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lasalocid sodium

Supplier Sponsors

CAS Number: 25999-20-6Picture of molecule3D/inchi
Other(deleted CASRN):33913-39-2
ECHA EINECS - REACH Pre-Reg:247-400-3
FDA UNII: W2S5C71Y3G
Beilstein Number:3875309
MDL:MFCD00078065
Molecular Weight:612.77977928
Formula:C34 H53 Na O8
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 0.3115 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Lasalocid sodium >95% by HPLC
Odor: characteristic
Use: A polyether ionophore with potent antibacterial activity; an animal health product for treatment of coccidia
Santa Cruz Biotechnology
For experimental / research use only.
Lasalocid Sodium ≥95%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Lasalocid A sodium salt 97%
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for lasalocid sodium usage levels up to:
 not for fragrance use.
 
Recommendation for lasalocid sodium flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Safety and efficacy of Avatec® 150G (lasalocid A sodium) for chickens for fattening and chickens reared for laying, and modification of the terms of authorisation for chickens for fattening, chickens reared for laying, turkeys for fattening, minor avian s
View page or View pdf

Safety and efficacy of Avatec® 150G (lasalocid A sodium) as a feed additive for chickens for fattening and chickens reared for laying
View page or View pdf

Safety and efficacy of a feed additive consisting of lasalocid A sodium and nicarbazin (Nilablend™ 200G) for chickens for fattening (Zoetis Belgium SA)
View page or View pdf

EPI System: View
Daily Med:search
AIDS Citations:Search
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EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6426773
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0025999206
RTECS:GP4180000 for cas# 25999-20-6
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6426773
Pubchem (cas):25999-20-6
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.90.4100
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 avatec 150G
 bovate 20
 bovatec 150FP
 lasalocid A monosodium salt
 lasalocid sodium salt
 sodium lasalocid A
 

Articles:

