isosorbide
1,4:3,6-dianhydro-D-glucitol

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  CODE125294 CODE125294
  Product(s):
  652-67-5 Isosorbide

Name: (3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol CAS Number: 652-67-5 3D/inchi Other(deleted CASRN): 151380-60-8 ECHA EINECS - REACH Pre-Reg: 211-492-3 FDA UNII: WXR179L51S Nikkaji Web: J7.077G Beilstein Number: 0080510 MDL: MFCD00064827 XlogP3: -1.40 (est) Molecular Weight: 146.14250000 Formula: C6 H10 O4 BioActivity Summary: listing NMR Predictor: Predict (works with chrome, Edge or firefox) Category:indirect food additives: adhesives and components of coatings   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search DG SANTE Food Contact Materials: 1,4:3,6-dianhydro-D-glucitol   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Melting Point: 62.50 °C. @ 760.00 mm Hg Boiling Point: 372.05 °C. @ 760.00 mm Hg (est) Flash Point: 354.00 °F. TCC ( 178.80 °C. ) (est) logP (o/w): -1.194 (est) Soluble in:   water, 4.714e+005 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: BOC Sciences For experimental / research use only. Isosorbide Carbosynth For experimental / research use only. 1,4:3,6-Dianhydro-D-glucitol Sigma-Aldrich: Aldrich For experimental / research use only. Dianhydro-D-glucitol 98% sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: intraperitoneal-mouse LD50 13600 mg/kg Drugs in Japan Vol. 6, Pg. 71, 1982. intravenous-mouse LD50 6870 mg/kg BRAIN AND COVERINGS: CHANGES IN CEREBRAL SPINAL FLUID Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 15, 1969. oral-mouse LD50 289 mg/kg Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 187, 1969. intravenous-rat LD50 11000 mg/kg Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(4), Pg. 158S, 1968. oral-rat LD50 24150 mg/kg Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 15, 1969. Dermal Toxicity: Not determined Inhalation Toxicity: Not determined   Safety in Use Information: Category: indirect food additives: adhesives and components of coatings Recommendation for isosorbide usage levels up to:   not for fragrance use.   Recommendation for isosorbide flavor usage levels up to:   not for flavor use.   Safety References: European Food Safety Authority (EFSA) reference(s): Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to a 15th list of substances for food contact materials View page or View pdf Scientific Opinion on the safety evaluation of the substance, 1,4:3,6-dianhydrosorbitol, CAS No 652-67-5, for use in food contact materials View page or View pdf EPI System: View ClinicalTrials.gov:search Daily Med:search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA Substance Registry Services (TSCA):652-67-5 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :12597 National Institute of Allergy and Infectious Diseases:Data WGK Germany:2 (3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol Chemidplus:0000652675 RTECS:LZ4380000 for cas# 652-67-5   References:   (3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol NIST Chemistry WebBook: Search Inchi Canada Domestic Sub. List: 652-67-5 Pubchem (cid): 12597 Pubchem (sid): 134977138   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements FDA Indirect Additives used in Food Contact Substances: View CHEMBL: View Golm Metabolome Database: Search KEGG (GenomeNet): D00347 HMDB (The Human Metabolome Database): Search Export Tariff Code: 2932.90.5000 MedlinePlusSupp: View ChemSpider: View Wikipedia: View EFSA Update of results on the monitoring of furan levels in food: Read Report EFSA Previous report: Results on the monitoring of furan levels in food: Read Report EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report Formulations/Preparations: ismotic (alcon), oral as 45% solution.   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms:   devicoran 1,4:3,6- dianhydro-D-glucitol 1,4:3,6- dianhydro-dextro-glucitol D-1,4:3,6- dianhydroglucitol 1,4- dianhydrosorbitol D- glucitol, 1,4:3,6-dianhydro-   glucitol, 1,4:3,6-dianhydro-, D- (3S,3aR,6R,6aR)- hexahydro-furo[3,2-b]furan-3,6-diol (3R,3aR,6S,6aR)- hexahydrofuro[3,2-b]furan-3,6-diol (3S,3aR,6R,6aR)-2,3,3a,5,6,6a- hexahydrofuro[3,2-b]furan-3,6-diol (3R,3aR,6S,6aR)- hexahydrofuro[3,2-b]furane-3,6-diol   hydronol   ismotic (+)-D-iso sorbide iso sorbidum   Articles:   None found yet. 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Notes: 1,4:3,6-dianhydro d-glucitol. chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma.