EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

hydroxypropyl methyl cellulose
cellulose, 2-hydroxypropyl methyl ether

Supplier Sponsors

CAS Number: 9004-65-3
Other(deleted CASRN):11106-33-5
Formula:C3 H8 O2.x-C H4 O.x-unspecified
Category:multipurpose additives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
1973 Hydroxypropylmethyl cellulose View - review
GRN 190 Hydroxypropyl methylcellulose View - notice PDF
GRN 213 Hydroxypropyl methylcellulose - expanded substitution pattern (HPMC-ESP) View - notice PDF
JECFA Food Additive: Hydroxypropylmethyl cellulose
GSFA Codex: Hydroxypropyl methyl cellulose (464)
DG SANTE Food Additives:hydroxypropyl methyl cellulose
DG SANTE Food Contact Materials:hydroxypropyl methyl cellulose
FDA Regulation:
Subpart I--Multipurpose Additives
Sec. 172.874 Hydroxypropyl methylcellulose.

Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.

Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.

Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact Surfaces
Sec. 177.1960 Vinyl chloride-hexene-1 copolymers.
Physical Properties:
Appearance:white to pale yello powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antistatic agents
binding agents
emulsion stabilisers
film formers
viscosity controlling agents
American International Chemical, LLC.
Benecel™ hydroxypropylmethylcellulose
Odor: odorless
Use: Benecel methylcellulose (MC) and hydroxypropylmethylcellulose (HPMC) are versatile, multifunctional food gums that are unique because they reversibly gel at elevated temperatures. This family of products is compatible with nearly all common food ingredients. Benecel MC and HPMC perform many functions in processed foods, depending on type, grade, use level and conditions. Among these functions are thermal gelation, film formation, thickening, binding and water retention. The polymeric structure of these products, which is different from other cellulosics, improves cohesion, texture and mouthfeel. Small amounts of Benecel MC and HPMC significantly enhance emulsion stability as well. This is particularly useful in stabilizing whipped toppings and desserts.
BOC Sciences
For experimental / research use only.
(Hydroxypropyl)methyl cellulose - Viscocity 3000-5600 cP
Dow Chemical
Hydroxypropyl Methylcellulose
ECSA Chemicals
ECSA Chemicals
Graham Chemical
Hydroxypropyl Methyl Cellulose
Indis NV
For experimental / research use only.
Hydroxypropyl Methyl Cellulose
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
(Hydroxypropyl)methyl cellulose
For experimental / research use only.
Silver Fern Chemical
Hydroxypropyl Methylcellulose
Odor: characteristic
Use: HPMC is commonly used in the food industry as a thickening agent, stabilizer, and emulsifier. It also has applications in tile adhesives, cement, pharmaceuticals, paints and coatings, cosmetics, and detergents.
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 5200 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 112, 1950.

intraperitoneal-mouse LD50 5000 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 112, 1950.

intraperitoneal-mammal (species unspecified) LD50 > 2000 mg/kg
Toksikologicheskii Vestnik. Vol. (6), Pg. 41, 1999.

oral-mammal (species unspecified) LD50 > 10000 mg/kg
Toksikologicheskii Vestnik. Vol. (6), Pg. 41, 1999.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
multipurpose additives
Recommendation for hydroxypropyl methyl cellulose usage levels up to:
 not for fragrance use.
Recommendation for hydroxypropyl methyl cellulose flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Safety of a change in specifications for the food additive hydroxypropyl methyl cellulose (E 464)
View page or View pdf

Re-evaluation of celluloses E 460(i), E 460(ii), E 461, E 462, E 463, E 464, E 465, E 466, E 468 and E 469 as food additives
View page or View pdf

Safety and efficacy of hydroxypropyl methyl cellulose for all animal species
View page or View pdf

EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):9004-65-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
RTECS:NF9125000 for cas# 9004-65-3
Canada Domestic Sub. List:9004-65-3
Pubchem (sid):135020744
Other Information:
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):HMDB33369
Export Tariff Code:3912.39.0000
FDA Listing of Food Additive Status:View
Potential Blenders and core components note
None Found
Potential Uses:
 binding agents
 emulsion stabilisers
 film formers
 viscosity controlling agents
Occurrence (nature, food, other):note
 not found in nature
 cellulose hydroxypropyl methyl ether
 cellulose, 2-hydroxypropyl methyl ether
2-hydroxypropyl cellulose methyl ether
2-hydroxypropyl methyl cellulose
 hydroxypropyl methylcellulose
 hydroxypropylmethyl cellulose
 methyl cellulose, propylene glycol ether
 methyl hydroxypropyl cellulose


