germanium dioxide
germanium(IV) oxide
 
Notes:
has antimutagenic effects.
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dioxogermane (Click)
CAS Number: 1310-53-8Picture of molecule
Other: 12687-69-3
ECHA EINECS - REACH Pre-Reg: 215-180-8
FDA UNII: 5O6CM4W76A
MDL: MFCD00011030
Molecular Weight: 104.62840000
Formula: Ge O2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antimicrobial agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
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Physical Properties:
Appearance: white powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 6.23900 @  25.00 °C.
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antimicrobial agents
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Suppliers:
BOC Sciences
For experimental / research use only.
Germanium dioxide 99.99%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Germanium(IV) oxide ≥99.99% trace metals basis
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-guinea pig LDLo  400 mg/kg
Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.

oral-man TDLo  1614 mg/kg/22W
BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Nephron. Vol. 54, Pg. 53, 1990.

intraperitoneal-mouse LD50  1550 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 671, 1978.

oral-mouse LD50  1250 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 71, 1982.

intraperitoneal-rat LD50  750 mg/kg
LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 8, Pg. 466, 1953.

oral-rat LD50  1250 mg/kg
"Investigations in the Field of Organogermanium Chemistry," Rijkens, F., and G.J.M. Van Der Kerk, Utrecht, Netherlands, Schotanus & Jens Utrecht N.V., 1964Vol. -, Pg. 95, 1964.

Dermal Toxicity:
subcutaneous-mouse LD50 2550 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 773, 1981.

subcutaneous-rabbit LD50 845 mg/kg
Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.

subcutaneous-rat LD50 1910 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 773, 1981.

Inhalation Toxicity:
inhalation-rat LC50 > 1420 mg/m3/4H
SKIN AND APPENDAGES (SKIN): HAIR: OTHER LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Food and Chemical Toxicology. Vol. 32, Pg. 1037, 1994.

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Safety in Use Information:
Category: antimicrobial agents
Recommendation for germanium dioxide usage levels up to:
 not for fragrance use.
 
