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hydrated aluminum silicate

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CAS Number: 12428-46-5
Other(deleted CASRN):14696-93-6
FDA UNII: Search
CAS Number: 1332-58-7
Other(deleted CASRN):1026990-70-4
ECHA EC Number:310-194-1
Category:anticaking agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
186.1256 Clay (kaolin) (packaging) View - review
EU SANCO Aluminium silicate (Kaolin) View - review
JECFA Food Additive: Aluminium Silicate
GSFA Codex: Aluminium silicate (559)
DG SANTE Food Additives:kaolin
DG SANTE Food Contact Materials:kaolin
FDA Mainterm (IAUFC):1332-58-7 ; CLAY (KAOLIN)
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Insoluble in:
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: abrasives
anticaking agents
bulking agents
opacifying agents
BOC Sciences
For experimental / research use only.
Aluminum silicate 95%
Bristol Botanicals
Kaolin clay powder
Charkit Chemical
Charkit Chemical
Charkit Chemical
ECSA Chemicals
ECSA Chemicals
ECSA Chemicals
Glentham Life Sciences
Jarchem Industries
Jarxotic™ WC-NS
Kraft Chemical
Kaolin Clay
Penta International
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
anticaking agents
Recommendation for kaolin usage levels up to:
 not for fragrance use.
Recommendation for kaolin flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Safety of aluminium from dietary intake[1] - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC)
View page or View pdf

Conclusion on the peer review of the pesticide risk assessment of the active substance aluminium silicate
View page or View pdf

Dietary exposure to aluminium-containing food additives
View page or View pdf

Scientific Opinion on the safety assessment of the substances, kaolin and polyacrylic acid, sodium salt, for use in food contact materials
View page or View pdf

Outcome of the consultation with Member States, the applicant and EFSA on the pesticide risk assessment of confirmatory data for the active substance aluminium silicate
View page or View pdf

Retrospective analysis of the immunotoxic effects of plant protection products as reported in the Draft Assessment Reports for their peer review at EU level
View page or View pdf

Safety and efficacy of a natural mixture of illite, montmorillonite and kaolinite (Argile Verte du Velay) as a feed additive for all animal species
View page or View pdf

NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):12428-46-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:nwg
RTECS:GF1670500 for cas# 12428-46-5
EPA/NOAA CAMEO:hazardous materials
Pubchem (sid):135287507
Pubchem (sid):135263887
Other Information:
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2507.00.0000
FDA Listing of Food Additive Status:View
FDA Color Additive Status ListView
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
 cosmetic colorants
Occurrence (nature, food, other):note
 found in nature
hydrated aluminum silicate
 aluminum silicate hydrated
 c.i. 77004 (Al/hyd)
 china clay
 ci 77004 (Al/hyd)


