| Name: | (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one |
| CAS Number: | 50-23-7 |  3D/inchi
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| Other(deleted CASRN): | 8056-08-4 |
| ECHA EINECS - REACH Pre-Reg: | 200-020-1 |
| FDA UNII: | WI4X0X7BPJ |
| Nikkaji Web: | J1.908I |
| MDL: | MFCD00011654 |
| XlogP3: | 1.60 (est) |
| Molecular Weight: | 362.46610000 |
| Formula: | C21 H30 O5 |
| BioActivity Summary: | listing |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 220.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 566.45 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 1.350000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 591.00 °F. TCC ( 310.40 °C. ) (est)
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| logP (o/w): | 1.610 |
| Soluble in: |
| | water, 320 mg/L @ 25 °C (exp) | | | water, 219.6 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-man TDLo 400 mg/kg/10D-
BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS
Psychopharmacology Vol. 145, Pg. 260, 1999.
intraperitoneal-rat LD50 150 mg/kg
Japanese Journal of Pharmacology. Vol. 21, Pg. 377, 1971.
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| Dermal Toxicity: |
subcutaneous-mouse LD50 > 500 mg/kg
Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(3), Pg. 26, 1990.
subcutaneous-rat LD50 449 mg/kg
Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for hydrocortisone usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for hydrocortisone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| Carcinogenic Potency Database:Search |
| EPA Substance Registry Services (TSCA):50-23-7 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :5754 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one |
| Chemidplus:0000050237 |
| RTECS:GM8925000 for cas# 50-23-7 |
References:
| | (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 50-23-7 |
| Pubchem (cid): | 5754 |
| Pubchem (sid): | 134971010 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| KEGG (GenomeNet): | C00735 |
| HMDB (The Human Metabolome Database): | HMDB00063 |
| FooDB: | FDB021888 |
| Export Tariff Code: | 2937.21.0020 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations:
•ointment: 0.5% cortizone-5, (pfizer), 1% cortizone-10, (pfizer), hydroskin, (rugby), 2.5% hytone, (dermik). pledgets (saturated with solution): 0.5% massengill medicated soft cloth towelette (with parabens and propylene glycol), (glaxosmithkline). solution: 1% cortaid faststick maximum strength (with alcohol and methylparaben), (pfizer), cortaid spray maximum strength (with alcohol and methylparaben), (pfizer), cortizone-10 scalp itch formula liquid (with alcohol sd 40-2 60% vv, benzyl alcohol, and propylene glycol), (pfizer), penecort (with alcohol sd 40-2 57%, benzyl alcohol, and propylene glycol), (allergan), texacort (with sd alcohol 33% and propylene glycol), (sirius), 2.5% texacort, (sirius).
•lotion: 0.5% hydroskin, (rugby). 1% ala-cort, (del-ray), aquanil hc (with benzyl alcohol), (person & covey), cetacort (with parabens), (healthpoint), dermacort (with benzyl alcohol), (solvay) hydroskin, (rugby) lacticare-hc, (stiefel) nutracort (with parabens), (healthpoint), sarnol hc, (stiefel), 2% ala-scalpt, (del-ray); 2.5% hydrocortisone lotion, (glades), hydrocortisone lotion, (major), hytone (with propylene glycol), (dermik), lacticare-hc, (stiefel), nutracort (with parabens), (healthpoint), proctocream-hc (with benzyl alcohol), (physicians total care).
•topical: cream: 0.5% cortizone-5 (with aloe and parabens), (pfizer), cortizone for kids ( with aloe and parabens), (pfizer); 1% ala-cort, (del-ray), cortaid intensive therapy (with parabens and propylene glycol), (pfizer), cortizone-10 (with aloe and parabens), (pfizer), cortizone-10 external anal itch relief creme ( with aloe and parabens), (pfizer), dermacort, (solvay), dermicort (republic), hydroskin, (rugby), hytone (with propylene glycol), (dermik), penecort (with benzyl alcohol and propylene glycol), (allergan), preparation h hydrocortisone (with parabens and propylene glycol), (wyeth); 2.5% anusol-hc (with benzyl alcohol and propylene glycol), (pfizer), hytone (with propylene glycol), (dermik). gel: 1% cortagel extra strength, (norstar).
•rectal: cream: 1 proctocort ( with benzyl alcohol and propylene glycol), (monarch); suspension: 100 mg60 ml cortenema ( with methylparaben), (solvay), hydrocortisone enema, (copley).
•powder: (available by nonproprietary name). rectal: aerosol, foam suspension: 10% cortifoam (with parabens, propylene glycol, and chlorofluorohydrocarbon propellants), (schwarz). suppositories: 25 mg anucort-hc, (g&w), anu-med hc, (major), anusol-hc, (pfizer). hemorrhoidal-hc, (alpharma), hemorrhoidal-hc, (cmc), hemorrhoidal-hc, (sandoz), hemorrhoidal-hc, (rugby), hemorrhoidal-hc, (udl), hemril-hc uniserts, (upsher-smith), hydrocortisone acetate suppositories, (paddock), hydrocortisone acetate suppositories, (teva), hydrocortisone acetate suppositories, (udl), hydrocortisone acetate suppositories, (united research), 30 mg proctocort, (monarch). hydrocortisone acetate
•powder: oral: tablets: 5 mg cortef (scored), (pfizer); 10 mg cortef (scored), (pfizer), hydrocortone (scored), (merck); 20 mg cortef (scored), (pfizer).
