hydroxypropyl cellulose
cellulose, 2-hydroxypropyl ether
component of contact lens wetting solutions. Hydroxypropyl cellulose (cellulose, 2-hydroxypropyl ether) is a derivative of cellulose with both water solubility and organic solubility. Hydroxypropyl cellulose acts to stabilize and thicken the precorneal tear film and prolong the tear film breakup time which is usually accelerated in patients with dry eye states. Hydroxypropyl cellulose also acts to lubricate and protect the eye. Hydroxypropyl cellulose usually reduces the signs and symptoms resulting from moderate to severe dry eye syndromes, such as conjunctival hyperemia, corneal and conjunctival staining with rose bengal, exudation, itching, burning, foreign body sensation, smarting, photophobia, dryness and blurred or cloudy vision. Progressive visual deterioration which occurs in some patients may be retarded, halted, or sometimes reversed.
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      H0386 Hydroxypropyl Cellulose (150-400mPa·s, 2% in Water at 20°C)
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CAS Number: 9004-64-2 
Other: 1374408-53-3
FDA UNII: 2165RE0K14
MDL: MFCD00132688
Formula: C3 H8 O2.x-unspecified
Category: multipurpose additives, foam promoter, mouthfeel, stabilizer
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
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Perfumer and Flavorist: Search
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US Patents: Search
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PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
FR DOC # 2011-17928 Food Additives Permitted for Direct Addition to Food for Human Consumption; Hydroxypropyl Cellulose Pages 41687 - 41689 View-petition PDF
JECFA Food Additive: Hydroxypropyl Cellulose
GSFA Codex: Hydroxypropyl cellulose (463)
DG SANTE Food Additives: hydroxypropyl cellulose
DG SANTE Food Contact Materials: hydroxypropyl cellulose
FDA Regulation:
Subpart I--Multipurpose Additives
Sec. 172.870 Hydroxypropyl cellulose.

Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1200 Cellophane.

Subpart B--Drugs
Sec. 73.1001 Diluents in color additive mixtures for drug use exempt from certification.
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Physical Properties:
Appearance: white to pale yellow powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
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Organoleptic Properties:
Odor Description:
at 100.00 %. 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: binding agents
emulsifying agents
emulsion stabilisers
film formers
viscosity controlling agents
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AeroWhip™ hydroxypropylcellulose
Odor: odorless
Use: AeroWhip 630 hydroxypropylcellulose (HPC) is an optimized grade of HPC for stabilizing dairy and nondairy whipped toppings. In nondairy whipped toppings, AeroWhip 630 HPC creates stiff foams, increases overrun and controls syneresis. For dairy whipping creams, the amount of milk fat can be reduced significantly, leading to a healthier and more cost-effective product with a creamy mouthfeel. AeroWhip 630 HPC is compatible with common emulsifier and stabilizer ingredients.
Klucel™ hydroxypropylcellulose
Odor: odorless
Use: Klucel hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with a remarkable combination of properties. It combines organic solvent solubility, thermoplasticity and surface activity with the aqueous thickening and stabilizing properties characteristic of other water-soluble cellulose polymers available from Ashland. Klucel HPC films are flexible without plasticizers and non-tacky at high humidity.
PrimaFlo™ HP22 polymer solution
Odor: odorless
Use: PrimaFlo HP22 polymer solution is an aqueous solution of hydroxypropylcellulose (HPC) developed specifically for use as a film-former in personal care formulations. It is fully compatible with hydro-alcoholic systems. Typical use levels are 2 to 5 percent (wet basis). The benefit of PrimaFlo HPC versus Klucel™ hydroxypropylcellulose is that PrimaFlo is ready to use, saving the time and cost of dissolving.
Kraft Chemical
Santa Cruz Biotechnology
For experimental / research use only.
Hydroxypropyl Cellulose
Sigma-Aldrich: Aldrich
For experimental / research use only.
Hydroxypropyl cellulose
average Mw ∼80,000, average Mn ∼10,000, powder, 20 mesh particle size (99% through)
For experimental / research use only.
Hydroxypropyl Cellulose (150-400mPa·s, 2% in Water at 20°C)
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Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  10200 mg/kg
FAO Nutrition Meetings Report Series. Vol. 46A, Pg. 131, 1969.