PubMed:Volatile compounds and sensory attributes of wine from Cv. Merlot (Vitis vinifera L.) grown under differential levels of water deficit with or without a kaolin-based, foliar reflectant particle film.
PubMed:Review: nanocomposites in food packaging.
PubMed:Intraventricular neuropeptide Y decreases need-induced sodium appetite and increases pica in rats.
PubMed:Antiemetic Role of Thalidomide in a Rat Model of Cisplatin-Induced Emesis.
PubMed:Tranexamic acid induces kaolin intake stimulating a pathway involving tachykinin neurokinin 1 receptors in rats.
PubMed:Characterisation of mucilages extracted from seven Italian cultivars of flax.
PubMed:Comparison of the sequestering properties of yeast cell wall extract and hydrated sodium calcium aluminosilicate in three in vitro models accounting for the animal physiological bioavailability of zearalenone.
PubMed:Citrus aurantium and Rhodiola rosea in combination reduce visceral white adipose tissue and increase hypothalamic norepinephrine in a rat model of diet-induced obesity.
PubMed:Saponin and non-saponin fractions of red ginseng ameliorate cisplatin-induced pica in rats.
PubMed:Efficacy of barley based probiotic food mixture in treatment of pathogenic E.coli induced diarrhoea in mice.
PubMed:Oxidized trilinoleate and tridocosahexaenoate induce pica behavior and change locomotor activity.
PubMed:In vitro and in vivo efficacy of a hydrated sodium calcium aluminosilicate to bind and reduce aflatoxin residues in tissues of broiler chicks fed aflatoxin B1.
PubMed:Dioxin congener patterns in commercial catfish from the United States and the indication of mineral clays as the potential source.
PubMed:Influence of deficit irrigation and kaolin particle film on grape composition and volatile compounds in Merlot grape (Vitis vinifera L.).
PubMed:Capability of different non-nutritive feed additives on improving productive and physiological traits of broiler chicks fed diets with or without aflatoxin during the first 3 weeks of life.
PubMed:Comparison of emetic potencies of the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol.
PubMed:Evaluation of the effect of mycotoxin binders in animal feed on the analytical performance of standardised methods for the determination of mycotoxins in feed.
PubMed:Ginsenoside rich fraction of Panax ginseng C.A. Meyer improve feeding behavior following radiation-induced pica in rats.
PubMed:Electrocoagulation versus chemical coagulation: coagulation/flocculation mechanisms and resulting floc characteristics.
PubMed:Total allowable concentrations of monomeric inorganic aluminum and hydrated aluminum silicates in drinking water.
PubMed:[Ameliorative effect of Armillariella tabescens on cisplatin-induced gastrointestinal tract reaction in the rat].
PubMed:Ontogeny of antipredator performance in hatchery-reared Japanese anchovy Engraulis japonicus larvae exposed to visual or tactile predators in relation to turbidity.
PubMed:[Preventive and therapeutic effects of xiaobanxia fuling decoction on cisplatin-induced pica rats].
PubMed:Size and structure evolution of kaolin-Al(OH)3 flocs in the electroflocculation process: a study using static light scattering.
PubMed:Kaolinite ingestion facilitates restoration of body energy reserves during refeeding after prolonged fasting.
PubMed:The effect of inorganic particle concentration on bacteria-virus-nanoflagellate dynamics.
PubMed:Effects of controlled ingestion of kaolinite (5%) on food intake, gut morphology and in vitro motility in rats.
PubMed:Mineral intake independent from gastric irritation or pica by cell-dehydrated rats.
PubMed:Toxicity of aluminum silicates used in hemostatic dressings toward human umbilical veins endothelial cells, HeLa cells, and RAW267.4 mouse macrophages.
PubMed:Pharmacokinetics and pharmacodynamic effects of meloxicam in piglets subjected to a kaolin inflammation model.
PubMed:Yeast dynamics during the fermentation of brined green olives treated in the field with kaolin and Bordeaux mixture to control the olive fruit fly.
PubMed:Effect of kaolin and copper based products and of starter cultures on green table olive fermentation.
PubMed:Effect of three mycotoxin adsorbents on growth performance, nutrient retention and meat quality in broilers fed on mould-contaminated feed.
PubMed:Effects of cyclophosphamide on the kaolin consumption (pica behavior) in five strains of adult male rats.
PubMed:Behavioral, clinical, and pathological characterization of acid metalliferous water toxicity in mallards.
PubMed:QuikClot Combat Gauze use for hemorrhage control in military trauma: January 2009 Israel Defense Force experience in the Gaza Strip--a preliminary report of 14 cases.
PubMed:Volatile compounds and sensory attributes of wine from Cv. Merlot (Vitis vinifera L.) grown under differential levels of water deficit with or without a kaolin-based, foliar reflectant particle film.
PubMed:Effects of Korean ginseng root extract on cisplatin-induced emesis in a rat-pica model.
PubMed:Ketoprofen in piglets: enantioselective pharmacokinetics, pharmacodynamics and PK/PD modelling.
PubMed:Comparison of hydrated sodium calcium aluminosilicate and yeast cell wall on counteracting aflatoxicosis in broiler chicks.
PubMed:Particle-specific sorption/desorption properties determine test compound fate and bioavailability in toxicity tests with Chironomus riparius--high-resolution studies with lindane.
PubMed:Review: nanocomposites in food packaging.
PubMed:Time-course analysis of pica in rats using an automatic feeding monitoring system.
PubMed:Safety evaluation of new hemostatic agents, smectite granules, and kaolin-coated gauze in a vascular injury wound model in swine.
PubMed:Davalintide (AC2307), a novel amylin-mimetic peptide: enhanced pharmacological properties over native amylin to reduce food intake and body weight.
PubMed:Kaolinic clay derived PCDD/Fs in the feed chain from a sorting process for potatoes.
PubMed:Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat.
PubMed:Protease inhibitor-induced nausea and vomiting is attenuated by a peripherally acting, opioid-receptor antagonist in a rat model.
PubMed:Electroanalytical method for determination of lead(II) in orange and apple using kaolin modified platinum electrode.
PubMed:Pica as an adaptive response: Kaolin consumption helps rats recover from chemotherapy-induced illness.
PubMed:Interactions between ingested kaolinite and the intestinal mucosa in rat: proteomic and cellular evidences.
PubMed:Dispersal of Formulations of Fusarium oxysporum f. sp. erythroxyli and F. oxysporum f. sp. melonis by Ants.
PubMed:Evaluation of trace elements released by edible clays in physicochemically simulated physiological media.
PubMed:An overview of over the counter drugs in pregnancy and lactation.
PubMed:[Optimization of matrix formulation of effective parts cataplasm of Pogostemon cablin by uniform design].
PubMed:Radiological study of gastrointestinal motor activity after acute cisplatin in the rat. Temporal relationship with pica.
PubMed:Adsorption of Cry1Ab protein isolated from Bt transgenic rice on bentone, kaolin, humic acids, and soils.
PubMed:Efficacy of turmeric (Curcuma longa), containing a known level of curcumin, and a hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of aflatoxin in broiler chicks.
PubMed:Particle films for managing arthropod pests of apple.
PubMed:Kaolin affects blueberry maggot behavior on fruit.
PubMed:Influence of mixtures of kaolin particle film and synthetic insecticides on mortality of larval obliquebanded leafrollers (Lepidoptera: Tortricidae) from resistant and susceptible populations.
PubMed:Chemotherapy-induced pica and anorexia are reduced by common hepatic branch vagotomy in the rat.
PubMed:CLOCK regulates the circadian rhythm of kaolin-induced writhing behavior in mice.
PubMed:Pharmacological actions of the peptide hormone amylin in the long-term regulation of food intake, food preference, and body weight.
PubMed:Surface speciation of Cd(II) and Pb(II) on kaolinite by XAFS spectroscopy.
PubMed:WIN 55,212-2 prevents mechanical allodynia but not alterations in feeding behaviour induced by chronic cisplatin in the rat.
PubMed:Characteristics of aggregates formed by electroflocculation of a colloidal suspension.
PubMed:Formulation of stable Bacillus subtilis AH18 against temperature fluctuation with highly heat-resistant endospores and micropore inorganic carriers.
PubMed:Differential effects of dexamethasone, ondansetron and a tachykinin NK1 receptor antagonist (GR205171) on cisplatin-induced changes in behaviour, food intake, pica and gastric function in rats.
PubMed:The anti-cancer drug-induced pica in rats is related to their clinical emetogenic potential.