PubMed:Development of novel guava puree films containing chitosan nanoparticles.
PubMed:Effect of antifungal hydroxypropyl methylcellulose-lipid edible composite coatings on Penicillium decay development and postharvest quality of cold-stored "Ortanique" mandarins.
PubMed:Fatty acid effect on hydroxypropyl methylcellulose-beeswax edible film properties and postharvest quality of coated 'Ortanique' mandarins.
PubMed:The role of fat in flavor perception: effect of partition and viscosity in model emulsions.
PubMed:Shear rheology and filament stretching behaviour of xanthan gum and carboxymethyl cellulose solution in presence of saliva.
PubMed:Development of polysaccharides-based edible coatings for citrus fruits: a layer-by-layer approach.
PubMed:High-viscosity dietary fibers reduce adiposity and decrease hepatic steatosis in rats fed a high-fat diet.
PubMed:Near-infrared and fourier transform infrared chemometric methods for the quantification of crystalline tacrolimus from sustained-release amorphous solid dispersion.
PubMed:The influence of hydroxypropyl methylcellulose (HPMC) molecular weight, concentration and effect of food on in vivo erosion behavior of HPMC matrix tablets.
PubMed:Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro experimental simulation and computational verification.
PubMed:Microencapsulation of Lactobacillus acidophilus NCIMB 701748 in matrices containing soluble fibre by spray drying: Technological characterization, storage stability and survival after in vitro digestion.
PubMed:Evaluating food additives as antifungal agents against Monilinia fructicola in vitro and in hydroxypropyl methylcellulose-lipid composite edible coatings for plums.
PubMed:Hybrid HPMC nanocomposites containing bacterial cellulose nanocrystals and silver nanoparticles.
PubMed:Assessing the efficiency of polymeric excipients by atomistic molecular dynamics simulations.
PubMed:Enhanced bioavailability and bioefficacy of an amorphous solid dispersion of curcumin.
PubMed:Biopolymeric antimicrobial films: study of the influence of hydroxypropyl methylcellulose, tapioca starch and glycerol contents on physical properties.
PubMed:Preparation and characterization of a gastric floating dosage form of capecitabine.
PubMed:Phase behavior of concentrated hydroxypropyl methylcellulose solution in the presence of mono and divalent salt.
PubMed:Antifungal activity of food additives in vitro and as ingredients of hydroxypropyl methylcellulose-lipid edible coatings against Botrytis cinerea and Alternaria alternata on cherry tomato fruit.
PubMed:Developing hydroxypropyl methylcellulose/hydroxypropyl starch blends for use as capsule materials.
PubMed:Physicochemical and sensory properties of soy bread made with germinated, steamed, and roasted soy flour.
PubMed:Altered hepatic gene expression profiles associated with improved fatty liver, insulin resistance, and intestinal permeability after hydroxypropyl methylcellulose (HPMC) supplementation in diet-induced obese mice.
PubMed:Gastro-floating tablets of cephalexin: preparation and in vitro/in vivo evaluation.
PubMed:Encapsulation and Delivery of Crystalline Hydrophobic Nutraceuticals using Nanoemulsions: Factors Affecting Polymethoxyflavone Solubility.
PubMed:Effects of particle size, food, and capsule shell composition on the oral bioavailability of dabrafenib, a BRAF inhibitor, in patients with BRAF mutation-positive tumors.
PubMed:Mechanistic understanding of food effects: water diffusivity in gastrointestinal tract is an important parameter for the prediction of disintegration of solid oral dosage forms.
PubMed:Hydroxypropyl methylcellulose, a viscous soluble fiber, reduces insulin resistance and decreases fatty liver in Zucker Diabetic Fatty rats.
PubMed:Competitive adsorption between sugar beet pectin (SBP) and hydroxypropyl methylcellulose (HPMC) at the oil/water interface.
PubMed:Solid nanocrystalline dispersions of ziprasidone with enhanced bioavailability in the fasted state.
PubMed:Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.
PubMed:HPMC supplementation reduces abdominal fat content, intestinal permeability, inflammation, and insulin resistance in diet-induced obese mice.
PubMed:Effect of HPMC on the quality of wheat-free bread made from carob germ flour-starch mixtures.
PubMed:Antihyperglycemic and Antioxidative Effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in Mice Fed with a High Fat Diet.