Recommendation for germanium dioxide flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Daily Med: search
NLM Hazardous Substances Data Bank: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 1310-53-8
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 14796
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 dioxogermane
Chemidplus: 0001310538
RTECS: LY5240000 for cas# 1310-53-8
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References:
 dioxogermane
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 14796
Pubchem (sid): 134979983
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2825.60.0000
Haz-Map: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
grades: technical; semiconductor 99.999% pure.
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 dioxogermane
 germanium(IV) oxide
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Articles:
PubMed: Synthesis, Surface Properties and Antimicrobial Activity of Some Germanium Nonionic Surfactants.
PubMed: Determination of trace impurities in germanium dioxide by ICP-OES, ICP-MS and ETAAS after matrix volatilization: a long-run performance of the method.
PubMed: Surfactant-free synthesis of GeO(2) nanocrystals with controlled morphologies.
PubMed: Enhanced device performance of germanium nanowire junctionless (GeNW-JL) MOSFETs by germanide contact formation with Ar plasma treatment.
PubMed: Thermodynamic properties of the α-quartz-type and rutile-type GeO2 from first-principles calculations.
PubMed: Ab initio study of the high-temperature phase transition in crystalline GeO2.
PubMed: High-fidelity chemical patterning on oxide-free germanium.
PubMed: Surface-associated fucoxanthin mediates settlement of bacterial epiphytes on the rockweed Fucus vesiculosus.
PubMed: [Effects of germanium on cell growth, polysaccharide production and cellular redox status in suspension cultures of protocorm-like bodies of Dendrobium huoshanense].
PubMed: Synthesis and biological activity of 3-(2, 8, 9-trioxa-aza-1-germatricyclo [3. 3. 3. 0] undecane-1-yl)-caffeic acid.
PubMed: Metabolism of tellurium, antimony and germanium simultaneously administered to rats.
PubMed: Functional changes on ascending auditory pathway in rats caused by germanium dioxide exposure: an electrophysiological study.
PubMed: Dermal absorption of inorganic germanium in rats.
PubMed: Versatile biomimetic dendrimer templates used in the formation of TiO2 and GeO2.
PubMed: Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss.
PubMed: Germanium dioxide induces mitochondria-mediated apoptosis in Neuro-2A cells.
PubMed: Oxygen sites and network coordination in sodium germanate glasses and crystals: high-resolution oxygen-17 and sodium-23 NMR.
PubMed: Synthesis and structure of dilacunary decatungstogermanate, [gamma-GeW10O36]8-.
PubMed: Simulated structural and thermal properties of glassy and liquid germania.
PubMed: Cochlear damage due to germanium-induced mitochondrial dysfunction in guinea pigs.
PubMed: Germanium dioxide as internal standard for simplified trace determination of bromate, bromide, iodate and iodide by on-line coupling ion chromatography-inductively coupled plasma mass spectrometry.
PubMed: Analytical product study of germanium-containing medicine by different ICP-MS applications.
PubMed: GeO2 fibers: preparation, morphology and photoluminescence property.
PubMed: Synthesis, structural characterization, and thermal stability of a new layered germanate structure, Na4Ge16O28(OH)12.
PubMed: Structural refinements of high-pressure phases in germanium dioxide.
PubMed: The pathogenesis of experimental model of mitochondrial myopathy induced by germanium dioxide.
PubMed: Synthesis and crystal structure of a novel germanate: (NH4)4[(GeO2)3(GeO1.5F3)2].0.67H2O.
PubMed: Water structure around enkephalin near a GeO2 surface: a molecular dynamics study.
PubMed: [Effect of coordinational germanium compounds on enzyme synthesis and activity].
PubMed: Direct formation of Ge-C bonds from GeO(2).
PubMed: New opportunities for high-resolution solid-state NMR spectroscopy of oxide materials at 21.1- and 18.8-T fields.
PubMed: On the structure of Ge/GeO2 glasses.
PubMed: Preventive effect of germanium dioxide on the inhibition of gap junctional intercellular communication by TPA.
PubMed: L-Arginine treatment may prevent tubulointerstitial nephropathy caused by germanium dioxide.
PubMed: Kinetics of germanium dioxide in rats.
PubMed: Enzyme histochemical study of germanium dioxide-induced mitochondrial myopathy in rats.
PubMed: Hazard assessment of germanium supplements.
PubMed: Photoinduced absorption change in germanosilicate preforms: evidence for the color-center model of photosensitivity.
PubMed: Acute and subacute inhalation toxicity of germanium dioxide in rats.
PubMed: Influence of propagermanium (SK-818) on chemically induced renal lesions in rats.
PubMed: Low-frequency Raman scattering from CdS microcrystals embedded in a germanium dioxide glass matrix.
PubMed: Experimental germanium dioxide-induced neuropathy in rats.
PubMed: Chronic tubulointerstitial changes induced by germanium dioxide in comparison with carboxyethylgermanium sesquioxide.
PubMed: Nephrotoxicity and neurotoxicity in humans from organogermanium compounds and germanium dioxide.
PubMed: [The effect of silicon metabolism on genetic transformation in Bacillus subtilis].
PubMed: [An autopsy case of chronic germanium intoxication presenting peripheral neuropathy, spinal ataxia, and chronic renal failure].
PubMed: Dose dependency of germanium-dioxide-induced nephrotoxicity in rats.
PubMed: Experimental germanium myopathy.
PubMed: Nephrotoxicity in humans by the ultratrace element germanium.
PubMed: Subacute nephrotoxicity of germanium dioxide in the experimental animal.
PubMed: Germanium dioxide-induced nephropathy: a new type of renal disease.
PubMed: [Evaluation of germanium dioxide neurotoxicity in rats and monkeys].
PubMed: [A case of persistent renal dysfunction following chronic intake of germanium dioxide-containing food. A long-term clinical observation with repeated kidney biopsy].
PubMed: Germanium-induced nephropathy: report of two cases and review of the literature.
PubMed: [Combined effects of arsenous anhydride and germanium dioxide after their hygienic regulation in atmospheric air].
PubMed: Efficient single-pass Raman generation in a GeO2 optical fiber and its application to measurement of chromatic dispersion.
PubMed: Difference spectrophotometric assay of 1,2-diphenolic drugs in pharmaceutical formulations -III. The simultaneous assay of levodopa and benserazide.
PubMed: Difference spectrophotometric assay of 1,2-diphenolic drugs in pharmaceutical formulations II: Germanium dioxide reagent.
PubMed: Spectrophotometric extracave titrations-VII Titrations with di-2-naphthylthiocarbazone.
PubMed: Spectrophotometric extractive titrations-IV Determination of zinc in germanium dioxide and germanium chloride.
PubMed: Substitution of germanium for boron in plant growth.
PubMed: THE ERYTHROPOIETIC ACTION OF GERMANIUM DIOXIDE : II. THE SOURCE OF THE ERYTHROCYTHEMIA PRODUCED BY GERMANIUM DIOXIDE IN THE ALBINO RAT.
PubMed: THE ERYTHROPOIETIC ACTION OF GERMANIUM DIOXIDE.
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