EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

meso-erythritol
(2R,3S)-butane-1,2,3,4-tetrol

Supplier Sponsors

CAS Number: 149-32-6Picture of molecule3D/inchi
Other:10030-58-7
ECHA EINECS - REACH Pre-Reg:205-737-3
FDA UNII:RA96B954X6
Nikkaji Web:J43.360H
Beilstein Number:1719753
MDL:MFCD00004710
XlogP3:-2.30 (est)
Molecular Weight:122.12050000
Formula:C4 H10 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor enhancers, humectants, carriers, sweeteners
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 401 7 Erythritol View - notice PDF
GRN 382 Erythritol View - notice PDF
GRN 76 Erythritol View - notice PDF
GRN 208 Erythritol View - notice PDF
GRN 789 Erythritol View - notice PDF
JECFA Food Additive: Erythritol
FEMA Number:4819
FDA:No longer provide for the use of these seven synthetic flavoring substances
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 119.00 to 123.00 °C. @ 760.00 mm Hg
Boiling Point: 330.00 to 331.00 °C. @ 760.00 mm Hg
Flash Point: 408.00 °F. TCC ( 208.70 °C. ) (est)
logP (o/w): -2.996 (est)
Soluble in:
 water, 6.10E+05 mg/L @ 22 °C (exp)
 alcohol, slightly
Insoluble in:
 diethyl ether
 
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American International Chemical, LLC.
ERYTHRITOL FCC
Atlantic Chemicals
Erythritol
BOC Sciences
For experimental / research use only.
meso-Erythritol
Carbosynth
For experimental / research use only.
meso-Erythritol
Cargill, Inc.
Zerose® erythritol
Flavor: characteristic
Erythritol, a natural, zero calorie, high digestive tolerance polyol, provides bulk, texture, high cooling effect and preservative benefits of sucrose in sugar-free and calorie-reduced products. Erythritol is suitable for dental health, weight management and sugar avoiders.
Coompo
For experimental / research use only.
Erythritol from Plants ≥96%
ExtraSynthese
For experimental / research use only.
meso-Erythritol
Foodchem International
Erythritol
Jiangyin Healthway
Erythritol
New functional food ingredients
Jungbunzlauer Suisse
ERYLITE®
Flavor: sweet
ERYLITE® is a novel bulk sweetener with a caloric value close to zero. Chemically, it is a four-carbon sugar alcohol (polyol). ERYLITE® is produced by microbial fermentation of a carbohydrate substrate. It is the only all-natural sugar alcohol available today.
Kraft Chemical
Erythritol
O'Laughlin Industries
Erythritol /Stevia agglomerated blend
10 to 1 sugar sweetness
O'Laughlin Industries
Erythritol /Stevia agglomerated blend
5 to 1 sugar sweetness
O'Laughlin Industries
Erythritol, FCC
O'Laughlin Industries
ERYTHRITOL/ STEVIA CO-CRYSTALLIZED BLEND
O'Laughlin Industries
ERYTHRITOL/ STEVIA CO-CRYSTALLIZED BLEND
Penta International
meso-ERYTHRITOL
Prinova
Erythritol FCC
Santa Cruz Biotechnology
For experimental / research use only.
meso-Erythritol ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
meso-Erythritol ≥99%
Sinofi Food Ingredients
Erythritol
Flavor: characteristic
Sugar Substitutes, Chewing Gum, Beverages, Confections, Baking Food, Chocolate, Instant Coffee, Ice Cream.
TCI AMERICA
For experimental / research use only.
meso-Erythritol >99.0%(HPLC)(T)
The Ingredient House
RightSweet Erythritol
The Ingredient House
USDA Organic Erythritol
Viachem
Erythritol
Odor: bland
Use: Erythritol, C4H10O4, is a novel bulk sweetener with a caloric value close to zero. Chemically, it is a four-carbon sugar alcohol (polyol). Erythritol, a white crystalline powder, is made through fermentation.
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 7000 mg/kg
Proceedings of the Society for Experimental Biology and Medicine. Vol. 35, Pg. 98, 1936.

