EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
BT
 

sodium ascorbate
monosodium L-ascorbate

Sponsors

Name: sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate
CAS Number: 134-03-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 205-126-1
FDA UNII: S033EH8359
Nikkaji Web: J5.221C
Beilstein Number: 3767246
MDL: MFCD00082340
Molecular Weight: 198.10675928
Formula: C6 H7 Na O6
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
182.3731 Sodium L-ascorbate View-review
EU SANCO Sodium ascorbate View-review
JECFA Food Additive: Sodium Ascorbate
GSFA Codex: Sodium ascorbate (301)
DG SANTE Food Additives: sodium ascorbate
FDA Mainterm: SODIUM ASCORBATE
FDA Regulation:
FDA PART 155 -- CANNED VEGETABLES
Subpart B--Requirements for Specific Standardized Canned Vegetables
Sec. 155.200 Certain other canned vegetables.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart D--Chemical Preservatives
Sec. 182.3731 Sodium ascorbate.
 
Physical Properties:
Appearance: white crystalline powder (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
logP (o/w): -7.050 (est)
Soluble in:
 water, 620000 mg/L @ 25 °C (exp)
 alcohol, very slightly
 
Organoleptic Properties:
Odor Description:
at 100.00 %.
odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
 
Suppliers:
Aceto
Sodium Ascorbate
AIDP
Sodium Ascorbate Vitamin C 99.0-101.0%
Atlantic Chemicals
Ascorbate Sodium
BOC Sciences
For experimental / research use only.
Sodium ascorbate
ECSA Chemicals
Sodium Ascorbate
Company Profile
Farbest-Tallman Foods
Sodium Ascorbate 99% DC
Flavor: bland
It is used in dietary supplement applications including hard shell capsules and tablets.
Farbest-Tallman Foods
Sodium Ascorbate USP/FCC
Flavor: bland
It is used in food, beverage and dietary supplement applications as a Vitamin C source. Some applications include chewable vitamins, processed meats, nutrient enhanced beverages and foods.
Foodchem International
Sodium Ascorbate
Graham Chemical
Sodium Ascorbate
Kraft Chemical
Sodium Ascorbate
Penta International
SODIUM ASCORBATE
Prinova
Sodium Ascorbate FCC,USP,E301
Qingdao Dacon Trading
Sodium Ascorbate
Sigma-Aldrich: Sigma
For experimental / research use only.
(+)-Sodium L-ascorbate crystalline, ≥98%
Silver Fern Chemical
Sodium Ascorbate
Odor: characteristic
Use: Sodium Ascorbate is approved as a food additive in the USA, EU, Australia, and New Zealand. It is used as an antioxidant and an acidity regulator. Occasionally, it is used for preservation of diagnostic medicinals.
Sinofi Food Ingredients
Sodium Ascorbate
Odor: characteristic
Use: Antioxidants, Preservative, Nutrient, Dietary Supplement, Color Fixing Agent, Flavoring Agent, Preservative, Bacon, Chewing Gum, Dairy Products, Baby Products, Confections, Baking Food, Yogurt, Soft Drink, Beverage Powder, Fruit Juice, Puddings, Ice Cream, Fruit Sauces, Sauage, Meats, Cosmetics, Feed, Pharmaceutical.
TCI AMERICA
For experimental / research use only.
Sodium L-Ascorbate >98.0%(T)
Zhong Ya Chemical
Sodium Ascorbate
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: preservatives
Recommendation for sodium ascorbate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium ascorbate flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the use of sodium ascorbate as a food additive in vitamin D preparations intended to be used in formulae and weaning food for infants and young children
View page or View pdf
Scientific Opinion on the safety and efficacy of vitamin C (ascorbic acid, sodium ascorbate, calcium ascorbate, ascorbyl palmitate, sodium calcium ascorbyl phosphate and sodium ascorbyl phosphate) as a feed additive for all animal species based on a dossier submitted by DSM Nutritional Products Ltd
View page or View pdf
Scientific Opinion on the re-evaluation of ascorbic acid (E 300), sodium ascorbate (E 301) and calcium ascorbate (E 302) as food additives
View page or View pdf
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA GENetic TOXicology: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 134-03-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 23667548
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate
Chemidplus: 0000134032
EPA/NOAA CAMEO: hazardous materials
RTECS: CI7671000 for cas# 134-03-2
 
