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harmine hydrochloride hydrate
9H-pyrido[3,4-b]indole, 7-methoxy-1-methyl-, hydrochloride (1:1)

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Name:7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride
CAS Number: 343-27-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:206-443-8
FDA UNII: T89I34ODAA
MDL:MFCD00012641
Molecular Weight:248.71181000
Formula:C13 H13 Cl N2 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 264.00 to 266.00 °C. @ 760.00 mm Hg
Boiling Point: 421.40 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000001 mmHg @ 25.00 °C. (est)
Flash Point: 284.00 °F. TCC ( 139.80 °C. ) (est)
logP (o/w): 3.173 (est)
Soluble in:
 water, 13.66 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Harmine Hydrochloride >98%
Odor: characteristic
Use: Harmine hydrochloride has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation
Coompo
For experimental / research use only.
Harmine Hydrochloride from Plants ≥98%
Penta International
HARMINE HYDROCHLORIDE
Santa Cruz Biotechnology
For experimental / research use only.
Harmine hydrochloride ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Harmine Hydrochloride ∼98%
sds
TCI AMERICA
For experimental / research use only.
Harmine Hydrochloride >98.0%(HPLC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 38 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 79, Pg. 127, 1943.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for harmine hydrochloride hydrate usage levels up to:
 not for fragrance use.
 
Recommendation for harmine hydrochloride hydrate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5359389
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride
Chemidplus:0000343271
RTECS:MG9450000 for cas# 343-27-1
 
References:
 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5359389
Pubchem (sid):134974819
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2939.99.0000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 rue wild rue seeds
Search Trop Picture
 
Synonyms:
 harmine hydrochloride
 harmine monohydrochloride
 harmine, hydrochloride
7-methoxy-1-methyl-9H-pyrido(3,4-b)indole hydrochloride
7-methoxy-1-methyl-9H-pyrido[3,4-b]indole hydrochloride
7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride
7-methoxy-1-methylbeta-carboline, chloride
9H-pyrido(3,4-b)indole, 7-methoxy-1-methyl-, monohydrochloride
9H-pyrido[3,4-b]indole, 7-methoxy-1-methyl-, hydrochloride (1:1)
9H-pyrido[3,4-b]indole, 7-methoxy-1-methyl-, monohydrochloride
 

Articles:

PubMed:Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma.
PubMed:Negative-mode MALDI mass spectrometry for the analysis of pigments using tetrathiafulvalene as a matrix.
PubMed:Solid-phase fluorescence and ionization efficiency in negative-ion matrix-assisted laser desorption/ionization of neutral oligosaccharides: interaction between beta-carboline matrix and ammonium salt.
PubMed:Structural features controlling the binding of beta-carbolines to the benzodiazepine receptor.
 
Notes:
alkaloid isolated from seeds of peganum harmala l., zygophyllaceae. it is identical to banisterine, or telepathine, from banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western amazon region from related plants. it has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic parkinson disease in the 1920's.
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