EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

laevo-carnosine
N-b-alanyl-L-histidine

Supplier Sponsors

CAS Number: 305-84-0Picture of molecule3D/inchi
Other(deleted CASRN):7683-28-5
ECHA EINECS - REACH Pre-Reg:206-169-9
FDA UNII: 8HO6PVN24W
Nikkaji Web:J5.496H
Beilstein Number:0087671
MDL:MFCD00005207
XlogP3-AA:-4.00 (est)
Molecular Weight:226.23618000
Formula:C9 H14 N4 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents, multi-functional anti-aging peptide
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 260.00 °C. @ 760.00 mm Hg
Boiling Point: 656.00 to 657.00 °C. @ 760.00 mm Hg (est)
Flash Point: 663.00 °F. TCC ( 350.70 °C. ) (est)
logP (o/w): -2.972 (est)
Soluble in:
 water
 water, 5.503e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
AIDP
L-Carnosine 99% - 101%
AuNutra® Industries
L-Carnosine
BOC Sciences
For experimental / research use only.
L-Carnosine 95%
Charkit Chemical
CARNOSINE,L-
Glentham Life Sciences
L-Carnosine
Indis NV
For experimental / research use only.
L-Carnosine
Jiangyin Healthway
L-Carnosine
New functional food ingredients
Kingyoung Bio Technical
Carnosine
M.C.Biotec
Carnosine
Meafo
For experimental / research use only.
L-Carnosine 99%
Penta International
L-CARNOSINE
Sigma-Aldrich: Sigma
For experimental / research use only.
L-Carnosine ∼99%, crystalline
Symrise
Dragosine®
Life Essentials - Actives
Odor: characteristic
Use: Dragosine® (L-Carnosine) is a nature identical dipeptide (β-Alanyl-L-histidin) present in millimolar concentrations in muscle tissues. It protects cells against oxidative stress. In cosmetic products it is used as an anti-aging ingredient which has powerful anti-oxidant properties that stimulate collagen synthesis. New data confirm that Dragosine® dose dependently and significantly inhibits IRA-induced MMP-1 expression (in vitro assay) and is able to reduce the number of sunburn cells after UV exposure (ex vivo results).
Vigon International
Dragosine
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 > 14930 mg/kg
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
United States Patent Document. Vol. #4446149

intraperitoneal-mouse LD50 9087 mg/kg
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
United States Patent Document. Vol. #4446149

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents, multi-functional anti-aging peptide
Recommendation for laevo-carnosine usage levels up to:
 not for fragrance use.
 
Recommendation for laevo-carnosine flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the substantiation of a health claim related to beta-alanine and increase in physical performance during short-duration, high-intensity exercise pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):305-84-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :439224
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(2S)-2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
Chemidplus:0000305840
RTECS:MS3080000 for cas# 305-84-0
 
References:
 (2S)-2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):439224
Pubchem (sid):134974114
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
KEGG (GenomeNet):C00386
HMDB (The Human Metabolome Database):HMDB00033
FooDB:FDB000511
YMDB (Yeast Metabolome Database):YMDB01555
Export Tariff Code:2933.29.5000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
beta-alanyl-L-histidine
N-b-alanyl-L-histidine
N-(b-alanyl)-L-histidine
(2S)-2-(3-aminopropanamido)-3-(1H-imidazol-5-yl)propanoic acid
(2S)-2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
(2S)-2-(3-aminopropanoylamino)-3-imidazol-4-ylpropanoic acid
L-carnosine
 dragosine (Symrise)
 ignotine
 

Articles:

PubMed:Enhancing Antioxidant Activity of Sesamol at Frying Temperature by Addition of Additives through Reducing Volatility(*)
PubMed:L-carnosine modulates respiratory burst and reactive oxygen species production in neutrophil biochemistry and function: may oral dosage form of non-hydrolized dipeptide L-carnosine complement anti-infective anti-influenza flu treatment, prevention and self-care as an alternative to the conventional vaccination?
PubMed:Influence of lipid composition on physicochemical properties of nanoliposomes encapsulating natural dipeptide antioxidant l-carnosine.
PubMed:Self-assembly of a peptide amphiphile containing L-carnosine and its mixtures with a multilamellar vesicle forming lipid.
PubMed:Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats.
PubMed:Tuning the self-assembly of the bioactive dipeptide L-carnosine by incorporation of a bulky aromatic substituent.
PubMed:Effect of anserine ingestion on hyperglycemia and the autonomic nerves in rats and humans.
PubMed:Effect of anserine ingestion on the hyperglycemia and autonomic nerves in rats and humans.
PubMed:Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer.
PubMed:L-carnosine inhibits metastasis of SK-Hep-1 cells by inhibition of matrix metaoproteinase-9 expression and induction of an antimetastatic gene, nm23-H1.
PubMed:Nalpha-(1-deoxy-D-fructos-1-yl)-L-histidine ("D-Fructose-L-histidine"): a potent copper chelator from tomato powder.
PubMed:The cosmetic treatment of wrinkles.
 
Notes:
a naturally occurring dipeptide neuropeptide found in muscles. Occurs in meats Carnosine (beta-alanyl-L-histidine) is a dipeptide of the amino acids beta-alanine and histidine. It is highly concentrated in muscle and brain tissues.; Carnosine (beta-alanyl-L-histidine) is found exclusively in animal tissues. It is a dipeptide of the amino acids beta-alanine and histidine. Carnosine has the potential to suppress many of the biochemical changes (e.g., protein oxidation, glycation, AGE formation, and cross-linking) that accompany aging and associated pathologies (PMID 16804013). It is highly concentrated in muscle and brain tissues. Some autistics patients take it as a dietary supplement, and attribute an improvement in their condition to it. Supplemental carnosine may increase corticosterone levels. This may explain the "hyperactivity" seen in autistic subjects at higher doses. Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, ROS and free radicals scavenging ability (PMID 16406688); Some studies have detected beneficial effects of N-acetyl-carnosine in preventing and treating cataracts of the eyes; in one of these, carnosine was found to reduce cloudiness in rat lenses that were exposed to guanidine to cause cataracts. However, claims that carnosine confers these and other posited ophthamological benefits are, as of yet, insufficiently supported for endorsement by the mainstream medical community; Britain's Royal College of Ophthamologists, for instance, has asserted that neither safety nor efficacy has been sufficiently demonstrated to recommend carnosine's use as a topical treatment for cataracts.
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