Used in foods as a defoaming agent
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      H0091 Hexamethyldisiloxane >98.0%(GC)
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trimethyl(trimethylsilyloxy)silane (Click)
CAS Number: 107-46-0Picture of molecule
ECHA EINECS - REACH Pre-Reg: 203-492-7
Nikkaji Web: J3.247F
Beilstein Number: 1736258
MDL: MFCD00008265
Molecular Weight: 162.37926000
Formula: C6 H18 O Si2
NMR Predictor: Predict (works with chrome or firefox)
Category: antifoaming, emollient agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
Specific Gravity: 0.76400 @  25.00 °C.
Flash Point: 27.00 °F. TCC ( -2.78 °C. )
Soluble in:
 water, 0.93 mg/L @ 25 °C (exp)
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antifoaming agents
skin conditioning
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Santa Cruz Biotechnology
For experimental / research use only.
Hexamethyldisiloxane ≥98%
For experimental / research use only.
Hexamethyldisiloxane puriss., ≥98.5% (GC)
For experimental / research use only.
Hexamethyldisiloxane >98.0%(GC)
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Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-guinea pig LDLo  50000 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 332, 1948.

intraperitoneal-mouse LD50  4500 mg/kg
Russian Chemical Reviws Vol. 38, Pg. 975, 1969.

intraperitoneal-rat LDLo  1825 mg/kg
National Technical Information Service. Vol. OTS0572636

oral-rat LDLo  8 mL/kg
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 590, 1993.

Dermal Toxicity:
skin-rabbit LD50 16 mL/kg
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 590, 1993.

Inhalation Toxicity:
inhalation-rat LC50 15956 ppm/4H
National Technical Information Service. Vol. OTS0573658

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Safety in Use Information:
Category: antifoaming, emollient agents
Recommendation for disiloxane usage levels up to:
 not for fragrance use.
Recommendation for disiloxane flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 107-46-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 24764
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
Chemidplus: 0000107460
RTECS: JM9237000 for cas# 107-46-0
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NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 107-46-0
Pubchem (cid): 24764
Pubchem (sid): 135018296
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): HMDB33532
FooDB: FDB011592
Export Tariff Code: 2931.90.9010
Haz-Map: View
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
None Found
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Potential Uses:
 antifoaming agents 
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Occurrence (nature, food, other): note
 asparagus root
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 bay laurel plant
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 carob bean seed
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 cinnamon ceylon cinnamon bark
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 corn silk
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 cranberry fruit
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 cumin seed
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 hyssop plant
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 lettuce leaf
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 not found in nature
 pokeweed root
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 salsify seed
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 tea leaf
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 walnut black walnut pericarp
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 belsil DM 0.65
 silane, oxybis(trimethyl-
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PubMed: Formation of unexpected silicon- and disiloxane-bridged multiferrocenyl derivatives bearing Si-O-CH[double bond, length as m-dash]CH2 and Si-(CH2)2C(CH3)3 substituents via cleavage of tetrahydrofuran and trapping of its ring fragments.
PubMed: Reactivity of the Sterically Demanding Siloxanediol Mes2Si(OH)(µ-O)Si(OH)Mes2 Towards Water and Ether Molecules.
PubMed: Neutral and cationic bismuth compounds supported by bis(amidodimethyl)disiloxane ligands.
PubMed: Cu3(BTC)2 catalyzed dehydrogenative coupling of dimethylphenylsilane with phenol and homocoupling of dimethylphenylsilane to disiloxane.
PubMed: Improving the Solubility of Artificial Ligands of Streptavidin to Enable More Practical Reversible Switching of Protein Localization in Cells.
PubMed: Catalytic Synthesis of Saturated Oxygen Heterocycles by Hydrofunctionalization of Unactivated Olefins: Unprotected and Protected Strategies.
PubMed: Co-Catalyzed Hydroarylation of Unactivated Olefins.
