N-acetyl-laevo-glutamine
2-acetamido-5-amino-5-oxopentanoic acid
 
Notes:
N-Acetylglutamine (GIcNAc) is a modified amino acid (an acetylated analogue of glutamine), a metabolite present in normal human urine. The decomposition products of GIcNAc have been identified by NMR and HPLC-MS as N-acetyl-L-glutamic acid, N-(2,6-dioxo-3-piperidinyl) acetamide, pyroglutamic acid, glutamic acid, and glutamine. GIcNAc is used for parenteral nutrition as a source of glutamine, since glutamine is too unstable, but GIcNAc is very stable. In patients treated with aminoglycosides and/or glycopeptides, elevation GIcNAc in urine suggests renal tubular injury. High amounts of N-acetylated amino acids (i.e.: N-Acetylglutamine) were detected patient with aminoacylase I deficiency (EC 3.5.1.14, a homodimeric zinc-binding metalloenzyme located in the cytosol), a novel inborn error of metabolism. (PMID: 15331932, 11312773, 7952062, 2569664, 16274666) [HMDB]
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2-acetamido-5-amino-5-oxopentanoic acid (Click)
CAS Number: 2490-97-3Picture of molecule
Other: 30703-24-3
ECHA EINECS - REACH Pre-Reg: 219-647-7
FDA UNII: 01J18G9G97
Nikkaji Web: J33.403K
Beilstein Number: 1727471
MDL: MFCD00038159
XlogP3: -1.40 (est)
Molecular Weight: 188.18344000
Formula: C7 H12 N2 O4
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic ingredient for skin conditioning
 
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 197.00 °C. @ 760.00 mm Hg
Boiling Point: 604.91 °C. @ 760.00 mm Hg (est)
Flash Point: 90.00 °F. TCC ( 32.22 °C. )
logP (o/w): -2.635 (est)
Soluble in:
 water, 1.553e+005 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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Suppliers:
Glentham Life Sciences
Na-Acetyl-L-glutamine
Penta International
N-ACETYL-L-GLUTAMINE, Kosher
Sigma-Aldrich: Sigma
For experimental / research use only.
N-Acetyl-L-glutamine
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic ingredient for skin conditioning
Recommendation for N-acetyl-laevo-glutamine usage levels up to:
 not for fragrance use.
 
Recommendation for N-acetyl-laevo-glutamine flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 2490-97-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 25561
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 2-acetamido-5-amino-5-oxopentanoic acid
Chemidplus: 0002490973
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References:
 2-acetamido-5-amino-5-oxopentanoic acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 25561
Pubchem (sid): 135059846
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
Metabolomics Database: Search
KEGG (GenomeNet): D07063
HMDB (The Human Metabolome Database): HMDB06029
FooDB: FDB023808
YMDB (Yeast Metabolome Database): YMDB01757
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 aceglutamide
2-acetamido-5-amino-5-oxopentanoic acid
a-N-acetyl-L-glutamine
N-acetyl-L-glutamine
N-a-acetyl-L-glutamine
N(sup2)-acetyl-L-glutamine
N2-acetyl-L-glutamine
N(sup2)-acetyl-laevo-glutamine
N2-acetyl-laevo-glutamine
(2S)-2-(acetylamino)-4-carbamoylbutanoic acid
(2S)-4-carbamoyl-2-acetamidobutanoic acid
L-glutamine, N2-acetyl-
 glutamine, N2-acetyl-, L-
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