References:
 sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 134-03-2
Pubchem (cid): 23667548
Pubchem (sid): 135017006
 
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
CHEMBL: View
HMDB (The Human Metabolome Database): Search
FooDB: FDB001226
Export Tariff Code: 2936.27.0000
Haz-Map: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
EFSA Update of results on the monitoring of furan levels in food: Read Report
EFSA Previous report: Results on the monitoring of furan levels in food: Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report
Formulations/Preparations:
•cenolate (hospira), injection: 562.5 mgml (equivalent to 500 mgml ascorbic acid), in 1 and 2 ml amps (with 0.5% sodium hydrosulfite) •ascorbic acid (as ascorbic acid or sodium ascorbate): bulk: powder. oral: capsules, extended-release 250 mg 500 mg. lozenges 60 mg, solution 25 mgdrop, 100 mgml, 500 mg5 ml. tablets: 100 mg, 250 mg, 500 mg, 1 g. tablets, chewable ; 100 mg, 250 mg, 500 mg, 1 g. tablets, extended-release: 500 mg, 1 g. 1.5 g. (available from one or more manufacturer, distributor, andor repackager by generic (nonproprietary) name.) •ascorbic acid and sodium ascorbate are also commercially available in combination with other vitamins, minerals, amino acids, analgesic-antipyretics, anticholinergics, antihistamines, anti-inflammatory agents, cerebral stimulants, cough suppressants, enzymes, expectorants, hormones, infant formulas, keratolytic agents, laxatives, protein supplements, sedatives, and sympathomimetics. for iv infusion, ascorbic acid or sodium ascorbate is also commercially available in combination with other vitamins in caloric and electrolyte solutions.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 antioxidants 
 
Occurrence (nature, food, other): note
 not found in nature
 
Synonyms:
L-ascorbate, sodium
L-ascorbic acid sodium salt
L(+)-ascorbic acid sodium salt
laevo-ascorbic acid sodium salt
laevo-ascorbic acid sodium salt (1:1)
L-ascorbic acid, monosodium salt
L-ascorbic acid, sodium salt (1:1)
 sodium (2R)-2-[(1S)-1,2-bis(oxidanyl)ethyl]-4-oxidanyl-5-oxidanylidene-2H-furan-3-olate
 sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate
 sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate
 sodium L-ascorbate
(+)-sodium L-ascorbate
monosodium L-ascorbate
monosodium laevo-ascorbate
 vitamin C sodium
 vitamin C sodium salt
 

Articles:

