lithium carbonate
carbonic acid, lithium salt (1:2)
 
Notes:
a lithium salt, classified as a mood-stabilizing agent. lithium ion alters the metabolism of biogenic monoamines in the central nervous system, and affects multiple neurotransmission systems.
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dilithium;carbonate (Click)
CAS Number: 554-13-2Picture of molecule
Other: 12767-19-0
ECHA EINECS - REACH Pre-Reg: 209-062-5
FDA UNII: 2BMD2GNA4V
Nikkaji Web: J425A
Beilstein Number: 3999191
MDL: MFCD00011084
Molecular Weight: 73.89060000
Formula: C Li2 O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Appearance: white powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 2.11000 @  25.00 °C.
Melting Point: 723.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 333.60 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000026 mm/Hg @ 25.00 °C. (est)
Flash Point: 338.00 °F. TCC ( 169.80 °C. ) (est)
logP (o/w): -0.809 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: buffering agents
hair straightening agents
hair waving agents
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Suppliers:
Aceto
Lithium Carbonate
American Elements
Lithium Carbonate 99%
Odor: characteristic
Use: Lithium Carbonate is a water insoluble Lithium source that can easily be converted to other Lithium compounds, such as the oxide by heating (calcination). Carbonate compounds also give off carbon dioxide when treated with dilute acids. Lithium Carbonate is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
Santa Cruz Biotechnology
For experimental / research use only.
Lithium Carbonate ≥99%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Lithium carbonate 99.997% trace metals basis
Strem Chemicals
For experimental / research use only.
Lithium carbonate (99.99%-Li) PURATREM
Universal Preserv-A-Chem Inc.
LITHIUM CARBONATE POWDER USP
Odor: characteristic
Use: Lithium carbonate is used to treat mania, the elevated phase of bipolar disorder. Lithium ions interfere with ion transport processes that relay and amplify messages carried to the cells of the brain.
Universal Preserv-A-Chem Inc.
LITHIUM CARBONATE TECH GRADE
Universal Preserv-A-Chem Inc.
LITHIUM CARBONATE TECH GRADE
Odor: characteristic
Use: It is an additive in quick-setting cements, welding rods, and aluminum electrolysis melts. As a raw material, it is used in the production of glass, ceramics, enamel, and cathodes in lithium ion batteries. It can also be used as a catalyst for esterification.
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-dog LD50  500 mg/kg
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 436, 1972.

oral-human TDLo  4111 mg/kg
GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: TREMOR BEHAVIORAL: MUSCLE WEAKNESS
New England Journal of Medicine. Vol. 287, Pg. 867, 1972.

oral-man TDLo  8 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
American Journal of Psychiatry. Vol. 141, Pg. 909, 1984.

oral-man TDLo  54 mg/kg
BEHAVIORAL: SLEEP BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
New Zealand Medical Journal. Vol. 97, Pg. 23, 1984.

oral-man TDLo  1080 mg/kg/13W
SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"
Journal of Clinical Psychiatry. Vol. 47, Pg. 330, 1986.

oral-man TDLo  25000 mg/kg/4Y-I
BEHAVIORAL: TREMOR SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE
Journal of Clinical Psychiatry. Vol. 46, Pg. 292, 1985.

intraperitoneal-mouse LD50  236 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: EXCITEMENT
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973.

intravenous-mouse LD50  497 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973.

oral-mouse LD50  531 mg/kg
Russian Pharmacology and Toxicology Vol. 33, Pg. 266, 1970.

intraperitoneal-rat LD50  156 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973.

intravenous-rat LD50  241 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973.

oral-rat LD50  525 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973.

Dermal Toxicity:
subcutaneous-mouse LD50 413 mg/kg
Russian Pharmacology and Toxicology Vol. 33, Pg. 266, 1970.

subcutaneous-rat LD50 434 mg/kg
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for lithium carbonate usage levels up to:
 not for fragrance use.
 