PubMed:Performance of beef heifers supplemented with sodium lasalocid.
PubMed:Modification of plant cell wall structure accompanied by enhancement of saccharification efficiency using a chemical, lasalocid sodium.
PubMed:Efficacy of treatments with toltrazuril 7.5% and lasalocid sodium in sheep naturally infected with Eimeria spp.
PubMed:Evaluation of certain veterinary drug residues in food. Eighty-first report of the Joint FAO/WHO Expert Committee on Food Additives.
PubMed:Validation of a liquid chromatography-electrospray ionization tandem mass spectrometric method to determine six polyether ionophores in raw, UHT, pasteurized and powdered milk.
PubMed:Evaluation of certain veterinary drug residues in food. Seventy-eighth report of the Joint FAO/WHO Expert Committee on Food Additives.
PubMed:Influence of Ionophore Supplementation on Growth Performance, Dietary Energetics and Carcass Characteristics in Finishing Cattle during Period of Heat Stress.
PubMed:Determination of 20 coccidiostats in milk, duck muscle and non-avian muscle tissue using UHPLC-MS/MS.
PubMed:Trace level determination of polyether ionophores in feed.
PubMed:Synthesis, FT-IR, ¹H, ¹³CNMR, ESI MS and PM5 studies of a new Mannich base of polyether antibiotic - Lasalocid acid and its complexes with Liâº, Na⺠and K⺠cations.
PubMed:Determination of eleven coccidiostats in animal feed by liquid chromatography-tandem mass spectrometry at cross contamination levels.
PubMed:Risk assessment of coccidostatics during feed cross-contamination: animal and human health aspects.
PubMed:Determination of ionophore coccidiostats in feeding stuffs by liquid chromatography-tandem mass spectrometry. Part II. Application to cross-contamination levels and non-targeted feed.
PubMed:Direct aqueous supercritical fluid extraction coupled on-line with liquid chromatography-tandem mass spectrometry for the analysis of polyether ionophore antibiotics in water.
PubMed:Multi-residue method for detecting coccidiostats at carry-over level in feed by HPLC-MS/MS.
PubMed:Effects of organophosphate phenyl saligenin phosphate and polyether carboxylic ionophore lasalocid on motor nerve conduction velocity, neuropathy target esterase enzyme activity, and clinical ataxia in chickens.
PubMed:Validation of a multi-residue liquid chromatography-tandem mass spectrometry confirmatory method for 10 anticoccidials in eggs according to Commission Decision 2002/657/EC.
PubMed:Effects of ionophores and antibiotics on in vitro hydrogen sulfide production, dry matter disappearance, and total gas production in cultures with a steam-flaked corn-based substrate with or without added sulfur.
PubMed:Determination of lasalocid sodium in animal feeds and premixes by reversed-phase liquid chromatography: collaborative study.
PubMed:Fragmentation studies on lasalocid acid by accurate mass electrospray mass spectrometry.
PubMed:Multinuclear NMR and FTIR studies of new polyoxaalkyl esters of lasalocid and their complexes with lithium and sodium cations.
PubMed:LC/MS confirmation of ionophores in animal feeds.
PubMed:A differential scanning calorimetry study of the interaction of lasalocid antibiotic with phospholipid bilayers.
PubMed:Evaluation of sodium bicarbonate, chloride, or sulfate with a coccidiostat in corn-soy or corn-soy-meat diets for broiler chickens.
PubMed:An analysis of the chronic oral toxicity of polyether ionophore antibiotics in animals.
PubMed:Effects of neurotransmitters, gut hormones, and inflammatory mediators on mucus discharge in rat colon.
PubMed:Eating barley too frequently or in excess decreases lambs' preference for barley but sodium bicarbonate and lasalocid attenuate the response.
PubMed:Observations on the mechanism of eggshell formation in the liver fluke, Fasciola hepatica.
PubMed:Sheep fed grain prefer foods and solutions that attenuate acidosis.
PubMed:7Li and 23Na NMR studies of transmembrane cation transport mediated by ionophore lasalocid A.
PubMed:Electrospray ionization and collision-induced dissociation of antibiotic polyether ionophores.
PubMed:Final-week performance of straight-run broilers as affected by early coccidiostat withdrawal followed by increased dietary salt.
PubMed:Unusual behavior of ion transport mediated by polyene antibiotics. Activation energies for the exchange of Na+ ions through liposomal membranes studied by 23Na-NMR spectroscopy.
PubMed:Lipolysis and biohydrogenation of soybean oil in the rumen in vitro: inhibition by antimicrobials.
PubMed:Functional evidence for an extracellular calcium receptor mechanism triggering tyrosine kinase activation associated with mouse keratinocyte differentiation.
PubMed:Lasalocid and biomimetic membranes: insertion in Langmuir films of lipids.
PubMed:Effects of lasalocid and monensin plus tylosin on serum metabolic hormones and clinical chemistry profiles of beef steers fed a 90% concentrate diet.
PubMed:Influence of some biological response modifiers on swelling of rat liver mitochondria in vitro.
PubMed:Effects of the accidental feeding of lasalocid sodium to broiler breeder chickens.
PubMed:Scanning X-ray microanalysis of microcarrier cultured endothelial cells: elemental changes during the transition to confluency and the effect of ionophore A23187.
PubMed:Effects of antibacterial agents on in vitro ovine ruminal biotransformation of the hepatotoxic pyrrolizidine alkaloid jacobine.
