glentham Life Sciences
Methylene Blue solution, 0.5% in water
Glentham Life Sciences
Methylene Blue, anhydrous (C.I. 52015)
Indis NV
For experimental / research use only.
Methylene Blue
Penta International
METHYLENE BLUE POWDER
Sigma-Aldrich
For experimental / research use only.
Methylene blue, certified by the Biological Stain Commission
TCI AMERICA
For experimental / research use only.
Methylene Blue [Ion association reagent for spectrophotometric analysis] >98.0%(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-cat LDLo 41 mg/kg
Annals of Internal Medicine. Vol. 7, Pg. 738, 1933.

intravenous-dog LDLo 50 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1366, 1935.

oral-dog LDLo 500 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1366, 1935.

intraperitoneal-mouse LD50 150 mg/kg
National Technical Information Service. Vol. AD691-490

intravenous-mouse LD50 77 mg/kg
Cesko-Slovenska Farmacie. Vol. 12, Pg. 94, 1963.

oral-mouse LD50 3500 mg/kg
Cesko-Slovenska Farmacie. Vol. 12, Pg. 94, 1963.

oral-rabbit LDLo 1000 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1366, 1935.

intraperitoneal-rat LD50 180 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 204, Pg. 288, 1947.

intravenous-rat LD50 1250 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 676, 1968.

oral-rat LD50 1180 mg/kg
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1334, 1986.

Dermal Toxicity:
subcutaneous-guinea pig LDLo 300 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1366, 1935.

subcutaneous-man TDLo 28 uL/kg
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
British Journal of Clinical Practice. Vol. 28, Pg. 289, 1974.

subcutaneous-rat LD50 190 mg/kg
Drugs in Japan Vol. -, Pg. 1185, 1990.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for methylene blue (c.i. 52015) usage levels up to:
 not for fragrance use.
 
Recommendation for methylene blue (c.i. 52015) flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Dyes used in aquaculture
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):61-73-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6099
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
[7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride
Chemidplus:0000061734
RTECS:SO5600000 for cas# 61-73-4
 
References:
 [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:61-73-4
Pubchem (cid):6099
Pubchem (sid):134971203
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C00220
HMDB (The Human Metabolome Database):Search
Export Tariff Code:3204.13.8000
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
oral: tablets: 65 mg methblue (manne), urolene blue (star). parenteral injection, for iv use: 10 mgml (available by nonproprietary name).
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 hair dyeing agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 basic blue 9
 basic blue 9 (c.i. 52015)
 basic blue trihydrate
 basic lake blue
 bleu de methylene
 c.i. 52015
 C.I. basic blue 9
 calcozine blue ZF
 ceruleum methylenum
 chromosmon
 ci 52015
 CI basic blue 9
 D and C blue no. 1
 D&C blue no. 1
7-(dimethylamino)-3-(methylimino)-3H-phenothiazine 3-methochloride
7-(dimethylamino)-N,N-dimethyl-3H-phenothiazin-3-iminium chloride
[7-(dimethylamino)dibenzo[b,e]1,4-thiazin-3-yl]dimethylamine, chloride
3,7-bis(dimethylamino)phenazathionium chloride
[7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride
[7-(dimethylamino)phenothiazin-3-ylidene]dimethylamine, chloride
3,7-bis(dimethylamino)phenothiazin-5-ium chloride
(7-dimethylaminophenothiazin-3-ylidene)-dimethyl-azanium chloride
 duasyn basic blue IAD
 ehrlich's reagent III
 external blue 1
 hidaco methylene blue salt free
 leather pure blue HB
 methanaminium, N-[7-(dimethylamino)-3H-phenothiazin-3-ylidene]-N-methyl-, chloride (1:1)
 methyl thioninium chloride
 phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride
3H-phenothiazine, 7-(dimethylamino)-3-(methylimino)-, 3-methochloride
 phenothiazinium, 3,7-bis(dimethylamino)-, chloride (1:1)
 rember
 sandocryl blue BRL
 schultz 1038
 schultz no. 1038
 solvent blue 8
 swiss blue
 tetramethylene blue
 urolene blue
 
 
Notes:
a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. solutions in water or alcohol have a deep blue color. methylene blue is used as a bacteriologic stain and as an indicator. it inhibits guanylate cyclase, and has been used to treat cyanide poisoning and to lower levels of methemoglobin.
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