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hydroquinine
quinine, 10,11-dihydro-

Supplier Sponsors

Name:(R)-(5-ethyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol
CAS Number: 522-66-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:208-334-0
FDA UNII: 31J3Q51T6L
Beilstein Number:091444
MDL:MFCD00151107
XlogP3:3.10 (est)
Molecular Weight:326.43962000
Formula:C20 H26 N2 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 172.50 °C. @ 760.00 mm Hg
Boiling Point: 498.40 °C. @ 760.00 mm Hg (est)
Flash Point: 491.00 °F. TCC ( 255.20 °C. ) (est)
logP (o/w): 3.770 (est)
Soluble in:
 water, 290 mg/L @ 25 °C (exp)
 water, 102.6 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Dihydroquinine
Santa Cruz Biotechnology
For experimental / research use only.
Hydroquinine
Sigma-Aldrich: Aldrich
For experimental / research use only.
Hydroquinine 98%
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for hydroquinine usage levels up to:
 not for fragrance use.
 
Recommendation for hydroquinine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10651
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(R)-(5-ethyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol
Chemidplus:0000522667
 
References:
 (R)-(5-ethyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):10651
Pubchem (sid):134977607
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2939.29.0050
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (8alpha,9R)- (9CI)
 dihydroquinine
(R)-(5-ethyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol
(9R)-6'-methoxy-10,11-dihydrocinchonan-9-ol
 quinine, 10,11-dihydro-
 

Articles:

PubMed:Silver(I)-directed growth of metal-organic complex nanocrystals with bidentate ligands of hydroquinine anthraquinone-1,4-diyl diethers as linkers at the water-chloroform interface.
PubMed:The molecular phenotype of endocapillary proliferation: novel therapeutic targets for IgA nephropathy.
PubMed:Catalytic and asymmetric fluorolactonisations of carboxylic acids through anion phase transfer.
PubMed:How do pseudoenantiomers structurally differ in the gas phase? An IR/UV spectroscopy study of jet-cooled hydroquinine and hydroquinidine.
PubMed:Interfacial self-assembly and characterization of chiral coordination polymer multilayers with bidentate ligands of hydroquinine anthraquinone-1,4-diyl diether as linkers.
PubMed:Enantioselective α-hydroxylation of β-ketoamides.
PubMed:Organocatalytic asymmetric biomimetic transamination of aromatic ketone to optically active amine.
PubMed:Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids.
PubMed:Modified asymmetric Strecker reaction of aldehyde with secondary amine: a protocol for the synthesis of S-clopidogrel (an antiplatelet agent).
PubMed:Microwave-assisted organocatalytic enantioselective intramolecular aza-Michael reaction with α,β-unsaturated ketones.
PubMed:Enantioselective Friedel-Crafts reaction of indoles with trifluoroacetaldehyde catalyzed by Cinchona alkaloids.
PubMed:Catalytic enantioselective protonation of enol trifluoroacetates by means of hydrogenocarbonates and cinchona alkaloids.
PubMed:A hybrid process for chiral separation of compound-forming systems.
PubMed:Preparation of heteroaryloxetanes and heteroarylazetidines by use of a Minisci reaction.
PubMed:Asymmetric synthesis of an N-acylpyrrolidine for inhibition of HCV polymerase.
PubMed:The role of contact chemoreception in egg-laying behaviour of locusts.
PubMed:Characterization of phenoloxidase activity in Sydney rock oysters (Saccostrea glomerata).
PubMed:[Adverse drug reactions in three older patients, even without changes in medication].
PubMed:Proliferation and morphological transformation of RMK cells exposed to hydroquinine containing ionomers.
PubMed:Prostaglandin biosynthesis by midgut tissue isolated from the tobacco hornworm, Manduca sexta.
PubMed:Hydroquinine pharmacokinetics after oral administration in adult patients with muscle cramps.
PubMed:Stage-specific effects of antimalarials on an Indian isolate of Plasmodium falciparum.
PubMed:Randomised controlled trial of hydroquinine in muscle cramps.
PubMed:Randomised controlled trial of hydroquinine in muscle cramps.
PubMed:Randomised controlled trial of hydroquinine in muscle cramps.
PubMed:Randomised controlled trial of hydroquinine in muscle cramps.
PubMed:Efficacy of hydroquinine in preventing frequent ordinary muscle cramp outlasts actual administration.
PubMed:[No difference in efficacy of hydroquinine and placebo in restless legs syndrome].
PubMed:Liquid chromatographic determination of quinine, hydroquinine, saccharin, and sodium benzoate in quinine beverages.
PubMed:[Study of antiviral effect of chlorine-substituted benzoquinine and hydroquinine].
PubMed:STUDY OF THE ACTION OF FOUR AROMATIC CINCHONA DERIVATIVES ON PNEUMOCOCCUS. A COMPARISON WITH OPTOCHIN.
 
Notes:
None found
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