•topical: cream: 0.5% corticaine (with parabens), (ucb); 0.5% (of hydrocortisone) cortaid sensitive skin formula (with aloe and parabens), (pfizer); 1% (of hydrocortisone) caldecort anti-itch (with propylene glycol), (novartis), cortaid maximum strength (with aloe and methylparaben), (pfizer), dermarest dricort, del dermtex hc (with menthol 1%), (pfeiffer), nupercainal hydrocortisone anti-itch cream (with propylene glycol), (novartis). lotion: 0.5% (of hydrocortisone) (available by nonproprietary name) ointment: 0.5% (of hydrocortisone) cortaid sensitive skin formula (with aloe and parabens), (pfizer); 1% anusert hc-1, (g&w). gynecort 10, (combe), lanacort 10, (combe); 1% (of hydrocortisone) anusol-hc-1, (pfizer), cortaid maximum strength (with aloe and methylparaben), (pfizer). paste: 0.5% orabase (hca), colgate solution 1% scalp-aid, (major), scalpcort maximum strength, clay-park 1% (of hydrocortisone) dermtex hc spray, (pfeiffer). hydrocortisone acetate
•topical: cream: 0.1% pandel (with parabens and propylene glycol), (savage) hydrocortisone buteprate
•topical: cream: 0.1% locoid (with methylparaben), (ferndale). ointment: 0.1% locoid, (ferndale). solution: 0.1% locoid (with isopropyl alcohol 50% and povidone), (ferndale). hydrocortisone butyrate
•topical: cream: 0.2% westcort (with propylene glycol), (westwood-squibb). ointment: 0.2% westcort (with propylene glycol), (westwood-squibb).
•parenteral: for injection: 100 mg (of hydrocortisone) a-hydrocort (with benzyl alcohol 18 mg in univial), (hospira), solu-cortef (preservative-free in vials or with benzyl alcohol 18 mg in act-o-vial), (pfizer); 250 mg (of hydrocortisone) a-hydrocort ( with benzyl alcohol 18 mg in univial), (hospira), solu-cortef (with benzyl alcohol 16.4 mg in act-o-vial), (pfizer); 500 mg (of hydrocortisone) a-hydrocort (with benzyl alcohol 36 mg in univial), (hospira), solu-cortef (with benzyl alcohol 33.4 mg in act-o-vial), (pfizer), 1 g (of hydrocortisone) a-hydrocort ( with benzyl alcohol 72 mg in univial), (hospira), solu-cortef ( with benzyl alcohol 66.9 mg in act-o-vial), (pfizer). hydrocortisone sodium succinate
•parenteral: injection: 50 mg (of hydrocortisone) per ml hydrocortone phosphate (with parabens and sodium bisulfite), (merck). hydrocortisone sodium phosphate
•powder: parenteral: injectable suspension: 25 mgml, 50 mgml hydrocortone acetate (with benzyl alcohol), (merck). hydrocortisone acetate
•grade: usp. also used as acetate and sodium succinate salts.
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acticort | | | aeroseb-HC | | | ala-cort | | | ala-scalp | | | anucort-HC | | | anusol HC | | | anusol-HC | | | balneol-HC | | | barseb HC | | | cetacort | | | cobadex | | | colocort | | | corhydron | | | cort-dome | | | cortanal | | | cortenema | | | corticreme | | | cortifan | | | cortiment | | | cortisol alcohol | | | cortispray | | | cortolotion | | | cortonema | | | cortoxide | | | cortril | | | cremesone | | | delacort | | | dermacort | | | dermocortal | | | dermolate | | | dihydrocostisone | | (8S,9S,10R,11S,13S,14S,17R)-11,17- | dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one | | | dioderm | | | dome-cort | | | domolene-HC | | | efcorbin | | | efcortelan | | | efcortelin | | | eldecort | | | eldercort | | | epicort | | | epiderm H | | | esiderm H | | | evacort | | | ficortril | | | flexicort | | | genacort | | | glycort | | | h-cort | | | heb-cort | | | hi-cor | | | hidro-colisona | | | hidrocortisona | | | hycort | | | hydrasson | | | hydro-adreson | | | hydro-colisona | | | hydro-RX | | | hydrocort | | | hydroskin | | | hydroxycorticosterone | | 17- | hydroxycorticosterone | | | hydroxycortisone | | | hytone | | | incortin-H | | | kendall's compound F | | | komed HC | | | lacticare-HC | | | locoid | | | lubricort | | | maintasone | | | medicort | | | meusicort | | | mildison | | | nogenic HC | | | nutracort | | | optef | | | otosone-F | | | penecort | | | permicort | | | polcort H | | | pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11b)- | | | pregn-4-ene-3,20-dione, 11b,17,21-trihydroxy- | | 4- | pregnene-11b,17a,21-triol-3,20-dione | | | rectoid | | | reichstein's substance M | | | scheroson F | | | signef | | | stie-cort | | | synacort | | | tarcortin | | | texacort | | | timocort | | | traumaide | | (11b)-11,17,21- | trihydroxypregn-4-ene-3,20-dione | | 11b,17,21- | trihydroxyprogesterone | | | zenoxone |
Articles:
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the main glucocorticoid secreted by the adrenal cortex. its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.; As an oral or injectable drug, cortisol is also known as hydrocortisone. It is used as an immunosuppressive drug, given by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients who need steroid treatment but cannot take oral medication, and peri-operatively in patients on long-term steroid treatment to prevent an Addisonian crisis.; Cortisol or Hydrocortisone is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress. It increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Its synthetic counterpart (hydrocortisone) is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortisol is synthesized from pregnenolone. The amount of cortisol present in the serum undergoes diurnal variation, with the highest levels present in the early morning, and lower levels in the evening, several hours after the onset of sleep.; Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation. [HMDB]
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