levodopa
L-tyrosine, 3-hydroxy-
 
Notes:
the naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. it is rapidly taken up by dopaminergic neurons and converted to dopamine. it is used for the treatment of parkinsonian disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system. Occurs in seedlings and pods of Vicia faba L-DOPA (L-3,4-dihydroxyphenylalanine; INN levodopa; trade names Sinemet, Parcopa, Atamet, Stalevo, Madopar, Prolopa, etc.) is a naturally-occurring dietary supplement and psychoactive drug found in certain kinds of food and herbs (e.g., Mucuna pruriens, or velvet bean), and is synthesized from the amino acid L-tyrosine in the mammalian body and brain. (Wikipedia)
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co.
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
      Email: Info
      Email: Sales
      Voice: 86-510-86023169
      Fax: 86-510-86023170
      Mobile0086-13093133011
      Services
      Biochemical
      Natural Food Colour
      New functional food ingredients
      Product(s):
      HLG0320 Levodopa
       
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(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid (Click)
CAS Number: 59-92-7Picture of molecule
ECHA EINECS - REACH Pre-Reg: 200-445-2
FDA UNII: 46627O600J
Nikkaji Web: J9.225H
Beilstein Number: 2215169
MDL: MFCD00002598
XlogP3: -2.70 (est)
Molecular Weight: 197.19047000
Formula: C9 H11 N O4
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Appearance: white powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 281.00 to  285.00 °C. @ 760.00 mm Hg
Boiling Point: 447.00 to  449.00 °C. @ 760.00 mm Hg
Flash Point: 437.00 °F. TCC ( 225.00 °C. )
logP (o/w): -1.154 (est)
Soluble in:
 water, 5000 mg/L @ 20 °C (exp)
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Organoleptic Properties:
Odor Type: odorless
Odor Strength: none
Odor Description:
at 100.00 %. 
odorless
 sweet  
Taste Description:
sweet
  
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Cosmetic Information:
None found
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Suppliers:
Ajinomoto USA
L-Dopa
Flavor: characteristic
L-dopa is not a core amino acid in terms of a building block for proteins. L-dopa is a synthetic protein for medical use.
Jiangyin Healthway
Levodopa
New functional food ingredients
Qingdao Dacon Trading
Levodopa
Sigma-Aldrich: Sigma
For experimental / research use only.
3,4-Dihydroxy-L-phenylalanine ≥98% (TLC)
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50  450 mg/kg
Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974.

oral-mouse LD50  2363 mg/kg
BEHAVIORAL: EXCITEMENT
Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974.

oral-rabbit LD50  609 mg/kg
Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974.

intraperitoneal-rat LD50  624 mg/kg
SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: EXCITEMENT SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974.

intravenous-rat LD50  > 100 mg/kg
Drugs in Japan Vol. 6, Pg. 905, 1982.

oral-bird - wild LD50  100 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.

oral-human TDLo  13000 mg/kg/1Y
BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Neurology, Neurosurgery and Psychiatry. Vol. 34, Pg. 668, 1971.

oral-human TDLo  156000 mg/kg/10Y
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TOXIC PSYCHOSIS BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Journal of Neurology, Neurosurgery and Psychiatry. Vol. 34, Pg. 502, 1971.

intraperitoneal-mouse LD50  588 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974.

unreported-mouse LDLo  3500 mg/kg
AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 153, Pg. 161, 1930.

oral-rat LD50  1780 mg/kg
BEHAVIORAL: AGGRESSION BEHAVIORAL: ATAXIA BEHAVIORAL: EXCITEMENT
Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974.

Dermal Toxicity:
subcutaneous-mouse LD50 4449 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 3, Pg. 186, 1972.

subcutaneous-rat LD50 2000 mg/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 3, Pg. 186, 1972.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: information only not used for fragrances or flavors
Recommendation for levodopa usage levels up to:
 not for fragrance use.
 
Recommendation for levodopa flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 59-92-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 6047
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
Chemidplus: 0000059927
RTECS: AY5600000 for cas# 59-92-7
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References:
 (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 6047
Pubchem (sid): 134972617
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
Metabolomics Database: Search
KEGG (GenomeNet): C00355
HMDB (The Human Metabolome Database): HMDB00181
FooDB: FDB000567
Export Tariff Code: 2922.50.4000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
•capsules usp: 100, 250, & 500 mg; tablets usp: 100, 250, & 500 mg. •levodopa is one of the main ingredients along with carbidopa in the drug sinemet (tablets) •levodopa is one of the main ingredients along with carbidopa in the drug atamet (tablets)
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 banana fruit
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 bean fava bean
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 bean fava bean flower
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 bean fava bean fruit
Search Trop  Picture
 bean fava bean leaf
Search Trop  Picture
 bean fava bean seed
Search Trop  Picture
 bean fava bean sprout
Search Trop  Picture
 bean fava bean stem
Search Trop  Picture
 lupinus spp.
Search Trop  Picture
 purslane plant
Search Trop  Picture
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Synonyms:
(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
(S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
3,4-dihydroxy-L-phenylalanine
3,4-dihydroxy-laevo-phenyl alanine
L-3,4-dihydroxyphenyl alanine
laevo-3,4-dihydroxyphenyl alanine
3,4-dihydroxyphenyl-laevo-alanine
L-3-(3,4-dihydroxyphenyl) alanine
laevo-3-(3,4-dihydroxyphenyl) alanine
L-beta-(3,4-dihydroxyphenyl)-alpha-alanine
laevo-beta-(3,4-dihydroxyphenyl)-alpha-alanine
3-(3,4-dihydroxyphenyl)-L-alanine
beta-(3,4-dihydroxyphenyl)-laevo-alanine
3,4-L-dihydroxyphenylalanine
L-3,4-dihydroxyphenylalanine
L-dopa
laevo-dopa
3-hydroxy-L-tyrosine
3-hydroxy-laevo-tyrosine
L-tyrosine, 3-hydroxy-
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