Info: EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
PubMed: Characterization of polyphenol oxidase activity in Ataulfo mango.
PubMed: Stability of microencapsulated L-5-methyltetrahydrofolate in fortified noodles.
PubMed: Quantification of DNA through a fluorescence biosensor based on click chemistry.
PubMed: Fluorescence sensor for Cu(II) in the serum sample based on click chemistry.
PubMed: Vitamin (B1, B2, B3 and B6) content and oxidative stability of Gastrocnemius muscle from dry-cured hams elaborated with different nitrifying salt contents and by two ageing times.
PubMed: Natural extracts versus sodium ascorbate to extend the shelf life of meat-based ready-to-eat meals.
PubMed: Wheat rolls fortified with microencapsulated L-5-methyltetrahydrofolic acid or equimolar folic acid increase blood folate concentrations to a similar extent in healthy men and women.
PubMed: Microencapsulation of L-5-methyltetrahydrofolic acid with ascorbate improves stability in baked bread products.
PubMed: Stability evaluation of freeze-dried Lactobacillus paracasei subsp. tolerance and Lactobacillus delbrueckii subsp. bulgaricus in oral capsules.
PubMed: Dog rose (Rosa canina L.) as a functional ingredient in porcine frankfurters without added sodium ascorbate and sodium nitrite.
PubMed: Effects of anticaking agents and relative humidity on the physical and chemical stability of powdered vitamin C.
PubMed: Thermal oxidation studies on reduced folate, L-5-methyltetrahydrofolic acid (L-5-MTHF) and strategies for stabilization using food matrices.
PubMed: Effect of sodium ascorbate dose on the shelf life stability of reduced nitrite liver p├ót├ęs.
PubMed: Use of fluorogenic probes to differentiate between hydrophilic and lipophilic antioxidant activity in a fish cell line.
PubMed: Tocopherol and ascorbate have contrasting effects on the viability of microencapsulated Lactobacillus rhamnosus GG.
PubMed: Determination of carbendazim, thiophanate, thiophanate-methyl and benomyl residues in agricultural products by liquid chromatography-tandem mass spectrometry.
PubMed: Edible mushroom (Flammulina velutipes) extract inhibits melanosis in Kuruma shrimp (Marsupenaeus japonicus).
PubMed: Iron regulates the uptake of ascorbic acid and the expression of sodium-dependent vitamin C transporter 1 (SVCT1) in human intestinal Caco-2 cells.
PubMed: Value-added use of mushroom ergothioneine as a colour stabilizer in processed fish meats.
PubMed: The effect of lutein, sesamol, ellagic acid and olive leaf extract on lipid oxidation and oxymyoglobin oxidation in bovine and porcine muscle model systems.
PubMed: Influence of simultaneous variations in temperature and relative humidity on chemical stability of two vitamin C forms and implications for shelf life models.
PubMed: Study of the lactic acid bacteria throughout the manufacture of dry-cured lac├│n (a Spanish traditional meat product). Effect of some additives.
PubMed: Effectiveness of a large-scale iron-fortified milk distribution program on anemia and iron deficiency in low-income young children in Mexico.
PubMed: Storage stability of freeze-dried Lactobacillus acidophilus (La-5) in relation to water activity and presence of oxygen and ascorbate.
PubMed: Application of multivariate analysis to the effects of additives on chemical and sensory quality of stored coffee brew.
PubMed: Physicochemical properties, and antioxidant and antimicrobial effects of garlic and onion powder in fresh pork belly and loin during refrigerated storage.
PubMed: Progress in herbicide determination with the thylakoid bioassay.
PubMed: Effect of Indian herbal hypoglycemic agents on antioxidant capacity and trace elements content in diabetic rats.
PubMed: Impact of deliquescence on the chemical stability of vitamins B1, B6, and C in powder blends.
PubMed: Influence of various preservatives on the quality of minced beef under modified atmosphere at chilled storage.
PubMed: Ascorbate, green tea and grape seed extracts increase the shelf life of low sulphite beef patties.
PubMed: Improved methods for the preparation of [3H]folate polyglutamates: biosynthesis with Lactobacillus casei and enzymatic synthesis with Escherichia coli folylpolyglutamate synthetase.
PubMed: Sodium ascorbate inhibits growth via the induction of cell cycle arrest and apoptosis in human malignant melanoma A375.S2 cells.
PubMed: Application of electron spin resonance spectroscopy and spin probes to investigate the effect of ingredients on changes in wheat dough during heating.
