EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

hydroxyethylpiperazine ethane sulfonic acid
1-piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-


Name:2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
CAS Number: 7365-45-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:230-907-9
Nikkaji Web:J29.038F
Beilstein Number:0883043
XlogP3-AA:-4.00 (est)
Molecular Weight:238.30726000
Formula:C8 H18 N2 O4 S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:buffering agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 234.00 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -2.670 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: buffering agents
BOC Sciences
For experimental / research use only.
HEPES >98%
EMD Millipore
For experimental / research use only.
HEPES, Free Acid, Molecular Biology Grade
Santa Cruz Biotechnology
For experimental / research use only.
HEPES ≥99%
Sigma-Aldrich: Sigma
For experimental / research use only.
HEPES ≥99.5% (titration)
For experimental / research use only.
2-[4-(2-Hydroxyethyl)-1-piperazinyl]ethanesulfonic Acid [Good's buffer component for biological research] >99.0%(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-quail LD50 > 316 mg/kg
Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
Category: buffering agents
Recommendation for hydroxyethylpiperazine ethane sulfonic acid usage levels up to:
 not for fragrance use.
Recommendation for hydroxyethylpiperazine ethane sulfonic acid flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):7365-45-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :23831
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
RTECS:TL6809000 for cas# 7365-45-9
 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:7365-45-9
Pubchem (cid):23831
Pubchem (sid):134987104
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.59.9500
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
4-(2-hydroxyethyl) piperazin-1-ylethane sulfonic acid
4-(2-hydroxyethyl)-1-piperazineethane sulfonic acid
4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid
2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
4-(2-hydroxyethyl)piperazin-1-ylethanesulphonic acid
N-2-hydroxyethylpiperazine N',2'-ethanesulfonic acid
N-2-hydroxyethylpiperazine-N-ethane sulfonic acid
N-2-hydroxyethylpiperazine-N'-ethanesulfonic acid
1-piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-


PubMed:Potassium conductance causing hyperpolarization of CA1 hippocampal neurons during hypoxia.
PubMed:Effects of CO2-HCO3- on catecholamine efflux from cat carotid body.
PubMed:Effects of in-vivo administration of taurine and HEPES on the inflammatory response in rats.
PubMed:Characterization of Na(+)-H+ exchange in segments of rat mesenteric artery.
PubMed:Cation transport in vascular endothelial cells and aging.
PubMed:Contrasting effects of HEPES vs HCO3(-)-buffered media on whole-cell currents in cultured chemoreceptors of the rat carotid body.
PubMed:Acid-base regulation of ion transport in rabbit ileum in vitro.
PubMed:Mitochondrial carbonic anhydrase is involved in rat renal glucose synthesis.
PubMed:Regulation of ion transport in porcine gallbladder: effects of VIP and norepinephrine.
PubMed:Serosal bicarbonate protects against acid injury to rabbit esophagus.
PubMed:Catalase protection of neuronal survival in vitro is not directed to the accumulation of peroxides in the culture medium.
PubMed:Influence of cell isolation and incubation procedures on Ca2+ dependence of glucose transport in isolated cardiac myocytes.
PubMed:Effects of inhibitors of Cl conductance on Cl self-exchange in rabbit cortical collecting tubule.
PubMed:Influence of surface pH on intracellular pH regulation in cardiac and skeletal muscle.
PubMed:Effect of hydroxyethylpiperazine N-2 ethane sulphonic acid (HEPES) on the thrombin clotting time and fibrin polymerisation.
PubMed:HEPES buffered media may induce prostaglandin release from macrophages in tissue culture.
PubMed:Effects of divalent cations on dynein cross bridging and ciliary microtubule sliding.
PubMed:The effect of different buffers on terminal deoxynucleotidyl transferase activity.
PubMed:Optimal conditions for protein synthesis in incubated slices of rat brain.
PubMed:Effect of pH on the immunogenicity of Mycoplasma pneumoniae.
a dipolar ionic buffer.
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