EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

hydroxypropyl cellulose
cellulose, 2-hydroxypropyl ether

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CAS Number: 9004-64-2
Formula:C3 H8 O2.x-unspecified
Category:multipurpose additives, foam promoter, mouthfeel, stabilizer
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
FR DOC # 2011-17928 Food Additives Permitted for Direct Addition to Food for Human Consumption; Hydroxypropyl Cellulose Pages 41687 - 41689 View-petition PDF
JECFA Food Additive: Hydroxypropyl Cellulose
GSFA Codex: Hydroxypropyl cellulose (463)
DG SANTE Food Additives:hydroxypropyl cellulose
DG SANTE Food Contact Materials:hydroxypropyl cellulose
FDA Regulation:
Subpart I--Multipurpose Additives
Sec. 172.870 Hydroxypropyl cellulose.

Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1200 Cellophane.

Subpart B--Drugs
Sec. 73.1001 Diluents in color additive mixtures for drug use exempt from certification.
Physical Properties:
Appearance:white to pale yellow powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: binding agents
emulsifying agents
emulsion stabilisers
film formers
viscosity controlling agents
AeroWhip™ hydroxypropylcellulose
Odor: odorless
Use: AeroWhip 630 hydroxypropylcellulose (HPC) is an optimized grade of HPC for stabilizing dairy and nondairy whipped toppings. In nondairy whipped toppings, AeroWhip 630 HPC creates stiff foams, increases overrun and controls syneresis. For dairy whipping creams, the amount of milk fat can be reduced significantly, leading to a healthier and more cost-effective product with a creamy mouthfeel. AeroWhip 630 HPC is compatible with common emulsifier and stabilizer ingredients.
Klucel™ hydroxypropylcellulose
Odor: odorless
Use: Klucel hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with a remarkable combination of properties. It combines organic solvent solubility, thermoplasticity and surface activity with the aqueous thickening and stabilizing properties characteristic of other water-soluble cellulose polymers available from Ashland. Klucel HPC films are flexible without plasticizers and non-tacky at high humidity.
PrimaFlo™ HP22 polymer solution
Odor: odorless
Use: PrimaFlo HP22 polymer solution is an aqueous solution of hydroxypropylcellulose (HPC) developed specifically for use as a film-former in personal care formulations. It is fully compatible with hydro-alcoholic systems. Typical use levels are 2 to 5 percent (wet basis). The benefit of PrimaFlo HPC versus Klucel™ hydroxypropylcellulose is that PrimaFlo is ready to use, saving the time and cost of dissolving.
BOC Sciences
For experimental / research use only.
Hydroxypropyl Cellulose
Kraft Chemical
Santa Cruz Biotechnology
For experimental / research use only.
Hydroxypropyl Cellulose
Sigma-Aldrich: Aldrich
For experimental / research use only.
Hydroxypropyl cellulose
average Mw ∼80,000, average Mn ∼10,000, powder, 20 mesh particle size (99% through)
For experimental / research use only.
Hydroxypropyl Cellulose (150-400mPa·s, 2% in Water at 20°C)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 10200 mg/kg
FAO Nutrition Meetings Report Series. Vol. 46A, Pg. 131, 1969.

intravenous-rat LD50 250 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.

intraperitoneal-rat LD50 > 25000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.

oral-mouse LD50 > 5000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.

intravenous-mouse LD50 > 500 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.

intraperitoneal-mouse LD50 > 25000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
Category: multipurpose additives, foam promoter, mouthfeel, stabilizer
Recommendation for hydroxypropyl cellulose usage levels up to:
 not for fragrance use.
Recommendation for hydroxypropyl cellulose flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Re-evaluation of celluloses E 460(i), E 460(ii), E 461, E 462, E 463, E 464, E 465, E 466, E 468 and E 469 as food additives
View page or View pdf

Safety of low-substituted hydroxypropyl cellulose (L-HPC) to be used as a food additive in food supplements in tablet form
View page or View pdf
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):9004-64-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
RTECS:NF9050000 for cas# 9004-64-2
Canada Domestic Sub. List:9004-64-2
Pubchem (sid):135020743
Other Information:
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):HMDB32337
Export Tariff Code:3912.39.0000
FDA Listing of Food Additive Status:View
Household Products:Search
Potential Blenders and core components note
None Found
Potential Uses:
 binding agents
 emulsion stabilisers
 film formers
 gel forming agents for perfumes
 viscosity controlling agents
Occurrence (nature, food, other):note
 not found in nature
 cellulose 2-hydroxypropyl ether
 cellulose hydroxypropyl ether
 cellulose, 2-hydroxypropyl ether
2-hydroxypropyl cellulose
 hydroxypropyl ether of cellulose
oxypropylated cellulose


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PubMed:High pressure homogenization to improve the stability of casein - hydroxypropyl cellulose aqueous systems.
PubMed:Fast and interference-free determination of glyphosate and glufosinate residues through electrophoresis in disposable microfluidic chips.
PubMed:Effects of molecular weight on permeability and microstructure of mixed ethyl-hydroxypropyl-cellulose films.
PubMed:Hydration properties of regioselectively etherified celluloses monitored by 2H and 13C solid-state MAS NMR spectroscopy.
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PubMed:Effect of water content on the structural reorganization and elastic properties of biopolymer films: a comparative study.
PubMed:From physical pharmacy to clinical pharmacology.
PubMed:Pharmacokinetics of a slow-release formulation of soybean isoflavones in healthy postmenopausal women.
PubMed:DNA separation by capillary electrophoresis with hydrophilic substituted celluloses as coating and sieving polymers. Application to the analysis of genetically modified meals.
PubMed:Comparison of neural network and multiple linear regression as dissolution predictors.
PubMed:Sol-gel composite films with controlled release of biocides.
PubMed:Isolation and characterization of the viscous, high-molecular-mass microbial carbohydrate fraction from faeces of healthy subjects and patients with Crohn's disease and the consequences for a therapeutic approach.
PubMed:Adherence of two film-forming medications to the oral mucosa.
PubMed:Evaluation of the correlation between in vivo and in vitro release. Effect of the force of contraction and food on drug release.
PubMed:[Anaphylaxis caused by carboxymethylcellulose: report of 2 cases of shock from injectable corticoids].
component of contact lens wetting solutions. Hydroxypropyl cellulose (cellulose, 2-hydroxypropyl ether) is a derivative of cellulose with both water solubility and organic solubility. Hydroxypropyl cellulose acts to stabilize and thicken the precorneal tear film and prolong the tear film breakup time which is usually accelerated in patients with dry eye states. Hydroxypropyl cellulose also acts to lubricate and protect the eye. Hydroxypropyl cellulose usually reduces the signs and symptoms resulting from moderate to severe dry eye syndromes, such as conjunctival hyperemia, corneal and conjunctival staining with rose bengal, exudation, itching, burning, foreign body sensation, smarting, photophobia, dryness and blurred or cloudy vision. Progressive visual deterioration which occurs in some patients may be retarded, halted, or sometimes reversed.
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