PubMed:Hydrocolloid carriers with filler inclusion for diltiazem hydrochloride release.
PubMed:[Examples of accidental and continuous exposures. ].
PubMed:Alternative management tactics for control of Phyllotreta cruciferae and Phyllotreta striolata (Coleoptera: Chrysomelidae) on Brassica rapa in Massachusetts.
PubMed:Altered feeding behaviour induced by long-term cisplatin in rats.
PubMed:Antiobesity action of peripheral exenatide (exendin-4) in rodents: effects on food intake, body weight, metabolic status and side-effect measures.
PubMed:Effects of ganoderma lucidum extract on chemotherapy-induced nausea and vomiting in a rat model.
PubMed:Novel approach on the risk assessment of oxidized fats and oils for perspectives of food safety and quality. I. Oxidized fats and oils induces neurotoxicity relating pica behavior and hypoactivity.
PubMed:Aflatoxin B1 binding to sorbents in bovine ruminal fluid.
PubMed:[Behavioral changes of rats under rotation stimulation].
PubMed:Competitive adsorption behavior of heavy metals on kaolinite.
PubMed:American ginseng berry extract and ginsenoside Re attenuate cisplatin-induced kaolin intake in rats.
PubMed:Identification and reduction of urinary aflatoxin metabolites in dogs.
PubMed:Application of adsorbent agents technology in the removal of aflatoxin B(1) and fumonisin B(1) from malt extract.
PubMed:Effects of chronic administration of D-003, a mixture of sugar cane wax high molecular acids, in beagle dogs.
PubMed:Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity.
PubMed:Methylnaltrexone prevents morphine-induced kaolin intake in the rat.
PubMed:An orexigenic role for mu-opioid receptors in the lateral parabrachial nucleus.
PubMed:Scutellaria baicalensis extract decreases cisplatin-induced pica in rats.
PubMed:Structure of dried cellular alginate matrix containing fillers provides extra protection for microorganisms against UVC radiation.
PubMed:Stable isotopes and fatty acids reveal that Chironomus riparius feeds selectively on added food in standardized toxicity tests.
PubMed:OTC drugs: categories I, II, and III.
PubMed:Over-the-counter medications in pregnancy.
PubMed:Potential for dietary protection against the effects of aflatoxins in animals.
PubMed:Characteristics of a bioflocculant produced by Bacillus mucilaginosus and its use in starch wastewater treatment.
PubMed:Six-month toxicity study of oral administration of D-003 in Sprague Dawley rats.
PubMed:Levels of polychlorinated dibenzo-p-dioxins and dibenzofurans in food of animal origin. The Swiss dioxin monitoring program.
PubMed:Differential action of ondansetron and dexamethasone to modify cisplatin-induced acute and delayed kaolin consumption ("pica") in rats.
PubMed:Establishment of an animal model for radiation-induced vomiting in rats using pica.
PubMed:Comprehensive study on dioxin contents in binder and anti-caking agent feed additives.
PubMed:Determination of PCDDs and PCDFs in different animal feed ingredients.
PubMed:[What a physician should know about zeolites].
PubMed:Effects of luminal nutrient absorption, intraluminal physical stimulation, and intravenous parenteral alimentation on the recovery responses of duodenal villus morphology following feed withdrawal in chickens.
PubMed:Development of formulations of biological agents for management of root rot of lettuce and cucumber.
PubMed:Intraventricular neuropeptide Y decreases need-induced sodium appetite and increases pica in rats.
PubMed:Bradykinin release from high molecular weight kininogen and increase in plasma kallikrein-like activity following sensory stimulation by food in the rat.
PubMed:Conditioned antisickness: indirect evidence from rats and direct evidence from ferrets that conditioning alleviates drug-induced nausea and emesis.
PubMed:NPY and food intake: discrepancies in the model.
PubMed:Effects of a hydrated sodium calcium aluminosilicate (T-Bind) on mycotoxicosis in young broiler chickens.
PubMed:The regulation of crystalline silica: an industry perspective.
PubMed:Cisplatin-induced pica behaviour in rats is prevented by antioxidants with antiemetic activity.
PubMed:Kininogen changes in human plasma following a test meal or insulin administration.
PubMed:Characterisation of inorganic microparticles in pigment cells of human gut associated lymphoid tissue.
PubMed:Treatment of diarrhoea in infants by medical doctors in Balochistan, Pakistan.
