EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

isobutyl methacrylate
methacrylic acid, isobutyl ester

Supplier Sponsors

Name:2-methylpropyl 2-methylprop-2-enoate
CAS Number: 97-86-9Picture of molecule3D/inchi
Other:266675-13-2
ECHA EINECS - REACH Pre-Reg:202-613-0
FDA UNII:V11534UYZ0
Nikkaji Web:J47.810E
Beilstein Number:1747595
MDL:MFCD00008931
XlogP3:2.70 (est)
Molecular Weight:142.19798000
Formula:C8 H14 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:film forming agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FLAVIS Number:09.586 (Old)
DG SANTE Food Flavourings:09.586 methacrylic acid, isobutyl ester
DG SANTE Food Contact Materials:methacrylic acid, isobutyl ester
FDA Mainterm (IAUFC):97-86-9 ; ISOBUTYL METHACRYLATE

 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.88200 to 0.88800 @ 25.00 °C.
Pounds per Gallon - (est).: 7.339 to 7.389
Refractive Index:1.40900 to 1.41500 @ 20.00 °C.
Boiling Point: 155.00 °C. @ 760.00 mm Hg
Vapor Pressure:3.630000 mmHg @ 25.00 °C.
Vapor Density:3.8 ( Air = 1 )
Flash Point: 111.00 °F. TCC ( 43.89 °C. )
logP (o/w): 2.660
Soluble in:
 alcohol
 water, 1300 mg/L @ 25 °C (exp)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: film formers
 
Suppliers:
Penta International
2-METHYLPROPYL-2-METHYL-2-PROPENOATE
Santa Cruz Biotechnology
For experimental / research use only.
isoButyl Methacrylate
Sigma-Aldrich: Aldrich
For experimental / research use only.
isoButyl Methacrylate 97%
Silver Fern Chemical
IBMA: Isobutyl Methacrylate
TCI AMERICA
For experimental / research use only.
isoButyl Methacrylate (stabilized with HQ) >98.0%(GC)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi N - Irritant, Dangerous for the environment.
R 10 - Flammable.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
R 43 - May cause sensitisation by skin contact.
R 50 - Very toxic to aquatic organisms.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 11990 mg/kg
Toxicology Letters. Vol. 11, Pg. 125, 1982.

intraperitoneal-mouse LD50 1340 mg/kg
Journal of Pharmaceutical Sciences. Vol. 62, Pg. 778, 1973.

intravenous-dog LDLo 134 uL/kg
Journal of Pharmaceutical Sciences. Vol. 63, Pg. 376, 1974.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
inhalation-mouse LCLo 29740 mg/m3/5H
Journal of Biomedical Materials Research. Vol. 8, Pg. 11, 1974.

inhalation-rat LCLo 200000 mg/m3/4H
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
National Technical Information Service. Vol. OTS0535667

 
Safety in Use Information:
Category: film forming agents
Recommendation for isobutyl methacrylate usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.012 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 3900 (μg/person/day)
Threshold of Concern:540 (μg/person/day)
Structure Class: II
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 7.0000035.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 5.0000025.00000
Edible ices, including sherbet and sorbet (03.0): 10.0000050.00000
Processed fruit (04.1): 7.0000035.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 10.0000050.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 5.0000025.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000050.00000
Ready-to-eat savouries (15.0): 20.00000100.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 5: Esters of 23 branched- and straight-chain aliphatic saturated primary alcohols and of one secondary alcohol, and 24 branched- and straight-chain unsaturated carboxylic acids from chemical groups 1, 2, and 5
View page or View pdf

Flavouring Group Evaluation 5, Revision 1 (FGE.05Rev1):Esters of branched- and straight-chain aliphatic saturated primary alcohols and of one secondary alcohol, and branched- and straight-chain unsaturated carboxylic acids from chemical groups 1, 2, and 5 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) [1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 62 (FGE.62) Consideration of linear and branched-chain aliphatic unsaturated, unconjugated alcohols, aldehydes, acids, and related esters evaluated by JECFA (61st meeting) structurally related to esters of branched- and straight-chain aliphatic saturated primary alcohols and of one secondary alcohol, and branched- and straight-chain unsaturated carboxylic acids evaluated by EFSA in FGE.05 (2005) and to straight- and branched-chain aliphatic unsaturated primary alcohols, aldehydes, carboxylic acids, and esters evaluated by EFSA in FGE.06 (2004) (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 71: Consideration of aliphatic, linear, alpha,beta-unsaturated carboxylic acids and related esters
View page or View pdf

Flavouring Group Evaluation 72 (FGE.72): Consideration of aliphatic, branched-chain saturated and unsaturated alcohols, aldehydes, acids, and related esters evaluated by the JECFA (61st meeting) structurally related to branched- and straight-chain unsaturated carboxylic acids. Esters of these and straight-chain aliphatic saturated alcohols evaluated by EFSA in FGE.05Rev2 (2010)
View page or View pdf

Flavouring Group Evaluation 5, Revision 2 (FGE.05Rev2): Branched- and straight-chain unsaturated carboxylic acids and esters of these with aliphatic saturated alcohols from chemical groups 1, 2, 3 and 5
View page or View pdf

EPI System: View
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):97-86-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7352
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2283
WGK Germany:1
2-methylpropyl 2-methylprop-2-enoate
Chemidplus:0000097869
EPA/NOAA CAMEO:hazardous materials
RTECS:OZ4900000 for cas# 97-86-9
 
References:
 2-methylpropyl 2-methylprop-2-enoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:97-86-9
Pubchem (cid):7352
Pubchem (sid):134970809
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2916.14.2050
Haz-Map:View
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Formulations/Preparations:
contains 25 ppm hydroquinone monomethyl ether as inhibitor.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 film formers
 
Occurrence (nature, food, other):note
 chamomile flower oil roman @ 0.33%
Data GC Search Trop Picture
 
Synonyms:
isobutyl 2-methyl prop-2-enoate
isobutyl 2-methyl-2-propenoate
isobutyl 2-methylacrylate
isobutyl 2-methylprop-2-enoate
isobutyl alpha-methacrylate
isobutyl methacrylate, inhibited [UN2283] [Flammable liquid]
 methacrylic acid isobutyl ester
 methacrylic acid, isobutyl ester
2-methyl-2-propenoic acid 2-methyl ester
2-methylpropyl 2-methyl-2-propenoate
2-methylpropyl 2-methylprop-2-enoate
2-methylpropyl 2-methylpropenoate
2-methylpropyl methacrylate
2-propenoic acid, 2-methyl-, 2-methylpropyl ester
 propenoic acid, 2-methyl, isobutyl ester
 

Articles:

PubMed:Assessment of the skin sensitising potency of the lower alkyl methacrylate esters.
PubMed:Investigation of bonding properties of denture bases to silicone-based soft denture liner immersed in isobutyl methacrylate and 2-hydroxyethyl methacrylate.
PubMed:Cytotoxicity of monomers, plasticizer and degradation by-products released from dental hard chairside reline resins.
PubMed:Direct patterning of intrinsically electron beam sensitive polymer brushes.
PubMed:Chain end distribution of block copolymer in two-dimensional microphase-separated structure studied by scanning near-field optical microscopy.
PubMed:Conformation of single block copolymer chain in two-dimensional microphase-separated structure studied by scanning near-field optical microscopy.
PubMed:Optical CO(2) sensor of the combination of colorimetric change of alpha-naphtholphthalein in poly(isobutyl methacrylate) and fluorescent porphyrin in polystyrene.
PubMed:Effect of molecular mobility of polymeric implants on soft tissue reactions: an in vivo study in rats.
PubMed:Self-assembled treelike patterns from an evaporating binary solution.
PubMed:Fabrication of hydroxyapatite-poly(epsilon-caprolactone) scaffolds by a combination of the extrusion and bi-axial lamination processes.
PubMed:Final report of the safety assessment of methacrylate ester monomers used in nail enhancement products.
PubMed:Development and application of methods for determination of residual monomer in dental acrylic resins using high performance liquid chromatography.
PubMed:Cytotoxic effects of dental resin liquids on primary gingival fibroblasts and periodontal ligament cells in vitro.
PubMed:Confinement and processing effects on glass transition temperature and physical aging in ultrathin polymer films: novel fluorescence measurements.
PubMed:Bonding strength between a hard chairside reline resin and a denture base material as influenced by surface treatment.
PubMed:Reinforcement of acrylic resins for provisional fixed restorations. Part I: Mechanical properties.
PubMed:A denture base resin with low water absorption.
PubMed:Carbohydrate-specific cell adhesion directly to glycosphingolipids separated on thin-layer chromatography plates.
PubMed:The mechanism of interaction between chlorhexidine digluconate and poly(2-hydroxyethyl methacrylate).
PubMed:PRESERVATION OF BIOLOGICAL SPECIMENS WITH ISOBUTYL METHACRYLATE POLYMER.
PubMed:EVALUATION OF ISOBUTYL METHACRYLATE POLYMER AS A MOUNTING MEDIUM.
PubMed:ISOBUTYL METHACRYLATE AS A MOUNTING MEDIUM FOR HISTOLOGICAL PREPARATIONS.
PubMed:A PLASTIC COVER GLASS, ISOBUTYL METHACRYLATE.
 
Notes:
None found
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