PubMed:Effects of lasalocid on coccidial infection and growth in young dairy calves.
PubMed:Effect of pH and Monensin on Glucose Transport by Fibrobacter succinogenes, a Cellulolytic Ruminal Bacterium.
PubMed:Action of exogenous potassium and calcium ions on in vitro metacyclogenesis in Trypanosoma cruzi.
PubMed:[Tyrosine protein kinase from cattle cerebral cortex: purification, characteristics, protein substrates for phosphorylation and inhibitors of activity].
PubMed:Polyether ionophores--effect on rumen function in feedlot cattle.
PubMed:Alterations in mitochondrial Ca2+ flux by the antibiotic X-537A (lasalocid-A).
PubMed:Xylose uptake by the ruminal bacterium Selenomonas ruminantium.
PubMed:Ionophores and nutrient digestion and absorption in ruminants.
PubMed:Evaluation of anti-coccidial drugs' inhibition of Neospora caninum development in cell cultures.
PubMed:Effect of lasalocid sodium and molasses on performance of fattening lambs and on rumen liquor and blood parameters.
PubMed:Liquid chromatographic determination of lasalocid sodium in chicken skin: interlaboratory study.
PubMed:Liquid chromatographic determination and gas chromatographic-mass spectrometric confirmation of lasalocid sodium in bovine liver: interlaboratory study.
PubMed:Determination of maduramicin by liquid chromatography with atomic absorption spectrometric detection.
PubMed:Long-term supplementation of lasalocid-sodium for beef bulls during grazing and subsequent finishing period.
PubMed:Effect of anabolic steroids, alone or in combination with antibiotics, on bull performance, carcass traits and meat quality characteristics.
PubMed:Influence of dietary electrolyte balance, source of added potassium and anticoccidial agents on the performance of male broilers.
PubMed:Electromechanical uncoupling in a molluscan muscle examined by the sucrose gap technique. The effect of calcium antagonist and agonist agents.
PubMed:In vitro testing of the anti-mycoplasma effect of some anti-coccidial drugs.
PubMed:Lasalocid and dietary sodium and potassium effects on mineral metabolism, ruminal volatile fatty acids and performance of finishing steers.
PubMed:Ion transport by lasalocid A across red-blood-cell membranes. A multinuclear NMR study.
PubMed:The effect of the accidental feeding of lasalocid sodium to breeder birds.
PubMed:Selective inhibition by dantrolene of caffeine-induced catecholamine release from perfused dog adrenals.
PubMed:Influence of lasalocid and monensin plus tylosin on comparative feeding value of steam-flaked versus dry-rolled corn in diets for feedlot cattle.
PubMed:Improvement of chemical analysis of antibiotics. XI. Simultaneous fluorodensitometric determination of polyether antibiotics.
PubMed:Cytosolic calcium and the action of vasopressin in toad urinary bladder.
PubMed:[In vitro study of various ionophore antibiotics and some of their derivatives. II. Characterization of the ionophore properties of the compounds in a model system for Na+ and K+ ions].
PubMed:The effect of high dietary cation concentration on methanogenesis by steers fed diets with and without ionophores.
PubMed:The histologic and functional characterization of enzymatically dispersed intestinal mast cells of nonhuman primates: effects of secretagogues and anti-allergic drugs on histamine secretion.
PubMed:Effects of dietary alfalfa:orchardgrass hay and lasalocid on nutrient utilization by gravid sows.
PubMed:Opposing interactions of ionophores (valinomycin and monensin) on calcium ion uptake in rat retinal preparations.
PubMed:Isolation and characterization of a novel thermophilic, freshwater methanogen.
PubMed:Sequence of ionophore conformational changes induced by a simulated membrane/water interface.
PubMed:Acquired immunity to Eimeria tenella in lasalocid-treated chickens.
PubMed:Influence of monensin and lasalocid on mineral metabolism and ruminal urease activity in steers.
PubMed:Performance, ruminal and serum characteristics of steers fed lasalocid on pasture.
PubMed:Efficacy of lasalocid sodium against mycoplasmas (preliminary communication).
PubMed:Calcium entry causes a prolonged refractory period in peptidergic neurons of Aplysia.
PubMed:Mechanism of histamine release from isolated mast cell granules by calcium with phosphatidyl serine.
PubMed:X-537A ionophore-mediated calcium transport and calcium phosphate formation in Pressman cells.
PubMed:A pyrolysis gas chromatographic-mass spectrometric confirmatory method for lasalocid sodium in bovine liver.
PubMed:Tissue residue regulatory method for the determination of lasalocid sodium in cattle liver using high-performance liquid chromatography with fluorometric detection.
PubMed:Effect of lasalocid sodium on rumen fermentation and digestion in sheep.
PubMed:Influence of membrane viscosity on the lateral and transverse mobility of carboxylic ionophores.
PubMed:Lateral and transverse mobility of ionophores A23187 and X537A in liposomes.
PubMed:Efficacy of lasalocid sodium against coccidiosis (Eimeria zuernii and Eimeria bovis) in calves.
PubMed:Correlation of the biosynthesis of prostaglandin and cyclic AMP in monolayer cultures of rabbit articular chondrocytes.
PubMed:Taurine-calcium interactions in frog rod outer segments: taurine effects on an ATP-dependent calcium translocation process.
PubMed:Calcium and histamine secretion from mast cells.
PubMed:Comparison of two forms and two levels of lasalocid with monensin on feedlot cattle performance.
