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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 465.80 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 456.00 °F. TCC ( 235.50 °C. ) (est)
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| logP (o/w): | 1.760 (est) |
| Soluble in: |
| | water, 722.8 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-rabbit LD50 320 ug/kg
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 97, 1972.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for lysergol usage levels up to: | | | not for fragrance use.
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| Recommendation for lysergol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | [(6aS,9S)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]methanol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 99212 |
| Pubchem (sid): | 135057547 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 9,10- | didehydro-6-methyl-8-hydroxymethylergoline | | 9,10- | didehydro-6-methylergoline-8beta-methanol | | | ergoline-8-methanol, 9,10-didehydro-6-methyl-, (8-beta)- (9CI) | | | ergoline-8-methanol, 9,10-didehydro-6-methyl-, (8beta)- (9CI) | | | ergoline-8beta-methanol, 9,10-didehydro-6-methyl- (8CI) | | | ergoline, 9,10-didehydro-8-hydroxymethyl-6-methyl- | | | lysergole | | [(6aS,9S)-7- | methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]methanol |
Articles:
| PubMed:Identification of legal highs--ergot alkaloid patterns in two Argyreia nervosa products. |
| PubMed:Bovine lateral saphenous veins exposed to ergopeptine alkaloids do not relax. |
| PubMed:Application of quantitative structure-activity relationship models of 5-HT1A receptor binding to virtual screening identifies novel and potent 5-HT1A ligands. |
| PubMed:Antibacterial and synergy of clavine alkaloid lysergol and its derivatives against nalidixic acid-resistant Escherichia coli. |
| PubMed:High-throughput screening with a miniaturized radioligand competition assay identifies new modulators of human α2-adrenoceptors. |
| PubMed:Lysergol monohydrate. |
| PubMed:Simultaneous quantification of berberine and lysergol by HPLC-UV: evidence that lysergol enhances the oral bioavailability of berberine in rats. |
| PubMed:Quantitative determination of bioactive alkaloids lysergol and chanoclavine in Ipomoea muricata by reversed-phase high-performance liquid chromatography. |
| PubMed:Changes in concentrations of lysergol in urine and prolactin in plasma, rectal temperature and respiration rate in sheep selected for resistance or susceptibility to ryegrass staggers and fed ergovaline. |
| PubMed:Enantioselective total synthesis of (+)-lysergic acid, (+)-lysergol, and (+)-isolysergol by palladium-catalyzed domino cyclization of allenes bearing amino and bromoindolyl groups. |
| PubMed:Enantioselective synthesis of (+)-isolysergol via ring-closing metathesis. |
| PubMed:Large-scale separation of clavine alkaloids from Ipomoea muricata by pH-zone-refining centrifugal partition chromatography. |
| PubMed:Total synthesis of (+/-)-lysergic acid, lysergol, and isolysergol by palladium-catalyzed domino cyclization of amino allenes bearing a bromoindolyl group. |
| PubMed:Ergot alkaloids in Norwegian wild grasses: a mass spectrometric approach. |
| PubMed:Detection of lysergic acid in ruminal fluid, urine, and in endophyte-infected tall fescue using high-performance liquid chromatography. |
| PubMed:Electrospray[+] tandem quadrupole mass spectrometry in the elucidation of ergot alkaloids chromatographed by HPLC: screening of grass or forage samples for novel toxic compounds. |
| PubMed:Fragmentation patterns of selected ergot alkaloids by electrospray ionization tandem quadrupole mass spectrometry. |
| PubMed:Ergot alkaloid transport across ruminant gastric tissues. |
| PubMed:[Potential role of serotonin-sensitive structures in amplification of duodenal motor activity due to irritation of sympathetic trunk]. |
| PubMed:Simple O-acylated derivatives of lysergol and dihydrolysergol-I: synthesis and interaction with 5-HT2A, 5-HT2C and 5-HT1B receptors, and alpha1 adrenergic receptors. |
| PubMed:Cycloalkanecarboxylic esters derived from lysergol, dihydrolysergol-I, and elymoclavine as partial agonists and antagonists at rat 5-HT2A receptors: pharmacological evidence that the indolo[4,3-fg]quinoline system of the ergolines is responsible for high 5-HT2A receptor affinity. |
| PubMed:Vaccination against ergot alkaloids and the effect of endophyte-infected fescue seed-based diets on rabbits. |
| PubMed:Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors. |
| PubMed:Naturally occurring clavines: antagonism/partial agonism at 5-HT2A receptors and antagonism at alpha 1-adrenoceptors in blood vessels. |
| PubMed:Ergot alkaloid glycosides with immunomodulatory activities. |
| PubMed:Antibody binding of circulating ergot alkaloids in cattle grazing tall fescue. |
| PubMed:Cell-specific coupling of the cloned human 5-HT1F receptor to multiple signal transduction pathways. |
| PubMed:5-Hydroxytryptamine (5-HT) contracts the guinea-pig isolated iliac artery via 5-HT1-like and 5-HT2 receptors. |
| PubMed:O-acylated lysergol and dihydrolysergol-I derivatives as competitive antagonists of 5-HT at 5-HT2 receptors of rat tail artery. Allosteric modulation instead of pseudoirreversible inhibition. |
| PubMed:Confirmation of LSD intoxication by analysis of serum and urine. |
| PubMed:Effect of ergot alkaloids from fungal endophyte-infected grasses on fall armyworm (Spodoptera frugiperda). |
| PubMed:Substituted ergolines: potential antipsychotics with unique profile. I. Psychopharmacological characterization. |
| PubMed:Substituted ergolines: potential antipsychotics with unique profile. II. Neurochemical characterization. |
| PubMed:Regulation of the immune response by ergot alkaloids. |
| PubMed:Synthesis of 10alpha-methoxy-delta8,9-lysergaldehyde from elymoclavine. |
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3D/inchi