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harmaline hydrochloride dihydrate
3H-pyrido[3,4-b]indolium, 4,9-dihydro-7-methoxy-1-methyl-, chloride (1:1)

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Name:7-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-9-ium;chloride
CAS Number: 6027-98-1Picture of molecule3D/inchi
FDA UNII: 5B4DGH2M9R
Beilstein Number:6493114
MDL:MFCD00150052
Molecular Weight:250.72775000
Formula:C13 H15 Cl N2 O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 234.00 to 236.00 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Harmaline hydrochloride dihydrate 98%
Odor: characteristic
Use: Harmaline hydrochloride dihydrate is an alkaloid isolated from the seed of Peganum harmala L. with an anti-tumor property.
Glentham Life Sciences
Harmaline Hydrochloride
Sigma-Aldrich: Sigma
For experimental / research use only.
Harmaline Hydrochloride Dihydrate ≥95%
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
subcutaneous-cat LDLo 100 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Transactions of the Royal Society of Edinburgh. Vol. 47, Pg. 245, 1909.

subcutaneous-frog LDLo 250 mg/kg
Transactions of the Royal Society of Edinburgh. Vol. 47, Pg. 245, 1909.

subcutaneous-guinea pig LDLo 100 mg/kg
Transactions of the Royal Society of Edinburgh. Vol. 47, Pg. 245, 1909.

subcutaneous-rabbit LDLo 100 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Transactions of the Royal Society of Edinburgh. Vol. 47, Pg. 245, 1909.

subcutaneous-rat LDLo 120 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Transactions of the Royal Society of Edinburgh. Vol. 47, Pg. 245, 1909.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for harmaline hydrochloride dihydrate usage levels up to:
 not for fragrance use.
 
Recommendation for harmaline hydrochloride dihydrate flavor usage levels up to:
 not for flavor use.
 
Safety References:
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :22381
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
7-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-9-ium;chloride
Chemidplus:0006027981
RTECS:MG8750000 for cas# 6027-98-1
 
References:
 7-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-9-ium;chloride
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):22381
Pubchem (sid):134987466
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2939.90.5000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 rue wild rue seeds
Search Trop Picture
 
Synonyms:
7-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-9-ium;chloride
3H-pyrido[3,4-b]indolium, 4,9-dihydro-7-methoxy-1-methyl-, chloride (1:1)
 

Articles:

PubMed:Harmaline-induced tremor in mice: videotape documentation and open questions about the model.
PubMed:Cross-resistance and biochemical studies with two classes of HeLa cell mutants resistant to cardiac glycosides. The unusual behavior of cardenolide SC4453.
PubMed:Substitution of natural conditioned and unconditioned stimuli by artificial stimuli does not prevent acquisition of conditioned taste aversion in rats.
PubMed:Central mediation of the conditioned taste aversion induced in rats by harmaline.
PubMed:Effect of harmine and harmaline hydrochloride on pregnancy in white rats.
 
Notes:
None found
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