PubMed:Correlation between catecholamine release and sodium pump inhibition in the perfused adrenal gland of the cat.
PubMed:Evaluation of lasalocid in salt against ovine Coccidia.
PubMed:Role of cytosolic calcium and sodium-calcium exchange in regulation of transepithelial sodium and water absorption.
PubMed:Organic calcium-antagonists and calcium-ionophores.
PubMed:Light-induced calcium fluxes from outer segment layer of vertebrate retinas.
PubMed:Mechanisms of ionophore-induced catecholamine secretion.
PubMed:Stimulus-secretion coupling in rat pancreas: role of sodium, calcium and cyclic nucleotides studied by X-537A and BrX-537A.
PubMed:The possible significance of intracellular pH in insulin release.
PubMed:Surface properties of membrane systems: interaction of electrolyte and lipid with Ca2+ ionophores.
PubMed:The influence of hypertonicity on histamine release from isolated rat mast cells.
PubMed:Ionophore-mediated cation translocation in artificial systems. II. - X537A-mediated calcium and sodium translocation.
PubMed:Synergistic effects of hypoglycaemic sulphonylureas and antibiotic ionophores upon calcium translocation.
PubMed:Effect of monensin and lasalocid-sodium on the growth of methanogenic and rumen saccharolytic bacteria.
PubMed:Effects of divalent cation ionophores on the neuron membrane of the crayfish.
PubMed:23Na-NMR study of the competition of biogenic amines with sodium ion for binding to lasalocid (X-537 A).
PubMed:[Mechanisms of histamine secretion in anaphylactic and anaphylactoid reactions].
PubMed:Ionophoretic model for Na-Ca counter transport.
PubMed:Liquid chromatography with fluorescence detection of lasalocid sodium in feeds and premixes.
PubMed:Some effects of the ionophore X-537A on the isolated rat tail artery.
PubMed:Electrogenic hyperpolarization in canine cardiac Purkinje fibres exposed to calcium ionophores.
PubMed:Polymerization of actin. V. A new organelle, the actomere, that initates the assembly of actin filaments in Thyone sperm.
PubMed:The complete assignment of the 13C NMR spectra of lasalocid and the sodium salt-complex of the antibiotic.
PubMed:Effects of carboxylic ionophore monensin on atrial contractility and Ca2+ regulation by isolated cardiac microsomes.
PubMed:The mechanism of histamine release induced by the ionophore X537A from isolated rat mast cells. I. Significance of monovalent cations, calcium, metabolic energy and temperature.
PubMed:The effect of the ionophores X-537A and A23187 on the noradrenaline output from peripheral adrenergic neurones in the presence of various divalent cations.
PubMed:Mechanism of histamine release induced by the ionophore X537A from isolated rat mast cells.
PubMed:Golgi apparatus and lectin-binding sites. Effects of Lasalocid (X537A).
PubMed:The role of calcium in transferrin and iron uptake by reticulocytes.
PubMed:Monomeric forms of the acid ionophore lasalocid A (X-537A) from polar solvents.
PubMed:The translocation of Ca2+ across phospholipid bilayers induced by a synthetic neutral Ca2+ -ionophore.
PubMed:Effects of the antibiotic ionophore X-537A on contractility and ionic exchange in rabbit ventricular myocardium.
PubMed:[Alternatives to digitalis therapy? Pharmacological basis].
PubMed:Anticoccidial activity of eight compounds in domestic mink.
PubMed:Free acid, anion, alkali, and alkaline earth complexes of lasalocid a (X537A) in methanol: structural and kinetic studies at the monomer level.
PubMed:Effects of an ionophore, X-537A, on mouse CNS cultures: a light and electron microscope study.
PubMed:Collaborative study of a modified extraction procedure for lasalocid sodium in feeds by microbiological assay.
PubMed:Effect of ionophores on intralysosomal pH.
PubMed:Dantrolene and the neuromuscular junction: evidence for intracellular calcium stores.
PubMed:Calcium and stimulus secretion coupling in the neurohypophysis. V. The effects of the Ca2+ ionophores A23187 and X537 A on vasopressin release and 45Ca2+ efflux; interactions with sodium and a verapamil analogue (D600).
PubMed:[Action of the "Ca-ionophore" X-537A on the electrolyte content and metabolism of Yoshida ascites tumour cells: a model for the analysis of Mg deficiency (author's transl)].
PubMed:Hydroxyl deformation frequencies as a probe of hydrogen bonding in lasalocid A (X-537A) and its sodium complex.
PubMed:Structural and kinetic studies of lasalocid A (X537A) and its silver, sodium, and barium salts in nonpolar solvents.
PubMed:Metabolic aspects of the secretion of stored compounds from blood platelets. IV. Effects of ionophore X537A on washed platelets.
PubMed:Collaborative study of a microbiological assay for lasalocid sodium in feeds.
PubMed:Lasalocid: resistance and cross-resistance studies in Eimeria tenella-infected chicks.
PubMed:Collaborative study of a spectrofluorometric method for lasalocid sodium in feeds.
PubMed:Slow Ca2+ and Na+ responses induced by isoproterenol and methylxanthines in isolated perfused guinea pig hearts exposed to elevated K+.
PubMed:The effect of substances releasing intracellular calcium ions on sodium-dependent calcium efflux from guinea-pig auricles.
PubMed:Cylinder plate assay for lasalocid sodium.
PubMed:Drugs in feeds. Spectrofluorometric determination of lasalocid sodium in finished feeds and premixes.
 
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