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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 97.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 329.20 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 307.00 °F. TCC ( 152.90 °C. ) (est)
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| logP (o/w): | 1.960 (est) |
| Soluble in: |
| | water, 271.2 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-dog LD50 180 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING
Japanese Journal of Antibiotics. Vol. 29, Pg. 439, 1976.
oral-dog LD50 200 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Japanese Journal of Antibiotics. Vol. 29, Pg. 439, 1976.
intraperitoneal-mouse LD50 75 mg/kg
Journal of Pharmacobio-Dynamics. Vol. 6, Pg. 922, 1983.
intravenous-mouse LD50 100 mg/kg
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Antibiotics. Vol. 22, Pg. 228, 1969.
oral-mouse LD50 180 mg/kg
Journal of Pharmacobio-Dynamics. Vol. 6, Pg. 922, 1983.
intravenous-rabbit LD50 150 mg/kg
Japanese Journal of Antibiotics. Vol. 29, Pg. 439, 1976.
oral-rabbit LD50 310 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Japanese Journal of Antibiotics. Vol. 29, Pg. 439, 1976.
intraperitoneal-rat LD50 250 mg/kg
Japanese Journal of Antibiotics. Vol. 29, Pg. 439, 1976.
intravenous-rat LD50 210 mg/kg
Japanese Journal of Antibiotics. Vol. 29, Pg. 439, 1976.
oral-rat LD50 480 mg/kg
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Japanese Journal of Antibiotics. Vol. 29, Pg. 439, 1976.
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| Dermal Toxicity: |
subcutaneous-mouse LD50 140 mg/kg
Japanese Journal of Antibiotics. Vol. 29, Pg. 439, 1976.
subcutaneous-rat LD50 300 mg/kg
Japanese Journal of Antibiotics. Vol. 29, Pg. 439, 1976.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for fusaric acid usage levels up to: | | | not for fragrance use.
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| Recommendation for fusaric acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 5- | butyl pyridine-3-carboxylic acid | | 5- | butyl-2-pyridinecarboxylic acid | | 5- | butylpicolinic acid | | 5- | butylpyridine-2-carboxylic acid | | 5-N- | butylpyridine-2-carboxylic acid | | | fusarinic acid | | | picolinic acid, 5-butyl- | | | picolinic acid, 5-butyl- (8CI)
| | 2- | pyridinecarboxylic acid, 5-butyl- |
Articles:
| PubMed:Native cell-death genes as candidates for developing wilt resistance in transgenic banana plants. |
| PubMed:Fusarium verticillioides SGE1 is required for full virulence and regulates expression of protein effector and secondary metabolite biosynthetic genes. |
| PubMed:Characterization of the fusaric acid gene cluster in Fusarium fujikuroi. |
| PubMed:The effects of different yeast extracts on secondary metabolite production in Fusarium. |
| PubMed:Determination of fusaric acid in maize using molecularly imprinted SPE clean-up. |
| PubMed:Contamination of bananas with beauvericin and fusaric acid produced by Fusarium oxysporum f. sp. cubense. |
| PubMed:Mycotoxins in corn and wheat silage in Israel. |
| PubMed:Masked mycotoxins: a review. |
| PubMed:Identification of gene clusters associated with fusaric acid, fusarin, and perithecial pigment production in Fusarium verticillioides. |
| PubMed:Single-kernel analysis of fumonisins and other fungal metabolites in maize from South African subsistence farmers. |
| PubMed:Ultrahigh-performance liquid chromatographic-tandem mass spectrometric multimycotoxin method for quantitating 26 mycotoxins in maize silage. |
| PubMed:Fusarium species (section Liseola) occurrence and natural incidence of beauvericin, fusaproliferin and fumonisins in maize hybrids harvested in Mexico. |
| PubMed:Nuclear magnetic resonance (NMR) studies on the biosynthesis of fusaric acid from Fusarium oxysporum f. sp. vasinfectum. |
| PubMed:Feed contaminated with Fusarium toxins alter lymphocyte proliferation and apoptosis in primiparous sows during the perinatal period. |
| PubMed:Identification, mycotoxin risk and pathogenicity of Fusarium species associated with fig endosepsis in Apulia, Italy. |
| PubMed:Effects of a deoxynivalenol-contaminated diet on the reproductive performance and immunoglobulin concentrations in pigs. |
| PubMed:[Study of specificity of fungistatic effect of trichothecene mycotoxins]. |
| PubMed:Bikaverin and fusaric acid from Fusarium oxysporum show antioomycete activity against Phytophthora infestans. |
| PubMed:Effects of foodborne Fusarium mycotoxins with and without a polymeric glucomannan mycotoxin adsorbent on food intake and nutrient digestibility, body weight, and physical and clinicopathologic variables of mature dogs. |
| PubMed:Mycotoxins and the pet food industry: toxicological evidence and risk assessment. |
| PubMed:Mycotoxin producing Fusarium species associated with plant disease on potato, wheat, corn and animal diseases in northwest Iran. |
| PubMed:Growth-inhibiting effects of concentrations of fusaric acid on the growth of Bacillus mojavensis and other biocontrol Bacillus species. |
| PubMed:Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on growth and immunological parameters of broiler chickens. |
| PubMed:Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on feed intake, serum chemistry, and hematology of horses, and the efficacy of a polymeric glucomannan mycotoxin adsorbent. |
| PubMed:Antioxidant nutrients and mycotoxins. |
| PubMed:Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on production and metabolism in broilers. |
| PubMed:Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick. |
| PubMed:Degradation and transformation of a potential natural herbicide in three soils. |
| PubMed:Fusaric acid and modification of the subchronic toxicity to rats of fumonisins in F. moniliforme culture material. |
| PubMed:Biological detoxification of fungal toxins and its use in plant breeding, feed and food production. |
| PubMed:Induction of food intake by a noradrenergic system using clonidine and fusaric acid in the neonatal chick. |
| PubMed:Production of fusaric acid by Fusarium species. |
| PubMed:Effects of mycotoxins on cytokine production and proliferation in EL-4 thymoma cells. |
| PubMed:Neuropharmacological studies on Fusarium toxins--II: Total toxin extract from F. oxysporum. |
| PubMed:Fusaric acid in Fusarium moniliforme cultures, corn, and feeds toxic to livestock and the neurochemical effects in the brain and pineal gland of rats. |
| PubMed:Decreased cell-mediated immunity and lack of skeletal problems in broiler chickens consuming diets amended with fusaric acid. |
| PubMed:Taxonomy and biology of Fusarium moniliforme. |
| PubMed:Biological and chemical characterization of metabolites of Fusarium moniliforme isolates. |
| PubMed:Dopamine-beta-hydroxylase inhibitors, feeding and locomotor activity: reinstatement of feeding following central norepinephrine. |
| PubMed:Mouse bioassay for Fusarium metabolites: rejection or acceptance when dissolved in drinking water. |
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a picolinic acid derivative isolated from various fusarium species. it has been proposed for a variety of therapeutic applications but is primarily used as a research tool. its mechanisms of action are poorly understood. it probably inhibits dopamine beta-hydroxylase, the enzyme that converts dopamine to norepinephrine. it may also have other actions, including the inhibition of cell proliferation and dna synthesis.
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3D/inchi