intravenous-rat LD50  250 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.

intraperitoneal-rat LD50  > 25000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.

oral-mouse LD50  > 5000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.

intravenous-mouse LD50  > 500 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.

intraperitoneal-mouse LD50  > 25000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: multipurpose additives, foam promoter, mouthfeel, stabilizer
Recommendation for hydroxypropyl cellulose usage levels up to:
 not for fragrance use.
Recommendation for hydroxypropyl cellulose flavor usage levels up to:
 not for flavor use.
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Safety References:
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 9004-64-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
Chemidplus: 0009004642
RTECS: NF9050000 for cas# 9004-64-2
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Canada Domestic Sub. List: 9004-64-2
Pubchem (sid): 135020743
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Other Information:
FDA Everything Added to Food in the United States (EAFUS): View
HMDB (The Human Metabolome Database): HMDB32337
FooDB: FDB009612
Export Tariff Code: 3912.39.0000
Haz-Map: View
Household Products: Search
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Potential Blenders and core components note
None Found
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Potential Uses:
 binding agents 
 emulsion stabilisers 
 film formers 
 gel forming agents for perfumes 
 viscosity controlling agents 
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Occurrence (nature, food, other): note
 not found in nature
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 cellulose 2-hydroxypropyl ether
 cellulose hydroxypropyl ether
 cellulose, 2-hydroxypropyl ether
2-hydroxypropyl cellulose
 hydroxypropyl ether of cellulose
oxypropylated cellulose
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PubMed: Interactive forces between lignin and cellulase as determined by atomic force microscopy.
PubMed: High pressure homogenization to improve the stability of casein - hydroxypropyl cellulose aqueous systems.
PubMed: Fast and interference-free determination of glyphosate and glufosinate residues through electrophoresis in disposable microfluidic chips.
PubMed: Effects of molecular weight on permeability and microstructure of mixed ethyl-hydroxypropyl-cellulose films.
PubMed: Hydration properties of regioselectively etherified celluloses monitored by 2H and 13C solid-state MAS NMR spectroscopy.
PubMed: Characterization of critical physical and mechanical properties of freeze-dried grape powder for development of a clinical patient delivery system.
PubMed: Lipoic acid nanoparticles: effect of polymeric stabilizer on appetite suppression.
PubMed: Formulation and evaluation of gastroretentive drug delivery system of propranolol hydrochloride.
PubMed: New bioactive biomaterials based on quaternized chitosan.
PubMed: Stabilization of hot-melt extrusion formulations containing solid solutions using polymer blends.
PubMed: In-vitro/in-vivo correlation of pulsatile drug release from press-coated tablet formulations: a pharmacoscintigraphic study in the beagle dog.
PubMed: Effect of water content on the structural reorganization and elastic properties of biopolymer films: a comparative study.
PubMed: From physical pharmacy to clinical pharmacology.
PubMed: Pharmacokinetics of a slow-release formulation of soybean isoflavones in healthy postmenopausal women.
PubMed: DNA separation by capillary electrophoresis with hydrophilic substituted celluloses as coating and sieving polymers. Application to the analysis of genetically modified meals.
PubMed: Comparison of neural network and multiple linear regression as dissolution predictors.
PubMed: Sol-gel composite films with controlled release of biocides.
PubMed: Isolation and characterization of the viscous, high-molecular-mass microbial carbohydrate fraction from faeces of healthy subjects and patients with Crohn's disease and the consequences for a therapeutic approach.
PubMed: Adherence of two film-forming medications to the oral mucosa.
PubMed: Evaluation of the correlation between in vivo and in vitro release. Effect of the force of contraction and food on drug release.
PubMed: [Anaphylaxis caused by carboxymethylcellulose: report of 2 cases of shock from injectable corticoids].
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