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manganese(II) chloride tetrahydrate
manganese(2+) chloride hydrate (1:2:4)

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CAS Number: 13446-34-9Picture of molecule3D/inchi
FDA UNII: QQE170PANO
MDL:MFCD00149792
Molecular Weight:197.90260500
Formula:H8 Cl2 Mn O4
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:food additive, dietary supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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FDA Mainterm (SATF):13446-34-9 ; MANGANESE CHLORIDE
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1446 Manganese chloride.


FDA PART 582 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart A--General Provisions
Sec. 582.80 Trace minerals added to animal feeds.
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:2.01000 @ 25.00 °C.
Boiling Point: 100.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:24.500000 mmHg @ 25.00 °C. (est)
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -1.380 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American Elements
Manganese(ii) Chloride Tetrahydrate 99%
Odor: characteristic
Use: Manganese Chloride Tetrahydrate is an excellent water soluble crystalline Manganese source for uses compatible with chlorides. Hydrate or anhydrous forms may be purchased. Chloride compounds can conduct electricity when fused or dissolved in water. Chloride materials can be decomposed by electrolysis to chlorine gas and the metal. They are formed through various chlorination processes whereby at least one chlorine anion (Cl-) is covalently bonded to the relevant metal or cation. Ultra high purity and proprietary formulations can be prepared. The chloride ion controls fluid equilibrium and pH levels in metabolic systems. They can form either inorganic or organic compounds. Manganese Chloride Tetrahydrate is generally immediately available in most volumes. Ultra high purity and high purity compositions improve both optical quality and usefulness as scientific standards. Nanoscale (See also Nanotechnology Information and Quantum Dots) elemental powders and suspensions, as alternative high surface area forms, may be considered. We also produce Manganese Chloride Solution. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
Manganese Chloride Tetrahydrate ACS
BOC Sciences
For experimental / research use only.
Manganese(II) chloride tetrahydrate Anhydrous, 97%
Charkit Chemical
MANGANESE (II) CHLORIDE ACS TETRAHYDRATE
Charkit Chemical
MANGANESE (II) CHLORIDE USP TETRAHYDRATE
Glentham Life Sciences
Manganese(II) chloride tetrahydrate
Penta International
MANGANESE CHLORIDE TETRAHYDRATE FCC
Penta International
MANGANESE CHLORIDE TETRAHYDRATE USP
Sigma-Aldrich
For experimental / research use only.
Manganese(II) chloride tetrahydrate 99.99% trace metals basis
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 144 mg/kg
Toxicology and Applied Pharmacology. Vol. 63, Pg. 461, 1982.

intraperitoneal-rat LD50 138 mg/kg
EHP, Environmental Health Perspectives. Vol. 10, Pg. 95, 1975.

oral-rat LD50 1484 mg/kg
EHP, Environmental Health Perspectives. Vol. 10, Pg. 95, 1975.

parenteral-rat LD50 225 mg/kg
Journal of Inorganic and Nuclear Chemistry. Vol. 41, Pg. 1507, 1979.

Dermal Toxicity:
subcutaneous-mouse LD50 320 mg/kg
Toxicology Letters. Vol. 69, Pg. 45, 1993.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
food additive, dietary supplements
Recommendation for manganese(II) chloride tetrahydrate usage levels up to:
 not for fragrance use.
 
Recommendation for manganese(II) chloride tetrahydrate flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :643989
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
dichloromanganese;tetrahydrate
Chemidplus:0013446349
RTECS:OO9650000 for cas# 13446-34-9
 
References:
 dichloromanganese;tetrahydrate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):643989
Pubchem (sid):134990402
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
KEGG (GenomeNet):D04852
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2827.39.5000
FDA Listing of Food Additive Status:View
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 dichloromanganese;tetrahydrate
 manganese chloride (MnCl2) tetrahydrate
 manganese chloride (MnCl2), tetrahydrate
 manganese chloride tetrahydrate
 manganese dichloride tetrahydrate
 manganese, dichloro-, tetrahydrate
 manganese(2+) chloride hydrate (1:2:4)
 manganesechloridetetrahydrate
 

Articles:

PubMed:Protective effects of sodium p-aminosalicylic acid on learning and memory via increasing the number of basal forebrain choline acetyltransferase neurons in manganese-exposed rats.
PubMed:Synthesis of manganese nanoparticles in the liquid phase plasma.
PubMed:MR signal changes on hepatobiliary imaging after oral ingestion of manganese chloride tetrahydrate: preliminary examination.
PubMed:Interactions between new quinolone antibacterials and diagnostic drug containing manganese.
PubMed:Intraductal papillary mucinous neoplasm penetrating to the stomach, duodenum, and jejunum demonstrated on MR cholangiopancreatography with an oral negative contrast agent.
PubMed:A new manganese-based oral contrast agent (CMC-001) for liver MRI: pharmacological and pharmaceutical aspects.
PubMed:Manganese chloride tetrahydrate (CMC-001) enhanced liver MRI: evaluation of efficacy and safety in healthy volunteers.
PubMed:Metal-organic frameworks based on unprecedented trinuclear and pentanuclear metal-tetrazole clusters as secondary building units.
PubMed:Manganese-based oral contrast agent for liver magnetic resonance imaging: evaluation of the time course and dose response of liver signal intensity enhancement.
PubMed:Synthesis, structural investigation and thermal properties of a novel manganese complex Mn2(DAT)2Cl4(H2O)4 (DAT=1,5-diaminotetrazole).
PubMed:Prospective comparative study of negative oral contrast agents for magnetic resonance cholangiopancreatography.
PubMed:Imaging liver metastases with a new oral manganese-based contrast agent.
PubMed:Effects of prenatal exposure to manganese on postnatal development and behavior in mice: influence of maternal restraint.
PubMed:Effects of long-term exposure to manganese chloride on fertility of male and female mice.
PubMed:Stability of Magnetically Levitated Liquid Bridges of Arbitrary Volume Subjected to Axial and Lateral Gravity.
PubMed:Effect of day of exposure on the developmental toxicity of manganese in mice.
PubMed:Relative efficacy of chelating agents on excretion and tissue distribution of manganese in mice.
PubMed:Maternal and developmental toxicity of manganese in the mouse.
PubMed:Synthesis and determination of manganese carbonate and manganese-54 carbonate.
 
Notes:
None found
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