PubMed:Effect of sodium bentonite or hydrated sodium calcium aluminosilicate on growth performance and tibia mineral concentrations in broiler chicks fed nutrient-deficient diets.
PubMed:Comparison of two hydrated sodium calcium aluminosilicate compounds to experimentally protect growing barrows from aflatoxicosis.
PubMed:Pica in rats is analogous to emesis: an animal model in emesis research.
PubMed:Effectiveness of different types of clay for reducing the detrimental effects of aflatoxin-contaminated diets on performance and serum profiles of weanling pigs.
PubMed:Effect of hydrated sodium calcium aluminosilicates on aflatoxicosis in broiler chicks.
PubMed:Potential ameliorators of aflatoxicosis in weanling/growing swine.
PubMed:Efficacy of a hydrated sodium calcium aluminosilicate to reduce the toxicity of aflatoxin and diacetoxyscirpenol.
PubMed:Evaluation of aluminosilicate compounds to reduce aflatoxin residues and toxicity to poultry and livestock: a review report.
PubMed:Haemorrhages due to defective blood coagulation do not occur in mice and guinea-pigs fed butylated hydroxytoluene, but nephrotoxicity is found in mice.
PubMed:Treatment of diarrhea of neonatal calves.
PubMed:Effects on aflatoxin M1 residues in milk by addition of hydrated sodium calcium aluminosilicate to aflatoxin-contaminated diets of dairy cows.
PubMed:Effects of a hydrated sodium calcium aluminosilicate on growing turkey poults during aflatoxicosis.
PubMed:Effect of short chain fatty acids on the performance and intestinal weight in germ-free and conventional chicks.
PubMed:Diminution of aflatoxin toxicity to growing lambs by dietary supplementation with hydrated sodium calcium aluminosilicate.
PubMed:Bulk prevents bacterial translocation induced by the oral administration of total parenteral nutrition solution.
PubMed:Diminution of aflatoxicosis in growing chickens by the dietary addition of a hydrated, sodium calcium aluminosilicate.
PubMed:Distribution of aflatoxins in tissues of growing pigs fed an aflatoxin-contaminated diet amended with a high affinity aluminosilicate sorbent.
PubMed:Detection and detoxification of aflatoxins: prevention of aflatoxicosis and aflatoxin residues with hydrated sodium calcium aluminosilicate.
PubMed:Plasma enteroglucagon, gastrin and peptide YY in conventional and germ-free rats refed with a fibre-free or fibre-supplemented diet.
PubMed:Factors influencing ingestion of particulate materials by mosquito larvae (Diptera: Culicidae).
PubMed:[A report on a disease caused by corn baked by coal mixed with kaolin].
PubMed:Role of mid-dorsal caudate nucleus in maintenance of body weight in rats on administration of foods with different caloric densities.
PubMed:Effects of an elemental diet, inert bulk and different types of dietary fibre on the response of the intestinal epithelium to refeeding in the rat and relationship to plasma gastrin, enteroglucagon, and PYY concentrations.
PubMed:Inhibited drinking and pica in rats following 2-deoxy-D-glucose.
PubMed:Proliferative effects of 'fibre' on the intestinal epithelium: relationship to gastrin, enteroglucagon and PYY.
PubMed:Early home oral rehydration therapy (ORT) in primary health care.
PubMed:Feeding rate of larval Aedes vexans stimulated by food substances.
PubMed:Regulation of food intake by brown Leghorn cockerels in response to dietary dilution with kaolin.
PubMed:Effects of addition of kaolin or cellulose to an elemental diet on intestinal cell proliferation in the mouse.
PubMed:A worldwide survey on the treatment of diarrhoeal disease by oral rehydration in 1979.
PubMed:Post-ingestive effects of quinine on intake of nutritive and non-nutritive substances.
PubMed:The effects of specified chemical meals on food intake.
PubMed:Reduced exudation and increased tissue proliferation during chronic inflammation in rats deprived of endogenous prostaglandin precursors.
PubMed:Ontogeny of controls of food intake in the rat: GI fill and glucoprivation.
PubMed:Palatability and caloric density as determinants of food intake in hyperphagic and normal rats.
PubMed:Food and energy intake of rats fed diets varying in energy concentration and density.
PubMed:Sorptive dusts for pest control.
PubMed:Histochemical changes in the rat small intestine associated with enhanced absorption after high bulk feeding.
None found
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