PubMed: Disiloxane Synthesis Based on Silicon-Hydrogen Bond Activation using Gold and Platinum on Carbon in Water or Heavy Water.
PubMed: In situ generated polysiloxanes stabilizing μ3-oxo bridged Sb3 triangles.
PubMed: Disiloxanes and Functionalized Silica Gels: One Route, Two Complementary Outcomes-Guanidinium and Pyridinium Ion-Exchangers.
PubMed: Dimer formation upon deprotonation: synthesis and structure of a m-terphenyl substituted (R,S)-dilithium disiloxanolate disilanol.
PubMed: Charge and Spin States in Schiff Base Metal Complexes with a Disiloxane Unit Exhibiting a Strong Noninnocent Ligand Character: Synthesis, Structure, Spectroelectrochemistry, and Theoretical Calculations.
PubMed: SILA-421 activity in vitro against rifampicin-susceptible and rifampicin-resistant Mycobacterium tuberculosis, and in vivo in a murine tuberculosis model.
PubMed: Silanetriols as Powerful Starting Materials for Selective Condensation to Bulky POSS Cages.
PubMed: Easily processable highly ordered Langmuir-Blodgett films of quaterthiophene disiloxane dimer for monolayer organic field-effect transistors.
PubMed: Catalytic hydroamination of unactivated olefins using a Co catalyst for complex molecule synthesis.
PubMed: Enhanced hydrolytic stability of siliceous surfaces modified with pendant dipodal silanes.
PubMed: A 3,4-trans-fused cyclic protecting group facilitates α-selective catalytic synthesis of 2-deoxyglycosides.
PubMed: Computational study of structural properties of lithium cation complexes with carbamate-modified disiloxanes.
PubMed: Study of carbamate-modified disiloxane in porous PVDF-HFP membranes: new electrolytes/separators for lithium-ion batteries.
PubMed: Chain length selectivity during the polycondensation of siloxane-containing esters and alcohols by immobilized Candida antarctica lipase B.
PubMed: Electron transport characteristics in nanosegregated columnar phases of perylene tetracarboxylic bisimide derivatives bearing oligosiloxane chains.
PubMed: Convergent synthesis of 4-O-phosphorylated L-glycero-D-manno-heptosyl lipopolysaccharide core oligosaccharides based on regioselective cleavage of a 6,7-O-tetraisopropyldisiloxane-1,3-diyl protecting group.
PubMed: Synthesis of lipase-catalysed silicone-polyesters and silicone-polyamides at elevated temperatures.
PubMed: Preparation of vinyl silyl ethers and disiloxanes via the silyl-Heck reaction of silyl ditriflates.
PubMed: 2-Acetyl-amino-1,3,4,6-tetra-O-(tri-methyl-silyl)-2-de-oxy-α-d-gluco-pyran-ose.
PubMed: Nucleophilic addition to silyl-protected five-membered ring oxocarbenium ions governed by stereoelectronic effects.
PubMed: Chemistry and structures of hexakis(halogenomethyl)-, hexakis(azidomethyl)-, and hexakis(nitratomethyl)disiloxanes.
PubMed: Effects of two disiloxanes ALIS-409 and ALIS-421 on chemoprevention in model experiments.
PubMed: Hyperconjugative interactions in permethylated siloxanes and ethers: the nature of the SiO bond.
PubMed: Activity of the efflux pump inhibitor SILA 421 against drug-resistant tuberculosis.
PubMed: Disiloxanes with cyclic or non-cyclic carbamate moieties as electrolytes for lithium-ion batteries.
PubMed: Disila-analogues of the synthetic retinoids EC23 and TTNN: synthesis, structure and biological evaluation.
PubMed: Tetraisopropyldisiloxane-1,3-diyl as a versatile protecting group for pentopyranosides.
PubMed: Chemical properties of 1,3-bis(3-methacryloxypropyl)-1,1,3,3-tetramethyldisiloxane-methyl methacrylate copolymer.