PubMed:Using white sorghum flour for gluten-free breadmaking.
PubMed:Viscous dietary fiber reduces adiposity and plasma leptin and increases muscle expression of fat oxidation genes in rats.
PubMed:Effect of solid content and composition of hydroxypropyl methylcellulose-lipid edible coatings on physico-chemical and nutritional quality of 'Oronules' mandarins.
PubMed:Comparative evaluation of the hypolipidemic effects of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) in high fat-fed mice.
PubMed:Dietary hydroxypropyl methylcellulose increases excretion of saturated and trans fats by hamsters fed fast food diets.
PubMed:Predicting the human in vivo performance of different oral capsule shell types using a novel in vitro dynamic gastric model.
PubMed:Supplementation of hydroxypropyl methylcellulose into yeast leavened all-whole grain barley bread potentiates cholesterol-lowering effect.
PubMed:Preparation and characterization of shellac-coated anthocyanin pectin beads as dietary colonic delivery system.
PubMed:How do xanthan and hydroxypropyl methylcellulose individually affect the physicochemical properties in a model gluten-free dough?
PubMed:Effect of antifungal hydroxypropyl methylcellulose-lipid edible composite coatings on Penicillium decay development and postharvest quality of cold-stored "Ortanique" mandarins.
PubMed:A possible application of magnetic resonance imaging for pharmaceutical research.
PubMed:Evaluation of certain food additives and contaminants.
PubMed:Physical and sensory properties of all-barley and all-oat breads with additional hydroxypropyl methylcellulose (HPMC) β-glucan.
PubMed:HPMC capsules: current status and future prospects.
PubMed:Assessment of hydroxypropyl methylcellulose, propylene glycol, polysorbate 80, and hydroxypropyl-β-cyclodextrin for use in developmental and reproductive toxicology studies.
PubMed:The effect of sucrose and salts in combination on the drug release behaviour of an HPMC matrix.
PubMed:Evaluation of the genotoxicity of chitosan nanoparticles for use in food packaging films.
PubMed:Comprehensive investigation of hydroxypropyl methylcellulose, propylene glycol, polysorbate 80, and hydroxypropyl-beta-cyclodextrin for use in general toxicology studies.
PubMed:Hypocholesterolemic effects of hydroxypropyl methylcellulose are mediated by altered gene expression in hepatic bile and cholesterol pathways of male hamsters.
PubMed:Composite edible films based on hydroxypropyl methylcellulose reinforced with microcrystalline cellulose nanoparticles.
PubMed:Baking loss of bread with special emphasis on increasing water holding capacity.
PubMed:Formulation and evaluation of gastroretentive drug delivery system of propranolol hydrochloride.
PubMed:Kinetics of adsorption of whey proteins and hydroxypropyl-methyl-cellulose mixtures at the air-water interface.
PubMed:Curative and preventive activity of hydroxypropyl methylcellulose-lipid edible composite coatings containing antifungal food additives to control citrus postharvest green and blue molds.
PubMed:Investigation of the effects of hydroalcoholic solutions on textural and rheological properties of various controlled release grades of hypromellose.
PubMed:Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 4. Age-related eye disease. SkQ1 returns vision to blind animals.
PubMed:Scintigraphic evaluation of colon targeting pectin-HPMC tablets in healthy volunteers.
PubMed:Fatty acid effect on hydroxypropyl methylcellulose-beeswax edible film properties and postharvest quality of coated 'Ortanique' mandarins.
PubMed:Effect of plasticizer type and amount on hydroxypropyl methylcellulose-beeswax edible film properties and postharvest quality of coated plums (cv. Angeleno).
PubMed:Properties of novel hydroxypropyl methylcellulose films containing chitosan nanoparticles.
PubMed:Simultaneous characterization of bile acid, sterols, and determination of acylglycerides in feces from soluble cellulose-fed hamsters using HPLC with evaporative light-scattering detection and APCI-MS.
PubMed:Safety assessment of hydroxypropyl methylcellulose as a food ingredient.
PubMed:Determination of methylcellulose and hydroxypropyl methylcellulose food gums in food and food products: collaborative study.
PubMed:Gluten-free sorghum bread improved by sourdough fermentation: biochemical, rheological, and microstructural background.