intravenous-dog LDLo 5000 mg/kg
"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 576, 1989.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor enhancers, humectants, carriers, sweeteners
Recommendation for meso-erythritol usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 28
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): 5000.0000012500.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: 5000.0000012500.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: 5000.0000012500.00000
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: 5000.0000012500.00000
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Statement in relation to the safety of erythritol (E 968) in light of new data, including a new paediatric study on the gastrointestinal tolerability of erythritol
View page or View pdf

ment on a refined dietary exposure assessment of erythritol (E 968) taking into account additional data provided
View page or View pdf

Scientific Opinion on the safety of the proposed extension of use of erythritol (E 968) as a food additive
View page or View pdf

Sugar-free hard confectionery with at least 90% erythritol and reduction of dental plaque which reduces the risk of dental caries: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):149-32-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :222285
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2R,3S)-butane-1,2,3,4-tetrol
Chemidplus:0000149326
RTECS:KF2000000 for cas# 149-32-6
 
References:
 (2R,3S)-butane-1,2,3,4-tetrol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:149-32-6
Pubchem (cid):222285
Pubchem (sid):134975586
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C00503
HMDB (The Human Metabolome Database):HMDB02994
Export Tariff Code:2940.00.6000
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
FAO:ERYTHRITOL
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 algae
Search PMC Picture
 
Synonyms:
 antierythrite
(R*,S*)-1,2,3,4-butane tetrol
(2R,3S)-butane-1,2,3,4-tetraol
(2R,3S)-butane-1,2,3,4-tetrol
meso-butane-1,2,3,4-tetrol
(2R,3S)-1,2,3,4-butanetetrol
(R*,R*)-1,2,3,4-butanetetrol
DL-1,2,3,4-butanetetrol
1,2,3,4-butanetetrol, (2R,3S)-
(2R,3S)-1,2,3,4-butantetrol
 erythrite
(R*,S*)-tetrahydroxybutane
DL-threitol
 

Articles:

PubMed:Amplification of Hofmeister Effect by Alcohols.
PubMed:Recognition of riboflavin and the capsular polysaccharide of Haemophilus influenzae type b by antibodies generated to the haptenic epitope D-ribitol.
PubMed:Gluconobacter cerevisiae sp. nov., isolated from the brewery environment.
PubMed:Flow of suspensions of carbon nanotubes carrying phase change materials through microchannels and heat transfer enhancement.
PubMed:Chemical constituents from Glyphaea brevis and Monodora myristica: chemotaxonomic significance.
PubMed:[Simultaneous determination of meso-erythritol and L-erythrulose in fermentation broth using high performance liquid chromatography].
PubMed:Enzymatic synthesis of novel branched sugar alcohols mediated by the transglycosylation reaction of pullulan-hydrolyzing amylase II (TVA II) cloned from Thermoactinomyces vulgaris R-47.
PubMed:Characterization and inactivation of the membrane-bound polyol dehydrogenase in Gluconobacter oxydans DSM 7145 reveals a role in meso-erythritol oxidation.
PubMed:Reactivity of poly-alcohols towards OH, NO3 and SO4- in aqueous solution.
PubMed:Nonviral vectors with a biosurfactant MEL-A promote gene transfection into solid tumors in the mouse abdominal cavity.
PubMed:Gluconobacter sphaericus (Ameyama 1975) comb. nov., a brown pigment-producing acetic acid bacterium in the Alphaproteobacteria.
PubMed:Analysis of erythritol in foods by polyclonal antibody-based indirect competitive ELISA.
PubMed:Production of different types of mannosylerythritol lipids as biosurfactants by the newly isolated yeast strains belonging to the genus Pseudozyma.
PubMed:Characterization of the genus Pseudozyma by the formation of glycolipid biosurfactants, mannosylerythritol lipids.
PubMed:Interstrand and intrastrand DNA-DNA cross-linking by 1,2,3,4-diepoxybutane: role of stereochemistry.
PubMed:Anaphylaxis to excipient mannitol: evidence for an immunoglobulin E-mediated mechanism.
PubMed:Pseudonocardia antarctica sp. nov. an Actinomycetes from McMurdo Dry Valleys, Antarctica.
PubMed:Determination of glycerol by gas chromatography using meso-erythritol as internal standard.
PubMed:Biosurfactant MEL-A dramatically increases gene transfection via membrane fusion.
PubMed:Herbaspirillum lusitanum sp. nov., a novel nitrogen-fixing bacterium associated with root nodules of Phaseolus vulgaris.
PubMed:Use of DSC to detect the heterogeneity of hydrothermal stability in the polyphenol-treated collagen matrix.
PubMed:New quinoproteins in oxidative fermentation.
PubMed:New developments in oxidative fermentation.
PubMed:Pseudomonas grimontii sp. nov.
PubMed:Modeling and measurements of solid-liquid and vapor-liquid equilibria of polyols and carbohydrates in aqueous solution.
PubMed:L-erythrulose production by oxidative fermentation is catalyzed by PQQ-containing membrane-bound dehydrogenase.
PubMed:Isolation of yeast Kurtzmanomyces sp. I-11, novel producer of mannosylerythritol lipid.
PubMed:Membrane-bound quinoprotein D-arabitol dehydrogenase of Gluconobacter suboxydans IFO 3257: a versatile enzyme for the oxidative fermentation of various ketoses.
PubMed:Phenotypic characterization of Microsporum canis isolated from cats and dogs.
PubMed:Herbaspirillum frisingense sp. nov., a new nitrogen-fixing bacterial species that occurs in C4-fibre plants.
PubMed:Determination of sugar alcohols in confectioneries by high-performance liquid chromatography after nitrobenzoylation.
PubMed:Characterization of a biosurfactant, mannosylerythritol lipid produced from Candida sp. SY16.
PubMed:Pseudomonas gessardii sp. nov. and Pseudomonas migulae sp. nov., two new species isolated from natural mineral waters.
PubMed:At physiological expression levels the Kidd blood group/urea transporter protein is not a water channel.
PubMed:Liquid chromatographic determination of sugar alcohols in beverages and foods after nitrobenzoylation.
PubMed:Emended description of Herbaspirillum; inclusion of [Pseudomonas] rubrisubalbicans, a milk plant pathogen, as Herbaspirillum rubrisubalbicans comb. nov.; and classification of a group of clinical isolates (EF group 1) as Herbaspirillum species 3.
PubMed:Nutritional physiology and taxonomy of human-pathogenic Cladosporium-Xylohypha species.
PubMed:Evidence for a glycerol pathway through aquaporin 1 (CHIP28) channels.
PubMed:Nutritional physiology and selective isolation of Exophiala dermatitidis.
PubMed:Possibility of allergic reaction to dentin primer--application on the skin of guinea pigs.
PubMed:Bonding efficacy of erythritol methacrylate solutions as dentin primers.
PubMed:Volumetric properties of polyols (ethylene glycol, glycerol, meso-erythritol, xylitol and mannitol) in relation to their membrane permeability: group additivity and estimation of the maximum radius of their molecules.
PubMed:Usefulness of trehalose fermentation and L-glutamic acid decarboxylation for identification of biochemically aberrant Providencia stuartii strains.
PubMed:The use of meso-erythritol sensitivity discs in the typing of Brucella strains.
PubMed:[Determination of biovars of Brucella melitensis by manometric character: epidemiological value and relation to serovars].
PubMed:Osmotic deformation of red blood cell ghosts induced by carbohydrates.
PubMed:Effect of intracytoplasmic membrane development on oxidation of sorbitol and other polyols by Gluconobacter oxydans.
PubMed:Biotypes of Proteus rettgeri.
PubMed:Investigations with 1,4-bis-(2'-mesyloxyethylamino)-1,4-dideoxy-meso-erythritol (R-74).
PubMed:IDENTIFICATION OF ALTRO-HEPTULOSE AND L-THREITOL AS PRODUCTS OF MESO-ERYTHRITOL OXIDATION BY ACETOBACTER SUBOXYDANS.
PubMed:A note on meso-erythritol, a metabolic product of Aspergillus terreus.
 
Notes:
a four-carbon sugar that is found in algae, fungi, and lichens. it is twice as sweet as sucrose and can be used as a coronary vasodilator.
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