PubMed: Assembly, growth, and catalytic activity of gold nanoparticles in hollow carbon nanofibers.
PubMed: Tetra-carbon-yl[bis-(diphenyl-phosphan-yl)tetra-methyl-disiloxane-κP,P']chromium(0).
PubMed: Anticancer effects of the organosilicon multidrug resistance modulator SILA 421.
PubMed: Highly mass-sensitive thin film plate acoustic resonators (FPAR).
PubMed: Self-assembly of linear and cyclic siloxane-containing mesogens: investigation of layered structures in bulk and thin films.
PubMed: Dissociation of the disilatricyclic diallylic dianion [(C4Ph4SiMe)2]-2 to the silole anion [MeSiC4Ph4]- by halide ion coordination or halide ion nucleophilic substitution at the silicon atom.
PubMed: A disiloxane-functionalized phosphonium-based ionic liquid as electrolyte for lithium-ion batteries.
PubMed: Synthesis of octyl S-glycosides of tri- to pentasaccharide fragments related to the GPI anchor of Trypanosoma brucei.
PubMed: Role of positive ions in determining the deposition rate and film chemistry of continuous wave hexamethyl disiloxane plasmas.
PubMed: Brønsted acid-promoted azide-olefin [3 + 2] cycloadditions for the preparation of contiguous aminopolyols: The importance of disiloxane ring size to a diastereoselective, bidirectional approach to zwittermicin A.
PubMed: Novel hard-block polyurethanes with high strength and transparency for biomedical applications.
PubMed: Vinyldisiloxanes: their synthesis, cross coupling and applications.
PubMed: An isolable bis-silylene oxide ("disilylenoxane") and its metal coordination.
PubMed: Unexpected formation of complexes between protonated organic ligand and neutral salt molecule studied by electrospray ionization mass spectrometry.
PubMed: The catalytic role of N-heterocyclic carbene in a metal-free conversion of carbon dioxide into methanol: a computational mechanism study.
PubMed: Si-C bond activation in the reaction of first generation Grubbs' catalyst with alkynylsilanes - formation of [Cl(2){P(C(6)H(11))(3)}(2)Ru(=CHCH=CHPh)] anddisiloxanes.
PubMed: Magnesium-mediated intramolecular reductive coupling: a stereoselective synthesis of C(2)-symmetric 3,4-bis-silyl-substituted adipic acid derivatives.
PubMed: Formation of two- and three-dimensional hybrid mesostructures from branched siloxane molecules.
PubMed: Tellurasiloxane cages containing Te(6)Si(4)O(12) and Te(6)Si(6)O(15) frameworks.
PubMed: SILA 421, an inhibitor of efflux pumps of cancer cells, enhances the killing of intracellular extensively drug-resistant tuberculosis (XDR-TB).
PubMed: Bis(η-penta-methyl-cyclo-penta-dien-yl)cobalt(II).
PubMed: Incorporation of Linear Spacer Molecules in Vapor Deposited Silicone Polymer Thin Films.
PubMed: Silanol-based pincer Pt(II) complexes: synthesis, structure, and unusual reactivity.
PubMed: Plasma treatments of PET meshes for fuel-water separation applications.
PubMed: Reduction of ribonucleosides to 2'-deoxyribonucleosides.
PubMed: Basic study of a new soft resin applied with bisfunctional siloxane oligomer.
PubMed: Elimination of plasmids by SILA compounds that inhibit efflux pumps of bacteria and cancer cells.
PubMed: Vascular activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance reverting agents in cancer cells.
PubMed: From a stable silylene to a mixed-valent disiloxane and an isolable silaformamide-borane complex with considerable silicon-oxygen double-bond character.
PubMed: Shell-cross-linked cylindrical Polyisoprene-b-polyferrocenylsilane (PI-b-PFS) block copolymer micelles: one-dimensional (1D) organometallic nanocylinders.