Recommendation for lithium carbonate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NIOSH International Chemical Safety Cards: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 554-13-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 11125
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 dilithium;carbonate
Chemidplus: 0000554132
EPA/NOAA CAMEO: hazardous materials
RTECS: 554-13-2
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References:
 dilithium;carbonate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 554-13-2
Pubchem (cid): 11125
Pubchem (sid): 134976148
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C07964
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2836.91.0050
Haz-Map: View
MedlinePlusSupp: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
grade: technical, cp
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 camcolit
 carbonic acid dilithium salt
 carbonic acid lithium salt
 carbonic acid lithium salt (Li2CO3)
 carbonic acid, dilithium salt
 carbonic acid, lithium salt (1:2)
 ceglution
 dilithium carbonate
 dilithium trioxidocarbonate
 dilithium;carbonate
 dilithium(1+) ion carbonate
 eskalith
 hypnorex
 lithicarb
 lithionate
 lithium carbonate (Li2CO3)
 lithium phasal
 lithiumcarbonate
 lithizine
 lithobid
 lithocarb
 lithonate
 lithotabs
 maniprex
 plenur
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Articles:
PubMed: Improving lithium therapeutics by crystal engineering of novel ionic cocrystals.
PubMed: Synergistic interaction between caloric restriction and amphetamine in food-unrelated approach behavior of rats.
PubMed: [Ramadan and bipolar disorder: Example of circadian rhythm disturbance and its impact on patients with bipolar disorders].
PubMed: Enrichment of mushrooms: an interesting strategy for the acquisition of lithium.
PubMed: Lipid peroxidation, antioxidant activities and stress protein (HSP72/73, GRP94) expression in kidney and liver of rats under lithium treatment.
PubMed: Neuroprotective and neurotrophic effects of long term lithium treatment in mouse brain.
PubMed: Gelatinous marrow transformation and hematopoietic atrophy in a miniature horse stallion.
PubMed: Commercial and non-commercial 'championing' of medications.
PubMed: Chronic lithium administration triggers an over-expression of GRP94 stress protein isoforms in mouse liver.
PubMed: Update on neuropsychiatric symptoms of dementia: evaluation and management.
PubMed: Aripiprazole therapy in 20 older adults with bipolar disorder: a 12-week, open-label trial.
PubMed: Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus.
PubMed: Clinical decision making in the treatment of mania.
PubMed: Monotherapy versus combined treatment with second-generation antipsychotics in bipolar disorder.
PubMed: An analysis of the efficacy of treatments for bipolar depression.
PubMed: Changes in growth rate and thyroid- and sex-hormones blood levels in rats under sub-chronic lithium treatment.
PubMed: [Side effects of low serum lithium concentrations on renal, thyroid, and sexual functions in male and female rats].
PubMed: Lithium intoxication, hypercalcemia and "accidentally" induced food and water aversion: a case report.
PubMed: Lithium interaction with the cyclooxygenase 2 inhibitors rofecoxib and celecoxib and other nonsteroidal anti-inflammatory drugs.
PubMed: Production of radioactive particles for use in environmental studies.
PubMed: Thermal dehydration-induced thirst in lithium-treated rats.
PubMed: A practical and convenient synthesis of hotrienol, an excellent fruity smelling compound.
PubMed: Effect of three different diets on the bioavailability of a sustained release lithium carbonate matrix tablet.
PubMed: Lithium's effects on rat liver glucose metabolism in vivo.
PubMed: Early North American research on lithium.
PubMed: Evaluation of the in vitro and in vivo performance of two sustained-release lithium carbonate matrix tablets. Effect of different diets on the bioavailability.
PubMed: Determination of discretionary salt intake in rural Guatemala and Benin to determine the iodine fortification of salt required to control iodine deficiency disorders: studies using lithium-labeled salt.
PubMed: Effect of lithium on hepatic lipid peroxidation and antioxidative enzymes under different dietary protein regimens.
PubMed: Lithium plus valproate as maintenance polypharmacy for patients with bipolar I disorder: a review.
PubMed: Lithium and neuroleptics in combination: is there enhancement of neurotoxicity leading to permanent sequelae?
PubMed: Effect of lithium carbonate on activity level and circadian period in different strains of rats.
PubMed: Combined action of lead and lithium on essential and nonessential elements in rat blood.
PubMed: Leukocytoclastic vasculitis caused by drug additives.
PubMed: Single daily dosage of lithium carbonate.
PubMed: Liberation of lithium from sustained release preparations. A comparison of seven registered brands.
PubMed: Daidzin and daidzein suppress free-choice ethanol intake by Syrian golden hamsters.
PubMed: Influence of high fat diet on steady state bioavailability of lithium carbonate in manic depressive patients - a preliminary report.
PubMed: Advances in therapy for hairy cell leukemia. A review.
PubMed: Lithium intoxication: a coordinated treatment approach.
PubMed: The pharmacologic treatment of conduct disorders and rage outbursts.
PubMed: Relative contributions of dietary sodium sources.
PubMed: The immune system is a key factor in the etiology of psychosocial disease.
PubMed: Lithium lengthens circadian period in a diurnal primate, Saimiri sciureus.
PubMed: Effect of lithium carbonate on mouse and rat embryos in vitro.
PubMed: The role of pharmacotherapy in anorexia nervosa and bulimia.
PubMed: Evaluation and management of premenstrual syndrome in clinical psychiatric practice.
PubMed: An assessment of the sources of dietary salt in a British population.
PubMed: The potential use of lithium as a marker for the assessment of the sources of dietary salt: cooking studies and physiological experiments in men.
PubMed: Manic-depressive illness in children: treatment with lithium carbonate.
PubMed: Comparing oral lithium carbonate and intraperitoneal lithium chloride chronic administrations on rats' activity levels.
PubMed: The effect of lithium carbonate administration on growth in the domestic fowl.
PubMed: Effects of acute oral administration of lithium compounds on multiple schedule performance in rats.
PubMed: A novel technique for assessing the sources of dietary sodium.
PubMed: Effects of lithium on [3H](-)quinuclidinyl benzilate [( 3H](-)QNB) binding to rat brain muscarinic cholinergic receptors.
PubMed: Haloperidol: a quarter century of experience.
PubMed: [Effect of lithium on fat, protein and water content in rats].
PubMed: Lithium carbonate and the drug lag.
PubMed: [Influence of lithium on the in vitro deiodination of L-thyroxine in the rat liver].
PubMed: Locomotor activity and plasma, red blood cell and cerebral cortex lithium concentration in inbred mice given lithium carbonate.
PubMed: Lithium orotate, carbonate and chloride: pharmacokinetics, polyuria in rats.
PubMed: Blood levels and management of lithium treatment.
PubMed: Lithium carbonate.
PubMed: Lithium carbonate: some recommendations.
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