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Category:indirect food additives: adhesives and components of coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.67700 to 0.68300 @ 25.00 °C.
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| Pounds per Gallon - (est).: | 5.633 to 5.683
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| Refractive Index: | 1.41500 to 1.42100 @ 20.00 °C.
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| Boiling Point: | 33.00 to 34.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 548.955017 mmHg @ 25.00 °C. (est) |
| Flash Point: | -65.00 °F. TCC ( -53.89 °C. )
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| logP (o/w): | 2.420 |
| Soluble in: |
| | alcohol | | | water, 642 mg/L @ 25 °C (exp) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
gavage-rat LD50 [sex: M,F] 2043.00 - 2210 mg/kg
Study not available
(Kimmerle & Solmecke, 1972)
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
inhalation-rat LC50 180 gm/m3/4H
Russian Pharmacology and Toxicology Vol. 31, Pg. 162, 1968.
inhalation-mouse LC50 139 gm/m3/2H
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 9(1), Pg. 36, 1965.
inhalation-mouse LC50 139000 mg/m3/2H
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 9(1), Pg. 36, 1965.
inhalation-rat LC50 180000 mg/m3/4H
BEHAVIORAL: GENERAL ANESTHETIC
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Russian Pharmacology and Toxicology Vol. 31, Pg. 162, 1968.
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Safety in Use Information:
| Category: | | indirect food additives: adhesives and components of coatings |
| Recommendation for isoprene usage levels up to: | | | not for fragrance use.
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| Recommendation for isoprene flavor usage levels up to: |
| | not for flavor use.
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| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.061 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 3700 (μg/person/day) |
| Threshold of Concern: | 1800 (μg/person/day) |
| Structure Class: | I |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1,3- | butadiene, 2-methyl- | | 2- | methyl 1,3-butadiene | | beta- | methyl bivinyl | | 2- | methyl butadiene | | 2- | methyl-1,3-butadiene | | 3- | methyl-1,3-butadiene | | 2- | methylbuta-1,3-diene | | 2- | methylbutadiene | | iso | pentadiene |
Articles:
| Info:ISOPRENE and TERPENES |
| US Patents:4,003,935 - 7-Methyl-octahydro-1,4-methano-naphthalen-6-one |
| PubMed:Biomarkers of infection with Plasmodium falciparum detected in human breath. |
| PubMed:Isoprenoids and phenylpropanoids are part of the antioxidant defense orchestrated daily by drought-stressed Platanus × acerifolia plants during Mediterranean summers. |
| PubMed:Double bond stereochemistry influences the susceptibility of short-chain isoprenoids and polyprenols to decomposition by thermo-oxidation. |
| PubMed:The role of oxidative stress on carotene production by Blakeslea trispora in submerged fermentation. |
| PubMed:Reconciling functions and evolution of isoprene emission in higher plants. |
| PubMed:Isoprene production in transgenic tobacco alters isoprenoid, non-structural carbohydrate and phenylpropanoid metabolism, and protects photosynthesis from drought stress. |
| PubMed:Isoprene improves photochemical efficiency and enhances heat dissipation in plants at physiological temperatures. |
| PubMed:Toward a photosynthetic microbial platform for terpenoid engineering. |
| PubMed:On the origin of water-soluble organic tracer compounds in fine aerosols in two cities: the case of Los Angeles and Barcelona. |
| PubMed:Rapid determination of coenzyme Q10 in food supplements using 1H NMR spectroscopy. |
| PubMed:[Regulation of isoprenoid pathway for enhanced production of linalool in Saccharomyces cerevisiae]. |
| PubMed:Early induction of apple fruitlet abscission is characterized by an increase of both isoprene emission and abscisic acid content. |
| PubMed:Chemoprevention of hepatocarcinogenesis with dietary isoprenic derivatives: cellular and molecular aspects. |
| PubMed:Effect of cigarette menthol content on mainstream smoke emissions. |
| PubMed:A novel application of the Margin of Exposure approach: segregation of tobacco smoke toxicants. |
| PubMed:The use of a novel tobacco treatment process to reduce toxicant yields in cigarette smoke. |
| PubMed:Engineering cyanobacteria for fuels and chemicals production. |
| PubMed:Identification of moderately halophilic bacteria from Thai fermented fish ( pla-ra ) and proposal of Virgibacillus siamensis sp. nov. |
| PubMed:Experimental setup and analytical methods for the non-invasive determination of volatile organic compounds, formaldehyde and NOx in exhaled human breath. |
| PubMed:Catabolism of citronellol and related acyclic terpenoids in pseudomonads. |
| PubMed:Bacillus siamensis sp. nov., isolated from salted crab (poo-khem) in Thailand. |
| PubMed:Nitrogen management is essential to prevent tropical oil palm plantations from causing ground-level ozone pollution. |
| PubMed:Biosynthesis and bioproduction of coenzyme Q10 by yeasts and other organisms. |
| PubMed:Determining concentration patterns of volatile compounds in exhaled breath by PTR-MS. |
| PubMed:[Foods fortified with phytosterins: their role in decreasing serum cholesterol level, their European Community authorization and requirements for placing them on the market]. |
| PubMed:Isoprene emissions influence herbivore feeding decisions. |
| PubMed:Release of isoprene and monoterpenes during the aerobic decomposition of orange wastes from laboratory incubation experiments. |
| PubMed:Toxicological evaluation of potassium sorbate added to cigarette tobacco. |
| PubMed:Piscibacillus salipiscarius gen. nov., sp. nov., a moderately halophilic bacterium from fermented fish (pla-ra) in Thailand. |
| PubMed:Unusual features of a recombinant apple alpha-farnesene synthase. |
| PubMed:Metabolic engineering of coenzyme Q by modification of isoprenoid side chain in plant. |
| PubMed:Potential applications of breath isoprene as a biomarker in modern medicine: a concise overview. |
| PubMed:Antileishmanial activity of the terpene nerolidol. |
| PubMed:Biosynthesis of irregular diterpenes in Anisotome lyallii by head-to-head coupling of geranyl diphosphate. |
| PubMed:Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis. |
| PubMed:Safety evaluation of a triterpenoid-rich extract from bamboo shavings. |
| PubMed:Arsenicicoccus bolidensis gen. nov., sp. nov., a novel actinomycete isolated from contaminated lake sediment. |
| PubMed:Effects of ventilation on the collection of exhaled breath in humans. |
| PubMed:Methyl palmitate: a novel product of the Medfly (Ceratitis capitata) corpus allatum. |
| PubMed:Reproductive fitness and quinone content of Caenorhabditis elegans clk-1 mutants fed coenzyme Q isoforms of varying length. |
| PubMed:Biosynthesis of anthecotuloide, an irregular sesquiterpene lactone from Anthemis cotula L. (Asteraceae) via a non-farnesyl diphosphate route. |
| PubMed:Increase of acetone and ammonia in urine headspace and breath during ovulation quantified using selected ion flow tube mass spectrometry. |
| PubMed:Volatile metabolites from actinomycetes. |
| PubMed:Modelling the responses to biological reactive intermediates: establishing the borderlines of risk. |
| PubMed:Volatile isoprenoid constituents of fruits, vegetables and herbs cumulatively suppress the proliferation of murine B16 melanoma and human HL-60 leukemia cells. |
| PubMed:Prediction of isoprene diepoxide levels in vivo in mouse, rat and man using enzyme kinetic data in vitro and physiologically-based pharmacokinetic modelling. |
| PubMed:Biosynthesis of the hemi- and monoterpene moieties of isoprenyl phenyl ethers from the liverwort Trichocolea tomentella. |
| PubMed:Trace gases in breath of healthy volunteers when fasting and after a protein-calorie meal: a preliminary study. |
| PubMed:Conjugation of isoprene monoepoxides with glutathione, catalyzed by alpha, mu, pi and theta-class glutathione S-transferases of rat and man. |
| PubMed:The biotransformation of isoprene and the two isoprene monoepoxides by human cytochrome P450 enzymes, compared to mouse and rat liver microsomes. |
| PubMed:Effect of crop development on biogenic emissions from plant populations grown in closed plant growth chambers. |
| PubMed:Changes of dolichol and dolichyl fatty acyl esters during the germination and development of soybeans. |
| PubMed:Indoor sources of mutagenic aerosol particulate matter: smoking, cooking and incense burning. |
| PubMed:Interactions of a model block copolymer drug delivery system with two serum proteins and myoglobin. |
| PubMed:Location and activity of ubiquinone 10 and ubiquinone analogues in model and biological membranes. |
| PubMed:Analysis of residual vulcanization accelerators in baby bottle rubber teats. |
| PubMed:Tissue damage and nutritional factors in experimental respiratory tract (Co-)carcinogenesis. |
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3D/inchi