PubMed:The role of fat in flavor perception: effect of partition and viscosity in model emulsions.
PubMed:Capillary electrophoresis for monitoring dityrosine and 3-bromotyrosine synthesis.
PubMed:Inhibition of Listeria monocytogenes on the surface of individually packaged hot dogs with a packaging film coating containing nisin.
PubMed:Influence of hydroxypropyl methylcellulose edible coating on fresh-keeping and storability of tomato.
PubMed:Oral mucosal bioadhesive tablets of pectin and HPMC: in vitro and in vivo evaluation.
PubMed:A three-month repeated oral administration study of a low viscosity grade of hydroxypropyl methylcellulose in rats.
PubMed:Reduced systemic availability of an antiarrhythmic drug, bidisomide, with meal co-administration: relationship with region-dependent intestinal absorption.
PubMed:[Reproductive and developmental toxicity study of a new antineoplastic agent, S-1 (IV)--Perinatal and postnatal study in rats by oral administration].
PubMed:Increased intestinal contents viscosity reduces cholesterol absorption efficiency in hamsters fed hydroxypropyl methylcellulose.
PubMed:In vitro/in vivo evaluation of two series of TA-5707F controlled release matrix tablets prepared with hydroxypropyl methyl cellulose derivatives with entero-soluble or gel-formation properties.
PubMed:Relationships between viscosity of hydroxypropyl methylcellulose and plasma cholesterol in hamsters.
PubMed:Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats.
PubMed:Evaluation of column flotation in the downstream processing of fermentation products: recovery of a genetically engineered alpha-amylase.
contains 2-hydroxypropyl cellulose ether & cellulose methyl ether; component of contact lens wetting solutions; sperm immobilizer. Thickening and binding agent approved for food use in USA and EU. Used in deep fried batters As a food additive, hypromellose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin. Its Codex Alimentarius code (E number) is E464.; Because hypromellose solution is a non-newtonian solution and exhibits pseudoplastic, more specifically, thixotropic behavior, various test methods are available, and the results of different methods and viscosmeters do not necessarily correspond to each other. Also, due to viscometer acceptable ranges of error, viscosity is typically given as a mean, or as a range. Typical viscosity test will specify the following:; Degree of substitution is the average level of methoxy substitution on the cellulose chain. Since there are maximum three possible sites of substitution with each cellulose molecule, this average value is a real number between 0 and 3. However, degree of substitution is often expressed in percentages.; Hypromellose (INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used as an ophthalmic lubricant, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.; Hypromellose is a solid, and is a slightly off-white to beige powder in appearance and may be formed into granules. The compound forms colloids when dissolved in water. Although non-toxic, it is combustible and can react vigorously with oxidising agents.; Hypromellose solutions were patented as a semisynthetic substitute for tear-film. Its molecular structure is predicated upon a base celluloid compound that is highly water soluble. Post-application, celluloid attributes of good water solubility reportedly aids in visual clarity. When applied, a hypromellose solution acts to swell and absorb water, thereby expanding the thickness of the tear-film. Hypromellose augmentation therefore results in extended lubricant time presence on the cornea, which theoretically results in decreased eye irritation, especially in dry climates, home, or work environments. On a molecular level, this polymer contains beta-linked D-glucose units that remain metabolically intact for days to weeks. On a manufacturing note, since hypromellose is a vegetarian substitute for gelatin, it is slightly more expensive to produce due to semisynthetic manufacturing processes. Aside from its widespread commercial and retail availability over the counter in a variety of products, Hypromellose 2% solution has been documented to be used during surgery to aid in corneal protection and during orbital surgery.
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