PubMed: Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics.
PubMed: Mechanism of oxymyoglobin oxidation in the presence of oxidizing lipids in bovine muscle.
PubMed: The effect of selected functional additives and heat treatment on nitrosamine content in pasteurized pork ham.
PubMed: Formulations of controlled atmosphere agents for packaged foods.
PubMed: Lack of promotion of urinary bladder carcinogenesis by sodium bicarbonate and/or L-ascorbic acid in male ODS/Shi-od/od rats synthesizing alpha 2 mu-globulin but not L-ascorbic acid.
PubMed: Comparison of vitamin C bioavailability after multiple or single oral dosing of different formulations in sheep.
PubMed: Enzymatic deconjugation of erythrocyte polyglutamyl folates during preparation for folate assay: investigation with reversed-phase liquid chromatography.
PubMed: Effect of vitamin C concentration and co-injection with calcium chloride on beef retail display color.
PubMed: Antioxidant effect of vitamin E and glutathione on lipid peroxidation in boar semen plasma.
PubMed: Growth of Listeria monocytogenes on vacuum-packed cooked meats: effects of pH, aw, nitrite and ascorbate.
PubMed: [Effect of preservatives on survival of Campylobacter jejuni in ground pork meat].
PubMed: An investigation of the antibacterial effect of carrot on Listeria monocytogenes.
PubMed: Ascorbate in the treatment of experimental transplanted melanoma.
PubMed: Inhibitory effects of Maharishi-4 and Maharishi-5 on microsomal lipid peroxidation.
PubMed: Participation of urinary Na+, K+, pH, and L-ascorbic acid in the proliferative response of the bladder epithelium after the oral administration of various salts and/or ascorbic acid to rats.
PubMed: Various sodium salts, potassium salts, a calcium salt and an ammonium salt induced ornithine decarboxylase and stimulated DNA synthesis in rat stomach mucosa.
PubMed: Nutritional value and safety in mice of proteins and their admixtures with carbohydrates and vitamin C after heating.
PubMed: Studies on antioxidants: their carcinogenic and modifying effects on chemical carcinogenesis.
PubMed: Effect of ascorbic acid on plasma calcium in guinea pigs.
PubMed: Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis.
PubMed: Methylation of liver DNA of rat and mouse by N-nitrosodimethylamine formed in vivo from dimethylamine and nitrite.
PubMed: Promoting effects of various chemicals in rat urinary bladder carcinogenesis initiated by N-nitroso-n-butyl-(4-hydroxybutyl)amine.
PubMed: Reduction of teratogenic effects of ethylenethiourea in rats by interaction with sodium nitrite in vivo.
PubMed: [Ascorbic acid and cancer of the duodenum. An experimental study (author's transl)].
PubMed: [Storage stability of Guelders smoked sausage (Gelderse rookworst) containing 20 per cent mechanically processed pork (author's transl)].
PubMed: Cell culture tumor promotion experiments with saccharin, phorbol myristate acetate and several common food materials.
PubMed: [Blockade of nitrogen oxide and nitrites by various substances].
PubMed: Dietary and other factors affecting nitrosomethylurea (NMU) formation in the rat stomach.
PubMed: Studies related to nitrosamide formation: nitrosation in solvent: water and solvent systems, nitrosomethylurea formation in the rat stomach and analysis of a fish product for ureas.
PubMed: Effect of sodium ascorbate on tumor induction in rats treated with morpholine and sodium nitrite, and with nitrosomorpholine.
PubMed: Rapid screening procedure for the determination of preservatives in ground beef: sulfites, benzoates, sorbates, and ascorbates.
PubMed: [Nitrosamines. Review].
PubMed: Induction of mouse lung adenomas by amines or ureas plus nitrite and by N-nitroso compounds: effect of ascorbate, gallic acid, thiocyanate, and caffeine.
PubMed: Pre-slaughter injection of sodium ascorbate as a method of inhibiting metmyoglobin formation in fresh beef.
PubMed: Effect of sodium ascorbate and sodium nitrite on toxin formation of Clostridium botulinum in wieners.
 
Notes:
a six carbon compound related to glucose. it is found naturally in citrus fruits and many vegetables. ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. its biologically active form, vitamin c, functions as a reducing agent and coenzyme in several metabolic pathways. vitamin c is considered an antioxidant. Antioxidant Sodium ascorbate is a compound with formula C6H7NaO6. It is the sodium salt of ascorbic acid.
 
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