PubMed: Computational Requirements for Simulating the Structures and Proton Activity of Silicaceous Materials.
PubMed: 1-Hydr-oxy-1,1,3,3,3-penta-phenyl-disiloxane, [Si(2)O(OH)(Ph)(5)], at 150 K.
PubMed: 1-Hydr-oxy-1,1,3,3,3-penta-phenyl-disiloxane, [Si(2)O(OH)(Ph)(5)], at 100 K.
PubMed: An ab initio and DFT study of structure and vibrational spectra of disiloxane H3SiOSiH3 conformers. Comparison to experimental data.
PubMed: Si-O bonded interactions in silicate crystals and molecules: a comparison.
PubMed: Naphthalene-1,8-diylbis(diphenylmethylium) as an organic two-electron oxidant: benzidine synthesis via oxidative self-coupling of N,N-dialkylanilines.
PubMed: Hydrolysis of fluorosilanes: a theoretical study.
PubMed: Synthesis of epothilones via a silicon-tethered RCM reaction.
PubMed: Fluoride-promoted cross-coupling reactions of alkenylsilanols. Elucidation of the mechanism through spectroscopic and kinetic analysis.
PubMed: Stereoselective dialkylation of the proximal hydroxy groups of calix- and thiacalix[4]arenes.
PubMed: Endgroup-assisted siloxane bond cleavage in the gas phase.
PubMed: Intramolecular syn and anti hydrosilylation and silicon-assisted cross-coupling: highly regio- and stereoselective synthesis of trisubstituted allylic alcohols.
PubMed: The influence of plasma proteins and platelets on oxygen radical production and F-actin distribution in neutrophils adhering to polymer surfaces.
PubMed: Palladium-catalyzed asymmetric diene cyclization/hydrosilylation employing functionalized silanes and disiloxanes.
PubMed: Tautomeric equilibrium between penta- and hexacoordinate silicon chelates. A chloride bridge between two pentacoordinate silicons.
PubMed: Syntheses and reactions of the fluorinated cyclic thionylphosphazene NSO(Ar)[NPF(2)]2(Ar = 4-t-BuC(6)H(4)-) with difunctional reagents.
PubMed: Permeation of substituted silanes and siloxanes through selected gloves and protective clothing.
PubMed: Synthesis of alpha-galactosylated fragments related to the core-structure of the GPI anchor of Trypanosoma brucei.
PubMed: Disiloxane-protected 2-deoxyribonolactone as an efficient precursor to 1,2-dideoxy-1-beta-aryl-D-ribofuranoses.
PubMed: NaY zeolite as host for the selective heterogeneous oxidation of silanes and olefins with hydrogen peroxide catalyzed by methyltrioxorhenium
PubMed: Surface modification using a commercial triple quadrupole mass spectrometer.
PubMed: Study of Bond Angles and Bond Lengths in Disiloxane and Related Molecules in Terms of the Topology of the Electron Density and Its Laplacian.
PubMed: Estimation of monomer content in polymethyl methacrylate contact lens materials by Raman spectroscopy.
PubMed: Synthesis of octyl O- and S-glycosides related to the GPI anchor of Trypanosoma brucei and their in vitro galactosylation by trypanosomal alpha-galactosyltransferases.
PubMed: The chemiluminescence response of neutrophils on polymer surfaces made by glow discharge plasma polymerization.
PubMed: RF-plasma-modified polystyrene surfaces for studying complement activation.
PubMed: Studies on contact lens materials.
PubMed: A theoretical study of the Si-O bond in disiloxane and related molecules.
PubMed: The siloxane bond in contact lens materials: the siloxanyl alkyl methacrylate copolymers.
PubMed: Gas-to-liquid permeation in silicon-containing, crosslinked, glassy copolymers of methyl methacrylate.
PubMed: Shear-induced hemolysis with commercial and glow discharge silicones.
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