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Category:information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | information only not used for fragrances or flavors |
| Recommendation for laevo-erythritol usage levels up to: | | | not for fragrance use.
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| Recommendation for laevo-erythritol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Sugar-free hard confectionery with at least 90% erythritol and reduction of dental plaque which reduces the risk of dental caries: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006
View page or View pdf
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| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :445969 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| (2S,3S)-butane-1,2,3,4-tetrol |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (2S,3S)- | butane-1,2,3,4-tetrol | | laevo- | butane-1,2,3,4-tetrol | | L-1,2,3,4- | butanetetraol | | (2S,3S)-1,2,3,4- | butanetetrol | | (S-(R*,R*))-1,2,3,4- | butanetetrol | | laevo-1,2,3,4- | butanetetrol | | 1,2,3,4- | butanetetrol, (2S,3S)- | | L- | erythritol | | L- | threitol | | laevo- | threitol |
Articles:
| PubMed:Recent developments and future prospects on bio-based polyesters derived from renewable resources: A review. |
| PubMed:Development and Validation of a High Pressure Liquid Chromatography-UV Method for the Determination of Treosulfan and Its Epoxy Metabolites in Human Plasma and Its Application in Pharmacokinetic Studies. |
| PubMed:Controlled co-delivery nanocarriers based on mixed micelles formed from cyclodextrin-conjugated and cross-linked copolymers. |
| PubMed:Searching for combinations of small-molecule correctors to restore f508del-cystic fibrosis transmembrane conductance regulator function and processing. |
| PubMed:Alditols and monosaccharides from sorghum vinegar can attenuate platelet aggregation by inhibiting cyclooxygenase-1 and thromboxane-A2 synthase. |
| PubMed:The 1,3-dipolar cycloaddition reaction of chiral carbohydrate-derived nitrone and olefin: towards long-chain sugars. |
| PubMed:2-methyl-L-erythritol glycosides from Gardenia jasminoides. |
| PubMed:Treosulfan-based conditioning before hematopoietic SCT: more than a BU look-alike. |
| PubMed:Alternating oligo[(2,3-O-isopropylidene-L-threitol)]-co-[(E,E)-1,4-bis(styryl)benzene]s: the linear chirality transmission additivity relationship in nematic liquid crystals. |
| PubMed:Novel generation of pH indicators for proton magnetic resonance spectroscopic imaging. |
| PubMed:Treatment of active secondary progressive multiple sclerosis with treosulfan. |
| PubMed:Synthesis of a salacinol analogue and its alpha-glucosidase inhibitory activity. |
| PubMed:Generation of an antibody specific to erythritol, a non-immunogenic food additive. |
| PubMed:Enthalpy of sublimation in the study of the solid state of organic compounds. Application to erythritol and threitol. |
| PubMed:Attempted synthesis of 2-acetamido and 2-amino derivatives of salacinol. Ring opening reactions. |
| PubMed:Determination of the enthalpy of solute-solvent interaction from the enthalpy of solution: aqueous solutions of erythritol and L-threitol. |
| PubMed:Towards carbohydrate derivatives of the ReI(CO)3 fragment. |
| PubMed:Synthesis of D-lyxitol and D-ribitol analogues of the naturally occurring glycosidase inhibitor salacinol. |
| PubMed:Conformational study of erythritol and threitol in the gas state by density functional theory calculations. |
| PubMed:Inhibition of the Escherichia coli RecA protein: zinc(II), copper(II) and mercury(II) trap RecA as inactive aggregates. |
| PubMed:Addition of treosulfan to a nonmyeloablative conditioning regimen results in enhanced chimerism and immunologic tolerance in an experimental allogeneic bone marrow transplant model. |
| PubMed:Action of treosulfan in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis and human lymphocytes. |
| PubMed:Aromatic compound glucosides, alkyl glucoside and glucide from the fruit of anise. |
| PubMed:Antileukaemic activity of treosulfan in xenografted human acute lymphoblastic leukaemias (ALL). |
| PubMed:Site-specific hydroxylation at polyguanosine in double-stranded DNA by nickel(II) in the presence of SH compounds: comparison with singlet oxygen-induced DNA damage. |
| PubMed:Saccharide Libraries as Potential Templates for Regio- and Chiroselective Introduction of Two Functional Groups into [60]Fullerene. |
| PubMed:Synthesis of 2-C-methyl-D-erythritol and 2-C-methyl-L-threitol; determination of the absolute configuration of 2-C-methyl-1,2,3,4-butanetetrol isolated. |
| PubMed:Purification and characterization of a NAD+-dependent sorbitol dehydrogenase from Japanese pear fruit. |
| PubMed:Investigation of bioavailability and pharmacokinetics of treosulfan capsules in patients with relapsed ovarian cancer. |
| PubMed:Asymmetric synthesis of axially chiral biaryls via desymmetrization of 2,2',6,6'-tetrahydroxybiphenyl using 1,4-Di-O-benzyl-L-threitol as a chiral template |
| PubMed:DNA alkylation and interstrand cross-linking by treosulfan. |
| PubMed:The alkylator treosulfan shows activity towards human renal-cell carcinoma in vivo and in vitro. |
| PubMed:Clinical pharmacokinetics of intravenous treosulfan in patients with advanced solid tumors. |
| PubMed:Stimulation of biosynthetic activity by novel succinate esters in rat pancreatic islets. |
| PubMed:Reversible inhibition of sheep liver sorbitol dehydrogenase by thiol compounds. |
| PubMed:Studies on L-threose as substrate for aldose reductase: a possible role in preventing protein glycation. |
| PubMed:Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin. |
| PubMed:Antitumor activity of treosulfan in human lung carcinomas. |
| PubMed:Evidence for a glycerol pathway through aquaporin 1 (CHIP28) channels. |
| PubMed:Ascorbic acid glycation: the reactions of L-threose in lens tissue. |
| PubMed:The crystal structure of D-threitol at 119 K and 198 K. |
| PubMed:Antitumor activity of treosulfan against human breast carcinomas. |
| PubMed:Inhibition of the alpha-L-arabinofuranosidase III of Monilinia fructigena by 1,4-dideoxy-1,4-imino-L-threitol and 1,4-dideoxy-1,4-imino-L-arabinitol. |
| PubMed:Purification and characterization of human liver sorbitol dehydrogenase. |
| PubMed:Contraction of guinea-pig lung parenchymal strips by substance P and related peptides. |
| PubMed:Biosynthesis of novel acidic phospholipid analogs in Escherichia coli. |
| PubMed:The effect of substance P and related peptides on the guinea-pig lung strip. |
| PubMed:New type bifunctional nitrosoureido derivatives with cytostatic activity. |
| PubMed:Detection and characterization of sorbitol dehydrogenase from apple callus tissue. |
| PubMed:Induction of chromosomal aberrations and mutations with isomeric forms of L-threitol-I,4-bismethanesulfonate in plant materials. |
| PubMed:Compounds derived from L-threitol 1,4-bismethanesulfonate. |
| PubMed:IDENTIFICATION OF ALTRO-HEPTULOSE AND L-THREITOL AS PRODUCTS OF MESO-ERYTHRITOL OXIDATION BY ACETOBACTER SUBOXYDANS. |
| PubMed:[ANALYSIS OF THE EFFECTS OF L-THREITOL-1,4-BISMETHANESULFONATE ON THE CHROMOSOMES OF VICIA FABA L]. |
| PubMed:L-Threitol dimethanesulfonate. |
| PubMed:Biochemistry of the wood-rotting fungi: 5. The production of d-threitol (l-erythritol) by Armillaria mellea (Vahl) Quélet. |
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3D/inchi